专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

JP2000247929A PRODUCTION OF 2-FLUOROCYCLOPROPANECARBOXYLIC ACID DERIVATIVE 失效
公开(公告)号：JP2000247929A
公开(公告)日：2000-09-12
申请号：JP4609999
申请日：1999-02-24
申请人： SUMITOMO CHEMICAL CO , DAIICHI SEIYAKU CO
发明人： KODERA TAKAHIRO , SASAKI MIKIO , WAKITA RYUHEI , YUKIMOTO YUSUKE
IPC分类号： B01J31/22 , C07B61/00 , C07C67/347 , C07C69/74 , C07C327/24
摘要： PROBLEM TO BE SOLVED: To obtain the subject compound useful as a synthetic intermediate for a new quinolone compound industrially and economically advantageously in a high yield by reacting a fluoroethylene with a diazoacetic acid derivative in a specific temperature range under pressure conditions. SOLUTION: (A) A fluoroethylene of formula I (X is H or a halogen) is reacted with (B) a diazoacetic acid derivative of formula II (R is a 1-10C alkoxy, aryloxy, aralkyloxy or the like) in the presence of a catalyst [preferably a catalyst composed of a transition metal atom of the group 8 (preferably rhodium) and a ligand (preferably a carboxylic acid-based or an amide-based ligand) by using 0.8-2 mols of the component A based on 1 mol of the component B under pressure at 0-100 deg.C to give (C) a 2-fluorocyclopropanecarboxylic acid derivative of formula III. Consequently the amount of the component A used can be reduced and the objective compound is obtained in a high yield.

2. 发明专利

JPH11228491A SEPARATION OF CIS/TRANS ISOMER MIXTURE OF 2-FLUOROCYCLOPROPANECARBOXYLIC ACID 失效
公开(公告)号：JPH11228491A
公开(公告)日：1999-08-24
申请号：JP3923498
申请日：1998-02-20
申请人： SUMITOMO CHEMICAL CO , DAIICHI SEIYAKU CO
发明人： WAKITA RYUHEI , NANBA TAKASHI , SASAKI MIKIO , YUKIMOTO YUSUKE
IPC分类号： C07C27/02 , C07C51/09 , C07C61/15
摘要： PROBLEM TO BE SOLVED: To provide a method for separating a cis/trans isomer mixture of 2-fluorocyclopropanecarboxylic acid by which the mixture is separated with little HF generation, and an apparatus made of a general purpose material can be used. SOLUTION: A cis/trans isomer mixture of 2-fluorocyclopropanecarboxylic acid is esterified to provide the cis/trans isomer mixture of a carboxylic acid ester, and the obtained ester isomer mixture is subjected to distillation separation to provide cis- or trans-2-fluorocyclopropanecarboxylic acid ester. The obtained cis- or trans-2-fluorocyclopropanecarboxylic acid ester is hydrolyzed to provide the objective cis- or trans-2-fluorocyclopropanecarboxylic acid in the method for separating the cis/trans isomer mixture of 2-f luorocyc lopropanecarboxylic acid.

3. 发明专利

JP2001000176A MICROORGANISM BELONGING TO GENUS BACILLUS 失效
公开(公告)号：JP2001000176A
公开(公告)日：2001-01-09
申请号：JP17203799
申请日：1999-06-18
申请人： DAIICHI SEIYAKU CO , SUMITOMO CHEMICAL CO
发明人： IMURA AKIHIRO , ITOU MIKIHIRO , TAKEMOTO TOMOHISA , SASAKI MIKIO
IPC分类号： C12N9/18 , C07C61/15 , C12N1/20 , C12P7/40 , C12R1/07
摘要： PROBLEM TO BE SOLVED: To obtain a new Bacillus microorganism producing an esterase which acts on an isomer mixture of a 2-chloro-2-fluorocyclopropane1-carboxylate to stereoselectively hydrolyze it and useful e.g. for producing raw materials for medicaments and agrochemicals. SOLUTION: This new Bacillus microorganism, Bacillus.DSC-5,032 strain (FERM P-17,405) produces an esterase which can produce optically active (1S,2 R)-2-chloro-2-fluorocyclopropane-1-carboxylic acid expressed by formula II [wherein R is an alkyl; and a wavy line means a mixture of a (1S)-isomer and a (1R)-isomer] and having an optical purity of >=95% by acting on a 2- chloro-2-f luorocyclopropane-1-carboxylate expressed by formula I [wherein its three-dimensional structure shows absolute configuration] so as to preferentially hydrolyze a (1S,2R)-2-chloro-2-fluorocyclopropane-1-carboxylate, and is useful e.g. for producing raw materials for a quinolone-based synthetic antibacterial drug and agrochemicals.

