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1. 发明专利

JP2005283308A Manufacturing method for probe array 审中-公开
标题翻译：探针阵列的制造方法
公开(公告)号：JP2005283308A
公开(公告)日：2005-10-13
申请号：JP2004097232
申请日：2004-03-29
申请人： Institute Of Physical & Chemical Research , Lintec Corp , リンテック株式会社 , 独立行政法人理化学研究所
发明人： YAMAMOTO HIROKO , OKABE HIDEAKI , TASHIRO HIDEO , KONDO YASUMITSU
IPC分类号： G01N33/53 , B01J19/00 , C12N15/09 , C40B40/06 , C40B60/14 , G01N37/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00387 , B01J2219/00475 , B01J2219/00511 , B01J2219/00538 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00662 , B01J2219/00677 , B01J2219/00722 , C40B40/06 , C40B60/14
摘要： PROBLEM TO BE SOLVED: To easily manufacture a probe array arrayed with probes in a hollow part of a cylindrical member.
SOLUTION: A flexible sheetlike member 11 having a probe fixing face 110 is formed into a cylindrical shape to constitute an inner circumferential face with the probe fixing face 110.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为了容易地制造在圆柱形构件的中空部分中用探针排列的探针阵列。解决方案：具有探针固定面110的柔性片状构件11形成为圆筒形状，以与探针固定面110构成内周面。版权所有（C）2006，JPO＆NCIPI

2. 发明专利

JP2005283306A Member for manufacturing probe array, and manufacturing method for probe array 审中-公开
标题翻译：制造探头阵列的会员和探头阵列的制造方法
公开(公告)号：JP2005283306A
公开(公告)日：2005-10-13
申请号：JP2004097230
申请日：2004-03-29
申请人： Institute Of Physical & Chemical Research , Lintec Corp , リンテック株式会社 , 独立行政法人理化学研究所
发明人： YAMAMOTO HIROKO , OKABE HIDEAKI , TASHIRO HIDEO , KONDO YASUMITSU
IPC分类号： G01N33/53 , B01J19/00 , C12M1/00 , C12N15/09 , C40B40/06 , C40B60/14 , G01N37/00
CPC分类号： B01J19/0046 , B01J2219/00387 , B01J2219/00475 , B01J2219/00511 , B01J2219/00538 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00662 , B01J2219/00677 , B01J2219/00722 , B82Y30/00 , C40B40/06 , C40B60/14
摘要： PROBLEM TO BE SOLVED: To provide a probe array manufacturing member capable of manufacturing a desired probe array immediately after determining an array for probes, and a probe array manufacturing method using the probe array manufacturing member.
SOLUTION: The probe array manufacturing members M
1 , M
2 , to M
n are cut to manufacture cut pieces F
1 , F
2 , to F
n , and a prescribed number of the cut pieces F
1 , F
2 , to F
n is peeled off from a separable sheet 13 to be bonded to a prescribed portion of a support member 2a via an adhesive layer 12.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种能够在确定用于探针的阵列之后立即制造期望的探针阵列的探针阵列制造构件，以及使用探针阵列制造构件的探针阵列制造方法。解决方案：切割探针阵列制造部件M 1，M 2 至M n ，以制造切割片F 1 ，F 2 到F n ，并且规定数量的切割件F 1 ，F 2 到F n 从可分离片13剥离，以通过粘合层12与支撑件2a的规定部分接合。（C）2006 ，JPO＆NCIPI

3. 发明专利

JP2006145400A Method of making bio-molecule interact with each other, and method of moving bio-molecule 有权
标题翻译：生物分子与每个其他物质相互作用的方法和移动生物分子的方法
公开(公告)号：JP2006145400A
公开(公告)日：2006-06-08
申请号：JP2004336333
申请日：2004-11-19
申请人： Institute Of Physical & Chemical Research , 独立行政法人理化学研究所
发明人： TASHIRO HIDEO , KONDO YASUMITSU , SHIMAMURA TAKAYUKI
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a means capable of promoting interaction in a bio-molecule micro array and increasing speed and sensitivity of the reaction. SOLUTION: In this interaction method, solution containing a target bio-molecule is arranged between a bio-molecule micro array having one or more spots where bio-molecules are fixed to the surface of a substrate and a counter electrode, and the bio-molecules fixed to the surface of the substrate are interacted with the target bio-molecule. The micro array has a conductive material surface in at least a part of the bio-molecule fixed surface, voltage is applied at a frequency of 0.01-10 Hz between the conductive material surface and the counter electrode to promote the interaction. In this moving method, the bio-molecules contained in the solution arranged between the substrate at least partly having the conductive material surface and the counter electrode is moved. Voltage is applied at a frequency of 0.01-10 Hz between the conductive material surface and the counter electrode to move the bio-molecules toward the substrate or the counter electrode. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供能够促进生物分子微阵列中的相互作用并增加反应速度和灵敏度的手段。解决方案：在这种相互作用方法中，含有靶生物分子的溶液被布置在具有一个或多个点的生物分子微阵列之间，其中生物分子固定在基底的表面和对电极上，固定在底物表面的生物分子与目标生物分子相互作用。微阵列在生物分子固定表面的至少一部分中具有导电材料表面，在导电材料表面和对电极之间以0.01-10Hz的频率施加电压以促进相互作用。在该移动方法中，包含在布置在至少部分具有导电材料表面的基底和对电极之间的溶液中的生物分子被移动。在导电材料表面和对电极之间以0.01-10Hz的频率施加电压，以将生物分子移向基板或对电极。版权所有（C）2006，JPO＆NCIPI

