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1. 发明专利

JPS6363381A RECOMBINANT VACCINIA VIRUS 失效
公开(公告)号：JPS6363381A
公开(公告)日：1988-03-19
申请号：JP20877286
申请日：1986-09-04
申请人： NAT INST HEALTH , NIPPON ZEON CO , CHIBA PREFECTURE
发明人： KOJIMA ASATO , YASUDA KANJI , GOTO HIROYUKI , NAKAZATO SAKIKO , KAMOGAWA KOICHI , MORITA MICHIO , WATANABE KUNIKO , KOBAYASHI HIROSHIGE
IPC分类号： C12N15/09 , A61K39/285 , C07K14/02 , C12N15/00 , C12N15/863 , C12P21/00 , C12R1/91
摘要： PURPOSE:To obtain a vaccinia virus having high safety and high immunity, closely integrating a DNA having promoter function and an adventitious DNA into an attenuated Lister temperature-sensitive variant. CONSTITUTION:An attenuated Lister temperature-sensitive variation vaccinia virus strain which shows no high-temperature multiplication in a rabbit hepatic cell and has a small box size on a chorio-allantonic membrane of hatched hen's egg is used. A DNA having promoter function and an adventitious DNA manifestable under the control of the promoter are closely integrated into a non-essential DNA range of the strain. A multiplication impotence temperature in the rabbit hepatic cell of the Lister temperature-sensitive variation vaccinia virus is preferably 41 deg.C. The DNA having the promoter function is preferably a promoter of an initial vaccinia virus gene to code 7.5K polypeptide.

2. 发明专利

JPH0544269B2 失效
公开(公告)号：JPH0544269B2
公开(公告)日：1993-07-05
申请号：JP18458985
申请日：1985-08-22
申请人： CHIBA PREFECTURE , NIPPON ZEON CO
发明人： OOI KYOSHI , MORITA MICHIO , SUZUKI KAZUYOSHI , HASHIZUME TAKESHI , YOSHIZAWA HANAKO , GOTO HIROYUKI , NAKAZATO SAKIKO , KAMOGAWA KOICHI
IPC分类号： C12N15/09 , A61K39/285 , A61P31/12 , C12N7/00 , C12N15/863 , C12Q1/68 , C12R1/92 , G01N33/50 , C12N7/01 , C12N15/64

3. 发明专利

JPS6244179A SEPARATION OF RECOMBINANT VACCINIA VIRUS 失效
公开(公告)号：JPS6244179A
公开(公告)日：1987-02-26
申请号：JP18458985
申请日：1985-08-22
申请人： CHIBA PREFECTURE , NIPPON ZEON CO
发明人： OI KIYOSHI , MORITA MICHIO , SUZUKI KAZUYOSHI , HASHIZUME TAKESHI , YOSHIZAWA HANAKO , GOTO HIROYUKI , NAKAZATO SAKIKO , KAMOGAWA KOICHI
IPC分类号： C12N15/09 , A61K39/285 , A61P31/12 , C12N7/00 , C12N15/863 , C12Q1/68 , C12R1/92 , G01N33/50
摘要： PURPOSE:To obtain a recombinant vaccinia virus in high efficiency with a simple operation, by inoculating a mixture of a specific mutant vaccinia virus and a recombinant vaccinia virus to a thymidine kinase-negative animal cell and culturing the cell. CONSTITUTION:A thymidine kinase-negative animal cell is inoculated with a mixture of (A) an attenuated Lister temperature-sensitive mutant vaccinia virus having a proliferation-inhibiting temperature of 40.5 deg.C in rabbit renal cell and giving a pox size of =5 days. The recombinant vaccinia virus (B) is selected from the formed plaque by the plaque hybridization technique using an extraneous DNA.

