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1. 发明专利

JP2011168556A Method for producing 5-aryl-3-amino-2-alkoxycarbonylthiophene compound 审中-公开
标题翻译： 5-亚氨基-3-氨基-2-烷氧羰基二苯醚化合物的制备方法
公开(公告)号：JP2011168556A
公开(公告)日：2011-09-01
申请号：JP2010035627
申请日：2010-02-22
申请人： Sumitomo Seika Chem Co Ltd , 住友精化株式会社
发明人： FUJITA KOJI , SATAKE SHUZO , ASHIKAWA MASAYASU , FUKADA KANAKO
IPC分类号： C07D333/40
摘要： PROBLEM TO BE SOLVED: To provide a method for simply producing a 5-aryl-3-amino-2-alkoxycarbonylthiophene compound useful as a medicine, etc., in a high yield.
SOLUTION: The method for producing a 5-aryl-3-amino-2-alkoxycarbonylthiophene compound represented by formula (4) (wherein R
1 is a hydrogen atom, halogen atom, 1C-4C alkyl, 1C-4C alkoxy, nitro or trifluoromethyl; R
2 is a hydrogen atom or 1C-4C alkyl) includes reacting an acetophenone compound which may be substituted or not with a halogen atom, a 1C-4C alkyl group, a 1C-4C alkoxy group, a nitro group or a trifluoromethyl group with an N-substituted formamide, a chlorinating agent and a hydroxylamine compound to give a 3-chloro-3-arylacrylonitrile compound containing an aryl group which may be substituted or not as the above, continuously, reacting the resultant compound with thioglycolic acid or a thioglycolic acid ester compound in the presence of a base.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供以高产率简单地制备用作药物等的5-芳基-3-氨基-2-烷氧基羰基噻吩化合物的方法。解决方案：制备由式（4）表示的5-芳基-3-氨基-2-烷氧基羰基噻吩化合物的方法（其中R 1 是氢原子，卤素原子，1C-4C 烷基，1C-4C烷氧基，硝基或三氟甲基; R 2是氢原子或1C-4C烷基）包括使可被取代或不与卤素原子取代的苯乙酮化合物，1C-4C 烷基，1C-4C烷氧基，硝基或三氟甲基与N-取代甲酰胺，氯化剂和羟胺化合物反应，得到含有可被取代的芳基的3-氯-3-芳基丙烯腈化合物或不如上所述，在碱的存在下，使所得化合物与巯基乙酸或巯基乙酸酯化合物反应。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2011132171A Method for producing phenol compound having carbonyl group 审中-公开
标题翻译：生产具有羰基的苯酚化合物的方法
公开(公告)号：JP2011132171A
公开(公告)日：2011-07-07
申请号：JP2009292953
申请日：2009-12-24
申请人： Sumitomo Seika Chem Co Ltd , 住友精化株式会社
发明人： HAMAGAWA MIYUKI , FUJITA KOJI , SATAKE SHUZO
IPC分类号： C07D307/80 , C07B61/00
摘要： PROBLEM TO BE SOLVED: To provide a method for readily obtaining a phenolic compound useful as a pharmaceutical intermediate in high yield.
SOLUTION: The method for producing the phenolic compound represented by formula (3) comprises condensing an ester compound represented by formula (1) and a benzofuran type aromatic compound.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供容易地获得用作高收率的药物中间体的酚类化合物的方法。解决方案：由式（3）表示的酚类化合物的制备方法包括将由式（1）表示的酯化合物和苯并呋喃型芳族化合物缩合。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2011016771A Method for producing hydroxythiophenol 审中-公开
标题翻译：生产羟基苯乙烯的方法
公开(公告)号：JP2011016771A
公开(公告)日：2011-01-27
申请号：JP2009163630
申请日：2009-07-10
申请人： Sumitomo Seika Chem Co Ltd , 住友精化株式会社
发明人： FUJITA KOJI , SATAKE SHUZO , YAMAMOTO MIKIO , ONOZUKA TOMOHIRO
IPC分类号： C07C319/12 , C07C323/20
摘要： PROBLEM TO BE SOLVED: To provide a method for easily and inexpensively producing hydroxythiophenol, an intermediate useful for various medicines and extremely important in synthesis of heterocyclic compounds, for example, 3-hydroxythiophenol useful as an intermediate for osteoporosis medicine.SOLUTION: The method for producing hydroxythiophenol represented by formula (2) includes reacting an alkoxy thiophenol compound represented by formula (1) (wherein R is 1C-4C alkyl) with an acid in the presence of thiophenol.
摘要翻译：要解决的问题：提供一种容易且廉价地制备羟基苯硫酚的方法，可用于各种药物的中间体和杂环化合物的合成中非常重要的中间体，例如可用作骨质疏松症药物中间体的3-羟基苯硫酚。方法：由式（2）表示的羟基苯硫酚的制备方法包括在苯硫酚存在下使式（1）表示的烷氧基苯硫酚化合物（其中R为1C-4C烷基）与酸反应。