4. 发明专利

JP2006275981A PROBE PLATE INCLUDING DNA PROBE FOR SCREENING CARCINOGENIC SUBSTANCE, MANUFACTURING METHOD THEREOF, AND cDNA SCREENING METHOD WITH USAGE OF THE PROBE PLATE 审中-公开
标题翻译：探针板包括用于筛选致癌物质的DNA探针，其制备方法和使用探针板的cDNA筛选方法
公开(公告)号：JP2006275981A
公开(公告)日：2006-10-12
申请号：JP2005099843
申请日：2005-03-30
申请人： Institute Of Physical & Chemical Research , Tama Tlo Kk , タマティーエルオー株式会社 , 独立行政法人理化学研究所
发明人： FURUHATA CHIE , TOBE KAORI , TASHIRO HIDEO , KONDO YASUMITSU , SUZUKI TAKAMASA
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , G01N33/574 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To generate a probe plate capable of selecting only oligonucleotide giving high selection to a carcinogenic substance, capable of conducting a test at the low cost in a short time as a DNA microarray, and capable of making high selective hybridization with a marked cDNA; and to achieve high selectivity, high efficiency and low cost of screening. SOLUTION: This DNA probe plate 10 is provided with a substrate 12, and a spot 14 including oligonucleotide adhered to the substrate; and the oligonucleotide is a base structure wherein 5'-end and 3'-end are G (guanine), C (cytosine), or two base sequences including the 5'-end and the 3'-end are GG, GC, CG, CC. Further, the manufacturing method of the DNA probe plate and the cDNA screening method with the usage of the probe plate are also provided. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：为了产生能够仅选择对致癌物质进行高选择的寡核苷酸的探针板，能够在短时间内作为DNA微阵列以低成本进行测试，并能够制备高选择性与标记的cDNA杂交; 并实现高选择性，高效率和低成本筛选。解决方案：该DNA探针板10具有底物12和包含寡核苷酸的斑点14，粘附于基底上; 并且寡核苷酸是其中5'端和3'末端是G（鸟嘌呤），C（胞嘧啶）或包括5'末端和3'末端的两个碱基序列是GG，GC，CG ，CC。此外，还提供了DNA探针板的制造方法和使用探针板的cDNA筛选方法。版权所有（C）2007，JPO＆INPIT

5. 发明专利

JP2008199927A Method for detecting nucleic acid, and genotyping method 审中-公开
标题翻译：检测核酸的方法和基因分型方法
公开(公告)号：JP2008199927A
公开(公告)日：2008-09-04
申请号：JP2007037885
申请日：2007-02-19
申请人： Institute Of Physical & Chemical Research , 独立行政法人理化学研究所
发明人： KONDO YASUMITSU , TASHIRO HIDEO
IPC分类号： C12Q1/68 , C12N15/09 , G01N21/78 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a new genotyping method capable of quickly performing genotyping and a new nucleic acid detection method which can be utilized in the genotyping method.
SOLUTION: The nucleic acid detection method comprises (1) a step of preparing a supporting member, having at least one kind of nucleic acid probe fixed to the member; (2) a step of preparing a labeled nucleic acid complementary to at least a part of the sequence of at least a part of the nucleic acid probe; (3) a step of keeping the labeled nucleic acid and a specimen nucleic acid in a specimen, in a hybridizable state; (4) a step of keeping the nucleic acid mixture, obtained by the step 3 and the nucleic acid probe fixed to the supporting member, in a hybridizable state; and (5) a step of measuring the labeled nucleic acid on the support member.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供能够快速进行基因分型的新的基因分型方法和可用于基因分型方法的新的核酸检测方法。解决方案：核酸检测方法包括（1）制备支撑构件的步骤，其具有固定到构件上的至少一种核酸探针; （2）制备与核酸探针的至少一部分序列的至少一部分互补的标记核酸的步骤; （3）将标记的核酸和标本核酸保持在可检测状态的步骤; （4）将通过步骤3获得的核酸混合物和固定在支撑构件上的核酸探针的核酸混合物保持在可混合状态的步骤; 和（5）测量载体上标记的核酸的步骤。版权所有（C）2008，JPO＆INPIT