4. 发明专利

JPH09124556A PRODUCTION OF HALOGENATED CYCLOPROPANE DERIVATIVE 失效
公开(公告)号：JPH09124556A
公开(公告)日：1997-05-13
申请号：JP983096
申请日：1996-01-24
申请人： DAIICHI SEIYAKU CO , SUMITOMO CHEMICAL CO
发明人： EHATA TSUTOMU , AKIBA TOSHIFUMI , IKETANI TAKANOBU , WAKITA RYUHEI , SASAKI MIKIO
IPC分类号： B01J31/16 , C07B53/00 , C07B61/00 , C07C67/347 , C07C69/74 , C07C231/12 , C07C231/18 , C07C233/58 , C07C255/56 , C07C327/24
摘要： PROBLEM TO BE SOLVED: To stereo-selectively and efficiently obtain the subject optically active compound useful as an intermediate for producing new synthetic quinolone antibacterial agents by reacting a vinylidene halide with a diazo compound in the presence of a specific catalyst. SOLUTION: (B) A compound of the formula: CH2 =CXF (X is Cl, Br, I) is reacted with (B) a compound of the formula: N2 HCOR [R is a 1-10C alkyloxy (substituted with a halogen), an aralkyloxy comprising a (substituted)aryl and a 1-10C alkyloxy, a (substituted) aryloxy, a (halogenated aryloxy, a (halogenated) 1-10C alkylthio, an aralkylthio comprising a (substituted) aryl and a 1-10C alkylthio, amino, etc.; the substituent of the substituted aryl is a halogen, a 1-10C (halogenated) alkyl, etc.,] to preferentially produce the compound of the formula wherein the steric configuration of the 1-position is the S-configuration.

5. 发明专利

JP2000086585A STEREOISOMERIZATION OF 2-HALO- FLUOROCYCLOPROPANECARBOXYLIC ACID DERIVATIVE 失效
公开(公告)号：JP2000086585A
公开(公告)日：2000-03-28
申请号：JP26021898
申请日：1998-09-14
申请人： SUMITOMO CHEMICAL CO , DAIICHI SEIYAKU CO
发明人： SASAKI MIKIO , NANBA TAKASHI , YUKIMOTO YUSUKE
IPC分类号： C07C67/333 , C07C69/743
摘要： PROBLEM TO BE SOLVED: To advance a stereoisomerization reaction and to convert a stereoisomer of a halofluorocyclopropanecarboxylic acid derivative regarded unnecessary into a necessary stereoisomer by treating the unnecessary stereoisomer with a base. SOLUTION: A 2-halo-2-fluorocyclopropanecarboxylic acid derivative of the formula (X is Cl, Br or I; R is a 1-10C alkoxy, an aryloxy, an aralkyloxy, a 1-10C alkylthio, an arylthio or the like; * is an asymmetric carbon atom) is treated with a base (preferably an alkyl metal alkoxide) to subject the 2- halo-2-fluorocyclopropanecarboxylic acid derivative to stereoisomerization. The reaction is preferably carried out by the treatment with the base in the presence of a Lewis acid (preferably a titanium tetraalkoxide). The (1S, 2R) derivative is isomerized into a (1R, 2R)derivative and the (1R, 2R)derivative is to the (1S, 2R)derivative, respectively to give an equilibrium mixture.