4. 发明专利

JP2011207803A Process for producing haloalkyl sulfide 审中-公开
标题翻译：硫酸铝生产工艺
公开(公告)号：JP2011207803A
公开(公告)日：2011-10-20
申请号：JP2010076426
申请日：2010-03-29
申请人： Sumitomo Seika Chem Co Ltd , 住友精化株式会社
发明人： ONOZUKA TOMOHIRO , FURUKAMI KENJI , UMEDA YUKI , SATAKE SHUZO
IPC分类号： C07C319/14 , C07B61/00 , C07C321/14
摘要： PROBLEM TO BE SOLVED: To provide a process for producing a haloalkyl sulfide efficiently by allowing an alkyl thiolate to react with a dihaloalkane.SOLUTION: An alkyl thiolate is allowed to react with a dihaloalkane in the presence of a phase transfer catalyst to produce a haloalkyl sulfide.
摘要翻译：要解决的问题：提供一种通过使烷基硫醇盐与二卤代烷烃反应来有效地制备卤代烷基硫化物的方法。溶液：在相转移催化剂存在下使烷基硫醇盐与二卤烷反应以产生卤代烷基硫化物。

5. 发明专利

JP2011001330A Method for producing 4-nitrophenyl chloroformate 审中-公开
标题翻译：生产4-硝基氯化镁的方法
公开(公告)号：JP2011001330A
公开(公告)日：2011-01-06
申请号：JP2009147284
申请日：2009-06-22
申请人： Sumitomo Seika Chem Co Ltd , 住友精化株式会社
发明人： TANAKA MUNEAKI , SATAKE SHUZO , WASHIZAKI KOHEI , ONOZUKA TOMOHIRO
IPC分类号： C07C201/12 , C07B61/00 , C07C205/43
摘要： PROBLEM TO BE SOLVED: To provide a method for producing safely, easily and in a high yield 4-nitrophenyl chloroformate useful as a medicinal intermediate, an amino blocking group or the like in a peptide synthesis field etc.SOLUTION: The method for producing 4-nitrophenyl chloroformate represented by formula (1) is characterized by reacting 4-nitrophenol with bis(trichloromethyl)carbonate in the presence of a basic compound.
摘要翻译：要解决的问题：提供一种在肽合成领域等中作为医药中间体，氨基封闭基团等有用的，高产率的氯代甲酸4-硝基苯酯的制备方法。解决方案：生产4 由式（1）表示的氯甲酸二硝基苯酯的特征在于在碱性化合物的存在下使4-硝基苯酚与双（三氯甲基）碳酸酯反应。

