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1. 发明专利

JP2009168818A Method of preserving reagent in minute flow apparatus for blood biochemical reactions, and biochemical inspection method using minute flow apparatus 审中-公开
标题翻译：用于血液生化反应的分流装置中的试剂保存方法和使用分钟流量装置的生物化学检查方法
公开(公告)号：JP2009168818A
公开(公告)日：2009-07-30
申请号：JP2009007700
申请日：2009-01-16
申请人： Samsung Electronics Co Ltd , 三星電子株式会社Samsung Electronics Co.,Ltd.
发明人： CHO YOON-KYOUNG , LIM HEE-KYUN , LEE JEONG-GUN , KIM KI-EUM , LEE SUNGHO , LEE CHAE-JOON
IPC分类号： G01N35/08 , G01N33/49 , G01N37/00
CPC分类号： B01L3/50273 , B01L2200/16 , B01L2300/0803 , B01L2300/0864 , B01L2300/087 , B01L2400/0409
摘要： PROBLEM TO BE SOLVED: To provide a method of preserving a reagent in a minute flow apparatus for blood biochemical reactions, and to provide a biochemical inspection method using the minute flow apparatus.
SOLUTION: The method of preserving the reagent in the minute flow apparatus includes the step of injecting the reagent into reaction chambers provided in the minute flow apparatus, and the step of freeze-drying the reagent in the state of being injected into the minute flow apparatus. The biochemical inspection method using the minute flow apparatus which employs the minute flow apparatus for biochemical inspections in which the reaction chambers holding the reagents for carrying out a biochemical inspection and fluid flow passages are provided, includes the step of injecting the reagents into the reaction chambers provided in the minute flow apparatus, and the step of freeze-drying the reagent in the state of being injected into the minute flow apparatus.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种在用于血液生化反应的微流量装置中保留试剂的方法，并提供使用微流量装置的生物化学检查方法。解决方案：在微流量装置中保存试剂的方法包括将试剂注入到微流量装置中所设置的反应室中的步骤，以及将试剂注入的方法冷冻干燥的步骤微流量装置。使用采用微流量装置进行生物化学检查的微流量装置的生物化学检查方法，其中容纳用于进行生物化学检查和流体流动通道的试剂的反应室包括将试剂注入反应室以及在注入微量流量装置的状态下将试剂冷冻干燥的步骤。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2006296427A Cell separation method using hydrophobic solid support 审中-公开
标题翻译：使用疏水性固体支持的细胞分离方法
公开(公告)号：JP2006296427A
公开(公告)日：2006-11-02
申请号：JP2006113753
申请日：2006-04-17
申请人： Samsung Electronics Co Ltd , 三星電子株式会社Samsung Electronics Co.,Ltd.
发明人： LIM HEE-KYUN , HWANG KYU-YOUN , KIM JOON-HO , NANGU KAKU , PARK CHIN-SUNG
IPC分类号： C12N7/00 , C12M1/26 , C12M3/00
CPC分类号： B01L3/502753 , B01L3/502746 , B01L2300/0681 , B01L2400/086 , B82Y30/00 , B82Y40/00 , C12M47/02
摘要： PROBLEM TO BE SOLVED: To provide a rapid and ready method of separating various kinds of cells or viruses. SOLUTION: The method of separating the cells or the viruses using a hydrophobic solid support comprises contacting a solution containing the cells or the viruses (which can be a clinic sample such as blood) and having pH 2.5-7, preferably 2.5-4 with a hydrophobic solid support having a water contact angle between 70 and 90 degrees. The device therefor is also provided. The support can have various kinds of structures such as a plane, a pillar, a bead and a sieve. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种分离各种细胞或病毒的快速和准备的方法。解决方案：使用疏水性固体支持物分离细胞或病毒的方法包括使含有细胞或病毒（其可以是临床样品如血液）并且具有pH 2.5-7，优选2.5- 4具有70至90度之间的水接触角的疏水性固体支持物。还提供了其设备。支撑体可以具有各种结构，例如平面，柱，珠和筛。版权所有（C）2007，JPO＆INPIT

