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1. 发明专利

JPH06181792A PRODUCTION OF NONINFECTIOUS STRUCTURAL PARTICLE CONTAINING SURFACE ANTIGEN PROTEIN OF VIRUS BELONGING TO FLAVIVIRUS FAMILY AND RECOMBINANT VIRUS USING THEREFOR 失效
公开(公告)号：JPH06181792A
公开(公告)日：1994-07-05
申请号：JP14556892
申请日：1992-06-05
申请人： NIPPON ZEON CO , TOKYO METROPOLITAN GOV
发明人： SATO TAKANORI , TAKAMURA CHIZUKO , KAMOGAWA KOICHI , YASUI KOTARO
IPC分类号： A61K39/12 , A61P31/12 , C12N7/00 , C12N7/01 , C12N15/09 , C12N15/40 , C12P21/02 , C12R1/92
摘要： PURPOSE:To provide a method for mass production of SHA-like particles giving properties similar to those of SHA particles highly valuable as a vaccine. CONSTITUTION:A recombinant virus incorporated with the E-protein of flavivirus family and a cDNA coding the protease therefor is produced and then cultured to obtain the objective SHA-like particles.

2. 发明专利

JPH02156896A PRODUCTION OF NON-CONSTITUTIVE PROTEIN OF JAPANESE ENCEPHALITIS VIRUS 失效
公开(公告)号：JPH02156896A
公开(公告)日：1990-06-15
申请号：JP31165688
申请日：1988-12-09
申请人： TOKYO METROPOLITAN GOV , NIPPON ZEON CO
发明人： YASUI KOTARO , MIYAMOTO MICHIKO , SATO TAKANORI
IPC分类号： C12P21/02 , A61K39/00 , C07K14/00 , C07K14/18 , C07K14/705 , C12N15/33 , C12N15/40 , C12R1/91
摘要： PURPOSE:To obtain the subject substance useful as a Japanese encephalitis vaccine, etc., on an industrial scale at a low cost by infecting an insect cell with a recombinant containing a cDNA coding a non-constitutive protein of Japanese encephalitis virus in a genom region non-essential to the proliferation of a baculovirus and culturing the virus. CONSTITUTION:Japanese encephalitis virus is extracted with phenol to collect virus genom RNA, the RNA is treated with a transcriptase and the prepared cDNA is treated with a restriction enzyme, linked to a vector and inserted into E.coli to effect the transformation of the cell. The transformed cell is screened to select a clone containing cDNA coding a non-constitutive protein of Japanese encephalitis virus. A part or total of the cDNA is integrated into a genom region non-essential to the proliferation of baculovirus and the recombinant baculovirus is infected to an insect cell and cultured to obtain the expressed non-constitutive protein of Japanese encephalitis virus.

3. 发明专利

JPH01285198A PRODUCTION F SURFACE ANTIGEN PROTEIN OF JAPANESE ENCEPHALITIS VIRUS 失效
公开(公告)号：JPH01285198A
公开(公告)日：1989-11-16
申请号：JP11531688
申请日：1988-05-12
申请人： MATSURA ZENJI , TOKYO METROPOLITAN GOV , NIPPON ZEON CO
发明人： MATSUURA ZENJI , YASUI KOTARO , SATO TAKANORI
IPC分类号： C12N15/09 , A61K39/00 , A61K39/12 , C07K14/00 , C07K14/18 , C07K14/705 , C12N15/33 , C12N15/866 , C12P21/02 , C12R1/91
摘要： PURPOSE:To produce the title protein in high efficiency, by infecting insect cells with the baculo virus incorporated with cDNA coding the surface antigen protein of Japanese encephalitis virus in a specific domain. CONSTITUTION:Insect cells are infected with the recombinant baculo virus incorporated with part or the whole of cDNA coding the surface antigen protein of Japanese encephalitis virus in a domain nonessential to the growth of baculo virus. The resultant insect virus is put to culture and the Japanese encephalitis virus surface antigen protein is recovered. it is preferable that this protein be incorporated with part or the whole of cDNA coding the surface antigen protein in combination with part or the whole of cDNA coding the prematrix protein or matrix protein of Japanese encephalitis virus.