6. 发明专利

JP2013256501A (e)-n-monoalkyl-3-oxo-3-(2-thienyl)propenamine and method for manufacturing the same as well as method for manufacturing (e, z)-n-monoalkyl-3-oxo-3-(2-thienyl) propenamine 有权
标题翻译：（E）-N-单甲基-3-氧代-3-（2-噻吩基）丙炔及其制备方法以及制备（E，Z）-N-单甲基-3-氧代-3-（2 -THIENYL）PROPENAMINE
公开(公告)号：JP2013256501A
公开(公告)日：2013-12-26
申请号：JP2013146139
申请日：2013-07-12
申请人： Sumitomo Seika Chem Co Ltd , 住友精化株式会社
发明人： SATAKE SHUZO , HAYASHISAKA TOKUYUKI , FUSHIYA ICHIRO , TANAKA MUNEAKI , KAGANO HIROKAZU
IPC分类号： C07D333/22
CPC分类号： C07D333/22
摘要： PROBLEM TO BE SOLVED: To provide an (E)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine expressed by formula (1) that is used in a method for manufacturing with ease and in a high yield an (E, Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine.SOLUTION: An (E)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine expressed by formula (1) is manufactured in such a way that a solution in which (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine is dissolved in a solvent, is kept at a temperature of 25°C or below to crystallize and from the deposited crystals the crystals with a particle diameter of 100 μm or less are fractionated. (E, Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine is manufactured in such a way that a reaction liquid which is obtained by the reaction of an alkali metal salt of β-oxo-β-(2-thienyl)propanal with a monoalkylamine compound is added with a water-insoluble organic solvent to liquid-separate into an organic layer, to which seed crystals containing the compound expressed by formula (1) are added and kept at a temperature of 25°C or below (In the formula, R is a 1-4C alkyl group.).
摘要翻译：要解决的问题：提供一种用于制备方法的式（1）表示的（E）-N-单烷基-3-氧代-3-（2-噻吩基）丙烯胺，并且以高产率a （E，Z）-N-单烷基-3-氧代-3-（2-噻吩基）丙烯胺。溶液：由式（（E，Z）-N-单烷基-3-氧代-3- 1）以使（Z）-N-单烷基-3-氧代-3-（2-噻吩基）丙烯胺溶解在溶剂中的溶液的温度保持在25℃以下的温度从析出的结晶中析出粒径为100μm以下的晶体。（E，Z）-N-单烷基-3-氧代-3-（2-噻吩基）丙烯胺的制备方法是使通过碱金属盐与氧化反应生成的反应液加入具有单烷基胺化合物的（2-噻吩基）丙醛与水不溶性有机溶剂一起液体分离成有机层，加入含有式（1）表示的化合物的晶种并保持在其中为25℃以下（式中，R为1-4C烷基）。

7. 发明专利

JP2012149016A Method for producing 3-(4-aminophenyl)-6,7-difluoro-1h-quinazoline-2,4-dione and salt thereof, method for producing quinazolinedione derivative useful for the production method, and imine derivative useful for the method for producing quinazolinedione derivative 审中-公开
标题翻译：用于生产3-（4-氨基苯基）-6,7-二氟-1H-喹唑啉-2,4-二酮及其盐的方法，用于生产用于生产方法的喹诺酮衍生物的方法和用于生产方法的有用的衍生物衍生物衍生物
公开(公告)号：JP2012149016A
公开(公告)日：2012-08-09
申请号：JP2011009770
申请日：2011-01-20
申请人： Sumitomo Seika Chem Co Ltd , 住友精化株式会社
发明人： TANAKA MUNEAKI , SATAKE SHUZO , ASHIKAWA MASAYASU , FUJIMOTO SHOHEI
IPC分类号： C07D239/96
摘要： PROBLEM TO BE SOLVED: To provide a method for producing inexpensively and safely an amino group-protected quinazolinedione derivative used as a production intermediate of an important medicine.SOLUTION: An amino group-protected quinazolinedione derivative represented by formula (2) is produced by using an amino group-protected derivative of 5,6-difluoro-3-(4-aminophenyl imino)-1,3-dihidro-indol-2-one which is a new imine derivative as a raw material.
摘要翻译：待解决的问题：提供一种廉价且安全地生产用作重要药物的生产中间体的氨基保护的喹唑啉二酮衍生物的方法。解决方案：通过使用5,6-二氟-3-（4-氨基苯基亚氨基）-1,3-二苯并咪唑的氨基保护的衍生物制备由式（2）表示的氨基保护的喹唑啉二酮衍生物，吲哚-2-酮，它是一种新的亚胺衍生物作为原料。版权所有（C）2012，JPO＆INPIT