6. 发明专利

JP2006145325A Interaction testing device of bio-molecule, interaction testing method of bio-molecule, melting temperature measuring method of bio-molecule, and array detection method of nucleic acid 有权
标题翻译：生物分子的相互作用测试装置，生物分子的相互作用测试方法，熔融温度测量方法的生物分子和核酸的阵列检测方法
公开(公告)号：JP2006145325A
公开(公告)日：2006-06-08
申请号：JP2004334302
申请日：2004-11-18
申请人： Institute Of Physical & Chemical Research , 独立行政法人理化学研究所
发明人： TASHIRO HIDEO , KONDO YASUMITSU , HATAKEYAMA SATORU , KOIKE TSUTOMU
IPC分类号： G01N33/53 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/68 , G01N21/03 , G01N21/05 , G01N21/64 , G01N21/78 , G01N25/02 , G01N25/04 , G01N33/483 , G01N33/58 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a means capable of rapidly forming an interaction between bio-molecules without requiring many samples or much time and manpower and capable of detecting the interaction between the bio-molecules on a real time basis. SOLUTION: This interaction testing device of the bio-molecules comprises a bio-molecule micro array 1 where bio-molecules are fixed onto a substrate, and a transparent electrode 2 disposed so as to be faced to the surface to which the bio-molecules of the micro array are fixed. The device has a non-conductive spacer 3 between the micro array 1 and a counter electrode 2, and a cavity 4 is formed of the micro array 1, the spacer 3, and the counter electrode 2. The micro array 1 has a conductive material surface 6 in at least a part of the bio-molecule fixed surface, and two through holes 5 leading to the cavity 4. One through hole is used for injecting solution to the cavity, and the other through hole is used for discharging the solution from the cavity. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供能够快速形成生物分子之间的相互作用而不需要许多样品或大量时间和人力并且能够实时检测生物分子之间的相互作用的手段。解决方案：生物分子的这种相互作用测试装置包括生物分子微阵列1，其中生物分子固定在基底上，透明电极2被设置为面对生物分子微阵列的分子是固定的。该器件在微阵列1和对电极2之间具有非导电间隔物3，并且空腔4由微阵列1，间隔物3和对电极2形成。微阵列1具有导电材料表面6在生物分子固定表面的至少一部分中，以及两个通孔5通向空腔4.一个通孔用于将溶液注入空腔，另一个通孔用于将溶液从空腔。版权所有（C）2006，JPO＆NCIPI

7. 发明专利

JP2005024532A Substrate for biomolecule microarray, biomolecule microarray, device and method for promoting interaction, and method of detecting interaction 有权
标题翻译：用于生物分子微生物，生物分子微生物学的基板，用于促进相互作用的装置和方法以及检测相互作用的方法
公开(公告)号：JP2005024532A
公开(公告)日：2005-01-27
申请号：JP2003391083
申请日：2003-11-20
申请人： Institute Of Physical & Chemical Research , 独立行政法人理化学研究所
发明人： TASHIRO HIDEO , KONDO YASUMITSU , KITSUNAI TOKUJI , HATAKEYAMA SATORU
IPC分类号： G01N33/53 , B01J19/00 , B01L3/00 , C12M1/00 , C12M1/40 , C12N15/09 , C12Q1/68 , C40B40/06 , C40B40/10 , G01N21/25 , G01N21/64 , G01N21/78 , G01N33/543 , G01N37/00
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00653 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/5085 , C40B40/06 , C40B40/10 , G01N21/253 , G01N21/6428 , G01N33/5438 , G01N2021/6482
摘要： PROBLEM TO BE SOLVED: To provide a means for quickening an interaction between a substrate having a biomolecule immobilizing area on a biomolecule microarray and a biomolecule, for promoting the interaction in a microsample, and for detecting and analyzing the interaction quickly and highly sensitively. SOLUTION: The present invention provides the substrate for the biomolecule microarray having a biomolecule immobilizing spot. The spot is, for example, projected on a substrate surface and has a plane for the spot in a top, and the substrate surface in the periphery of a spot part, a projected spot part side face, and the plane for the spot comprise a conductive substance. The microarray includes the substrate and the biomolecule, and the biomolecule is immobilized on the plane for the spot on the substrate. The present invention provides a biomolecule interaction promoting device having the array having the biomolecule immobilizing spot on the substrate, an electrode provided to be opposed to a face having the biomolecule immobilizing spot of the array, and an electrode for impressing an electric field between the array and the electrode. The present invention provides a biomolecule interaction promoting method using the device. The present invention provides a biomolecule interaction method and detection therefor. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种用于加速具有生物分子微阵列上的生物分子固定区域的基底与生物分子之间的相互作用的手段，用于促进微量样品中的相互作用，并用于快速和高度地检测和分析相互作用敏感地。解决方案：本发明提供了具有生物分子固定点的生物分子微阵列的底物。该点例如投影在基板表面上，并且具有用于顶部的点的平面，并且点部分的周边中的基板表面，突出的点部分侧面和用于点的平面包括导电物质。微阵列包括基质和生物分子，并且生物分子固定在基底上的斑点的平面上。本发明提供一种生物分子相互作用促进装置，其具有阵列上具有生物分子固定点的基板，设置成与具有阵列的生物分子固定点的面相对的电极，以及用于在阵列之间施加电场的电极和电极。本发明提供使用该装置的生物分子相互作用促进方法。本发明提供生物分子相互作用方法及其检测方法。版权所有（C）2005，JPO＆NCIPI

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