4. 发明专利

JPH06205672A PRODUCTION OF CHIMERAL PROTEIN HAVING ANTIGEN SITE OF SURFACE ANTIGEN PROTEIN OF JAPANESE ENCEPHALITIS VIRUS AND HEPATITIS B VIRUS AND RECOMBINANT BACULOVIRUS THEREFOR 失效
公开(公告)号：JPH06205672A
公开(公告)日：1994-07-26
申请号：JP6369992
申请日：1992-03-19
申请人： NIPPON ZEON CO , TOKYO METROPOLITAN GOV
发明人： SATO TAKANORI , TAKAMURA CHIZUKO , YASUDA ATSUSHI , KAMOGAWA KOICHI , YASUI KOTARO
IPC分类号： A61K39/155 , A61K39/29 , A61K39/295 , A61P31/12 , C12N7/00 , C12N7/01 , C12N15/09 , C12N15/62 , C12N15/86 , C12P21/02 , C12R1/91 , C12R1/92
摘要： PURPOSE:To provide a method for mass production of chimeral protein for polyvalent vaccine for virus, and to provide recombinant baculovirus therefor. CONSTITUTION:Firstly, recombinant baculovirus is produced by incorporating the nonessential domain of the genome of baculovirus with a DNA obtained by fusion between part of the cDNA coding the surface antigen protein of Japanese encephalitis virus and the DNA coding the surface antigen protein of hepatitis B virus. This recombinant baculovirus is then cultured to manifest a polyvalent vaccine. Thus, the objective chimeral protein usable as the polyvalent vaccine can be mass-produced.

5. 发明专利

JPH02303482A JAPANESE ENCEPHALITIS VIRUS NS1 GENE-RECOMBINANT VACCINIA VIRUS 失效
公开(公告)号：JPH02303482A
公开(公告)日：1990-12-17
申请号：JP12589489
申请日：1989-05-19
申请人： TOKYO METROPOLITAN GOV , NIPPON ZEON CO
发明人： YASUI KOTARO , TAKAMURA CHIZUKO , SATO TAKANORI , KAMOGAWA KOICHI
IPC分类号： C12N7/00 , A61K39/12 , C12N7/01 , C12N15/40 , C12N15/86 , C12R1/91
摘要： NEW MATERIAL:The subject virus obtained by integrating the whole cDNA or part of cDNA (e.g. non-constitutional protein-1 of Japanese encephalitis virus) coding non-constitutional protein of Japanese encephalitis virus into a genome region unessential to proliferation of vaccinia virus. USE:Live vaccine against Japanese encephalitis. PREPARATION:cDNA coding non-constitutional protein of Japanese encephalitis virus is prepared and the first recombinant vector into which DNA region unessential to proliferation of vaccinia virus was integrated is prepared. A region coding the nonconstitutional protein of Japanese encephalitis virus is inserted into the downstream side of promoter of the first recombinant vector to prepare the second recombinant vector. The second recombinant vector is transferred into an animal culture cell in which vaccinia virus was previously infected. A homologous recombinant is carried out between vector DNA and virus genome DNA to assemble the recombinant vaccinia virus.

