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1. 发明专利

JP2008102153A Quantitative hair folliculi absorption method 有权
标题翻译：定量头发微波吸收法
公开(公告)号：JP2008102153A
公开(公告)日：2008-05-01
申请号：JP2007312307
申请日：2007-12-03
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： TAKEOKA ERIKO , TAKAMOTO RYUICHI , HARIKI TOSHIO
IPC分类号： G01N33/50 , G01N33/15
摘要： PROBLEM TO BE SOLVED: To provide a means capable of easily/properly quantifying hair folliculi absorption capable of becoming a direct index of whether or not a test substance such as a medicine reaches an action point and sufficiently exerts desired effect.
SOLUTION: In this quantitative hair folliculi absorption method, the test subject is made to act on a skin model holding a pseudo state of a living body by a test subject amount penetrating hair follicle tissue, and a sorption amount of the test subject in the hair follicle tissue extracted from a dermal layer of its skin is measured. Alternatively, the test subject is made to act on hair follicle tissue collected from a human scalp by the test subject amount penetrating the hair follicle tissue, and a sorption amount of the test subject in the hair follicle tissue is measured.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供能够容易地/适当地定量毛囊吸收的装置，其能够成为诸如药物的测试物质是否达到作用点并充分发挥期望效果的直接指标。解决方案：在这种定量毛囊吸收方法中，使测试对象通过穿透毛囊组织的测试对象量和保持假体状态的皮肤模型作用，并且测试对象的吸附量在从其皮肤的真皮层提取的毛囊组织中测量。或者，使测试对象作用于通过渗透毛囊组织的测试对象量从人类头皮收集的毛囊组织，并测量毛囊组织中测试对象的吸附量。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2001174392A EVALUATION METHOD FOR SEBUM MIGRATION 失效
公开(公告)号：JP2001174392A
公开(公告)日：2001-06-29
申请号：JP35884099
申请日：1999-12-17
申请人： SHISEIDO CO LTD
发明人： TAKEOKA ERIKO , TAKAMOTO RYUICHI
IPC分类号： G01N13/04 , A61K8/00 , A61K8/34 , A61K31/045 , A61P17/14 , A61Q5/00 , A61Q7/00 , G01N33/00
摘要： PROBLEM TO BE SOLVED: To provide simple and exact means for judging whether or not a component to be used for a head skin or head hair reaches a point of application and a method for evaluating sebum migration of a specimen. SOLUTION: This method evaluates sebum migration of a specimen with an index of migration degree of the specimen to an artificial sebum by making one surface of a thin film 12 similar to a skin surface come into contact with the specimen, with the other side surface thereof in contact with an artificial sebum. In this method one side of the thin film has an open system. The artificial sebum is a fluid state. The thin film is a single layer silicone film a surface of which is subjected to keratin treatment. The specimen is made to come into contact with the keratin treatment side of the film. An evaluation kit for evaluating migration of sebum comprises (1) a sealing portion of an artificial sebum, provided in an opening portion thereof with fixing means capable of fixing and covering detachably the thin film; (2) a thin film similar to a skin surface layer to be fixed on and cover the opening portion of the sealing portion; and (3) an artificial sebum to be sealed in the sealing portion. The head skin and head hair composition contains isostearyl alcohol as a skin migration acceleration component.

3. 发明专利

JPH01191040A OPTOACOUSTIC MEASURING INSTRUMENT 失效
公开(公告)号：JPH01191040A
公开(公告)日：1989-08-01
申请号：JP1614488
申请日：1988-01-27
申请人： SHISEIDO CO LTD
发明人： SAWADA SHIRO , TAKAMOTO RYUICHI
IPC分类号： G01N21/00 , G01N21/17 , G01N29/00
摘要： PURPOSE:To obtain superior noise removing ability and to take a depth- directional analysis with high sensitivity by forming the part of a measurement- side cell nearby a body to be measured by using a light transmitting material and reducing the influence of reflected light and scattered light on the surface of the body to be measured. CONSTITUTION:The measurement-side cell 10 consists of a cylinder body which is open at one end and pressed almost airtightly against a sample surface and has a microphone installed at the other end, and the pressed sample is irradiated with light. A reference-side cell 12 consists of a cylinder body which is open at one end and pressed almost airtightly against the sample surface and has a microphone 26 installed at the other end. A measurement signal is obtained from the difference between the microphone outputs of both cells 10 and 12. At this time, the cell 10 is formed of the light transmissive material as to the periphery of the depression part for the sample. Then the reflected light and scattered light from the sample surface are guided out of the cells 10 and 12. Consequently, noises due to the reflected light, etc., are reduced greatly and the depth-directional analysis is taken with superior noise removing ability and high sensitivity.