6. 发明专利

JPH08268956A PRODUCTION OF 2-FLUOROCYCLOPROPANECARBOXYLIC ACID COMPOUND 失效
公开(公告)号：JPH08268956A
公开(公告)日：1996-10-15
申请号：JP1145296
申请日：1996-01-26
申请人： SUMITOMO CHEMICAL CO , DAIICHI SEIYAKU CO
发明人： ITAYA NOBUSHIGE , WAKITA RYUHEI , KUBO ASAKO , SASAKI MIKIO , NANBA TAKASHI , YUKIMOTO YUSUKE
IPC分类号： B01J25/02 , C07B61/00 , C07C51/377 , C07C61/15
摘要： PURPOSE: To easily obtain a 2-fluorocyclopropanecarboxylic acid compound in high yield in an industrially advantageous way a simple operation without the need of hydrogen feed, useful as an intermediate for e.g. medicines and agrochemicals, by spreading a Raney nickel alloy in the presence of a specific carboxylic acid compound. CONSTITUTION: This compound of formula II is obtained by using, in the presence of (A) a 2-halo-2-fluorocyclopropanecarboxylic acid compound of formula I (R is H or a lower alkyl; X is Cl, Br or I) (e.g. 2-chloro-2- fluorocyclopropanecarboxylic acid), (B) 0.1-1wt. time, based on the component A, of a Raney nickel alloy (e.g. containing 40-50wt.% of Ni) followed by spreading the component B. It is preferable that the spreading operation be conducted in the presence of a combination of a lower alkylenediamine with at least one kind of base selected from ammonia and organic bases (esp. ammonia, a lower alkylamine or lower amino alcohol).

7. 发明专利

JPH08198804A PRODUCTION OF 2-FLUOROCYCLOPROPANECARBOXYLIC ACID 失效
公开(公告)号：JPH08198804A
公开(公告)日：1996-08-06
申请号：JP1458095
申请日：1995-01-31
申请人： DAIICHI SEIYAKU CO , SUMITOMO CHEMICAL CO
发明人： ITAYA NOBUSHIGE , WAKITA RYUHEI , TANAHASHI ASAKO , SASAKI MIKIO , NANBA TAKASHI , YUKIMOTO YUSUKE
IPC分类号： B01J23/04 , B01J25/02 , C07B61/00 , C07C51/377 , C07C61/15
摘要： PURPOSE: To easily obtain the subject acid useful as an intermediate of pharmaceuticals, agrochemicals, etc., in high yield by performing reduction in an aqueous medium in the presence of Raney nickel catalyst wherein the catalyst is easily removed from the reaction mass. CONSTITUTION: (A) 2-Halo-2-fluorocyclopropanecarbonic acid of formula I (R is H or a lower alkyl; X is Cl, Br or I), e.g. 2-chloro-2- fluorocyclopropanecarbonic acid is reduced in an aqueous medium in the presence of (B) Raney nickel catalyst, preferably under the coexistence of (C) an organic base (ethylenediamine) and/or an inorganic base (NaOH or KOH) to obtain the objective acid of formula II, e.g. 2-fluorocyclopropanecarboxylic acid. Further, the component B is used at a ratio e.g. of 0.05-0.5 times in weight based on the component A in terms of dry weight.

8. 发明专利

JP2006036737A Production method for optically active nitroalcohol compound 审中-公开
标题翻译：光活性硝基化合物的生产方法
公开(公告)号：JP2006036737A
公开(公告)日：2006-02-09
申请号：JP2004223436
申请日：2004-07-30
申请人： Sumitomo Chemical Co Ltd , Sumitomo Pharmaceut Co Ltd , 住友化学株式会社 , 住友製薬株式会社
发明人： SASAKI MIKIO , YOKOYAMA TATSURO
IPC分类号： C07D213/30 , C07B61/00
摘要： PROBLEM TO BE SOLVED: To provide a production method for an optically active nitroalcohol compound of formula (4) (wherein R
1 and R
2 are each hydrogen atom, or the like; and * indicates an optically active carbon atom).
SOLUTION: In the production method for the optically active nitroalcohol compound of formula (4), a compound of formula (1) (wherein R
1 and R
2 are as indicated above) is reacted with nitromethane in the presence of a copper catalyst obtained by contacting a copper compound with an optically active bisoxazoline compound of formula (2) (wherein R
3 is an alkyl group, or the like; R
4 , R
5 and R
6 are identical to or different from each other and are each hydrogen atom, or the like; and * is as indicated above) or with an optically active diamine compound of formula (3) (wherein Ar is an aryl group, or the like; R
7 is an alkyl group, or the like; and * is as indicated above).
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：为了提供式（4）的光学活性硝基醇化合物（其中R 1和R 2各自为氢原子）的制备方法，或类似物;和*表示光学活性碳原子）。解决方案：在式（4）的光学活性硝基醇化合物的制备方法中，式（1）化合物（其中R 1 和R 2 如上所述）与硝基甲烷反应，在铜催化剂存在下，将铜化合物与式（2）的光学活性双恶唑啉化合物（其中R 3为烷基）或 R SP 3，R 6和R 6相同或不同，分别为氢原子等;和 *如上所述）或与式（3）的光学活性二胺化合物（其中Ar为芳基等; R 6为烷基等）和* 如上所述）。版权所有（C）2006，JPO＆NCIPI

