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    • 3. 发明公开
    • 항종양제로서의 비스(아크리딘카복스아미드) 및 비스(페나진카복스아미드)
    • BIS(ACRIDINECARBOXAMIDE)和BIS(PHENAZINECARBAMAMIDE)作为抗菌剂
    • KR1020000049252A
    • 2000-07-25
    • KR1019997003357
    • 1997-10-17
    • 제노바 리미티드
    • 데니윌리암알렉산더가마지스와르날라타아쿠리타야스파이서줄리안바굴리브루스찰스핀레이그래엠존
    • C07D219/04
    • C07C227/18C07D219/04C07C229/58
    • PURPOSE: Compounds useful as antitumor agents are provided which are bis(acridinecarboxamide) or bis(phenazinecarboxamide) derivatives having antitumor properties. CONSTITUTION: Bis(acridinecarboxamide) or bis(phenazinecarboxamide) derivatives are represented by formula (I), wherein each X, which can be the same or different in a given molecule, is -CH= or -N= each of R1 to R4 which can be the same or different, H, C1-C4 alkyl, OH, SH, NH2, C1-C4 alkoxy, aryloxy, NHR, N(R)2, SR, SO2R wherein R is C1-C4 alkyl, CF3, NO2 or halogen, or R1 and R2 together form a methylenedioxy group; each of R5 and R6, which can be the same or different, is H or C1-C4 alkyl; Z is (CH2)n, (CH2)nO(CH2)n, (CH2)nN(R7) (CH2)n, (CH2)nN(R7) (CH2)mN(R7) (CH2)n or (CH2)nN(CH2CH2)2N(CH2)n wherein R7 is H or C1-C4 alkyl and n and m, which can be the same or different, are each an integer of 1 to 4; or a pharmaceutically acceptable acid addition salt or N-oxide thereof; has activity as an antitumor and antibacterial agent.
    • 目的:提供可用作抗肿瘤剂的双(吖啶甲酰胺)或具有抗肿瘤性质的双(吩嗪甲酰胺)衍生物的化合物。 构成:双(吖啶甲酰胺)或双(吩嗪甲酰胺)衍生物由式(I)表示,其中在给定分子中可以相同或不同的每个X是-CH =或-N = R 1至R 4各自 可以相同或不同,H,C 1 -C 4烷基,OH,SH,NH 2,C 1 -C 4烷氧基,芳氧基,NHR,N(R)2,SR,SO 2 R,其中R是C 1 -C 4烷基,CF 3,NO 2或 卤素,或R1和R2一起形成亚甲二氧基; R 5和R 6可以相同或不同,为H或C 1 -C 4烷基; Z为(CH 2)n,(CH 2)n O(CH 2)n,(CH 2)n N(R 7)(CH 2)n,(CH 2)n N(R 7) nN(CH 2 CH 2)2 N(CH 2)n其中R 7为H或C 1 -C 4烷基,n和m可相同或不同,为1〜4的整数。 或其药学上可接受的酸加成盐或N-氧化物; 具有抗肿瘤和抗菌剂的作用。