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1. 发明专利

JPS62187426A PRODUCTION OF KETOPANTOATE AND/OR KETOPANTOLACTONE 失效
公开(公告)号：JPS62187426A
公开(公告)日：1987-08-15
申请号：JP22535085
申请日：1985-10-08
申请人： SEITETSU KAGAKU CO LTD
发明人： YAMADA HIDEAKI , SHIMIZU AKIRA , HATA HIROYUKI
IPC分类号： C12P7/50 , C07C59/215 , C07D307/60 , C12P17/04 , C12R1/01 , C12R1/15 , C12R1/34 , C12R1/365 , C12R1/62
摘要： PURPOSE:The selective oxidation of L-pantothenate salt and/or L-pantolactone is carried out using a specific microorganism in Nocardia or the like to produce the titled compound which is used as a precursor of D-pantolactone with industrial advantage. CONSTITUTION:The selective oxidation of L-pantothenate and/or L-pantolactone is effected by cultivating or using cell bodies of at least one selected from microorganisms in Nocardia, Rhodococcus, Nocardioides, Mycobacterium, Streptoporangium, Streptomyces or Chorinebacterium to produce the titled compound which is used in the production of pantothenic acid, advantageously. In the cultivation, a specific compound such as ethanol, sorbit or 1,3-propanediol is added to the culture medium or to the substrate solution to increase the oxidation ability of the cell bodies with more inexpensive compound than in the known method.

2. 发明专利

JPS6240288A CARBONYLREDUCTASE AND PRODUCTION THEREOF 失效
公开(公告)号：JPS6240288A
公开(公告)日：1987-02-21
申请号：JP17977585
申请日：1985-08-14
申请人： SEITETSU KAGAKU CO LTD
发明人： YAMADA HIDEAKI , SHIMIZU AKIRA , HATA HIROYUKI
IPC分类号： C12N9/02 , C12R1/785 , C12R1/845
摘要： PURPOSE:To collect carbonylreductase capable of reducing carbonyl groups in the presence of reduced form of nicotinamide adenine dinucleotide phosphate (NADPH), by cultivating a microorganism, belonging to the genus Mucor, etc., and having the ability to produce the titled substance capable of giving an alcohol of S-configuration. CONSTITUTION:A microorganism, belonging to the genus Mucor or Phizopus, e.g. Mucor rouxianus or Rhizopus oryzae, and having the ability to produce carbonylreductase is cultivated in a nurient culture medium by the spinner culture method with aeration to give microbial cells from the resultant culture fluid, and the carboylreductase is extracted from the interior of the microbial cells. The resultant carbonylreductase is capable of reducing carbonyl groups which are constituent units of conjugated polyketones in the presence of reduced form of nicotinamide dinucleotide phosphate (NADPH) to produce 1mol each alcohol of S-configuration and nicotinamide adenine dinucleotide phosphate (NADP ) from 1mol each carbonyl groups and NADPH. The optimum pH is 6-7, and the molecular weight measured by the gel filtration method is 54,000+ or -2,000.

3. 发明专利

JPS61234794A PRODUCTION OF L-CARNITINE 失效
公开(公告)号：JPS61234794A
公开(公告)日：1986-10-20
申请号：JP7792685
申请日：1985-04-11
申请人： SEITETSU KAGAKU CO LTD
发明人： KAWAMURA MASAO , AKUTSU SEIICHI , FUKUDA HIROSUKE , HATA HIROYUKI , MORISHITA TSUYOSHI , KANO KENJI , NISHIMORI HIROKUNI
IPC分类号： C12P41/00 , C12R1/01 , C12R1/02 , C12R1/025 , C12R1/05 , C12R1/06 , C12R1/065 , C12R1/07 , C12R1/13 , C12R1/145 , C12R1/15 , C12R1/18 , C12R1/185 , C12R1/20 , C12R1/22 , C12R1/225 , C12R1/265 , C12R1/365 , C12R1/37 , C12R1/38 , C12R1/41 , C12R1/42 , C12R1/425 , C12R1/44 , C12R1/46 , C12R1/465 , C12R1/63 , C12R1/64
摘要： PURPOSE:L-carnitine is obtained from crotonobetaine using cell bodies with increased carnitine hydro-lyase activity which is obtained by anaerobic cultivation in the presence of a carnitine hydrolyase inducer. CONSTITUTION:A microorganism capable of converting crotonobetaine into L-carnitine such as Escerichea coli IFO 3301 or Enterobacter cloacae IFO3320 is cultured under anaerobic conditions in the presence of a carnitine hydro-lyase inducer such as DL-carnitine or crotonobetaine to effect induction of carnitine hydro-lyase. The resultant enzyme is allowed to act on a solution containing crotonobetaine to hydrate the betaine asymmetrically to give optically active L-carnitin.

