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1. 发明专利

JPS61260900A METHOD FOR MEASURING ACTIVITY OF GAMMA-GLUTAMYL TRANSPEPTIDASE 失效
公开(公告)号：JPS61260900A
公开(公告)日：1986-11-19
申请号：JP10003485
申请日：1985-05-11
申请人： WAKO PURE CHEM IND LTD
发明人： TOKUDA KUNIAKI , MORII SEIJI , YAMANISHI KAZUHIKO
IPC分类号： C08B37/16 , C12Q1/48
摘要： PURPOSE:To improve the solubility of a substrate and measure readily and quantitatively the enzymic activity, by measuring the activity of gamma-glutamyl transpeptidase in the presence of a modified cyclodextrin in the method for measuring the titled substance using gamma-L-glutamyl-p-nitroanilide as the substrate. CONSTITUTION:The activity of gamma-glutamyl transpeptidase is measured in the presence of a modified cyclodextrin expressed by formula I or II using gamma-L- glutamyl-p-nitroanilide as a substrate. The modified cyclodextrin effectively entraps the substrate gamma-L-glutamyl-p-nitroanilide and improves the water- solubility of the substrate without suppressing the enzymic activity of the gamma- glutamyl transpeptidase (gamma-GTP). Thus, the enzymic activity of the titled substance can be readily and quantitatively measured.

2. 发明专利

JPH0368868B2 失效
公开(公告)号：JPH0368868B2
公开(公告)日：1991-10-30
申请号：JP18249783
申请日：1983-09-30
申请人： WAKO PURE CHEM IND LTD
发明人： OGATA HIROSHI , YAMASATO FUJIO , ISHIHARA MASAMI , OOBA HITOSHI , MORII SEIJI , HAYASHIDA KAZUYOSHI
IPC分类号： C07D417/04 , C07D257/00 , C07D257/04 , C07D277/00 , C12Q1/26 , G01N33/92

3. 发明专利

JPH01197493A NOVEL 2-CHLORONITROPHENYL PHOSPHATE AND METHOD FOR MEASURING PHOSPHATASE ACTIVITY USING SAID PHOSPHATE 失效
公开(公告)号：JPH01197493A
公开(公告)日：1989-08-09
申请号：JP2147988
申请日：1988-02-01
申请人： WAKO PURE CHEM IND LTD
发明人： TAKAYAMA KOICHI , TOKUDA KUNIAKI , MORII SEIJI
IPC分类号： C12Q1/42 , C07F9/12
摘要： NEW MATERIAL:A compound expressed by formula I (A is K, ammonium, ethyl-2-hydroxyethylammonium, 1,1-dimethyl-2-bydroxpthylammonium, etc.). USE:A substrate for measuring phosphatase activity and photoreceptor participating in photochemical reaction excellent in preservation and thermal stability and further solubility in water. PREPARATION:For example, 2-chloronitrophenol expressed by formula II is dissolved in a solvent, such as benzene, and reacted with phosphorus oxychloride in the presence of a deacidifying agent, such as pyridine, to provide a phenyl phosphoryl chloride derivative expressed by formula III, which is then hydrolyzed. The resultant phenyl pbosphate derivative expressed by formula IV is subjected to reaction for forming a salt with the corresponding base or salts.

4. 发明专利

JPS63122701A NOVEL CYCLODEXTRIN DERIVATIVE AND PRODUCTION THEREOF 失效
公开(公告)号：JPS63122701A
公开(公告)日：1988-05-26
申请号：JP26885486
申请日：1986-11-12
申请人： WAKO PURE CHEM IND LTD
发明人： TOKUDA KUNIAKI , MORII SEIJI , YAMANISHI KAZUHIKO
IPC分类号： C08B37/16
摘要： PURPOSE:To obtain a novel cyclodextrin derivative with clathration effect, thus useful as a solubilizing agent for sparingly water-soluble substances, by reaction between a 3-halo-1-propanol and cyclodextrin in the presence of a base. CONSTITUTION:A reaction is carried out, in the presence of a base either between (1) a 3-halo-(1-propanol or 1-halo-2-methyl-2-propanol of formula I or II (X is halogen), respectively and (2) cyclodextrin or between (3) 2-methyl-1,2- propylene oxide and (4) cyclodextrin to obtain the objective derivative, i.e., cyclodextrin-hydroxyalkyl ether of formula III [n is 6-8; two or more of 3Xn Rs are groups of formula IV or V (m is 1-5), the rest being H]. This compound is useful as a solubilizing agent or stabilizer for sparingly water-soluble pharmaceuticals in the drug sector and for sparingly water-soluble color- developing agents and substrates in the clinical testing field.

5. 发明专利

JPS60160896A MEASURING METHOD OF ACTIVITY OF GAMMA-GLUTAMYL- TRANSPEPTIDASE 失效
公开(公告)号：JPS60160896A
公开(公告)日：1985-08-22
申请号：JP1658984
申请日：1984-01-31
申请人： WAKO PURE CHEM IND LTD
发明人： YAMASATO FUJIO , MORII SEIJI , SAMEJIMA KAZUHIKO , ISHIHARA MASAMI
IPC分类号： C12Q1/48
摘要： PURPOSE:To measure easily and quantitatively enzymatic activity of gamma-glutamyltranspeptidase, by adding a modified cyclodextrin to a measurement system so that water solubility of a substrate, L-gamma-glutamyl-p-nitronilide, is extremely improved. CONSTITUTION:In measuring enzymatic activity of gamma-glutamyl-transpeptidase by using L-gamma-nitroanilide as a substrate, a modified cyclodextrin shown by the formula beta-CD(-OH)21-m(-OH)m [CD is cyclodextrin residue; X is NO2, PO3H, SO3H, -(CH2)nY; Y is -SO3H, or -CO2H; m is 1-5, n is 1-4 integer] such as beta-CD (-OH)21-2(NO2)2 is added to a measurement system.