4. 发明专利

JPS6244178A RECOMBINANT VACCINIA VIRUS 失效
公开(公告)号：JPS6244178A
公开(公告)日：1987-02-26
申请号：JP18459085
申请日：1985-08-22
申请人： CHIBA PREFECTURE , NIPPON ZEON CO
发明人： OI KIYOSHI , MORITA MICHIO , SUZUKI KAZUYOSHI , HASHIZUME TAKESHI , YOSHIZAWA HANAKO , GOTO HIROYUKI , NAKAZATO SAKIKO , KAMOGAWA KOICHI
IPC分类号： C12N15/09 , A61K39/285 , C12N7/00 , C12N15/863
摘要： PURPOSE:To obtain a recombinant vaccinia virus giving weak side reaction after vaccination, by integrating an extraneous DNA to the non-essential DNA region of a specific attenuated Lister temperature-sensitive mutant vaccinia virus strain. CONSTITUTION:The objective recombinant vaccinia virus is produced by integrating an extraneous DNA to the non-essential DNA region of an attenuated Lister temperature-sensitive mutant vaccinia virus strain exhibiting no proliferation property in rabbit renal cell and having small pox size on the chorion of embryonated hen egg. The vaccinia virus to be integrated with the extraneous DNA is an attenutated temperature-sensitive mutant strain of Lister virus which gives smaller pox size (

5. 发明专利

JPH06100465A RECOMBINANT LIVE VACCINE OF VIRUS BELONGING TO FAMILY FLAVIVIRUS 失效
公开(公告)号：JPH06100465A
公开(公告)日：1994-04-12
申请号：JP25448192
申请日：1992-09-24
申请人： NIPPON ZEON CO , CHIBA PREFECTURE
发明人： SATO TAKANORI , KAMOGAWA KOICHI , HORIUCHI KIYOSHI , WATANABE KUNIKO
IPC分类号： A61K39/12 , A61K39/275 , A61K39/295 , A61P31/12 , C12N7/00 , C12N7/01 , C12N15/09 , C12N15/40
摘要： PURPOSE:To provide a live vaccine having increased neutralizing antibody value. CONSTITUTION:High neutralizing antibody value can be attained by using a live vaccine composed mainly of a mixture of (A) a recombinant vaccinia virus expressing surface antigen protein originated from virus belonging to the family Flavivirus and (B) a recombinant vaccinia virus expressing a protease originated from virus belonging to the family Flavivirus or composed mainly of a recombinant vaccinia virus expressing a surface antigen protein and a protease originated from virus belonging to the family Flavivirus.

6. 发明专利

JPH11346786A NEW CYTOKINE, ITS GENE RECOMBINANT AND ITS UTILIZATION 失效
公开(公告)号：JPH11346786A
公开(公告)日：1999-12-21
申请号：JP9832999
申请日：1999-04-06
申请人： NIPPON ZEON CO , US AGRICULTURE
发明人： LILLEHOJ HYUN S , CHOI KANG , TSUZAKI YOSHINARI , KAMOGAWA KOICHI
IPC分类号： C12N15/09 , A61K31/00 , A61K35/12 , A61K35/74 , A61K35/76 , A61K36/06 , A61K38/00 , A61K39/00 , A61K39/39 , A61P31/00 , C07K14/54 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , A61K35/70 , A61K35/72
摘要： PROBLEM TO BE SOLVED: To obtain a new cytokine having a specific amino acid sequence, comprising an isolated interleukin 15-polypeptide derived from birds and useful as a preventive medicine, a therapeutic medicine or an adjuvant, etc. for birds infectious diseases having high immunecompetence. SOLUTION: This new cytokine comprises an isolated new interleukin 15-polypeptide derived from birds containing >=70% polypeptide comprising an amino acid sequence described in the formula, a part of amino acid sequence expressing T cell receptor comprising γ,δ-subunit and having proliferation stimulation activity of T lymphocyte derived from birds or an amino acid sequence in which proliferation stimulation activity of T cell receptor derived from birds expressing T cell receptor comprising γ,δ-subunit is >=70% of a polypeptide comprising the amino acid sequence described in the formula and at least >=85% amino acids have substitution, variation, loss or insertion of one or more amino acids of amino acid sequence described in the formula and is useful as a preventive medicine or a therapeutic medicine or an adjuvant, etc., for birds infectious diseases.