4. 发明专利

JPS61234788A PRODUCTION OF L-CARNITINE 失效
公开(公告)号：JPS61234788A
公开(公告)日：1986-10-20
申请号：JP7792585
申请日：1985-04-11
申请人： SEITETSU KAGAKU CO LTD
发明人： KAWAMURA MASAO , AKUTSU SEIICHI , FUKUDA HIROSUKE , HATA HIROYUKI , MORISHITA TSUYOSHI , KANO KENJI , NISHIMORI HIROKUNI
IPC分类号： C12P13/00 , C12R1/01 , C12R1/185 , C12R1/20 , C12R1/265 , C12R1/42 , C12R1/425
摘要： PURPOSE:To obtain efficiently optically active L-carnitine from crotonobetaine, by cultivating a bacterium in the presence of crotonobetaine anaerobically. CONSTITUTION:A bacterium (Escherichia coli LF03301, Proteus vulgaris IF03851, etc.) is anaerobically cultivated in the presence of crotonobetaine at 15-60 deg.C at 3-9 pH to give efficiently L-carnitine from crotonobetaine. In the cultivation under an anaerobic condition, complicated culture control such as aeration, stirring, etc. is not required, so that incidental facilities can be reduced. USE:Remedying acute or chronic myocardial ischemia in the cardiovascular system, breast pang, arrhythmia of heart or caardiac incompetence.

5. 发明专利

JPS6130557B2 失效
公开(公告)号：JPS6130557B2
公开(公告)日：1986-07-14
申请号：JP497383
申请日：1983-01-13
申请人： SEITETSU KAGAKU CO LTD
发明人： YAMADA HIDEAKI , SHIMIZU AKIRA , HATA HIROYUKI
IPC分类号： C12P17/04 , C12P7/42 , C12R1/785 , C12R1/845

6. 发明专利

JPS60188064A ISATIN REDUCTASE AND ITS PREPARATION 失效
公开(公告)号：JPS60188064A
公开(公告)日：1985-09-25
申请号：JP4614084
申请日：1984-03-09
申请人： SEITETSU KAGAKU CO LTD
发明人： YAMADA HIDEAKI , SHIMIZU AKIRA , HATA HIROYUKI
IPC分类号： C12N9/02 , C12R1/01 , C12R1/025 , C12R1/06 , C12R1/13 , C12R1/15 , C12R1/265 , C12R1/38 , C12R1/425 , C12R1/44 , C12R1/64 , C12R1/645 , C12R1/66 , C12R1/72 , C12R1/77 , C12R1/78 , C12R1/785 , C12R1/80 , C12R1/84 , C12R1/845 , C12R1/85 , C12R1/88
摘要： PURPOSE:To produce novel isatin reductase capable of reducing isatin in the presence of NADPH, by culturing a microbial strain belonging to Mucor genus, etc. CONSTITUTION:A microbial strain belonging to Mucor genus, Rhizopus genus, Aspergillus genus, etc. and capable of producing novel isatin reductase, e.g. Mucor subtilisimus IFO 6338 is inoculated in a nutrient medium, and cultured at 15-50 deg.C and 3-10pH under aerobic condition. The objective novel isatin reductase is separated from the cultured microbial cell.

7. 发明专利

JPS59164749A Preparation of alpha-keto acid and/or its salt 失效
标题翻译：阿尔卡特酸和/或其盐的制备
公开(公告)号：JPS59164749A
公开(公告)日：1984-09-17
申请号：JP3970183
申请日：1983-03-09
申请人： Seitetsu Kagaku Co Ltd
发明人： KAWAMURA MASAO , AKUTSU SEIICHI , TAKAHASHI MASAHIDE , HATA HIROYUKI , MORISHITA TSUYOSHI , NISHIMORI HIROKUNI
IPC分类号： C07C59/185 , C07C51/00 , C07C51/09 , C07C51/373 , C07C59/205 , C07C59/21 , C07C59/76 , C07C67/00
摘要： PURPOSE: To prepare the titled compound useful industrially as pharmaceuticals, etc., economically, in high yield, by reacting an aldehyde with an oxalic acid ester in the presence of a metal alcoholate, and hydrolyzing the product with an alkali.
CONSTITUTION: The objective compound of formula II is prepared by reacting the aldehyde of formula I (R
1 and R
2 are 1W18C alkyl, halogen-substituted alkyl, 3W8C cycloalkyl, or aromatic hydrocarbon group) with an oxalic acid ester of formula (COOR
3 )
2 (R
3 is 1W5C alkyl) in the presence of a metal alcoholate of formula ROM (R is 1W18C alkyl; M is alkali metal or alkaline earth metal), preferably in a solvent such as methyl alcohol, dioxane, etc. at -70W +50°C, preferably at 8W12°C, hydrolyzing the reaction mixture with an alkali such as sodium hydroxide, and treating the product with a mineral acid. The molar ratio of the compound of formula I to the oxalic acid ester preferably 1.0W1.2.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：在金属醇化物的存在下，通过使醛与草酸酯反应，并以碱的方式使产物水解，从经济上高效率地制备作为药物等在工业上有用的标题化合物。结构式：式II的目的化合物是通过使式I的醛（R1和R2是1-18C烷基，卤素取代的烷基，3-8C环烷基或芳族烃基）与式（III）的草酸酯反应制备的， COOR3）2（R3为1-5C烷基）在式ROM的金属醇化物（R为1-18C烷基; M为碱金属或碱土金属）的存在下，优选在溶剂如甲醇，二恶烷，在-70- + 50℃，优选在8-12℃，用碱如氢氧化钠水解反应混合物，并用无机酸处理该产物。式I化合物与草酸酯的摩尔比优选为1.0-1.2。

