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1. 发明专利

JPS63304990A EXTRACTION OF ACTIVE INGREDIENT IN CELL 失效
公开(公告)号：JPS63304990A
公开(公告)日：1988-12-13
申请号：JP14046187
申请日：1987-06-04
申请人： MEIJI SEIKA KAISHA , AGENCY IND SCIENCE TECHN
发明人： TAKEBE HIDEAKI , MATSUNOBU TOSHIO , SATO ATSUYUKI , HIRUTA OSAMU , UOTANI KAZUMICHI , NAKAGAWA KOJI , WATANABE TADAO , FUKATSU SHUNZO
IPC分类号： C12P1/00 , C12N9/42 , C12P1/02 , C12P7/64 , C12R1/07 , C12R1/645
摘要： PURPOSE:To efficiently extract an active ingredient in cells from a mold containing chitosan in a cell wall, by using chitosanase, a cell wall dissolving enzyme. CONSTITUTION:A mold belonging to the order Mucorales or Moriliales is cultivated in an agar medium to form a spore, which is transplanted to a liquid medium and the mold is multiplied to accumulate an active ingredient in the cell. The prepared cell is directly dispersed in an aqueous solution or a buffer solution or washed and dispersed, mixed with a cell wall dissolving enzyme containing chitosanase derived from Bacillus pumilus BN-262 (FERM P-8814) and slowly shaken at 30-40 deg.C for 6-8hr to extract the active ingredient. beta-1,3- Glucanase, cellulase or chitinase may be used as the cell wall dissolving enzyme except chitosanase.

2. 发明专利

JPS63287480A PRODUCTION OF MOLD PROTOPLAST 失效
公开(公告)号：JPS63287480A
公开(公告)日：1988-11-24
申请号：JP12005887
申请日：1987-05-19
申请人： MEIJI SEIKA KAISHA
发明人： TAKEBE HIDEAKI , MATSUNOBU TOSHIO , SATO ATSUYUKI , HIRUTA OSAMU , UOTANI KAZUMICHI , NAKAGAWA KOJI , WATANABE TADAO , FUKATSU SHUNZO
IPC分类号： C12N15/02 , C12N1/14 , C12N15/00
摘要： PURPOSE:To efficiently form a mold having chitosan in a cell wall into a protoplast, by using a cell wall lytic enzyme chitosanase. CONSTITUTION:A mold belonging to the genus Rhizopus, Mucor, Mortierella, etc., or the genus Trichoderma, etc., of the order Moriliales is cultivated in a culture medium to form spores, which are then transplanted into a liquid culture medium to collect just germinated young spores. Mycelia are washed and subsequently suspended in a buffer solution and previously prepared cell wall lytic enzyme containing chitosanase produced by Bacillus pumilus (FERM P-8814) is added in an optional order and gently shaken at 15-30 deg.C, preferably 20-25 deg.C for 1-8hr, preferably 3-7hr to form a protoplast. beta-1,3-Glucanase, cellulase, chitinase, etc., are used alone or in combination of two or more thereof as the cell wall lytic enzyme other than the chitosanase.

3. 发明专利

JPS62135407A TRICHOGENOUS AGENT 失效
公开(公告)号：JPS62135407A
公开(公告)日：1987-06-18
申请号：JP27609985
申请日：1985-12-10
申请人： MEIJI SEIKA KAISHA
发明人： YANAIHARA NOBORU , WATANABE TADAO , KASAI MICHIYUKI , SATO TOYOMI , KITSUKOUJI TOSHIYASU
IPC分类号： A61K8/00 , A61K8/44 , A61K8/64 , A61Q5/00 , A61Q7/00
摘要： PURPOSE:A trichogenous agent, containing a basic peptide in which amino acids, e.g. histidine, serine, aspartic acid, alanine, valine, phenylalanine, etc., are oriented in a straight line as an active ingredient, having blood stream increasing action and capable of exhibiting improved effect. CONSTITUTION:A trichogenous agent containing a basic peptide, expressed by the formula and having 28 amino acids oriented in a straight line and 3326 molecular weight as an active ingredient. When the above-mentioned peptide is applied to the skin, improved effect on hair production or growth can be exhibited by local blood stream increasing action. The preferred form of the trichogenous agent includes a semisolid material containing an ointment base, e.g. white oil, absorption base, e.g. hydrophilic vaseline, W/O type milky lotion base, O/W type milky lotion base, water-soluble base, e.g. polyethylene glycol ointment, etc., as a base material. A peripheral vasodilator, keratolytic agent, humectant, germicide, etc., may be added.