3. 发明专利

JP2006171005A METHOD OF REGULATING pH OF SAMPLE SOLUTION 有权
标题翻译：调节样品溶液pH值的方法
公开(公告)号：JP2006171005A
公开(公告)日：2006-06-29
申请号：JP2005363918
申请日：2005-12-16
申请人： Samsung Electronics Co Ltd , 三星電子株式会社Samsung Electronics Co.,Ltd.
发明人： LEE HUN-JOO , KIM JOON-HO , YOO CHANG-EUN , HWANG KYU-YOUN , LIM HEE-KYUN
IPC分类号： G01N1/00 , G01N1/10 , G01N37/00
CPC分类号： G05D21/02 , B01D61/422 , B01L3/50273 , B01L2200/14 , B01L2300/0867 , B01L2400/0415 , C02F1/4618 , C02F2103/02 , C02F2201/4611 , C02F2201/46115 , C02F2201/4618 , C02F2209/06 , Y02E60/366
摘要： PROBLEM TO BE SOLVED: To provide a means for regulating a pH of a sample solution, using a micro fluid element, without providing a process for adding and/or removing a solution for regulating the pH.
SOLUTION: This method of regulating the pH of the sample solution includes a process for making the solution containing a compound of a standard oxidation-reduction potential lower than that of water flow from a flowing-in port of an anode chamber into the anode chamber, using the micro fluid element provided with an electrolytic element with the anode chamber and a cathode chamber, a process for making the solution containing a compound of a standard oxidation-reduction potential higher than that of water flow from a flowing-in port of the cathode chamber into the cathode chamber, a process for impressing a voltage to electrodes provided in the anode chamber and the cathode chamber to conduct electrolysis, and a process for mixing electrolytes in the anode chamber and the cathode chamber with the same volume, and volumes of the anode chamber and the cathode chamber are regulated at a prescribed ratio according to the target pH of the sample solution obtained by mixing the electrolytes in the anode chamber and the cathode chamber.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供使用微流体元件调节样品溶液的pH的方法，而不提供用于添加和/或除去用于调节pH的溶液的方法。解决方案：这种调节样品溶液的pH的方法包括使含有标准氧化还原电位低于从阳极室的流入口流入水中的化合物的溶液的溶液的方法，阳极室，使用设置有阳极室的电解元件的微流体元件和阴极室，使含有比来自流入口的水流高的标准氧化还原电位的化合物的溶液的方法阴极室的阴极室的电压施加到设置在阳极室和阴极室中的电极进行电解的工序，以及在阳极室和阴极室中以相同体积混合电解质的工序，以及根据通过混合电解获得的样品溶液的目标pH，阳极室和阴极室的体积以规定的比例调节在阳极室和阴极室中。版权所有（C）2006，JPO＆NCIPI

4. 发明专利

JP2010178750A Cell separation method using hydrophobic solid support 审中-公开
标题翻译：使用疏水性固体支持的细胞分离方法
公开(公告)号：JP2010178750A
公开(公告)日：2010-08-19
申请号：JP2010083048
申请日：2010-03-31
申请人： Samsung Electronics Co Ltd , 三星電子株式会社Samsung Electronics Co.,Ltd.
发明人： LIM HEE-KYUN , HWANG KYU-YOUN , KIM JOON-HO , NANGU KAKU , PARK CHIN-SUNG
IPC分类号： C12Q1/02 , C12M1/34 , C12N1/20 , C12N5/00 , C12N7/02
摘要： PROBLEM TO BE SOLVED: To provide a rapid and ready method for separating cells or viruses. SOLUTION: The method for separating the cells or the viruses using a hydrophobic solid support comprises a step of contacting a solution containing the cells or the viruses with a hydrophobic solid support having a water contact angle between 70 and 90 degrees. The viruses are selected from the group consisting of bacteria, bacteriophages, plant cells, animal cells, plant viruses and animal viruses, and the hydrophobic solid support is selected from the group consisting of various kinds of structures such as a plane, a pillar, a bead and a sieve. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供用于分离细胞或病毒的快速且便捷的方法。解决方案：使用疏水性固体支持物分离细胞或病毒的方法包括使含有细胞或病毒的溶液与水接触角在70度和90度之间的疏水性固体支持物接触的步骤。病毒选自细菌，噬菌体，植物细胞，动物细胞，植物病毒和动物病毒，疏水性固体支持体选自各种结构，如平面，柱状，珠子和筛子。版权所有（C）2010，JPO＆INPIT

