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1. 发明专利

JPS5936690A Novel oligomannoside and its preparation 失效
标题翻译：新的寡核苷酸及其制备
公开(公告)号：JPS5936690A
公开(公告)日：1984-02-28
申请号：JP14666282
申请日：1982-08-24
申请人： Rikagaku Kenkyusho , Sapporo Breweries Ltd
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , MORI YOSHITADA
IPC分类号： C07H3/06 , C07H13/06 , C07H15/18
摘要： NEW MATERIAL:An oligomannoside shown by the formula I (R is H, or benzyl; R
1 WR
4 are H, benzyl, or acetyl).
USE: Useful as an intermediate for synthesizing mannan having an antitumor activity and a reagent for elucidating biological significance of the mannan.
PROCESS: A compound shown by the formula II (R is benzyl) is reacted with a novel saccharide donor compound shown by the formula III (Ac is acetyl; X is halogen) to give a compound, which is deacetylated, and reacted with a compound shown by the formula VI (R
1 WR
4 are acetyl, or benzyl), and, if necessary, the reaction product is deacetylated and/or debenzylated to give a compound shown by the formula I . The novel compound shown by the formula III, for example, is obtained by converting α-D-mannose into allyl α-D-mannopyranoside, tritylating the reaction product at 6-position, allylating it at 3-position, detritylating it, benzylating it 2-, 4-, and 6-positions, deallylating it, acetylating it to give a halide.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：新材料：式I所示的寡聚糖苷（R为H或苄基; R 1 -R 4为H，苄基或乙酰基）。用途：可用作合成具有抗肿瘤活性的甘露聚糖的中间体和用于阐明甘露聚糖的生物学意义的试剂。方法：将式II化合物（R为苄基）与式III所示的新型糖供体化合物（Ac为乙酰基; X为卤素）反应，得到脱乙酰化的化合物，并与化合物由式VI（R 1 -R 4）表示的是乙酰基或苄基），如果需要，反应产物被脱乙酰化和/或脱苄基化，得到式I所示的化合物。式III所示的新化合物，例如通过将α-D-甘露糖转化成烯丙基-α-D-吡喃甘露糖苷获得，将反应产物在6-位三苯甲基化，在3-位上烯丙基化，使其脱苄基化，使其苄化 2-，4-和6-位，脱气，乙酰化得到卤化物。

2. 发明专利

JPS5936691A Novel oligomannoside and its preparation 失效
标题翻译：新的寡核苷酸及其制备
公开(公告)号：JPS5936691A
公开(公告)日：1984-02-28
申请号：JP14666382
申请日：1982-08-24
申请人： Rikagaku Kenkyusho , Sapporo Breweries Ltd
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , MORI YOSHITADA
IPC分类号： C07H3/06 , C07H13/06 , C07H15/18 , C08B37/00
摘要： NEW MATERIAL:An oligomannoside shown by the formula I (R is H, or benzyl; R' is H, or acetyl; n is 1W5).
USE: Useful as an intermediate for synthesizing mannan having an antitumor activity and a reagent for elucidating biologial significance of the mannan.
PROCESS: A novel compound shown by the formula II (Bn is benzyl) as a saccharide acceptor is reacted with a novel compound shown by the formula III(Ac is acetyl; X is halogen) as a saccharide donor in the presence of both a silver salt (e.g., Ag
2 CO
3 , AgClO
4 , etc.) or a mercury salt [e.g., HgBr
2 , Hg(CN)
2 , etc.], and a dehydrohalogenating agent to give a disaccharide compound shown by the formula IV (R is H, or Ac). If necessary, this compound is deacetylated to give a compound, which as a new saccharide acceptor is reacted with the saccharide donor compound shown by the formula III, the prepared compound is deacetylated, the reaction product as a new saccharide acceptor is subjected to the repetition of the above-mentioned reactions so that the saccharide chain is extended, and, if necessary, the resultant compound is deacetylated, debenzylated to give a compound shown by the formula I .
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：新材料：式I所示的寡甘露糖苷（R为H或苄基; R'为H或乙酰基; n为1-5）。用途：可用作合成具有抗肿瘤活性的甘露聚糖的中间体和用于阐明甘露聚糖的生物学意义的试剂。方法：作为糖受体的通式II（Bn是苄基）所示的新化合物与式III所示的新化合物（Ac是乙酰基; X是卤素）作为糖供体在存在两银的情况下反应盐（例如Ag 2 CO 3，AgClO 4等）或汞盐[例如HgBr 2，Hg（CN）2等]和脱卤化氢剂，得到式IV所示的二糖化合物（R为H，或 AC）。如果需要，该化合物脱乙酰化得到化合物，其作为新的糖受体与式III所示的糖供体化合物反应，所制备的化合物脱乙酰化，作为新糖受体的反应产物经受重复的上述反应，使得糖链延长，并且如果需要，所得化合物脱乙酰，脱苄基化，得到式I所示的化合物。

