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1. 发明专利

JPH0425276B2 失效
公开(公告)号：JPH0425276B2
公开(公告)日：1992-04-30
申请号：JP15395883
申请日：1983-08-23
申请人： RIKAGAKU KENKYUSHO , SATSUHORO BIIRU KK
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , MORI YOSHITADA
IPC分类号： C07H3/06 , C07H13/06 , C07H13/08 , C07H15/18

2. 发明专利

JPH0425275B2 失效
公开(公告)号：JPH0425275B2
公开(公告)日：1992-04-30
申请号：JP15395783
申请日：1983-08-23
申请人： RIKAGAKU KENKYUSHO , SATSUHORO BIIRU KK
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , MORI YOSHITADA
IPC分类号： C07H3/06 , C07H13/06 , C07H15/18 , C08B37/00

3. 发明专利

JPH0441154B2 失效
公开(公告)号：JPH0441154B2
公开(公告)日：1992-07-07
申请号：JP15395683
申请日：1983-08-23
申请人： RIKAGAKU KENKYUSHO , SATSUHORO BIIRU KK
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , MORI YOSHITADA
IPC分类号： C07H3/06 , C07H13/06 , C07H15/18

4. 发明专利

JPH0259836B2 失效
公开(公告)号：JPH0259836B2
公开(公告)日：1990-12-13
申请号：JP14666282
申请日：1982-08-24
申请人： RIKAGAKU KENKYUSHO , SATSUHORO BIIRU KK
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , MORI YOSHITADA
IPC分类号： C07H3/06 , C07H13/06 , C07H15/18

5. 发明专利

JPH025762B2 失效
公开(公告)号：JPH025762B2
公开(公告)日：1990-02-05
申请号：JP14666482
申请日：1982-08-24
申请人： RIKAGAKU KENKYUSHO , SATSUHORO BIIRU KK
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , MORI YOSHITADA
IPC分类号： C08B37/00 , A61K31/715 , A61P35/00

6. 发明专利

JPS627173B2 失效
公开(公告)号：JPS627173B2
公开(公告)日：1987-02-16
申请号：JP17316884
申请日：1984-08-22
申请人： SATSUHORO BIIRU KK , DAISERU KAGAKU KOGYO KK , ITO ETSUO
发明人： TAKEO SHUN , YAMAMOTO HISAO , KATO HISAO , WATANABE NOBUHIRO , KAMIMURA MINORU , UCHIDA TERUKAZU , MORI YOSHITADA
IPC分类号： C07H3/00 , A61K31/715 , A61K36/899 , A61K38/21 , A61K39/39 , A61P31/04 , A61P35/00 , A61P37/04 , A61P43/00 , C08B37/00

7. 发明专利

JPS6045589A NOVEL OLIGOMANNOSIDE AND ITS PREPARATION 失效
公开(公告)号：JPS6045589A
公开(公告)日：1985-03-12
申请号：JP15395883
申请日：1983-08-23
申请人： RIKAGAKU KENKYUSHO , SAPPORO BREWERIES
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , MORI YOSHITADA
IPC分类号： C07H3/06 , C07H13/06 , C07H13/08 , C07H15/18
摘要： NEW MATERIAL:The compound of formula I (R is H or benzyl; R' is H or acetyl). USE:Synthetic intermediate of mannan having physilogical activity such as antineoplastic activity. PREPARATION:The compound of formula II (R is benzyl) is made to react with the compound of formula III (R' is acetyl; X is halogen) preferably in a solvent such as 1,2-dichloroethane, chlorogorm, etc. in the presence of molecular sieve 4A, etc. and a catalyst such as HgBr2, at -30-+150 deg.C for 1-8hr. If necessary, the reaction product is deacetylated and debenzylated to obtain the compound of formula I .

