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1. 发明专利

JPH06331624A REAGENT COMPOSITION FOR ZINC SULFATE TURBIDITY TEST 失效
公开(公告)号：JPH06331624A
公开(公告)日：1994-12-02
申请号：JP13998393
申请日：1993-05-19
申请人： WAKO PURE CHEM IND LTD
发明人： HAMADA KEIKO , TOKUDA KUNIAKI
IPC分类号： G01N31/22 , G01N33/50 , G01N33/52
摘要： PURPOSE:To provide a reagent composition for a zinc sulfate turbidity test (ZTT) which eliminates the unstability of a reagent caused by pH fluctuation during the ZTT, keeps good correlation with standard method, and is remarkably excellent in reproducibility and stability against the lapse of days. CONSTITUTION:A reagent composition for a zinc sulfate turbidity test comprises a zinc sulfate, a bis (2-hydroxyethyl) iminotris(hydroxymethyl) methane as a buffer, and an acidifier for regulating to the desired pH.

2. 发明专利

JPH0383915A TRANSMUCOSAL PREPARATION 失效
公开(公告)号：JPH0383915A
公开(公告)日：1991-04-09
申请号：JP22093689
申请日：1989-08-28
申请人： WAKO PURE CHEM IND LTD
发明人： KAMIKAMA KANEHITO , IRIE TETSUYOSHI , TOKUDA KUNIAKI
IPC分类号： A61K9/02 , A61K38/28
摘要： PURPOSE:To provide a transmucosal preparation having high bioavailability, low tissue-injuring action and low mucosa-irritating property and administered into rectums by adding a hydroxyalkyl derivative of cyclodextrin as an absorption-accelerating agent to a hydrophilic drug ingredient. CONSTITUTION:A transmucosal preparation contains a hydrophilic drug ingredient (especially preferably insulin) and a hydroxyalkyl derivative of cyclodextrin. The hydrophilic drug ingredient is preferably insulin and the preparation is preferably administered into a rectum. The hydroxyalkyl derivative of the cyclodextrin is preferably a compound prepared by introducing approximately two-seven

3. 发明专利

JPH01131202A NOVEL ENTERIC MOLECULE CAPSULE 失效
公开(公告)号：JPH01131202A
公开(公告)日：1989-05-24
申请号：JP21200688
申请日：1988-08-26
申请人： WAKO PURE CHEM IND LTD
发明人： KAMIKAMA KANEHITO , HIRAYAMA FUMITOSHI , TOKUDA KUNIAKI , MORII SEIJI
IPC分类号： A61K47/40 , A61K47/00 , C08B37/16
摘要： PURPOSE:To provide a stable enteric molecule capsule composed of a specific cyclodextrin derivative and exhibiting excellent characteristics as an enteric carrier for drugs. CONSTITUTION:The objective enteric molecule capsule contains a cyclodextrin derivative of formula I [n is 6-8; R is 2-4C carboxyalkyl, 2-4C alkyl or H; provided that at least one of R is 2-4C carboxyalkyl, 3-(3n-1) R groups are 2-4C alkyl and the remaining R groups are H]. Among the cyclodextrin derivatives of formula I, especially preferable compound is a beta-cyclodextrin derivative of formula II having a solubility of

4. 发明专利

JPS6461430A DRUG CARRIER WITH LOW IRRITANCY 失效
公开(公告)号：JPS6461430A
公开(公告)日：1989-03-08
申请号：JP21673787
申请日：1987-08-31
申请人： WAKO PURE CHEM IND LTD
发明人： KAMIKAMA KANEHITO , HIRAYAMA FUMITOSHI , TOKUDA KUNIAKI , MORII SEIJI
IPC分类号： A61K47/40 , A61K47/00
摘要： PURPOSE:To obtain a drug carrier with low irritancy, useful as an injection or various mucosal application agents and having solubilizing and stabilizing ability, by using a specific cyclodextrin derivative utilizing low hemolytic activity, tissual traumatism and local irritancy, etc. thereof. CONSTITUTION:A drug carrier obtained by utilizing any or all of the low hemolytic activity or/and hemolytic activity inhibitory action, low tissual traumatism or/and tissual traumatism preventing action, local irritancy or/and local irritancy reducing action of a cyclodextrin derivative expressed by the formula (n is 6-8; R is 2-hydroxyethyl, H, etc.) as the drug carrier. The above-mentioned derivative has high solubility in water and thermal sterilization is readily carried out without causing deterioration in solubility at high temperatures and release of complexes. Excretion into urine is rapid and possibility of acute and chronic toxicity is extremely low. Thereby the derivative can be used as a drug carrier with low irritancy for injection, mucosal application agent (e.g. oral cavity) for internal use, mucosal application agent (e.g. eye or ear) for external use, etc.

5. 发明专利

JPS63235865A ANALYSIS OF COMPONENT 失效
公开(公告)号：JPS63235865A
公开(公告)日：1988-09-30
申请号：JP7057487
申请日：1987-03-25
申请人： WAKO PURE CHEM IND LTD
发明人： TOKUDA KUNIAKI , TOYAMA TAKANORI
IPC分类号： G01N33/48 , G01N33/483 , G01N33/493
摘要： PURPOSE:To remove nitrite ion affecting a measured value handily and without involving increase in reaction operation step, complication of operation and the like, by adding a specified nitrogen-containing organic compound to a reagent for analysis. CONSTITUTION:One, two or more kinds of a nitrogen-containing organic compounds selected from a group as given by formulas I-IV are added to a reagent for analysis for analyzing. In the formulas, R -R represent sulfonic group, carboxylic group or the like independently and R represents 1-4C alkyl group, 1-4C hydroxy alkyl group or the like. R and R represent 1-4C alkyl group, 1-4C amino alkyl group or the like independently. R represents 1-4C alkyl group or hydrogen atom. R -R represent 1-4C alkyl group or phenyl group. An example of the nitrogen-containing organic compound is m-amino benzoate sodium, p-amino salicylate or the like. An object to be measured is, for example, residual chlorine, chloric ion and trace protein.