3. 发明专利

JPS6045589A NOVEL OLIGOMANNOSIDE AND ITS PREPARATION 失效
公开(公告)号：JPS6045589A
公开(公告)日：1985-03-12
申请号：JP15395883
申请日：1983-08-23
申请人： RIKAGAKU KENKYUSHO , SAPPORO BREWERIES
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , MORI YOSHITADA
IPC分类号： C07H3/06 , C07H13/06 , C07H13/08 , C07H15/18
摘要： NEW MATERIAL:The compound of formula I (R is H or benzyl; R' is H or acetyl). USE:Synthetic intermediate of mannan having physilogical activity such as antineoplastic activity. PREPARATION:The compound of formula II (R is benzyl) is made to react with the compound of formula III (R' is acetyl; X is halogen) preferably in a solvent such as 1,2-dichloroethane, chlorogorm, etc. in the presence of molecular sieve 4A, etc. and a catalyst such as HgBr2, at -30-+150 deg.C for 1-8hr. If necessary, the reaction product is deacetylated and debenzylated to obtain the compound of formula I .

4. 发明专利

JPS6045588A NOVEL OLIGOMANNOSIDE AND ITS PREPARATION 失效
公开(公告)号：JPS6045588A
公开(公告)日：1985-03-12
申请号：JP15395783
申请日：1983-08-23
申请人： RIKAGAKU KENKYUSHO , SAPPORO BREWERIES
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , MORI YOSHITADA
IPC分类号： C07H3/06 , C07H13/06 , C07H15/18 , C08B37/00
摘要： NEW MATERIAL:The compound of formula I [R is H or benzyl; Y is H, acetyl or group of formula II (R' is H or acetyl)]. USE:Synthetic intermediate of mannan having physiological activity such as antineoplastic activity. PREPARATION:The compound of formula III (R is benzyl) is made to react with the compound of formula IV (R' is acetyl; X is halogen) preferably in a solvent such as 1,2-dichloroethane, chloroform, etc. in the presene of a molecular sieve 4A, etc. and a catalyst such as HgBr2 at -30-+150 deg.C for 1-8hr. If necessary, the product is subjected to the deacetylation and debenzylation to afford the compound of formula I wherein Y is acetyl.

5. 发明专利

JPS6045587A NOVEL OLIGOMANNOSIDE AND ITS PREPARATION 失效
公开(公告)号：JPS6045587A
公开(公告)日：1985-03-12
申请号：JP15395683
申请日：1983-08-23
申请人： RIKAGAKU KENKYUSHO , SAPPORO BREWERIES
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , MORI YOSHITADA
IPC分类号： C07H3/06 , C07H13/06 , C07H15/18
摘要： NEW MATERIAL:The compound of formula I (R is H or acetyl; R' is H or benzyl; Y is H or group of formula II). USE:Synthetic intermediate od mannan having antineoplastic activity. PREPARATION:The compound of formula III (R' is benzyl) is made to react with the compound of formula IV (R is acetyl; X is halogen) preferably in a solvent such as 1,2-dichloroethane, etc. in the presence of a catalyst such as AgOS2CF3, etc. at -30-+150 deg.C for 1-8hr. The reaction product is optionally subjected to the deacetylation and debenzylation process to obtain the compound of formula I wherein Y is H. The reaction is preferably carried out by adding a molecular sieve to the reaction system to remove the acid such as HBr produced by the reaction.

6. 发明专利

JPS5936101A Novel oligomannoside and manufacture of the same 失效
标题翻译：新的低聚糖和其制造方法
公开(公告)号：JPS5936101A
公开(公告)日：1984-02-28
申请号：JP14666482
申请日：1982-08-24
申请人： Rikagaku Kenkyusho , Sapporo Breweries Ltd
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , MORI YOSHITADA
IPC分类号： C08B37/00 , A61K31/715 , A61P35/00
摘要： NEW MATERIAL:An oligomannoside of formula I (R
1 and R
2 are each H, acetyl or benzyl).
USE: As an intermediate for the mannan with antitumor activity, and an regent for the elucidation of the biological significance of said mannan.
PROCESS: First, a compound of formula II (Ac is acetyl) is made to react with benzyl alcohol in the presence of a Lewis acid catalyst followed by deacetylation to prepare a novel compound of formula III (Bn is benzyl). Secondly, this novel compound is allowed to react with the compound of the formula II mentioned above to obtain a disaccharide, which is then further made to react with a compound of formula IV (X is halogen) to produce a trisaccharide followed by deacetylation to obtain a triol trisaccharide. Thirdly, this trisaccharide is further allowed to react with a compound of formula V so that the ratio of the number of molecules of the former to the latter is 1:3 and also, if required, carriying out the protective group removal thus manufacturing the objective nonasaccharide of the formula I . Both the disaccharide and trisaccharide mentioned above are also novel compounds.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：新材料：式I的低聚半乳糖苷（R1和R2各自为H，乙酰基或苄基）。用途：作为具有抗肿瘤活性的甘露聚糖的中间体，以及阐明所述甘露聚糖的生物学意义的药剂。方法：首先，使式II化合物（Ac是乙酰基）在苯甲醇中在路易斯酸催化剂存在下反应，然后脱乙酰以制备新的式III化合物（Bn是苄基）。其次，使该新化合物与上述式II的化合物反应，得到二糖，然后进一步与式IV化合物（X为卤素）反应，生成三糖，然后脱乙酰，得到三醇三糖。第三，进一步使该三糖与式V的化合物反应，使得前者与后者的分子数之比为1:3，并且，如果需要的话，将保护基团除去，从而制造目标式I的非糖。上述二糖和三糖都是新化合物。

