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1. 发明专利

JP2008241704A New stress biomarker and its application 有权
标题翻译：新应用生物标记及其应用
公开(公告)号：JP2008241704A
公开(公告)日：2008-10-09
申请号：JP2008046643
申请日：2008-02-27
申请人： Prima Meat Packers Ltd , Shizuokaken Koritsu Daigaku Hojin , プリマハム株式会社 , 静岡県公立大学法人
发明人： AKIMOTO MASANOBU , NAMIOKA MAKOTO , KATO AYAKO , NAKAYAMA TSUTOMU , OHASHI NORIO , NAITO HIROYOSHI
IPC分类号： G01N27/447 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/573
摘要： PROBLEM TO BE SOLVED: To provide a screening method of a stress inhibitor substance or stress fortifier substance utilizing a new stress biomarker, how to determine stress, and a stress diagnostic kit.
SOLUTION: In this method, serum of a rat with stress loaded through water-submersion arresting is tested to two-dimensional electrophoresis. The two-dimensional electrophoretic images of before and after stress load are compared, using any one of proteins such as apolipoprotein H, fetuin β, actin β, or enolase β after stress load as a marker. For example, when detected quantity of the actin β, enolase β, apolipoprotein H, or fetuin β is varying compared with the case of serum sampled from healthy mammal, the mammal intended for evaluation is determined to undergo stress.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供使用新的应激生物标志物的应激抑制物质或应激强化剂物质的筛选方法，如何确定应激和应激诊断试剂盒。解决方案：在这种方法中，测试通过水 - 浸没阻滞加载的应力的大鼠血清进行二维电泳。比较应激负荷前后的二维电泳图像，使用任何一种蛋白质，如载脂蛋白H，胎球蛋白β，肌动蛋白β或烯醇化酶β作为标记。例如，当检测到的肌动蛋白β，烯醇化酶β，载脂蛋白H或胎球蛋白β的量与从健康哺乳动物取样的血清的情况相比变化时，要评价的哺乳动物被测定为经受应激。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2011191057A Method for determination of potential depression patient 审中-公开
标题翻译：用于确定潜在抑郁症患者的方法
公开(公告)号：JP2011191057A
公开(公告)日：2011-09-29
申请号：JP2008177241
申请日：2008-07-07
申请人： Prima Meat Packers Ltd , Shizuokaken Koritsu Daigaku Hojin , プリマハム株式会社 , 静岡県公立大学法人
发明人： AKIMOTO MASANOBU , KATO AYAKO , NAKAYAMA TSUTOMU , OHASHI NORIO , SHIMOI KAYOKO , SAKAKIBARA HIROYUKI
IPC分类号： G01N33/573 , G01N33/543
CPC分类号： G01N33/6893 , G01N2333/9123 , G01N2800/304
摘要： PROBLEM TO BE SOLVED: To provide a method for easily discriminating a person, who ordinarily and socially lives without trouble and realizes no depressive state but having high possibility suffering from depression, from a healthy person.
SOLUTION: Creatine kinase-M in a sample such as blood serum is measured using an anti-creatine kinase-MM monoclonal antibody, for example by sandwich ELISA and this measured value is compared with a preset standard value to evaluate that an examinee corresponds to a potential depression patient (a score by a CES-D scale is 17 or above) when the concentration of creatine kinase-M in the blood serum of the examinee is low. Further, if the measured value by the sandwich ELISA is a definite level or below, for example, 4 ppm, preferably 3 ppm or below, the examinee is evaluated to correspond to the potential depression patient.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种方法，用于容易地区分来自健康人的通常和社会生活没有麻烦，没有实现抑郁状态但具有高抑郁症可能性的人的人。解决方案：使用抗肌酸激酶-MM单克隆抗体例如通过夹心ELISA测量样品如血清中的肌酸激酶-M，并将该测量值与预设的标准值进行比较，以评估受试者对应于受试者的血清中肌酸激酶-M浓度低的潜在抑郁症患者（CES-D量表评分为17以上）。此外，如果通过夹心ELISA的测定值为一定程度以下，例如4ppm，优选为3ppm以下，则对被检查者进行评价，以对应于潜在的抑郁患者。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2007225607A Method of screening antistress agent, and method of determining effectiveness thereof 审中-公开
标题翻译：筛选抗微生物剂的方法和确定其有效性的方法
公开(公告)号：JP2007225607A
公开(公告)日：2007-09-06
申请号：JP2007018249
申请日：2007-01-29
申请人： Prima Meat Packers Ltd , Shizuoka Prefecture , プリマハム株式会社 , 静岡県
发明人： AKIMOTO MASANOBU , NAMIOKA MAKOTO , NAKAYAMA TSUTOMU , OHASHI NORIO , NAITO HIROYOSHI
IPC分类号： G01N27/447 , C12Q1/28 , G01N33/15 , G01N33/483 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a method of screening an antistress agent, a method of determining effectiveness of the antistress drug, and a kit for determining the effectiveness of the antistress drug, using a novel antistress biomarker. SOLUTION: A serum collected from a mammal animal taking the antistress agent is subjected to two-dimensional electrophoresis to detect one or more kinds selected from a group comprising plasminogen, a fragment of about 35kDa including the 1015-th moiety to 1218-th moiety of α1-macroglobulin, a fragment of about 35kDa including the 1450-th moiety to 1737-th moiety of a complement component 4a and glutathione peroxidase, and the effectiveness of the antistress agent is determined, based on comparison/evaluation with the case where the antistress agent is not applied. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种抗抑制剂的筛选方法，确定抗抑郁药物的有效性的方法，以及使用新型抗抑郁生物标记物确定抗抑郁药物的有效性的试剂盒。解决方案：使用抗抑制剂从哺乳动物采集的血清进行二维电泳，以检测选自包含纤维蛋白溶酶原的组中的一种或多种，包括第1015位至1218位的约35kDa的片段， α部分的α1-巨球蛋白，包括补体成分4a和谷胱甘肽过氧化物酶的第1450个部分至第1737个部分的约35kDa的片段，并且基于与病例的比较/评价来确定抗抑郁药的有效性哪里没有应用抗阻剂。版权所有（C）2007，JPO＆INPIT

