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1. 发明专利

JP2000247929A PRODUCTION OF 2-FLUOROCYCLOPROPANECARBOXYLIC ACID DERIVATIVE 失效
公开(公告)号：JP2000247929A
公开(公告)日：2000-09-12
申请号：JP4609999
申请日：1999-02-24
申请人： SUMITOMO CHEMICAL CO , DAIICHI SEIYAKU CO
发明人： KODERA TAKAHIRO , SASAKI MIKIO , WAKITA RYUHEI , YUKIMOTO YUSUKE
IPC分类号： B01J31/22 , C07B61/00 , C07C67/347 , C07C69/74 , C07C327/24
摘要： PROBLEM TO BE SOLVED: To obtain the subject compound useful as a synthetic intermediate for a new quinolone compound industrially and economically advantageously in a high yield by reacting a fluoroethylene with a diazoacetic acid derivative in a specific temperature range under pressure conditions. SOLUTION: (A) A fluoroethylene of formula I (X is H or a halogen) is reacted with (B) a diazoacetic acid derivative of formula II (R is a 1-10C alkoxy, aryloxy, aralkyloxy or the like) in the presence of a catalyst [preferably a catalyst composed of a transition metal atom of the group 8 (preferably rhodium) and a ligand (preferably a carboxylic acid-based or an amide-based ligand) by using 0.8-2 mols of the component A based on 1 mol of the component B under pressure at 0-100 deg.C to give (C) a 2-fluorocyclopropanecarboxylic acid derivative of formula III. Consequently the amount of the component A used can be reduced and the objective compound is obtained in a high yield.

2. 发明专利

JP2000159725A CRYSTALLIZATION OF PHENYLACETIC ACID COMPOUNDS 失效
公开(公告)号：JP2000159725A
公开(公告)日：2000-06-13
申请号：JP33252098
申请日：1998-11-24
申请人： SUMITOMO CHEMICAL CO
发明人： MIKI MASAYUKI , KODERA TAKAHIRO , ARATAKE YUICHIRO
IPC分类号： C07C51/43 , C07C57/30 , C07C57/32 , C07C57/58
摘要： PROBLEM TO BE SOLVED: To provide a method for crystallizing a phenylacetic acid compound, capable of obtaining the crystals having relatively large diameters and not blocking after filtered, by crystallizing the oil-in-water drop type dispersion of the phenylacetic acid compound at the freezing point of the phenylacetic acid compound or lower. SOLUTION: This method for crystallizing a phenylacetic acid compound comprises cooling the oil-in-water drop type dispersion of the phenylacetic acid compound of the formula (R1 is H or a halogen; R2 is H or a lower alkyl) (for example, phenylacetic acid, 2-fluorophenylacetic acid, s-α-isopropyl-p- fluorophenylacetic acid), for example, a dispersion obtained by acidifying the alkali metal or alkaline earth metal salt of the acetic acid compound with a mineral acid (for example, sulfuric acid) at the melting point of the phenylacetic acid compound or higher, at the freezing point of the phenylacetic acid compound or lower, preferably at a cooling rate of 0.5-30 deg.C per hr, at the final temperature of 5-50 deg.C for 0-3 hr.

3. 发明专利

JPH07124401A PRODUCTION OF ORGANIC COMPOUND CRYSTAL 失效
公开(公告)号：JPH07124401A
公开(公告)日：1995-05-16
申请号：JP27366993
申请日：1993-11-01
申请人： SUMITOMO CHEMICAL CO
发明人： AZUMAI TAKAYUKI , USHIO HIDEKI , FUJIMOTO YUKARI , MATSUMOTO TSUTOMU , MINAMII MASAYOSHI , YASUNAGA KATSUICHI , SOGABE HIROSHI , KODERA TAKAHIRO
IPC分类号： B01D9/02
摘要： PURPOSE:To efficiently obtain crystals having large particle diameter by dissolv ing or suspending an organic compound sparingly soluble in water in an organic solvent immiscible in water, next pouring into water under stirring and evaporat ing and removing the organic solvent while stirring. CONSTITUTION:The organic compound sparingly soluble in water is dissolved or suspended in the organic solvent immiscible in water such as benzene or toluene. Then, the obtained solution or suspension is poured into water under stirring and the organic solvent is evaporated and removed while stirring so that the poured solution or suspension is kept in a dispersed state in water, preferably in a dispersed state as the liquid drops. Then the crystallized and grown particles are precipitated in the water and are easily captured by filtration or the like.