5. 发明专利

JP2007195538A MICRO FLOW DEVICE FOR ELECTROCHEMICALLY ADJUSTING pH OF FLUID, AND METHOD FOR ADJUSTING pH BY UTILIZING THE SAME 有权
标题翻译：用于电化学调节流体pH的微流动装置，以及利用其调节pH的方法
公开(公告)号：JP2007195538A
公开(公告)日：2007-08-09
申请号：JP2006301359
申请日：2006-11-07
申请人： Samsung Electronics Co Ltd , 三星電子株式会社Samsung Electronics Co.,Ltd.
发明人： LEE HUN-JOO , KIM JOON-HO , JEONG SUNG-YOUNG , LIM HEE-KYUN
IPC分类号： C12M1/00 , B01J19/08 , B01J47/00 , C12N15/09
CPC分类号： B01D61/44 , B01L3/502707 , B01L2200/0684 , B01L2300/10 , B01L2400/0487
摘要： PROBLEM TO BE SOLVED: To provide a micro flow device for electrochemically adjusting the pH of fluid and a method for adjusting pH by utilizing the same. SOLUTION: This micro flow device has a chamber 105 equipped with a metal capable of adsorbing hydrogen gas as a cathode 101 and a metal without reacting with water since it has a higher standard oxidation potential than that of water, as an anode 103. Gas is not produced by electrolysis in the chamber. Since the gas is not generated during the electrolysis, problems such as solution flow obstruction, flow regulation inhibition, mixing inhibition, reaction inhibition and problems caused by gas bubbles in a micro flow channel such as heat generation and substance transfer do not occur, and a gas-discharging port and separated gas-removing device are not required so as to be able to contribute to the small-sizing of the micro flow device. Also, since there is no generation of the gas during the electrolysis, the pH of the fluid in the micro flow device can be adjusted quickly and easily. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于电化学调节流体pH的微流量装置以及利用该微流量装置调节pH的方法。解决方案：该微流量装置具有装有能够吸附氢气作为阴极101的金属的室105和不与水反应的金属，因为它具有比水高的标准氧化电位作为阳极103 气体不是通过电解室产生的。由于在电解期间不产生气体，所以不会发生溶液流动阻塞，流动调节抑制，混合抑制，反应抑制以及微流路中的气泡引起的问题，例如发热和物质转移等问题，不需要气体排出口和分离的气体除去装置，以便能够有助于微流量装置的小型化。此外，由于在电解期间不产生气体，所以可以快速且容易地调节微流量装置中的流体的pH。版权所有（C）2007，JPO＆INPIT