4. 发明专利

JP2002060313A SKIN CARE PREPARATION 失效
公开(公告)号：JP2002060313A
公开(公告)日：2002-02-26
申请号：JP2000246782
申请日：2000-08-16
申请人： SHISEIDO CO LTD
发明人： ABE KOJI , NABESHIMA HISAYA , TAKEOKA ERIKO , TAKAMOTO RYUICHI
IPC分类号： A61K8/30 , A61K8/00 , A61K8/02 , A61K8/33 , A61K8/36 , A61K8/40 , A61K8/41 , A61K8/44 , A61K8/49 , A61K31/047 , A61K31/133 , A61K31/19 , A61K31/198 , A61K31/20 , A61K31/205 , A61K31/255 , A61K31/4164 , A61K31/7028 , A61K31/7048 , A61P17/00 , A61Q19/00 , A61Q19/02 , A61K7/00 , A61K7/48
摘要： PROBLEM TO BE SOLVED: To obtain a skin care preparation which raises a bleaching effect of a hydroquinone glycoside, an alkoxysalicylic acid and/or its salt and α- glycosyl-L-ascorbic acid and is excellent in an improving effect on chapped skin. SOLUTION: This skin care preparation is obtained by formulating a bleaching agent selected from a hydroquinone glycoside, an alkoxysalicylic acid and α-glycosyl-L-ascorbic acid with one or more kinds of betaine derivatives, a higher fatty acid and one or more kinds selected from L-serine, D-serine, DL- serine, alanine and aminomethylpropanediol.

5. 发明专利

JPH0389146A EVALUATING APPARATUS OF PERCUTANEOUS ABSORPTION 失效
公开(公告)号：JPH0389146A
公开(公告)日：1991-04-15
申请号：JP22522189
申请日：1989-08-31
申请人： SHISEIDO CO LTD
发明人： TAKAMOTO RYUICHI , NANBA RYUJIRO , NAKADA OKITSUGU , MATSUOKA MASAHIRO , SAWADA SHIRO
IPC分类号： G01N33/15 , G01N1/10 , G01N21/00 , G01N29/00
摘要： PURPOSE:To measure the emitting process of a medicine from a basic agent on the skin and the permeating process of the medicine through the skin respectively by the acoustooptic measurement and absorption photometry simultaneously and in real time by applying an acoustooptic measuring apparatus as a vertical diffusion cell. CONSTITUTION:A sensor part of this evaluating apparatus is comprised of an acoustooptic sensor part a vertical diffusion cell, an absorption photometry measuring part and a processing part. An acoustooptic sensor has a microphone arranged at an upper end thereof. The neighborhood of a pressing part at a lower end of the acoustooptic sensor is made of light-permeable material. Laser beams are introduced via an optical fiber to the acoustooptic sensor to irradiate a sample on the skin. An acoustooptic signal generated at this time is received and processed by the microphone, whereby the emitting process of a medicine from a basic agent on the skin is measured. At the same time, the permeating process of the medicine through the skin is simultaneously measured. The vertical diffusion cell is formed of silica to make part to be irradiated a rectangular parallelepiped. The absorption photometry part measures the light passing through the diffusion cell by a photocell. The laser beams are spectrally separated at this time, one intaraoduced to the diffusion cell to obtain a measuring signal of the absorption and the other introduced to the photocell as a reference signal.