9. 发明专利

JP2001181236A METHOD FOR PRODUCING CYCLOPROPANECARBOXYLIC ACID DERIVATIVE 失效
公开(公告)号：JP2001181236A
公开(公告)日：2001-07-03
申请号：JP36747299
申请日：1999-12-24
申请人： SUMITOMO CHEMICAL CO
发明人： SASAKI MIKIO
IPC分类号： C07D317/30 , B01J31/22 , C07B61/00 , C07C67/347 , C07C69/74 , C07C69/757
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a cyclopropanecarboxylic acid derivative expressed by general formula (4) in a better yield. SOLUTION: This method for producing the cyclopropanecarboxylic acid derivative (4) is provided by reacting a diazoacetic acid ester of general formula (1): N2CHOOR1, with an olefin of general formula (2) in the presence of a rhodium catalyst expressed by the formula (3): Rh2(OCOCPH3)4.

10. 发明专利

JP2005336083A Method for producing aromatic amino compound 审中-公开
标题翻译：生产芳族氨基化合物的方法
公开(公告)号：JP2005336083A
公开(公告)日：2005-12-08
申请号：JP2004155794
申请日：2004-05-26
申请人： Sumitomo Chemical Co Ltd , Sumitomo Pharmaceut Co Ltd , 住友化学株式会社 , 住友製薬株式会社
发明人： UENO ATSUSHI , SASAKI MIKIO
IPC分类号： C07D295/14 , C07B61/00 , C07C209/10 , C07C211/54 , C07C211/55 , C07C211/56 , C07C253/30 , C07C255/58 , C07C269/06 , C07C271/24
摘要： PROBLEM TO BE SOLVED: To provide a method for advantageously producing an objective aromatic amino compound by using a weak base such as potassium carbonate.
SOLUTION: The method for producing the aromatic amino compound represented by formula (3) involves reacting an aromatic compound represented by formula (1) with an amino compound represented by formula (2) in the presence of a homogeneous palladium catalyst comprising a bidentate ligand soluble in an organic solvent and a palladium compound, and the base. A carbonate, phosphate, acetate, trifluoroacetate, bicarbonate, hydrogen phosphate or fluoride of an alkali or alkaline earth metal is used as the base, and the reaction is carried out in the coexistence of water. In formula (1), Ar is an aryl group which may be substituted or the like, and X is a leaving group. In formula (2), R
1 is an alkyl group which may be substituted or the like, and R
2 is a hydrogen atom, an alkyl group which may be substituted or the like. In formula (3), Ar, R
1 and R
2 denote the same meanings as the above.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供通过使用弱碱如碳酸钾有利地制备目标芳香族氨基化合物的方法。解决方案：由式（3）表示的芳族氨基化合物的制备方法包括使式（1）表示的芳族化合物与式（2）表示的氨基化合物在含有二齿配位体可溶于有机溶剂和钯化合物，以及碱。使用碳酸盐，磷酸盐，乙酸盐，三氟乙酸盐，碳酸氢盐，磷酸氢盐或碱金属或碱土金属的氟化物作为碱，反应在水的共存下进行。式（1）中，Ar为可以被取代的芳基等，X为离去基。在式（2）中，R 1是可以被取代的烷基，R 2是氢原子，可被取代的烷基或类似。在式（3）中，Ar，R“SP”1和R“SP 2”表示与上述相同的含义。版权所有（C）2006，JPO＆NCIPI

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式