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    • 1. 发明专利
    • Purification of mononucleic acid and its relating substance
    • 单一酸的纯化及其相关物质
    • JPS59152397A
    • 1984-08-31
    • JP2606183
    • 1983-02-18
    • Mitsubishi Chem Ind Ltd
    • YOKOTA KENJIKUSANO HIROSHIMIYATA EIJISUGAWARA TOYOKAZU
    • C12P19/34B01J41/04C07H1/08C07H19/10C07H19/20C12P19/32C12P19/36
    • PURPOSE: To separate and purify a nucleic acid-relating substance useful as pharmaceuticals and seasonings, in high efficiency, by the column chromatography using a specific weakly basic anion exchange resin having amide bond as a packing agent.
      CONSTITUTION: Crude mononucleic acid or its relating substance (excluding riboflavin-5'-monophosphate) is purified to obtain the objective substance by the chromatography using a column packed with a weakly basic anion exchange resin having a crosslinked poly(meth)acrylic acid ester skeleton, wherein at least a part of the ester bond is converted to the amide bond of formula I [R
      1 is group of formula II (n is 2W6); R
      3 and R
      4 are H or 1W6C alkyl) or group of formula III (m is 2W4)].
      COPYRIGHT: (C)1984,JPO&Japio
    • 目的:通过使用具有酰胺键的特定弱碱性阴离子交换树脂作为包装剂的柱色谱法,高效分离和纯化用作药物和调味料的核酸相关物质。 构成:使用填充有具有交联的聚(甲基)丙烯酸酯骨架的弱碱性阴离子交换树脂的柱,通过色谱法纯化粗单核酸或其相关物质(不包括核黄素-5'-一磷酸)得到目标物质 ,其中酯键的至少一部分转化为式I的酰胺键[R 1为式II基团(n为2-6); R3和R4是H或1-6C烷基)或式III的基团(m是2-4)]。