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1. 发明专利

JPH11271820A Method and device for wavelength conversion using nonlinear optical element, and laser system 失效
标题翻译：使用非线性光学元件和激光系统进行波长转换的方法和装置
公开(公告)号：JPH11271820A
公开(公告)日：1999-10-08
申请号：JP7613998
申请日：1998-03-24
申请人： Nidek Co Ltd , Rikagaku Kenkyusho , 株式会社ニデック , 理化学研究所
发明人： TASHIRO HIDEO , WADA TOMOYUKI , YAMADA TAKESHI
IPC分类号： G02F1/35 , G02F1/37
CPC分类号： G02F1/3501 , G02F2001/3505
摘要： PROBLEM TO BE SOLVED: To stably maintain wavelength conversion characteristics of nonlinear optical crystal for a long period by making laser light incident on cerium lithium borate crystal arranged under a vacuum and performing wavelength conversion.
SOLUTION: The nonlinear optical crystal 12 as a wavelength converting element such as cerium lithium borate crystal is arranged in a metallic vacuum container 11, made of stainless steel, in the wavelength converting device 10. A light beam enters the vacuum container 11 through its input-side optical window 13a having specific transmissivity and has its wavelength converted by interacting with the nonlinear optical crystal 12 and is emitted from the output-side optical window 13b. For the optical windows 13a and 13b, quartz, etc., having no light absorption in a wavelength range of 200 to 3,000 nm is used. A vacuum sealing valve 14 is provided to the upper part of the vacuum container 11. The part formed of the main body of the vacuum container 11, optical windows 13a and 13b, and vacuum sealing valve 14 is sealed with O rings 15a, 15b, and 15c and a vacuum of about 10
0 to 10
2 Torr is held in the vacuum container 11.
COPYRIGHT: (C)1999,JPO
摘要翻译：要解决的问题：通过使入射在真空下布置的硼酸铈锂晶体上进行激光并进行波长转换，来长时间稳定地保持非线性光学晶体的波长转换特性。解决方案：作为波长转换元件如硼酸锂硼酸盐晶体的非线性光学晶体12在波长转换装置10中布置在由不锈钢制成的金属真空容器11中。光束通过其输入端进入真空容器11 具有特定透射率的光学窗口13a，并且通过与非线性光学晶体12相互作用而将其波长转换并从输出侧光学窗口13b发射。对于光学窗口13a和13b，使用在200〜3000nm的波长范围内没有光吸收的石英等。在真空容器11的上部设有真空密封阀14.由真空容器11的主体，光学窗口13a，13b，真空密封阀14构成的部分用O形环15a，15b密封，并且在真空容器11中保持15c至大约10至10 2 Torr的真空。

2. 发明专利

JP2011013000A Method for analyzing biochip, and system for automatic analysis of the same 审中-公开
标题翻译：生物分析方法及其自动分析系统
公开(公告)号：JP2011013000A
公开(公告)日：2011-01-20
申请号：JP2009155249
申请日：2009-06-30
申请人： Consonal Biotechnologies Co Ltd , Institute Of Physical & Chemical Research , 株式会社コンソナルバイオテクノロジーズ , 独立行政法人理化学研究所
发明人： TASHIRO HIDEO , ITO YOSHIHIRO
IPC分类号： G01N33/53 , G01N21/76 , G01N33/543 , G01N35/04 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a method for analyzing a biochip capable of rapidly obtaining a measuring result, by automating a reaction detection process of a specimen and an antigen after the specimen is sampled, using the biochip loaded with antigens of many kinds of allergens which are mutually independent, that is, isolated spots, and to provide a system for automatic analysis of biochip.SOLUTION: A consistent system for automatic analysis of biochip is provided with the biochip 2 loaded with the antigen as the spot 6; a prefilter for removing serum component from a sampled blood specimen and a reagent cassette 4a becoming a pair along with the biochip 2, can rapidly obtain an analysis and measurement result, by automating the respective processings from the reaction of the biochip 2, to which the specimen is added, with the antigen, the reaction with an antibody, cleaning and the addition of a detection reagent to the detection of chemoluminescence, shortens the analysis and measurement time and attains micronization of an installation area.
摘要翻译：要解决的问题：提供一种用于分析能够快速获得测量结果的生物芯片的方法，通过使样本采集后的样品和抗原的反应检测过程自动化，使用装载有多种过敏原抗原的生物芯片这是相互独立的，也就是孤立斑点，并提供生物芯片自动分析系统。解决方案：将生物芯片2作为斑点6装载抗生素的生物芯片2，提供一个生物芯片自动分析系统。用于从取样的血液样本中除去血清成分的预过滤器和与生物芯片2一起成为一对的试剂盒4a可以通过使生物芯片2的反应自动化，从而快速获得分析和测量结果，加入标本，用抗原，与抗体反应，清洗和添加检测试剂以检测化学发光，缩短分析和测量时间，达到安装区域的微粉化。