8. 发明专利

JP2012051842A Method for producing nitrothiophenol 审中-公开
标题翻译：生产硝基苯酚的方法
公开(公告)号：JP2012051842A
公开(公告)日：2012-03-15
申请号：JP2010196243
申请日：2010-09-01
申请人： Sumitomo Seika Chem Co Ltd , 住友精化株式会社
发明人： FUJITA KOJI , SATAKE SHUZO , ASHIKAWA MASAYASU
IPC分类号： C07C319/28 , C07C319/06 , C07C323/09
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a nitrothiophenol, by which the nitrothiophenol can be obtained in high purity.SOLUTION: The method for producing the nitrothiophenol comprises a nitrothiophenol production process and a purification process. The nitrothiophenol production process comprises hydrolyzing a specific halomethylthionitrobenzene to obtain a mixture containing the nitrothiophenol. The purification process comprises treating the mixture with an alkali compound in the presence of the aqueous solution of the alkali compound and a hydrophobic organic solvent, separating the water phase from the organic solvent phase, and then treating the water phase with an acid compound in the presence of an aqueous solution of the acid compound and the hydrophobic organic solvent to isolate the nitrothiophenol from the mixture, thereby purifying.
摘要翻译：待解决的问题：提供硝基苯硫酚的制备方法，通过该方法可以获得高纯度的硝基苯硫酚。解决方案：硝基苯硫酚的制备方法包括硝基苯硫酚生产方法和纯化方法。硝基苯硫酚的制备方法包括水解特定的卤代甲硫基硝基苯，得到含有硝基苯硫酚的混合物。纯化方法包括在碱性化合物的水溶液和疏水性有机溶剂的存在下用碱性化合物处理混合物，将水相与有机溶剂相分离，然后用酸化合物处理水相存在酸化合物和疏水性有机溶剂的水溶液以从混合物中分离出硝基苯硫酚，从而进行纯化。版权所有（C）2012，JPO＆INPIT

9. 发明专利

JP2012041288A Method of producing thiophene sulfonyl carbamate 审中-公开
标题翻译：生产噻吩磺酸碳酸酯的方法
公开(公告)号：JP2012041288A
公开(公告)日：2012-03-01
申请号：JP2010182675
申请日：2010-08-18
申请人： Sumitomo Seika Chem Co Ltd , 住友精化株式会社
发明人： TANAKA MUNEAKI , SATAKE SHUZO , FURUKAMI KENJI , KOBAYASHI TETSUYA
IPC分类号： C07D333/34
摘要： PROBLEM TO BE SOLVED: To provide a method of producing thiophene sulfonyl carbamate useful as an intermediate of a medicine, a pesticide or the like efficiently and by high purity.SOLUTION: The method comprises reacting thiophene sulfonamide expressed by formula (1) (wherein Xdenotes a hydrogen atom or a halogen atom), and alkyl halocarbonate expressed by X-CO-OR (wherein Xdenotes a halogen atom, and R denotes a 1-4C alkyl group) in a hydrophilic organic solvent in the presence of an alkali metal carbonate and water to produce thiophene sulfonyl carbamate expressed by formula (3) (wherein Xdenotes the same atom as that of formula (1), and R denotes a 1-4C alkyl group).
摘要翻译：待解决的问题：提供以有效和高纯度生产用作药物，农药等的中间体的噻吩磺酰基氨基甲酸酯的方法。解决方案：该方法包括使由式（1）表示的噻吩磺酰胺（其中X 1 表示氢原子或卤素原子）和由X'表示的卤代碳酸烷基酯反应，亲水性（其中X 2 表示卤素原子，R表示1-4C烷基）有机溶剂在碱金属碳酸盐和水的存在下反应以制备由式（3）表示的噻吩磺酰氨基甲酸酯（其中X 1 表示与式（1）相同的原子，，R表示1-4C烷基）。版权所有（C）2012，JPO＆INPIT

10. 发明专利

JP2011079766A Method for preparing 4-halophenyl alkyl sulfone 审中-公开
标题翻译：制备4-羟基苯甲酸钠的方法
公开(公告)号：JP2011079766A
公开(公告)日：2011-04-21
申请号：JP2009232611
申请日：2009-10-06
申请人： Sumitomo Seika Chem Co Ltd , 住友精化株式会社
发明人： ASHIKAWA MASAYASU , WAKIMURA KENICHI , SATAKE SHUZO
IPC分类号： C07C315/02 , C07C317/14
摘要： PROBLEM TO BE SOLVED: To provide a method for readily preparing 4-halophenyl alkyl sulfone useful as a synthetic intermediate of a pharmaceutical product etc. with an industrial advantage and in a high yield.
SOLUTION: The method for preparing 4-halophenyl alkyl sulfone represented by formula (3) includes: reacting phenyl akyl sulfide with halogen; and subsequently reacting the resulting 4-halophenyl alkyl sulfide represented by formula (2) (wherein R is 1-4C alkyl group; and X is halogen atom) with an oxidizing agent.
COPYRIGHT: (C)2011,JPO&INPIT

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