4. 发明专利

JP2007225606A Novel stress biomarker and application thereof 有权
标题翻译：新型应力生物标记及其应用
公开(公告)号：JP2007225606A
公开(公告)日：2007-09-06
申请号：JP2007018164
申请日：2007-01-29
申请人： Prima Meat Packers Ltd , Shizuoka Prefecture , プリマハム株式会社 , 静岡県
发明人： AKIMOTO MASANOBU , NAMIOKA MAKOTO , NAKAYAMA TSUTOMU , OHASHI NORIO , NAITO HIROYOSHI
IPC分类号： G01N33/68 , G01N27/447 , G01N33/15 , G01N33/483 , G01N33/50 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide a screening method, a stress determination method, and a stress diagnostic kit, for a stress restraint substance or a stress promoting substance, which use a novel stress biomarker. SOLUTION: A serum of a rat loaded with a stress by submerged restraint is subjected to two-dimensional electrophoresis. An electrophoretic image before loaded with the stress is compared with an electrophoretic image after loaded with the stress, and this screening method/stress determination method/kit of the present invention uses any protein selected from a group comprising apolipoprotein E, apolipoprotein A-IV, haptoglobin, and a vitamin-D coupled protein precursor, which are detected as two or more kinds of spots appearing in 5.0-6.2 of isoelectric point range after loaded with the stress, in 30kDa-60kDa of molecular weight range. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种使用新型应力生物标志物的应力抑制物质或应激促进物质的筛选方法，应力测定方法和应力诊断试剂盒。解决方案：通过浸没式约束装载应力的大鼠血清进行二维电泳。加载应力后的电泳图像与加压后的电泳图像进行比较，本发明的筛选方法/应激测定方法/试剂盒使用选自载脂蛋白E，载脂蛋白A-IV，触珠蛋白和维生素-D偶联蛋白前体，其分子量范围为30kDa-60kDa，被检测为在加载胁迫后出现在等电点范围的5.0-6.2中的两种或更多种斑点。版权所有（C）2007，JPO＆INPIT

5. 发明专利

JP2007093597A Novel stress biomarker and applications thereof 有权
标题翻译：新型应力生物标记及其应用
公开(公告)号：JP2007093597A
公开(公告)日：2007-04-12
申请号：JP2006240039
申请日：2006-09-05
申请人： Prima Meat Packers Ltd , プリマハム株式会社
发明人： AKIMOTO MASANOBU , NAMIOKA MAKOTO , ARIHARA KEIZO , TOMITA KOHEI , ISHIKAWA SHINICHI , ITO MAKOTO , NAKAYAMA TSUTOMU , OHASHI NORIO , KATO AYAKO
IPC分类号： G01N27/447
摘要： PROBLEM TO BE SOLVED: To provide a screening method of stress-inhibiting substance or stress-enhancing substance, a stress determination method, or a stress diagnostic kit that utilizes a novel stress biomarker. SOLUTION: The serum of a rat loaded with stress by 10-hour submersion constraint is tested by two-dimensional electrophoresis. Electrophoretic images of two-dimensional electrophoresis before and after stress loading are compared, and protein, such as creatine kinase isozyme (CK-MM) detected as four kinds of spots which appear at pH 6.0-7.0 and molecular weight 40-55 kD after stress loading, is used as a marker. The stomach is immediately extracted after blood collection, the area of ulcerated part is measured, and the ratio of the area of the ulcerated part to that of the stomach as a whole is taken as the ulcer index (%). The ulcer index of stress-related gastric ulcer by the submersion constraint test was about 20%. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供应激抑制物质或应激增强物质的筛选方法，应力测定方法或利用新型应激生物标志物的应激诊断试剂盒。解决方案：通过二维电泳测试通过10小时浸没约束负载压力的大鼠血清。比较应激负荷前后二维电泳的电泳图像，肌酸激酶同功酶（CK-MM）等蛋白质检测出4种斑点，出现在pH 6.0-7.0，应激后分子量40〜55 kD 加载，用作标记。采集后立即抽出胃，测定溃疡部位的面积，将溃疡部位与胃部整体面积的比例作为溃疡指数（％）。通过淹没约束试验，应激相关胃溃疡溃疡指数约为20％。版权所有（C）2007，JPO＆INPIT

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