3. 发明专利

JP2010231237A Wavelength conversion method and device thereof 有权
标题翻译：波长转换方法及其装置
公开(公告)号：JP2010231237A
公开(公告)日：2010-10-14
申请号：JP2010154440
申请日：2010-07-07
申请人： Institute Of Physical & Chemical Research , 独立行政法人理化学研究所
发明人： WADA TOMOYUKI , TASHIRO HIDEO , MORITA MASATAKA
IPC分类号： G02F1/37 , G01M11/00 , G01N21/63 , G02F1/35
CPC分类号： G01N21/636 , G01M11/00 , G02F1/3501 , G02F1/37
摘要： PROBLEM TO BE SOLVED: To maintain high conversion efficiency of non-linear optical crystals and to stably use the non-linear optical crystals for a long period without reducing outputs when various non-linear optical crystals for non-linear wavelength conversion, such as a CLBO crystal, are used for converting the wavelength of a laser beam.
SOLUTION: Before actually using a non-linear optical crystal as a wavelength conversion element, the non-linear optical crystal is previously evaluated, wherein the non-linear optical crystal is moved to change a position on which a laser beam is made incident and the output of a laser beam emitted from the non-linear optical crystal on each changed position is detected.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题为了保持非线性光学晶体的高转换效率并且在用于非线性波长转换的各种非线性光学晶体时长时间稳定地使用非线性光学晶体而不降低输出，例如CLBO晶体，用于转换激光束的波长。解决方案：在实际使用非线性光学晶体作为波长转换元件之前，预先评估非线性光学晶体，其中移动非线性光学晶体以改变其上形成激光束的位置检测在每个改变位置上从非线性光学晶体发射的激光束的输出。版权所有（C）2011，JPO＆INPIT

4. 发明专利

JP2008199927A Method for detecting nucleic acid, and genotyping method 审中-公开
标题翻译：检测核酸的方法和基因分型方法
公开(公告)号：JP2008199927A
公开(公告)日：2008-09-04
申请号：JP2007037885
申请日：2007-02-19
申请人： Institute Of Physical & Chemical Research , 独立行政法人理化学研究所
发明人： KONDO YASUMITSU , TASHIRO HIDEO
IPC分类号： C12Q1/68 , C12N15/09 , G01N21/78 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a new genotyping method capable of quickly performing genotyping and a new nucleic acid detection method which can be utilized in the genotyping method.
SOLUTION: The nucleic acid detection method comprises (1) a step of preparing a supporting member, having at least one kind of nucleic acid probe fixed to the member; (2) a step of preparing a labeled nucleic acid complementary to at least a part of the sequence of at least a part of the nucleic acid probe; (3) a step of keeping the labeled nucleic acid and a specimen nucleic acid in a specimen, in a hybridizable state; (4) a step of keeping the nucleic acid mixture, obtained by the step 3 and the nucleic acid probe fixed to the supporting member, in a hybridizable state; and (5) a step of measuring the labeled nucleic acid on the support member.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供能够快速进行基因分型的新的基因分型方法和可用于基因分型方法的新的核酸检测方法。解决方案：核酸检测方法包括（1）制备支撑构件的步骤，其具有固定到构件上的至少一种核酸探针; （2）制备与核酸探针的至少一部分序列的至少一部分互补的标记核酸的步骤; （3）将标记的核酸和标本核酸保持在可检测状态的步骤; （4）将通过步骤3获得的核酸混合物和固定在支撑构件上的核酸探针的核酸混合物保持在可混合状态的步骤; 和（5）测量载体上标记的核酸的步骤。版权所有（C）2008，JPO＆INPIT

5. 发明专利

JP2005283308A Manufacturing method for probe array 审中-公开
标题翻译：探针阵列的制造方法
公开(公告)号：JP2005283308A
公开(公告)日：2005-10-13
申请号：JP2004097232
申请日：2004-03-29
申请人： Institute Of Physical & Chemical Research , Lintec Corp , リンテック株式会社 , 独立行政法人理化学研究所
发明人： YAMAMOTO HIROKO , OKABE HIDEAKI , TASHIRO HIDEO , KONDO YASUMITSU
IPC分类号： G01N33/53 , B01J19/00 , C12N15/09 , C40B40/06 , C40B60/14 , G01N37/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00387 , B01J2219/00475 , B01J2219/00511 , B01J2219/00538 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00662 , B01J2219/00677 , B01J2219/00722 , C40B40/06 , C40B60/14
摘要： PROBLEM TO BE SOLVED: To easily manufacture a probe array arrayed with probes in a hollow part of a cylindrical member.
SOLUTION: A flexible sheetlike member 11 having a probe fixing face 110 is formed into a cylindrical shape to constitute an inner circumferential face with the probe fixing face 110.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为了容易地制造在圆柱形构件的中空部分中用探针排列的探针阵列。解决方案：具有探针固定面110的柔性片状构件11形成为圆筒形状，以与探针固定面110构成内周面。版权所有（C）2006，JPO＆NCIPI