4. 发明专利

JP2006336959A Manufacturing facility maintained cleanliness 审中-公开
标题翻译：制造设备维护清洁
公开(公告)号：JP2006336959A
公开(公告)日：2006-12-14
申请号：JP2005163782
申请日：2005-06-03
申请人： Sumitomo Chemical Co Ltd , 住友化学株式会社
发明人： SHINOMIYA HAJIME , KODERA TAKAHIRO
IPC分类号： F24F7/06
摘要： PROBLEM TO BE SOLVED: To provide a manufacturing facility capable of moving an article in an operation chamber of low cleanliness easily and speedily to an operation chamber of high cleanliness and capable of maintaining cleanliness in the operation chamber of high cleanliness.
SOLUTION: The manufacturing facility is equipped with at least one cleaning chamber and a plurality of operation chambers and has such a structure that the cleaning chamber is equipped with a cleaning facility and dust removing facility, the pressure in the cleaning chamber is adjusted to be higher than all the operation chambers and the plurality of operation chambers respectively communicate with the cleaning chamber through respective different doorways.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：解决的问题：提供一种制造设备，其能够将清洁度低的操作室内的物品容易且快速地移动到高清洁度的操作室，并且能够保持高清洁度的操作室中的清洁度。解决方案：制造设备配备有至少一个清洁室和多个操作室，并且具有清洁室配备有清洁设备和除尘设备的结构，调节清洁室中的压力高于所有操作室，并且多个操作室通过相应的不同门口分别与清洁室连通。版权所有（C）2007，JPO＆INPIT

5. 发明专利

JP2006282527A Cyclohexane derivative and method for producing the same 有权
标题翻译：环己烷衍生物及其制备方法
公开(公告)号：JP2006282527A
公开(公告)日：2006-10-19
申请号：JP2005101692
申请日：2005-03-31
申请人： Dainippon Sumitomo Pharma Co Ltd , Sumitomo Chemical Co Ltd , 住友化学株式会社 , 大日本住友製薬株式会社
发明人： YAGI HIDEKI , KODERA TAKAHIRO , KURUMAYA MASAHIKO , TANAKA KAZUYUKI
IPC分类号： C07C309/66 , C07C303/28 , C07C303/44
摘要： PROBLEM TO BE SOLVED: To provide (1R, 2R)-1,2-bis(methanesulfonyloxymethyl)cyclohexane crystals which have a high bulk density, after dried, hardly dust, and can easily be handled, and to provide a method for producing the same.
SOLUTION: This method for producing the crystals of the compound represented by formula (1) is characterized by dissolving and crystallizing a crude product containing the compound represented by formula (1) or its enantiomer and giving a powder X-ray diffraction diagram having peak strengths at 12.2°±0.2°, 17.9°±0.2°, 21.0°±0.2°, and 19.8°±0.2° and having the highest strength at the 21.0°±0.2°in at least one organic solvent selected from ester solvents and ketone solvents.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供具有高堆积密度，干燥后几乎不灰尘并且易于处理的（1R，2R）-1,2-双（甲磺酰氧甲基）环己烷晶体，并提供方法为了生产相同。解决方案：用于制备由式（1）表示的化合物的晶体的方法的特征在于将含有由式（1）表示的化合物或其对映体的粗产物溶解并结晶，得到粉末X射线衍射图在12.2°±0.2°，17.9°±0.2°，21.0°±0.2°和19.8°±0.2°处具有峰值强度，并且在至少一种选自酯溶剂的有机溶剂中在21.0°±0.2°具有最高强度和酮类溶剂。版权所有（C）2007，JPO＆INPIT