6. 发明专利

JPS59109191A Assay of bile acid 失效
标题翻译：胆酸测定
公开(公告)号：JPS59109191A
公开(公告)日：1984-06-23
申请号：JP21950982
申请日：1982-12-15
申请人： Wako Pure Chem Ind Ltd
发明人： YAMASATO FUJIO , TOKUDA KUNIAKI , NOGUCHI HIDEKO
IPC分类号： G01N33/50 , C12Q1/26
摘要： PURPOSE: To assay bile acid in humors efficiently, by treating a humor specimen with iodic acid or its salt, subjecting it to an oxidation-reduction reaction.
CONSTITUTION: In assaying bile acid in humors by oxidizing bile acid with 3α- hydroxy steroid dehydrogenase to give NADH, treating NADH with a transferase or a middle electron carrier so that a tetrazolium salt is reduced, determining prepared formazan at a visible part, a humor specimen is treated with 0.001W2.0wt% calculated as iodic acid concentration of iodic acid and/or its salt such as sodium salt, potassium salt, etc. at ≤4.0pH.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过用碘酸或其盐处理幽默标本，对其进行氧化还原反应，以有效的方法测定幽门菌中的胆汁酸。构成：通过用3α-羟基类固醇脱氢酶氧化胆汁酸来产生NADH，以转移酶或中间电子载体处理NADH，从而降低四唑鎓盐，测定可见部分中制备的甲，，幽默在<= 4.0pH时，以碘酸和/或其盐如钠盐，钾盐等的碘酸浓度计算，以0.001-2.0重量％计算样品。

7. 发明专利

JPS5614949A MEASURING METHOD OF QUANTITY OF CREATININE 失效
公开(公告)号：JPS5614949A
公开(公告)日：1981-02-13
申请号：JP9130279
申请日：1979-07-18
申请人： WAKO PURE CHEM IND LTD
发明人： KASAHARA KAN , TOKUDA KUNIAKI , TAKAGI YASUSHI
IPC分类号： G01N33/70
摘要： PURPOSE:To dispense with special previous treatment of bilirubin, by using periodic acid or its salt as an oxidizer and using an alcohol as a substance to remove excess periodic acid. CONSTITUTION:To measure the quantity of creatinine in humor by using picric acid, a sample is oxidized by periodic acid or its salt and the excess oxidizer is disposed of by an alcohol. Periodic acid, potassium periodate, ammonium periodate, sodium periodate or the like is used as said periodic acid or its salt for the oxidization. Methyl alcohol, ethyl alcohol, propyl alcohol, butyl alcohol, a polyhydric alcohol such as glycerin, ethylene glycol and ethlene glycol monomethyl ether or a mixture of these alcohol is used as said alcohol.

8. 发明专利

JPS5492391A MEASURING OF PEROXIDE SUBSTANCE 失效
公开(公告)号：JPS5492391A
公开(公告)日：1979-07-21
申请号：JP15907077
申请日：1977-12-29
申请人： WAKO PURE CHEM IND LTD
发明人： KASAHARA KAN , YAMANISHI KAZUHIKO , HANADA TOSHIROU , TOKUDA KUNIAKI , OBATA SHINZOU
IPC分类号： G01N33/50 , C12Q1/28 , G01N31/00 , G01N31/22

9. 发明专利

JPS512488A TAIEKICHUNYOSANNO SOKUTEIHOHO 失效
公开(公告)号：JPS512488A
公开(公告)日：1976-01-10
申请号：JP7260674
申请日：1974-06-25
申请人： WAKO PURE CHEM IND LTD
发明人： TOOYAMA TAKANORI , UEMATSU YOSHIKO , TOKUDA KUNIAKI , NAGAOKA JOJI
IPC分类号： G01N33/50 , G01N31/00 , G01N31/22

10. 发明专利

JPH0518978A BILIRUBIN MEASURING METHOD 失效
公开(公告)号：JPH0518978A
公开(公告)日：1993-01-26
申请号：JP33580591
申请日：1991-10-30
申请人： WAKO PURE CHEM IND LTD
发明人： TOKUDA KUNIAKI , TANIMOTO KAZUHITO
IPC分类号： C12Q1/26 , G01N33/72
摘要： PURPOSE:To obtain a bilirubin measuring method which measures the optical change of a living body fluid sample by making vanadate ions or tervalent manganese ions to act on the sample as an oxidizing agent. CONSTITUTION:This bilirubin measuring method uses vanadate ions or tervalent manganese ions as a bilirubin oxidizing agent and, when bilirubin is directly measured, one or more kinds of compounds selected out of the group of hydrazines, hydroxylamines, oximes, aliphatic polyhydric amines, phenols, water- soluble high polymers, and nonionic surface active agents are used as an indirect bilirubin reaction retarding agent. This bilirubin measuring method can settle all of such problems that bilirubin measuring methods cannot be well applied to automatic analytical equipment, have bad correlation with the diazo method, reagents for measurement are not stable, and so on.

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