6. 发明专利

JPS6474982A RECOMBINANT VACCINIA VIRUS 失效
公开(公告)号：JPS6474982A
公开(公告)日：1989-03-20
申请号：JP23149687
申请日：1987-09-16
申请人： NAT INST HEALTH , TOKYO METROPOLITAN GOV , NIPPON ZEON CO
发明人： YASUI KOTARO , KOJIMA ASATO , YASUDA ATSUSHI , SATO TAKANORI
IPC分类号： A61K39/12 , A61K39/00 , A61K39/285 , C07K14/18 , C12N7/00 , C12N7/01 , C12N15/00 , C12N15/09 , C12R1/91
摘要： PURPOSE:To obtain the title virus which is used as a vaccin, by building the DNA coding the E protein in Japanese encephalitis virus into the genome region nonessential for propagation of vaccinia virus. CONSTITUTION:The cDNA (4118) coding the surface antigen protein is isolated from the cDNA in the sagayama line of Japanese encephalitis virus, connected to another cDNA (2-20) whose sequence partially overlaps in the N-terminal at the Aaf II site to give the cDNA (203) perfectly covering the E protein. The fragments of J7 of 1.6kbp, J4 of 2.1kbp, and J6 of 2.4kbp are prepared from the cDNA, and inserted into pAK8 including the polylinker and vaccinia virus 7.5k promoter, and the resultant pAKJ7, pAKJ67 and pAKJ6 are introduced into RK-13 cells which is inoculated with attenuated small pox line LA to give recombinant vaccinia virus LAJ7, LAJ4 and LAJ6.

7. 发明专利

JP2010195691A Method for producing asymmetrical azine compound 有权
标题翻译：用于生产非对称AZINE化合物的方法
公开(公告)号：JP2010195691A
公开(公告)日：2010-09-09
申请号：JP2009039593
申请日：2009-02-23
申请人： Japan Finechem Co Inc , Nippon Zeon Co Ltd , 日本ゼオン株式会社 , 株式会社日本ファインケム
发明人： KAMIMURA SADAO , SATO TAKANORI , NEMUGAKI SHUICHI , NAKANO YASUYUKI
IPC分类号： C07C249/16 , C07C251/88
摘要： PROBLEM TO BE SOLVED: To provide a method for producing an asymmetrical azine compound.
SOLUTION: The method for producing an asymmetrical azine compound represented by formula (I) is characterized by including a process 1 of reacting an aldehyde compound with hydrazine in an alcohol, in water, or in a mixed solution of an alcohol and water to obtain a reaction liquid, a process 2 of isolating a hydrazone compound from the resulting reaction liquid, and a process 3 of reacting the isolated hydrazone compound with an aldehyde compound (in the formula, R
1 and R
2 each represents an OH group or a COOH group; X
1 to X
8 each represents H, -C(=O)-OR
3 or the like; and R
3 represents an alkyl group or the like).
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供一种制备不对称吖嗪化合物的方法。解决方案：制备由式（I）表示的不对称吖嗪化合物的方法的特征在于包括使醛化合物与肼在醇中，在水中或在醇和水的混合溶液中反应的方法1 得到反应液，从得到的反应液中分离腙化合物的工序2和使分离的腙化合物与醛化合物反应的方法3（式中，R SB> 1和/ 每个代表OH基团或COOH基团; X 至X 各自表示H，-C（= O） SP> 3 等; R 3是表示烷基等。版权所有（C）2010，JPO＆INPIT

8. 发明专利

JP2007230903A Antiviral peptide and antiviral agent 有权
标题翻译：抗菌肽和抗病毒剂
公开(公告)号：JP2007230903A
公开(公告)日：2007-09-13
申请号：JP2006053816
申请日：2006-02-28
申请人： Nippon Zeon Co Ltd , Toagosei Co Ltd , 日本ゼオン株式会社 , 東亞合成株式会社
发明人： YOSHIDA TETSUHIKO , KOBAYASHI NAOKO , SATO TAKANORI
IPC分类号： A61K38/00 , A61P31/12 , C07K7/06 , C07K7/08 , C07K14/005
CPC分类号： G01N33/56983 , A61K38/00 , C07K14/005 , C07K14/4703 , C07K2319/09 , C07K2319/095 , C12N2740/16322
摘要： PROBLEM TO BE SOLVED: To provide an artificially designed antiviral peptide absent in the nature; and to provide an antiviral agent containing the peptide as an essential component.
SOLUTION: The antiviral agent contains the artificially designed peptide absent in the nature as the essential component. The antiviral peptide has at least one unit of an amino acid sequence constituted of at least five continuous amino acid residues known as a nuclear localization signal sequence (NLS) or an amino acid sequence obtained by partially modifying the NLS, and at least one unit of an amino acid sequence constituted of at least five continuous amino acid residues known as a nuclear export signal sequence (NES) or an amino acid sequence obtained by partially modifying the NES.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供人造设计的抗病毒肽在自然界中不存在; 并提供含有肽作为必需成分的抗病毒剂。解决方案：抗病毒剂含有人造设计的肽作为必需组分不存在于自然界中。抗病毒肽具有至少一个氨基酸序列的单元，该氨基酸序列由称为核定位信号序列（NLS）的至少五个连续氨基酸残基或通过部分修饰NLS得到的氨基酸序列构成，以及至少一个单位由至少五个称为核出口信号序列（NES）的连续氨基酸残基或通过部分修饰NES获得的氨基酸序列构成的氨基酸序列。版权所有（C）2007，JPO＆INPIT