6. 发明专利

JP2006166916A Microfluidic device comprising electrolysis device for lysing cell or virus and method for lysing cells or virus using the same 有权
标题翻译：包含用于诱导细胞或病毒的电解装置的微流体装置以及使用该细胞或病毒的细胞或病毒的方法
公开(公告)号：JP2006166916A
公开(公告)日：2006-06-29
申请号：JP2005363915
申请日：2005-12-16
申请人： Samsung Electronics Co Ltd , 三星電子株式会社Samsung Electronics Co.,Ltd.
发明人： LEE HUN-JOO , KIM JOON-HO , YOO CHANG-EUN , LIM HEE-KYUN , HWANG KYU-YOUN , MA SOO-MIN , MIN JUN-HONG
IPC分类号： C12M1/00 , C12N15/09
CPC分类号： C12N1/066 , C12M47/06
摘要： PROBLEM TO BE SOLVED: To provide a microfluidic device comprising electrolysis device for lysing cell or virus and to provide a method for lysing cells or virus using the same. SOLUTION: The microfluidic device includes an electrolysis device for lysing cell or virus which includes an anode chamber, a cathode chamber and a separator membrane, in which the separator is installed between the anode chamber and the cathode chamber, the anode chamber includes an inlet and an outlet for an anode chamber solution and an electrode, and the cathode chamber includes an inlet and an outlet for a cathode chamber solution and an electrode, and the method of lysing cells or virus using the same. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种微流体装置，其包括用于裂解细胞或病毒的电解装置，并提供使用该细胞或病毒裂解细胞或病毒的方法。解决方案：微流体装置包括用于裂解细胞或病毒的电解装置，其包括阳极室，阴极室和分隔膜，其中分离器安装在阳极室和阴极室之间，阳极室包括用于阳极室溶液和电极的入口和出口，阴极室包括用于阴极室溶液和电极的入口和出口，以及使用该阴极室溶液和电极裂解细胞或病毒的方法。版权所有（C）2006，JPO＆NCIPI

7. 发明专利

JP2010124829A System and method for processing target material 审中-公开
标题翻译：用于处理目标材料的系统和方法
公开(公告)号：JP2010124829A
公开(公告)日：2010-06-10
申请号：JP2009141238
申请日：2009-06-12
申请人： Samsung Electronics Co Ltd , 三星電子株式会社Samsung Electronics Co.,Ltd.
发明人： CHUNG WOON-SEOK , NANGU KAKU , KIM JOON-HO , HWANG KYU-YOUN , LIM HEE-KYUN
IPC分类号： C12M1/00 , C12Q1/68 , G01N33/50
CPC分类号： G01N33/53 , B01L3/502738 , B01L7/00 , B01L7/52 , B01L2200/10 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/1822 , B01L2300/1827 , B01L2400/0409 , B01L2400/0677 , G01N21/07 , G01N33/48 , G01N35/00029 , G01N2035/00099 , G01N2035/00148 , G01N2035/00158 , G01N2035/00495 , Y10T436/111666
摘要： PROBLEM TO BE SOLVED: To provide a system and method for processing a target material which automatically performs the treatment process for the target material such as extracting a specific target material, etc., from a sample. SOLUTION: The system for processing the target material includes; a cartridge which stores a material which reacts with the target material, and may include at least one chamber and at least one valve connected to the at least one chamber, a first module which may be loaded with the at least one cartridge and may rotate, a second module which may selectively open or close the at least one valve, a third module which may selectively control the temperature of the at least one chamber, and a control module which may control the first module, the second module and the third module. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于处理目标材料的系统和方法，该目标材料自动地执行目标材料的处理过程，例如从样品中提取特定的目标材料等。解决方案：用于处理目标材料的系统包括：存储与所述目标材料反应的材料的盒，并且可以包括至少一个室和连接到所述至少一个室的至少一个阀;第一模块，其可装载有所述至少一个筒并且可旋转，可以选择性地打开或关闭所述至少一个阀的第二模块，可以选择性地控制所述至少一个室的温度的第三模块以及可以控制所述第一模块，所述第二模块和所述第三模块的控制模块。版权所有（C）2010，JPO＆INPIT

