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1. 发明专利

JPS6178719A Composite transfusion 失效
标题翻译：复合材料传输
公开(公告)号：JPS6178719A
公开(公告)日：1986-04-22
申请号：JP20106684
申请日：1984-09-25
申请人： Tanabe Seiyaku Co Ltd , Terumo Corp
发明人： SAMEJIMA MASAYOSHI , MATSUDA SABURO , WAKABAYASHI TOSHIO , HAYAKAWA NAOKI
IPC分类号： A61K9/08 , A23L1/304 , A23L1/305 , A61K31/195 , A61K31/40 , A61K31/405 , A61K31/415 , A61K31/70 , A61K33/00 , A61K38/00 , A61K38/01
CPC分类号： A61K33/00 , A23L33/16 , A23L33/175 , A61K38/01 , A61K31/7004 , A61K2300/00
摘要： PURPOSE: To provide a composite transfusion containing a reducing sugar, physiological amino acid and electrolyte at specific balanced ratio, excellent from nutritional viewpoint, and capable of suppressing the browning phenomenon.
CONSTITUTION: The objective composite transfusion essentially resistant to discoloration can be prepared by using a reducing sugar (e.g. glucose, maltose, etc.), physiological amino acids, and electrolytes of the table I at ratios and amounts shown in the table. The concentration product of the reducing sugar and amino acid is preferably 7W25, especially 12W24 to improve the stability of the transfusion. The pH of the transfusion is preferably 4.0W6.0. It can be prepared according to the method used in the preparation of transfusion or injections, and may be sterilized by heating. Since the transfusion can be used as it is without combining with other agent, various problems caused by the combined use, e.g. variation of pH, contamination with microorganisms and foreign materials, etc., can be avoided.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：目的：提供以均衡比例含有还原糖，生理氨基酸和电解质的复合输液，营养观点优良，能抑制褐变现象。构成：可以通过使用表I所示比例和量的表I的还原糖（例如葡萄糖，麦芽糖等），生理氨基酸和电解质来制备基本上抗变色的目的复合输液。还原糖和氨基酸的浓度乘积优选为7-25，特别是12-24，以提高输血的稳定性。输血的pH优选为4.0-6.0。可以根据输血或注射制剂中使用的方法制备，可以通过加热灭菌。由于输液可以原样使用而不与其他药剂组合使用，所以由组合使用引起的各种问题，例如，可以避免pH的变化，微生物和异物的污染等。

2. 发明专利

JPH09182778A TRANSFUSION CONTAINING AMINO ACID AND REDUCING SUGAR ELECTROLYTE 失效
公开(公告)号：JPH09182778A
公开(公告)日：1997-07-15
申请号：JP25906895
申请日：1995-10-05
申请人： TERUMO CORP , TANABE SEIYAKU CO
发明人： HAYAKAWA NAOKI , UEHARA HIROSHI , SHIBATA KAZUKO
IPC分类号： A61J1/10 , A61J1/14 , A61J3/00 , A61K9/08
摘要： PROBLEM TO BE SOLVED: To prevent Maillard reaction between amino acid and reducing sugar to suppress change with aging such as browning, resulting in increasing in keeping quality by storing a transfusion filled in a first medical vessel into an air impermeable second vessel with an oxygen scavenger. SOLUTION: A transfusion containing amino acid, reducing sugar, and electrolyte is filled in one air permeable first medical vessel to form a bag transfusion, the transfusion in the first medical vessel is stored in an air impermeable second vessel with an oxygen scavenger to prevent Maillard reaction between amino acid and reducing sugar. A three-layer laminate film bag body 1 in which a 15μm-thick biaxial oriented vinylon film and a 60μm-thick polyethylene film are laminated in this order is formed in such a manner that laminate polyethylene film is exposed inwardly and its circumference edge is welded with a heat seal 4, and the transfusion 2 in the bag and the oxygen scavenger 4 are stored and sealed in the bag 1.