6. 发明专利

JPH0516837B2 失效
公开(公告)号：JPH0516837B2
公开(公告)日：1993-03-05
申请号：JP1658984
申请日：1984-01-31
申请人： WAKO PURE CHEM IND LTD
发明人： YAMASATO FUJIO , MORII SEIJI , SAMEJIMA KAZUHIKO , ISHIHARA MASAMI
IPC分类号： C12Q1/48

7. 发明专利

JPH01131202A NOVEL ENTERIC MOLECULE CAPSULE 失效
公开(公告)号：JPH01131202A
公开(公告)日：1989-05-24
申请号：JP21200688
申请日：1988-08-26
申请人： WAKO PURE CHEM IND LTD
发明人： KAMIKAMA KANEHITO , HIRAYAMA FUMITOSHI , TOKUDA KUNIAKI , MORII SEIJI
IPC分类号： A61K47/40 , A61K47/00 , C08B37/16
摘要： PURPOSE:To provide a stable enteric molecule capsule composed of a specific cyclodextrin derivative and exhibiting excellent characteristics as an enteric carrier for drugs. CONSTITUTION:The objective enteric molecule capsule contains a cyclodextrin derivative of formula I [n is 6-8; R is 2-4C carboxyalkyl, 2-4C alkyl or H; provided that at least one of R is 2-4C carboxyalkyl, 3-(3n-1) R groups are 2-4C alkyl and the remaining R groups are H]. Among the cyclodextrin derivatives of formula I, especially preferable compound is a beta-cyclodextrin derivative of formula II having a solubility of

8. 发明专利

JPS6461430A DRUG CARRIER WITH LOW IRRITANCY 失效
公开(公告)号：JPS6461430A
公开(公告)日：1989-03-08
申请号：JP21673787
申请日：1987-08-31
申请人： WAKO PURE CHEM IND LTD
发明人： KAMIKAMA KANEHITO , HIRAYAMA FUMITOSHI , TOKUDA KUNIAKI , MORII SEIJI
IPC分类号： A61K47/40 , A61K47/00
摘要： PURPOSE:To obtain a drug carrier with low irritancy, useful as an injection or various mucosal application agents and having solubilizing and stabilizing ability, by using a specific cyclodextrin derivative utilizing low hemolytic activity, tissual traumatism and local irritancy, etc. thereof. CONSTITUTION:A drug carrier obtained by utilizing any or all of the low hemolytic activity or/and hemolytic activity inhibitory action, low tissual traumatism or/and tissual traumatism preventing action, local irritancy or/and local irritancy reducing action of a cyclodextrin derivative expressed by the formula (n is 6-8; R is 2-hydroxyethyl, H, etc.) as the drug carrier. The above-mentioned derivative has high solubility in water and thermal sterilization is readily carried out without causing deterioration in solubility at high temperatures and release of complexes. Excretion into urine is rapid and possibility of acute and chronic toxicity is extremely low. Thereby the derivative can be used as a drug carrier with low irritancy for injection, mucosal application agent (e.g. oral cavity) for internal use, mucosal application agent (e.g. eye or ear) for external use, etc.

9. 发明专利

JPS6075470A WATER-SOLUBLE TETRAZOLIUM COMPOUND AND DETERMINATION USING IT 失效
公开(公告)号：JPS6075470A
公开(公告)日：1985-04-27
申请号：JP18249783
申请日：1983-09-30
申请人： WAKO PURE CHEM IND LTD
发明人： OGATA HIROSHI , YAMASATO FUJIO , ISHIHARA MASAMI , OOBA HITOSHI , MORII SEIJI , HAYASHIDA KAZUYOSHI
IPC分类号： C07D417/04 , C07D257/00 , C07D257/04 , C07D277/00 , C12Q1/26 , G01N33/92
摘要： NEW MATERIAL:A compound shown by the formula I (R is nitrophenyl, or group shown by the formula II; R and R are H, lower alkyl, or R and R form aromatic ring; R is group shown by the formula III; R is H, or COOH; R is H, NO2, CN, halogen, or NR R ; R and R are lower alkyl which may have OH; R is polyethylene glycol residue; X is halogen). EXAMPLE:2-( p-Nitrophenyl )-3-{ p-(N,N-diethylamino)phenyl }-5-[p-{hydroxy.poly- (oxy-1,2-ethanediyl)}phenyl]-2H-tetrazolium chloride. USE:A water-soluble reagent useful for determination of a reductive substance, having improved linearity of calibration curve of formed water-soluble formazan. PREPARATION:A reaction product of p-nitrophenylhydrazine and p-R3-substituted benzaldehyde is reacted with a solution of diazotized N,N-diethyl-p-phenylenediamine, prepared formazane is oxidized to give the compound of the example.

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