8. 发明专利

JPS6045588A NOVEL OLIGOMANNOSIDE AND ITS PREPARATION 失效
公开(公告)号：JPS6045588A
公开(公告)日：1985-03-12
申请号：JP15395783
申请日：1983-08-23
申请人： RIKAGAKU KENKYUSHO , SAPPORO BREWERIES
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , MORI YOSHITADA
IPC分类号： C07H3/06 , C07H13/06 , C07H15/18 , C08B37/00
摘要： NEW MATERIAL:The compound of formula I [R is H or benzyl; Y is H, acetyl or group of formula II (R' is H or acetyl)]. USE:Synthetic intermediate of mannan having physiological activity such as antineoplastic activity. PREPARATION:The compound of formula III (R is benzyl) is made to react with the compound of formula IV (R' is acetyl; X is halogen) preferably in a solvent such as 1,2-dichloroethane, chloroform, etc. in the presene of a molecular sieve 4A, etc. and a catalyst such as HgBr2 at -30-+150 deg.C for 1-8hr. If necessary, the product is subjected to the deacetylation and debenzylation to afford the compound of formula I wherein Y is acetyl.

9. 发明专利

JPS6045587A NOVEL OLIGOMANNOSIDE AND ITS PREPARATION 失效
公开(公告)号：JPS6045587A
公开(公告)日：1985-03-12
申请号：JP15395683
申请日：1983-08-23
申请人： RIKAGAKU KENKYUSHO , SAPPORO BREWERIES
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , MORI YOSHITADA
IPC分类号： C07H3/06 , C07H13/06 , C07H15/18
摘要： NEW MATERIAL:The compound of formula I (R is H or acetyl; R' is H or benzyl; Y is H or group of formula II). USE:Synthetic intermediate od mannan having antineoplastic activity. PREPARATION:The compound of formula III (R' is benzyl) is made to react with the compound of formula IV (R is acetyl; X is halogen) preferably in a solvent such as 1,2-dichloroethane, etc. in the presence of a catalyst such as AgOS2CF3, etc. at -30-+150 deg.C for 1-8hr. The reaction product is optionally subjected to the deacetylation and debenzylation process to obtain the compound of formula I wherein Y is H. The reaction is preferably carried out by adding a molecular sieve to the reaction system to remove the acid such as HBr produced by the reaction.

10. 发明专利

JPS5936101A Novel oligomannoside and manufacture of the same 失效
标题翻译：新的低聚糖和其制造方法
公开(公告)号：JPS5936101A
公开(公告)日：1984-02-28
申请号：JP14666482
申请日：1982-08-24
申请人： Rikagaku Kenkyusho , Sapporo Breweries Ltd
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , MORI YOSHITADA
IPC分类号： C08B37/00 , A61K31/715 , A61P35/00
摘要： NEW MATERIAL:An oligomannoside of formula I (R
1 and R
2 are each H, acetyl or benzyl).
USE: As an intermediate for the mannan with antitumor activity, and an regent for the elucidation of the biological significance of said mannan.
PROCESS: First, a compound of formula II (Ac is acetyl) is made to react with benzyl alcohol in the presence of a Lewis acid catalyst followed by deacetylation to prepare a novel compound of formula III (Bn is benzyl). Secondly, this novel compound is allowed to react with the compound of the formula II mentioned above to obtain a disaccharide, which is then further made to react with a compound of formula IV (X is halogen) to produce a trisaccharide followed by deacetylation to obtain a triol trisaccharide. Thirdly, this trisaccharide is further allowed to react with a compound of formula V so that the ratio of the number of molecules of the former to the latter is 1:3 and also, if required, carriying out the protective group removal thus manufacturing the objective nonasaccharide of the formula I . Both the disaccharide and trisaccharide mentioned above are also novel compounds.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：新材料：式I的低聚半乳糖苷（R1和R2各自为H，乙酰基或苄基）。用途：作为具有抗肿瘤活性的甘露聚糖的中间体，以及阐明所述甘露聚糖的生物学意义的药剂。方法：首先，使式II化合物（Ac是乙酰基）在苯甲醇中在路易斯酸催化剂存在下反应，然后脱乙酰以制备新的式III化合物（Bn是苄基）。其次，使该新化合物与上述式II的化合物反应，得到二糖，然后进一步与式IV化合物（X为卤素）反应，生成三糖，然后脱乙酰，得到三醇三糖。第三，进一步使该三糖与式V的化合物反应，使得前者与后者的分子数之比为1:3，并且，如果需要的话，将保护基团除去，从而制造目标式I的非糖。上述二糖和三糖都是新化合物。

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