6. 发明专利

JP2002071682A HAIR ABSORPTION ASSAY 失效
公开(公告)号：JP2002071682A
公开(公告)日：2002-03-12
申请号：JP2000330836
申请日：2000-10-30
申请人： SHISEIDO CO LTD
发明人： TAKEOKA ERIKO , TAKAMOTO RYUICHI , HARIKI TOSHIO
IPC分类号： G01N33/50 , A61K8/00 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/42 , A61K8/92 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q7/00 , A61Q9/04 , G01N33/15 , A61K7/06 , A61K7/075 , A61K7/08 , A61K7/155
摘要： PROBLEM TO BE SOLVED: To provide a means for promoting absorption through pores in the skins by finding a means that can easily and accurately determine absorptivity through pores in the skins. SOLUTION: This hair absorption assay of medicine which associates the amount of medicine permeating the root of hair, with an index of the amount of medicine absorbed through pores in the skins, and a composition for scalp and hair containing oil content whose I.O.B. value is 0.06-4.0, are provided to solve the problem.

7. 发明专利

JPH0798275A FLUOROMETRIC ANALYZER 失效
公开(公告)号：JPH0798275A
公开(公告)日：1995-04-11
申请号：JP24179793
申请日：1993-09-28
申请人： SHISEIDO CO LTD , IRIKA KIKI KK
发明人： SHIROTA OSAMU , OTSU YUTAKA , YAMAGUCHI MICHIHIRO , TAKAMOTO RYUICHI , TAKAMATSU TASUKU , MATSUOKA MASAHIRO , TSURUTA HISAO
IPC分类号： G01N21/64 , G01N30/74
摘要： PURPOSE:To make it possible to perform fluorometric analysis by providing an optical-wavelength converting means comprising nonlinear crystal, wherein a polarization domain, which is periodically inverted is formed, in the light path of the output light of a semiconductor laser. CONSTITUTION:The output light of a semiconductor laser 1 is guided through an optical fiber 2. An SHG(second higher-hamonic-wave generator) comprising nonlinear crystal (ferroelectric crystal), wherein a polarization domain which is periodically inverted is formed, is arranged in the halfway of the fiber 2, and the optical wavelength is converted. The wavelength of the output light of the laser 1 is converted into the second output light having the half wavelength. The output light of the element 3 is converged on a flow cell 4 through an objective lens 2b. The end part of a fiber 5 is arranged at the side surface of a sample chamber 4b. The fluorescence emitted from the sample in the sample chamber 4b is guided into a photomultiplier 6. The output of the photomultiplier 6 is analyzed with a computer 7. The semiconductor laser light 1 having the long wavelength is converted into the short wavelength by using the SHG element 3 in this way, and the fluorometric analysis can be performed.

8. 发明专利

JPH04357440A PHOTOACOUSTIC CELL AND PHOTOACOUSTIC MEASURING APPARATUS 失效
公开(公告)号：JPH04357440A
公开(公告)日：1992-12-10
申请号：JP19316491
申请日：1991-08-01
申请人： SHISEIDO CO LTD
发明人： TAKAMOTO RYUICHI , NANBA RYUJIRO , MATSUOKA MASAHIRO , SAWADA SHIRO
IPC分类号： A61B5/00 , A61B10/00 , G01N21/00 , G01N21/17 , G01N29/00 , G01N29/24 , G01N29/34
摘要： PURPOSE:To obtain a photoacoustic measuring apparatus having a photoacoustic cell used as both of a hermetically closed type and an open type capable of performing in-vivo/in-situ measurement at an arbitrary place of a sample with high sensitivity and high accuracy, obtaining data in a depth direction and equipped with a high sensitive small-sized hermetically closed cell simple to use. CONSTITUTION:A sample chamber 15 is formed to one end of a light guide 14 so as to be integrated with the light guide 14 and an acoustic signal is taken out by an L-shaped pipe 16. By fitting a sample holder 70 to the sample chamber 15, the sample chamber 15 can be also used as a hermetically closed cell. The volume of the sample chamber 15 and the length of the pipe 16 can be regulated and the optimum sensitivity is obtained by regulation.

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