6. 发明专利

JP2004294099A Raman probe and raman scattering measuring device using it 审中-公开
公开(公告)号：JP2004294099A
公开(公告)日：2004-10-21
申请号：JP2003083318
申请日：2003-03-25
申请人： Institute Of Physical & Chemical Research , Machida Endscope Co Ltd , 株式会社町田製作所 , 独立行政法人理化学研究所
发明人： KOMACHI YUICHI , TASHIRO HIDEO , AIZAWA KATSUO
IPC分类号： G01N21/65 , F21V8/00 , G01J3/44 , G02B6/032
CPC分类号： G02B6/032 , G01J3/44 , G02B6/0096
摘要： PROBLEM TO BE SOLVED: To provide a Raman probe and a Raman scattering measuring device using it, prevent the occurrence of Raman scattering which will be an obstacle to measurement.
SOLUTION: A hollow guiding path 10 in which an optical transfer body (a core) is gas or vacuum such as air not causing Raman scattering is used as a Raman probe.
COPYRIGHT: (C)2005,JPO&NCIPI

7. 发明专利

JP2004042545A Photo-setting pigmented molding method and device using the method 有权
公开(公告)号：JP2004042545A
公开(公告)日：2004-02-12
申请号：JP2002205814
申请日：2002-07-15
申请人： Inst Of Physical & Chemical Res , 理化学研究所
发明人： YAMAZAWA KENJI , TASHIRO HIDEO
IPC分类号： B29C67/00
摘要： PROBLEM TO BE SOLVED: To provide a photo-setting pigmented molding method by which a pigmented part is formed in a short time without an outer peripheral wall and a pigmented region is finely divided easily and a multi-color or full-color molding process is easily achieved, and to provide a device using the method.
SOLUTION: This method comprises an uncured layer forming process (A) for forming an uncured layer 2a of a photo-setting resin 2 and a pigmented curing process (B) for dripping a coloring matter 8 for pigmenting to the uncured layer and irradiating a position where the coloring matter 8 drips with a curing light 9. Simultaneously with the dripping of the coloring matter 8 to the uncured layer 2a of the photo-setting resin 2, the position where the coloring matter 8 drips is irradiated with the curing light 9 and the uncured layer 2a is cured. Consequently, the pigmented part is formed in a short time in the same conventional way as without the outer peripheral wall.
COPYRIGHT: (C)2004,JPO

8. 发明专利

JP2003057236A Method for manufacturing biomolecule microarray and spot apparatus 审中-公开
标题翻译：制造生物分子微量元素和点阵装置的方法
公开(公告)号：JP2003057236A
公开(公告)日：2003-02-26
申请号：JP2001243930
申请日：2001-08-10
申请人： Inst Of Physical & Chemical Res , Thk Co Ltd , Thk株式会社 , 理化学研究所
发明人： TASHIRO HIDEO , KITSUNAI TOKUJI , KONDO YASUMITSU , SHIRAI TAKEKI , NAKAZAWA TOJI , IIMURA AKIHIRO
IPC分类号： G01N33/53 , C12Q1/68 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a method and an apparatus for manufacturing a quantitative biomolecule microarray which accurately spots a solution containing probe biomolecules to solid-phase parts for receiving the probe biomolecules.
SOLUTION: A substrate with a plurality of the solid-phase parts for receiving the probe biomolecules (referred to as solid-phase parts, in the following), capable of specifically and quantitatively receiving the probe biomolecules in their surfaces is prepared. The solution containing the probe biomolecules is spotted to the solid-phase parts, and the probe biomolecules contained in the solution are immobilized to the solid-phase parts (the spotting of the solution is performed, in such a way that all the surface of one solid-phase part is covered with one droplet of the solution, and the one droplet contains the number of the probe biomolecules that the one solid-phase part is capable of receiving or more) in the method for manufacturing the biomolecule microarray and the apparatus used for the method. The substrate comprises alignment marks in its surface for the positioning of the substrate. The solid-phase parts are positioned with location relation to the alignment marks. The spotting of the solution is performed to the solid-phase parts positioned with locational relation to the alignment marks.
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：提供一种用于制造定量生物分子微阵列的方法和装置，其将含有探针生物分子的溶液精确地定位到用于接收探针生物分子的固相部分。解决方案：制备具有多个用于接收能够在其表面上特异性和定量地接收探针生物分子的探针生物分子（以下称为固相部分）的固相部分的基底。将含有探针生物分子的溶液点样固相，将溶液中包含的探针生物分子固定在固相部分（以溶液的点样，以一个在制造生物分子微阵列的方法和使用的装置的方法中，固相部分被一滴溶液覆盖，并且一个液滴包含一个固相部分能够接收的多个探针生物分子）为方法。衬底包括其表面中的对准标记用于衬底的定位。固相部分与定位标记位置关系定位。对与定位标记有定位关系的固相部分进行溶液的点样。