6. 发明专利

JP2006176538A Method for producing tetrazole compound 审中-公开
标题翻译：生产四唑化合物的方法
公开(公告)号：JP2006176538A
公开(公告)日：2006-07-06
申请号：JP2006076064
申请日：2006-03-20
申请人： Sumitomo Chemical Co Ltd , 住友化学株式会社
发明人： USHIO HIDEKI , YASUNAGA KATSUICHI , SOGABE HIROSHI , KODERA TAKAHIRO
IPC分类号： C07D405/04
摘要： PROBLEM TO BE SOLVED: To provide a method for profitably producing a tetrazole compound in a good filterability state in an excellent reaction yield.
SOLUTION: This method for producing the tetrazole compound (1) (R
1 is H, a halogen, nitro, OH, an alkyl, R
2 CONH, or the like; R
2 is phenyl which may be substituted with R
3 ; R
3 is a 1 to 20C alkyl which may be substituted with phenyl, or a 1 to 20C alkoxy which may be substituted with phenyl) comprises reacting an amide compound (3) with a dehydrating agent in an organic solvent and then reacting the obtained nitrile compound (2) with an azide compound without isolating the nitrile compound (2) is characterized by pouring the reaction mixture containing the above-mentioned compound together with a water-immiscible organic solvent in water under stirring, continuing the stirring, and simultaneously distilling away the organic solvent to obtain the tetrazole compound.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供以良好的过滤性状态有利地生产具有良好的反应产率的四唑化合物的方法。解决方案：用于制备四唑化合物（1）的方法（R 1 SP 1是H，卤素，硝基，OH，烷基，R 2 SP 2 CONH或 R 2是可以被R 3 3取代的苯基; R 3是可以被苯基取代的1至20个C烷基，或可被苯基取代的1〜20个碳原子的烷氧基）包括使酰胺化合物（3）与脱水剂在有机溶剂中反应，然后使得到的腈化合物（2）与叠氮化合物反应而不分离腈化合物 2）的特征在于在搅拌下将含有上述化合物的反应混合物与水不混溶的有机溶剂一起倒入水中，继续搅拌，同时蒸除有机溶剂，得到四唑化合物。版权所有（C）2006，JPO＆NCIPI

7. 发明专利

JPH08277288A PRODUCTION OF TETRAZOLE COMPOUND 失效
公开(公告)号：JPH08277288A
公开(公告)日：1996-10-22
申请号：JP8114895
申请日：1995-04-06
申请人： SUMITOMO CHEMICAL CO
发明人： USHIO HIDEKI , YASUNAGA KATSUICHI , SOGABE HIROSHI , KODERA TAKAHIRO
IPC分类号： C07D213/16 , C07B63/00 , C07D311/24 , C07D405/04
摘要： PURPOSE: To profitably produce a tetrazole compound by reacting a 2-cyano-4- oxo-4H-benzopyrane compound with an azide compound in an organic solvent, pouring the reaction product in water with stirring, and subsequently distilling off the organic solvent to deposit crystals having large particle diameters. CONSTITUTION: A method for producing a tetrazole compound comprises reacting a nitrile compound of formula I [R is H, a halogen, nitro, OH, a 1-20C alkyl, a 10-20C alkoxy, a group of formula: R CONH (R is phenyl which may be substituted), etc.] (e.g. 2-cyano-4-oxo-4H-benzopyrane) with an azide compound (e.g. sodium azide) in an organic solvent (e.g. N,N- dimethylformaldehyde) in the presence of a catalyst (e.g. ammonium chloride), pouring the reaction mixture containing the obtained tetrazole compound (salt) of formula II together with an organic solvent (e.g. toluene) immiscible with water with stirring, distilling off the organic solvent with stirring to deposite the crystals in water. Thus, the objective tetrazole compound of formula II is profitably obtained.

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