8. 发明专利

JP2006176521A Method for separating nucleic acid 有权
标题翻译：分离核酸的方法
公开(公告)号：JP2006176521A
公开(公告)日：2006-07-06
申请号：JP2005367060
申请日：2005-12-20
申请人： Samsung Electronics Co Ltd , 三星電子株式会社Samsung Electronics Co.,Ltd.
发明人： HWANG KYU-YOUN , KIM JOON-HO , YOO CHANG-EUN , LEE HUN-JOO , LIM HEE-KYUN , JEONG SUNG-YOUNG , SHIM JEO-YOUNG
IPC分类号： C07H1/06 , B01J20/26 , B01J20/34 , C07H21/00 , C07H21/04 , C12N15/09
CPC分类号： C12N15/1006 , B01D15/361 , B01D15/364 , B01J20/3285 , B01J43/00 , C12Q1/6806 , C12Q2527/119 , C12Q2523/308
摘要： PROBLEM TO BE SOLVED: To provide a method for separating a nucleic acid with a substance binding to the nucleic acid at a high rate and releasing the nucleic acid in high efficiency, when pH is raised, by which the nucleic acid can quickly and high efficiently be separated. SOLUTION: This method for separating a nucleic acid from a sample comprises a process for bringing the sample containing the nucleic acid into contact with a two functional groups-having substance having an amino group and a carboxy group and taking a positive charge at the first pH to bind the nucleic acid to the two functional groups-having substance, and a process for releasing the bound nucleic acid at the higher second pH than the first pH, is characterized in that the two functional groups-having substance is a specific substance. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种用于以高速率与核酸结合的物质分离核酸的方法，并且当提高pH时，核酸可以快速释放并高效地分离。解决方案：用于从样品中分离核酸的方法包括使含有核酸的样品与具有氨基和羧基的物质的两个官能团接触并将正电荷置于将核酸与具有两个官能团的物质结合的第一pH以及在比第一pH高的第二pH下释放结合的核酸的方法的特征在于具有物质的两个官能团是具体的物质。版权所有（C）2006，JPO＆NCIPI

9. 发明专利

JP2005058234A Pcr primer set for detecting hepatitis b, and method for detecting hepatitis b and using the primer set 审中-公开
标题翻译：用于检测乙型肝炎的PCR引物组和用于检测乙型肝炎和使用PRIMER SET的方法
公开(公告)号：JP2005058234A
公开(公告)日：2005-03-10
申请号：JP2004231611
申请日：2004-08-06
申请人： Samsung Electronics Co Ltd , 三星電子株式会社
发明人： LEE YOUNG-SUN , HAN JUNG-IM , HWANG JUNG-JOO , KIM MI-KYUNG , CHO YOON-KYOUNG , LIM HEE-KYUN , KIM YOUNG-A
IPC分类号： C12N15/09 , C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/706 , C12Q2565/629 , C12Q2565/543 , C12Q2531/113
摘要： PROBLEM TO BE SOLVED: To provide a PCR primer set for detecting hepatitis B, and to provide a method for detecting hepatitis B and using the primer set. SOLUTION: Provided are a primer set selected from a group consisting of primers having a specific base sequence, a method for detecting hepatitis B and including a step of PCR by using the primer set, and a hepatitis B detection kit including the primer set. Thereby, hepatitis B is quickly and accurately diagnosed. COPYRIGHT: (C)2005,JPO&NCIPI

10. 发明专利

JP2006325592A METHOD FOR SEPARATION OF CELL OR VIRUS AND KIT THEREFORE 审中-公开
公开(公告)号：JP2006325592A
公开(公告)日：2006-12-07
申请号：JP2006144587
申请日：2006-05-24
申请人： SAMSUNG ELECTRONICS CO LTD
发明人： HWANG KYU-YOUN , LIM HEE-KYUN , KIM JOON-HO
IPC分类号： C12N1/20 , C12N5/04 , C12N5/06 , C12N7/02
摘要： PROBLEM TO BE SOLVED: To provide a method for the separation of cells or viruses taking advantage of phase separation and provide a kit for the separation method for cells and viruses. SOLUTION: The method for the separation of cells or viruses contains a step to suspend a specimen containing cells or viruses in a cosmotropic salt solution having pH of 3-6, a step to add a cationic polymer to the suspension obtained by the former step to agglomerate the cells or viruses, a step to deposit the composite material composed of the cells or viruses and the cationic polymer obtained by the above agglomeration step to a solid substrate by the phase separation of the cationic polymer, and a step to separate the solid substrate carrying the cells and viruses and obtained by the deposition step from the suspension liquid. The invention further provides a cell or virus separation kit for the separation method. COPYRIGHT: (C)2007,JPO&INPIT

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