9. 发明专利

JP2013024605A Substrate for biochemical reaction, system for processing biochemical reaction, and method for draining liquid from the substrate 有权
标题翻译：用于生物反应的基质，用于处理生物化学反应的系统，以及用于从基底排出液体的方法
公开(公告)号：JP2013024605A
公开(公告)日：2013-02-04
申请号：JP2011157198
申请日：2011-07-15
申请人： Institute Of Physical & Chemical Research , 独立行政法人理化学研究所 , Consonal Biotechnologies Co Ltd , 株式会社コンソナルバイオテクノロジーズ
发明人： TASHIRO HIDEO , MATSUSHITA HARUHIKO , ITO YOSHIHIRO , MATSUE KIYOMI
IPC分类号： G01N35/02 , C12M1/34 , G01N33/543 , G01N35/10
摘要： PROBLEM TO BE SOLVED: To provide a substrate for biochemical reaction having a novel structure and a method for draining liquid from the substrate.SOLUTION: In a chip for biochemical reaction 10, there are provided, on a surface 1A, a cylindrical wall part 2 protruding from the surface 1A and a hydrophobic ring 4 of which height from the surface 1A is negligible at a predetermined distance from and inside the cylindrical wall part 2. An area enclosed by the hydrophobic ring 4 is a probe fixing region 5 for fixing a probe for biochemical reaction.

10. 发明专利

JP2006145325A Interaction testing device of bio-molecule, interaction testing method of bio-molecule, melting temperature measuring method of bio-molecule, and array detection method of nucleic acid 有权
标题翻译：生物分子的相互作用测试装置，生物分子的相互作用测试方法，熔融温度测量方法的生物分子和核酸的阵列检测方法
公开(公告)号：JP2006145325A
公开(公告)日：2006-06-08
申请号：JP2004334302
申请日：2004-11-18
申请人： Institute Of Physical & Chemical Research , 独立行政法人理化学研究所
发明人： TASHIRO HIDEO , KONDO YASUMITSU , HATAKEYAMA SATORU , KOIKE TSUTOMU
IPC分类号： G01N33/53 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/68 , G01N21/03 , G01N21/05 , G01N21/64 , G01N21/78 , G01N25/02 , G01N25/04 , G01N33/483 , G01N33/58 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a means capable of rapidly forming an interaction between bio-molecules without requiring many samples or much time and manpower and capable of detecting the interaction between the bio-molecules on a real time basis. SOLUTION: This interaction testing device of the bio-molecules comprises a bio-molecule micro array 1 where bio-molecules are fixed onto a substrate, and a transparent electrode 2 disposed so as to be faced to the surface to which the bio-molecules of the micro array are fixed. The device has a non-conductive spacer 3 between the micro array 1 and a counter electrode 2, and a cavity 4 is formed of the micro array 1, the spacer 3, and the counter electrode 2. The micro array 1 has a conductive material surface 6 in at least a part of the bio-molecule fixed surface, and two through holes 5 leading to the cavity 4. One through hole is used for injecting solution to the cavity, and the other through hole is used for discharging the solution from the cavity. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供能够快速形成生物分子之间的相互作用而不需要许多样品或大量时间和人力并且能够实时检测生物分子之间的相互作用的手段。解决方案：生物分子的这种相互作用测试装置包括生物分子微阵列1，其中生物分子固定在基底上，透明电极2被设置为面对生物分子微阵列的分子是固定的。该器件在微阵列1和对电极2之间具有非导电间隔物3，并且空腔4由微阵列1，间隔物3和对电极2形成。微阵列1具有导电材料表面6在生物分子固定表面的至少一部分中，以及两个通孔5通向空腔4.一个通孔用于将溶液注入空腔，另一个通孔用于将溶液从空腔。版权所有（C）2006，JPO＆NCIPI

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