8. 发明专利

JPS5531035A PREPARATION OF PARAAHYDROXYBENZALDEHYDE 失效
公开(公告)号：JPS5531035A
公开(公告)日：1980-03-05
申请号：JP10398478
申请日：1978-08-25
申请人： SEITETSU KAGAKU CO LTD
发明人： KAWAMURA MASAO , NISHI TADAAKI , KATOU KUNIKIYO , ONOUE AKIRA , HATA HIROYUKI , KANAZAWA TADASHI , TAKEMORI SHINICHI
IPC分类号： C07C47/565 , C07C45/00 , C07C45/64 , C07C47/56 , C07C67/00
摘要： PURPOSE:To prepare the title compound useful as an intermediate of medicine, pesticide, perfumery, etc., easily and economically, by treating p-aminobenzaldehyde and/or its polymer with a mineral acid in a specific solvent, diazotizing the product at low temperature, and hydrolyzing the diazotized compound. CONSTITUTION:The title compound is prepared by (1) reacting p-aminobenzaldehyde and/or its polymer obtained by the reaction of p-nitrotoluene with sodium polysulfide in an alkaline aqueous solution containing an alcohol, with a mineral acid such as sulfuric acid, etc. in a solvent composed of a water-soluble organic solvent such as alcohol, cyclic ether, lower fatty acid, etc. and water, (2) diazotizing the reaction product at a low temperature by conventional process, and (3) hydrolyzing the diazotized product. The weight ratio of the organic solvent to p-aminobenzaldehyde is pref. 1.5-5 to 1; the molar ratio of the mineral acid to the aldehyde is pref. 1.0-2.0 to 1; and the volume ratio of water to the organic solvent is pref. 0.1-50 to 1.

9. 发明专利

JPS6244189A PRODUCTION OF GAMMA-BUTYROBETAINE 失效
公开(公告)号：JPS6244189A
公开(公告)日：1987-02-26
申请号：JP18537585
申请日：1985-08-22
申请人： SEITETSU KAGAKU CO LTD
发明人： KAWAMURA MASAO , AKUTSU SEIICHI , FUKUDA HIROSUKE , HATA HIROYUKI , MORISHITA TSUYOSHI , KANO KENJI , NISHIMORI HIROKUNI
IPC分类号： C12P13/00 , C12R1/01 , C12R1/02 , C12R1/025 , C12R1/05 , C12R1/065 , C12R1/07 , C12R1/13 , C12R1/145 , C12R1/15 , C12R1/18 , C12R1/185 , C12R1/20 , C12R1/22 , C12R1/225 , C12R1/265 , C12R1/32 , C12R1/365 , C12R1/37 , C12R1/38 , C12R1/42 , C12R1/425 , C12R1/44 , C12R1/46 , C12R1/465 , C12R1/63 , C12R1/64
摘要： PURPOSE:To produce gamma-butyrobetaine efficiently on an industrial scale at a low cost, by culturing a microbial strain in a medium containing a specific substance. CONSTITUTION:DL-carnitine or crotonobetaine is added to a medium composed of a carbon source (e.g. glucose), nitrogen source (e.g. peptone), inorganic ion (e.g. Mg ion), minor organic nutrient (e.g. vitamin, amino acid, etc.), etc. A microbial strain belonging to Escherichia genus, Enterobacter genus, etc., such as Escherichia coil IFO 3301, Enterobacter cloacae IFO 3320, etc., is inoculated in the above medium and cultured at 15-60 deg.C and 3-9 pH for 1-10 days.

10. 发明专利

JPS61282351A 3-CYANO-2-PROPENYLTRIMETHYLAMMONIUM SALT AND PRODUCTION THEREOF 失效
公开(公告)号：JPS61282351A
公开(公告)日：1986-12-12
申请号：JP12457285
申请日：1985-06-08
申请人： SEITETSU KAGAKU CO LTD
发明人： KAWAMURA MASAO , AKUTSU SEIICHI , FUKUDA HIROSUKE , HATA HIROYUKI , MORISHITA TSUYOSHI , KANO KENJI , NISHIMORI HIROKUNI
IPC分类号： C07C255/30 , C07C67/00 , C07C253/00 , C07C253/30
摘要： NEW MATERIAL:A compound expressed by formula I (X is Cl or Br). EXAMPLE:3-Cyano-2-propenyltrimethylammonium chloride. USE:A precursor for l-carnitine useful as a remedy for chronic myocardial ischemia or angina pectoris, etc. PREPARATION:According to the reaction formula, carnitinenitrile expressed by formula II is dehydrated with acetic anhydride as a dehydrating agent to give the aimed compound expressed by formula I. The reaction is carried out using dl-carnitinenitrile as the carnitinenitrile at 80-140 deg.C, preferably 100-120 deg.C for 20-50hr, preferably >=35hr. The amount of the acetic anhydride to be used is equimolar amount - about 3 mol based on the compound expressed by formula II.

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