9. 发明专利

JPH1028586A NON-ESSENTIAL REGION OF AVIPOXVIRUS, RECOMBINANT AVIPOXVIRUS AND VACCINE USING THIS REGION 失效
公开(公告)号：JPH1028586A
公开(公告)日：1998-02-03
申请号：JP20779796
申请日：1996-07-18
申请人： NIPPON ZEON CO
发明人： SATO TAKANORI , OKUDA HISASHI
IPC分类号： C12N15/09 , A61K39/00 , A61K39/12 , A61K39/17 , A61P31/12 , C07H21/04 , C07K14/065 , C12N7/00 , C12N7/01 , C12N15/00 , C12R1/92
摘要： PROBLEM TO BE SOLVED: To obtain a new non-essential region for the growth of a avipoxvirus(APV), without reducing the growth of a recombinant APV simultaneously containing an E. coli β-galactosidase gene and a specific promoter in a chicken body and useful as a vaccine, etc. SOLUTION: This non-essential region of avipoxvirus(APV) is a genom region non-essential for the growth of the avipoxvirus, capable of obtaining a recombinant APV by inserting thereto a β-galactosidase gene derived from an E. coli together with vaccinia virus 7.5K promoter and having a growing capability in a chicken body not substantially reduced when comparing with that before the insertion of the β-galactosidase gene, and giving a recombinant APV not reducing the growing capability in spite of the insertion of a foreign gene, and useful as an anti-Newcastle disease vaccine, etc., by using a gene encoding an F antigen and an HN antigen of the Newcastle disease virus as the foreign gene.

10. 发明专利

JPH03148066A MEMBRANE FOR DIAGNOSING VIRUS INFECTIOUS DISEASE AND DIAGNOSTIC METHOD 失效
公开(公告)号：JPH03148066A
公开(公告)日：1991-06-24
申请号：JP28855889
申请日：1989-11-06
申请人： NIPPON ZEON CO
发明人： SATO TAKANORI , TAKAMURA CHIZUKO , KAMOGAWA KOICHI
IPC分类号： G01N33/569 , A61B10/00
摘要： PURPOSE:To make it possible to diagnose the difference between the infections of affinous viruses efficiently and accurately by attaching two or more kinds of specific antigens which have affinous relation on one membrane carrier, and bringing the antigens into contact with the serum of a body under test. CONSTITUTION:With respect to virus which is the object of diagnosis, there is the cross reaction of antibodies between the virus and the antigen of an affinous virus. Serum to be inspected becomes positive by the reaction with a plurality of the virus antigens. When the deterministic judgment is difficult, there is no special restriction. In practical application, epidemic viruses in the same region are combined in response to purposes. The antigen wherein the peculiarity of the virus is maintained is formed. Then, the respective specific antigens are dropped on one membrane carrier without mixing and without loosing pecurialities. The antigens are sucked, and solvent is removed. Then the antigens are attached. The serum is diluted so that the reactivity with the antibody in the serum to be inspected becomes equal. The membrane is immersed into the serum to be inspected which is diluted at a constant temperature, and the virus antigens and the serum are brought into contact. Thus the infected viruses are diagnosed based on the amount of bondings between the antigens and the antibodies in the serum.

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