7. 发明专利

JPH03148066A MEMBRANE FOR DIAGNOSING VIRUS INFECTIOUS DISEASE AND DIAGNOSTIC METHOD 失效
公开(公告)号：JPH03148066A
公开(公告)日：1991-06-24
申请号：JP28855889
申请日：1989-11-06
申请人： NIPPON ZEON CO
发明人： SATO TAKANORI , TAKAMURA CHIZUKO , KAMOGAWA KOICHI
IPC分类号： G01N33/569 , A61B10/00
摘要： PURPOSE:To make it possible to diagnose the difference between the infections of affinous viruses efficiently and accurately by attaching two or more kinds of specific antigens which have affinous relation on one membrane carrier, and bringing the antigens into contact with the serum of a body under test. CONSTITUTION:With respect to virus which is the object of diagnosis, there is the cross reaction of antibodies between the virus and the antigen of an affinous virus. Serum to be inspected becomes positive by the reaction with a plurality of the virus antigens. When the deterministic judgment is difficult, there is no special restriction. In practical application, epidemic viruses in the same region are combined in response to purposes. The antigen wherein the peculiarity of the virus is maintained is formed. Then, the respective specific antigens are dropped on one membrane carrier without mixing and without loosing pecurialities. The antigens are sucked, and solvent is removed. Then the antigens are attached. The serum is diluted so that the reactivity with the antibody in the serum to be inspected becomes equal. The membrane is immersed into the serum to be inspected which is diluted at a constant temperature, and the virus antigens and the serum are brought into contact. Thus the infected viruses are diagnosed based on the amount of bondings between the antigens and the antibodies in the serum.

8. 发明专利

JPH01269497A PRODUCTION OF L-SERINE AND CRUDE ENZYME TO BE USED THEREFOR 失效
公开(公告)号：JPH01269497A
公开(公告)日：1989-10-26
申请号：JP9965688
申请日：1988-04-22
申请人： NIPPON ZEON CO
发明人： NAGAYA ATSUSHI , MIYAMOTO SHIGEMI , KAMOGAWA KOICHI
IPC分类号： C12P13/06 , C12N9/10 , C12R1/19
摘要： PURPOSE:To efficiently obtain L-serine by reaction between Gly and formaldehyde using crude enzyme prepared by putting a culture solution of serine hydroxymethyl transferase-producing bacteria to a specific treatment. CONSTITUTION:Firstly, bacteria having serine hydroxymethyl transferase- producing potential is put to culture. Second, a culture solution of said bacteria, mycelia or mycelia-treated product is heat-treated in the presence of glycine to obtain a crude enzyme. Thence, an enzymatic reaction is carried out between the glycine and formaldehyde using said crude enzyme as an enzymatic source. Said bacteria is pref. Escherichia coli produced by introducing the GlyA gene governing service hydroxymethyl transferase into mycelia using a recombinant technique.

9. 发明专利

JPH0122809B2 失效
公开(公告)号：JPH0122809B2
公开(公告)日：1989-04-27
申请号：JP12221781
申请日：1981-08-04
申请人： NIPPON ZEON CO
发明人： MITSUTA YASUHIRO , MIHIRA TAKAYUKI , KAMOGAWA KOICHI
IPC分类号： B01F17/00 , B01J13/00

10. 发明专利

JPH09271383A RECOMBINED VIRUS, ITS PRODUCTION AND ITS UTILIZATION 失效
公开(公告)号：JPH09271383A
公开(公告)日：1997-10-21
申请号：JP10617996
申请日：1996-04-03
申请人： NIPPON ZEON CO
发明人： OKUDA HISASHI , FUJISAWA AYUMI , KAMOGAWA KOICHI
IPC分类号： C12N15/09 , A61K39/12 , A61K39/17 , A61K39/255 , A61P31/12 , C12N7/00 , C12N7/04
摘要： PROBLEM TO BE SOLVED: To obtain a new virus useful for low toxic vaccines, etc., by inserting a different kind of foreign gene into a region which is formed from genome DNAs originated from at least plural viruses different in strains and which is not essential to the proliferation of the chimera virus. SOLUTION: This chimera-recombined virus is obtained by inserting a different kind of foreign gene into a region which is formed from at least genome DNAs originated from two or more kinds of viruses different in strains and which is not essential to the proliferation of the chimera virus. The new chimera-recombined virus is high in a virus infection-protecting effect, low in toxicity, and useful for mammalian vaccines, avian vaccines, etc. In the chimera-recombined virus, the NP strain of fowlpox virus, etc., is used as a parent virus, and a gene originated from a virus such as Newcastle disease virus, Marek's disease virus, infectious bursal disease virus and infectious laryngotracheobronchitis virus is used as the different kind of foreign antigen gene. The chimera-recombined virus is obtained by infecting a host cell with both the parent virus and a virus recombined with the gene.

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