7. 发明专利

JPH0369509B2 失效
公开(公告)号：JPH0369509B2
公开(公告)日：1991-11-01
申请号：JP14233083
申请日：1983-08-03
申请人： SAPPORO BREWERIES
发明人： YOSHIGI HISAHIRO , KONNO TAKAHIDE , MORI YOSHITADA
IPC分类号： C12N9/26 , C12P19/14 , C12R1/07 , C12R1/085

8. 发明专利

JPH01144955A NOVEL PRODUCTION PROCESS FOR YEAST ESSENCE 失效
公开(公告)号：JPH01144955A
公开(公告)日：1989-06-07
申请号：JP30258787
申请日：1987-11-30
申请人： SAPPORO BREWERIES
发明人： IKEDA TETSUYA , MASUDA YOSHINORI , SUDA YOSHIYUKI , MORI YOSHITADA
IPC分类号： A23L1/28 , A23L27/10 , C12N1/16
摘要： PURPOSE:To obtain a yeast essence of good taste, free from yeast odor even if a stored yeast is used, by adding a fermentable saccharide to a yeast suspension to activate the yeast followed by extraction and protein precipitation treatment of the resultant yeast-extracted solution. CONSTITUTION:A yeast suspension is incorporated with a fermentable saccharide (pref. glucose) to activate the yeast followed by extraction (pref. by self digestion or thermal extraction process) and protein precipitation treatment of the resulting yeast-extracted solution, thus obtaining the objective yeast essence.

9. 发明专利

JPS592681A Preparation of ratafia of ume (japanese apricot) 失效
标题翻译： UME（日本APRICOT）的RATAFIA的制备
公开(公告)号：JPS592681A
公开(公告)日：1984-01-09
申请号：JP11138682
申请日：1982-06-28
申请人： Sapporo Breweries Ltd
发明人： MORI YOSHITADA , KOBAYASHI KOUHEI
IPC分类号： C12G3/02
摘要： PURPOSE: To prepare a ratafia of Ume (Japanese apricot) having refreshing taste and well-mellowed flavor, by adjusting Ume juice from which organic acids are partially removed by ultrafiltration to a specific acidity and saccharide concentration, fermenting it.
CONSTITUTION: Ume juice is subjected to ultrafiltration using an ultrafilter paper having 500W1,000 fractional molecular weight at 5W15°C at 3W5kg/cm
2 pressure so that organic acids are partially removed, and it is concentrated to about 10W15% volume ratio. The filtered water is added to the concentrated solution so that it is diluted to 0.4W1.0% acidity, and, if necessary, a saccharide is added to the solution so that it is adjusted to 15W20wt% saccharide concentration. It is then sterilized to give a raw material for preparing a Ume ratafia. A yeast such as Saccharomyces cerevisiae IAM-4175, etc. is added to the raw material, which is fermented at 20W25°C for 10W14 days.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过将通过超滤部分去除有机酸的含水果汁调整至特定的酸度和糖浓度来制备具有清爽口味和良好味道的美味（日本杏）的百日咳酵母，发酵。构成：使用500-15000份分子量的超滤纸在5至5℃至3-5kg / cm 2压力下对Ume汁进行超滤，从而部分去除有机酸，并将其浓缩至约 10-15％体积比。将过滤的水加入到浓缩溶液中，使其稀释至0.4-1.0％的酸度，如果需要，向溶液中加入糖，使其调节至15-20重量％的糖浓度。然后将其灭菌以制备用于制备尿素的原料。向20-25℃发酵10-14天的原料中加入酿酒酵母IAM-4175等酵母。

10. 发明专利

JPS6434911A CARIOSTATIC COMPOSITION 失效
公开(公告)号：JPS6434911A
公开(公告)日：1989-02-06
申请号：JP18884987
申请日：1987-07-30
申请人： SAPPORO BREWERIES
发明人： KONNO TAKAHIDE , UCHIDA TERUKAZU , MORI YOSHITADA
IPC分类号： A23G4/00 , A61K8/33 , A61K8/66 , A61K38/46 , A61Q11/00
摘要： PURPOSE:To provide the titled composition containing two kinds of dextranases having different actions, effective in decreasing the amount of material attached to smooth surface by Streptococcus mutans and exhibiting high cariostatic effect. CONSTITUTION:The objective composition contains (A) a conventionally used endo-type dextranase, e.g. endo-type dextranase produced by microorganisms of Penicillium genus and (B) an exo-type dextranase, e.g. glucodextranase and/or isomaltodextranase originated from Arthrobacter globiformus at a weight ratio (A:B) of 1:(0.1-3), preferably 1:(0.5-1.5).

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