3. 发明专利

JPS62221621A COMPLEX TRANSFUSION SOLUTION 失效
公开(公告)号：JPS62221621A
公开(公告)日：1987-09-29
申请号：JP6649686
申请日：1986-03-24
申请人： TANABE SEIYAKU CO , TERUMO CORP
发明人： SAMEJIMA MASAYOSHI , MATSUDA SABURO , WAKABAYASHI TOSHIO , HAYAKAWA NAOKI
IPC分类号： A61K31/165 , A61K9/08 , A61K31/195 , A61K31/198 , A61K31/40 , A61K31/405 , A61K31/415 , A61K38/00 , A61P3/00 , A61P3/12
摘要： PURPOSE:A complex transfusion solution, containing a reducing sugar, physiological amino acids and electrolytes at composition ratios balanced within specific ranges and capable of exhibiting nutritionally improved effect and suppressing the browning phenomenon by the Maillard reaction. CONSTITUTION:A complex transfusion solution obtained by blending a reducing sugar, preferably glucose or maltose which is a physiological caloric source with an amino acid mixture which is a nitrogen source and electrolytes in amounts blended shown in the table. Cysteine and/or cystine in the amino acid mixture may be partially or wholly replaced by methionine and tyrosine may be partially or wholly replaced by phenylalanine. The concentration of the reducing sugar is preferably within the range of 6-8wt/vol% and the concentration of the total amino acids is preferably within the range of 2.5-3.5wt/vol%. From the viewpoint of the stabilization of the pharmaceutical, the respective concentrations are preferably adjusted to give 7-25, particularly 17-23 product of the concentrations of both the reducing sugar and total amino acid.

4. 发明专利

JPH0380509B2 失效
公开(公告)号：JPH0380509B2
公开(公告)日：1991-12-25
申请号：JP19100882
申请日：1982-10-30
申请人： TERUMO CORP
发明人： IWAMOTO TOMYUKI , HAYAKAWA NAOKI , PPONDA HARUO , MARUYAMA TETSUPEI
IPC分类号： B65D81/20 , A61J1/10 , A61M1/14 , A61M5/00

5. 发明专利

JPS57206447A PLASTIC CONTAINER RECEIVING LIQUID DRUG PASTURIZED WITH HIGH PRESSURE STEAM AND PRODUCTION THEREOF 失效
公开(公告)号：JPS57206447A
公开(公告)日：1982-12-17
申请号：JP9039281
申请日：1981-06-12
申请人： TERUMO CORP
发明人： IWAMOTO TOMIYUKI , HAYAKAWA NAOKI , MATSUBARA SHIGERU
IPC分类号： B65D81/20 , A61J1/00 , A61J1/05 , A61J1/10 , A61J1/14 , A61J1/16 , A61L2/00 , A61L2/06 , A61L2/07 , A61L2/26

6. 发明专利

JPS63275346A PACKAGE OF INFUSION AGENT 失效
公开(公告)号：JPS63275346A
公开(公告)日：1988-11-14
申请号：JP10971287
申请日：1987-05-07
申请人： TERUMO CORP
发明人： HAYAKAWA NAOKI , UEHARA HIROSHI , SHIBATA KAZUKO , OKAMOTO KAZUO
IPC分类号： A61J1/10 , A61J1/00
摘要： PURPOSE:To prevent the generation of a browning phenomenon or peroxide, by receiving a medical primary container having air permeability filled with an infusion agent composed of a specific aqueous solution in a secondary packing container impervious to oxygen along with a deoxidizing agent. CONSTITUTION:A primary container such as a bottle or bat made of a synthetic resin having air permeability is field with an infusion agent composed of an aqueous solution containing amino acid or the like or an O/W type emulsion containing highly unsaturated fatty acid and received in a secondary packing container, which is made of a three-layer laminate film having a biaxially stretched film whose oxygen permeability is 1.0cc/m /24hr or less at 20 deg.C at relative humidity of 60% as an intermediate layer, along with a deoxidizing agent. Whereupon, the interior of the secondary packing container is held to a low oxygen state and, even when the primary container received therein has air permeability, invading oxygen is little and the concn. of molecular oxygen in the infusion agent does not become high. Therefore, the formation of a browning phenomenon or peroxide can be prevented even when the infusion agent is preserved over a long period of time.

7. 发明专利

JPS63275345A PACKAGE OF INFUSION SOLUTION CONTAINING AMINO ACID AND REDUCING SUGAR 失效
公开(公告)号：JPS63275345A
公开(公告)日：1988-11-14
申请号：JP10971187
申请日：1987-05-07
申请人： TERUMO CORP
发明人： HAYAKAWA NAOKI , UEHARA HIROSHI , SHIBATA KAZUKO
IPC分类号： A61J1/10 , A61J1/00 , A61J3/00
摘要： PURPOSE:To prevent the generation of browning due to Maillard reaction, by receiving a medical primary container having air permeability filled with an infusion solution composed of a specific aqueous solution in a secondary packing container impervious to oxygen along with a deoxidizing agent. CONSTITUTION:A primary container such as a bottle or bag made of a synthetic resin having air permeability is filled with an infusion solution composed of an aqueous solution containing amino acid and reducing sugar and received in a secondary packing container, which is made of a three-layer laminate film having a biaxially stretched vinylon film whose oxygen permeability is 1.0cc/m /24hr or less at 20 deg.C at relative humidity of 60% as an intermediate layer, along with a deoxidizing gent. Whereupon, the interior of the secondary packing container is held to a low oxygen state and, even when the primary container received therein has gas permeability, the concn. of molecular oxygen in the infusion solution does not become high. Therefore, even when the infusion solution is preserved over a long period of time, it can be prevented that Maillard reaction is promoted thereby to generate browning.

8. 发明专利

JPS6343368B2 失效
公开(公告)号：JPS6343368B2
公开(公告)日：1988-08-30
申请号：JP9381983
申请日：1983-05-27
申请人： TERUMO CORP
发明人： HAYAKAWA NAOKI , SHIGEMATSU TERUKO , WAKABAYASHI TOSHIO
IPC分类号： A61K31/06 , A61K9/08 , A61K31/14 , A61K31/195 , A61K31/20 , A61K31/24 , A61K31/30 , A61K31/42 , A61K31/70 , A61P3/00

9. 发明专利

JPH0246450B2 失效
公开(公告)号：JPH0246450B2
公开(公告)日：1990-10-16
申请号：JP19100982
申请日：1982-10-30
申请人： TERUMO CORP
发明人： IWAMOTO TOMYUKI , HAYAKAWA NAOKI , PPONDA HARUO , MARUYAMA TETSUPEI
IPC分类号： B65B55/10 , A61J1/00 , A61J1/05 , A61J1/16 , A61L2/00 , B65B31/02 , B65B55/02 , B65B55/06

10. 发明专利

JPS59219232A SUGAR TRANSFUSION SOLUTION 失效
公开(公告)号：JPS59219232A
公开(公告)日：1984-12-10
申请号：JP9382083
申请日：1983-05-27
申请人： TERUMO CORP
发明人： WAKABAYASHI TOSHIO , HAYAKAWA NAOKI
IPC分类号： A61K31/195 , A61K9/08 , A61K31/19 , A61K31/70 , A61K33/06 , A61K33/14 , A61K33/20 , A61K33/24 , A61K33/30 , A61K33/42 , A61P3/00
摘要： PURPOSE:To provide a sugar transfusion solution exhibiting excellent nutrient- supplying effect by intravenous injection, and useful as a remedying transfusion solution for the patient of diabetes, etc. having lowered resistance to sugar, by adding palatinose to an aqueous solution. CONSTITUTION:The objective sugar transfusion solution contains palatinose in an aqueous solution. The preferable concentration ranges of sugars and the electrolyte elements in the aqueous solution are shown in Table 1. The transfusion solution is preferably filled in a plastic container to prevent the formation of flakes. Since the direct intravenous injection of glucose is avoided in the above transfusion solution, the rapid increase in the blood sugar level can be inhibited, and the transfusion can be applied to the patient of diabetes or postoperative diabetes having lowered resistance to sugar. The palatinose can be prepared by converting sucrose with an enzyme existing in a specific bacterium.

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