4. 发明专利

JPS6248399A REAGENT FOR MEASURING ENZYMATIC ACTIVITY 失效
公开(公告)号：JPS6248399A
公开(公告)日：1987-03-03
申请号：JP18861385
申请日：1985-08-29
申请人： MEIJI SEIKA KAISHA , SANKO JUNYAKU KK
发明人： HARAKAWA KIYOMI , YOSHIDA KENJI , WATANABE TADAO , KANEJIMA TOSHIHITO , YAMAMOTO YOSHIMI , YANO TADAO
IPC分类号： C12Q1/34 , G01N33/50
摘要： PURPOSE:The titled reagent for raising solubility (dissolution rate and dissolution concentration) of a substrate and measuring sensitivity, comprising an inclusion compound and a solvent except water. CONSTITUTION:A reagent for measuring activity of N-acetyl-beta-D- glucosaminidase[E.C.3.2.1.30] using 2-chloro-4-nitrophenyl-N-acetyl-beta-D- glucosaminide as a substrate is obtained by dissolving one or more inclusion compounds selected from 13-crown-6,15-crown-5,12-crown-4, (dimethyl-)alpha- cyclodextrin, (dimethyl-)beta-cyclodextrin, (dimethyl-)gamma-cyclodextrin and L-poly-beta- cyclodextrin in one or more solvents selected from aliphatic alcohols (e.g., methanol, etc.,) and glycols (e.g., ethylene glycol) except water.

5. 发明专利

JPS617209A Hair tonic composition 失效
标题翻译：发胶组合物
公开(公告)号：JPS617209A
公开(公告)日：1986-01-13
申请号：JP12529284
申请日：1984-06-20
申请人： Meiji Seika Kaisha Ltd
发明人： MATSUO YUTAKA , YANAIHARA NOBORU , WATANABE TADAO , SATOU TOYOMI , KITSUKOUJI TOSHIYASU , KADOSAWA HIROYUKI , HIRANO FUMIYA
IPC分类号： A61K8/00 , A61K8/34 , A61K8/37 , A61K8/64 , A61Q5/00 , A61Q7/00 , C07K7/22
CPC分类号： A61K8/64 , A61Q5/00 , A61Q7/00 , C07K7/22
摘要： PURPOSE: A hair tonic composition that is formed by combining substance P and substance P-like piptides as a hair tonic ingredient with a higher fatty alcohol as a percutaneous absorption control assistant, a carboxyvinyl polymer and a base, thus showing improved hair tonic effect.
CONSTITUTION: At least one selected from substance P of formula I, substance P-like peptide of formula II (X is residue of pyroglutamic acid, piptide containing 1W5 aminoacids, nucleoside) and their acid adducts, as hair tonic ingredients, is combined with at least one selected from higher fatty alcohols and carboxyvinyl polymers polymers as a percutaneous absorption controller and a known base material for hair tonics. The addition of the assistant enable the hair tonic component to be fed duratively to skins at an adjusted rate. Further, the addition of lower alkanol or glycol as an accelerator of percutaneous permeation remarkably improves hair tonic effect.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：目的：通过将物质P和物质P样刺鼻肽作为头发补品成分与高级脂肪醇作为经皮吸收控制助剂，羧基乙烯基聚合物和碱组合而形成的发丝组合物，从而显示出改善的滋养效果。构成：选自式I物质P中的至少一种，式II物质P样肽（X为焦谷氨酸的残基，含有1-5个氨基酸的角叉菜苷，核苷）及其酸加成物作为滋补成分组合选自高级脂肪醇和羧基乙烯基聚合物聚合物中的至少一种作为经皮吸收控制剂和用于发质的已知基材。助剂的添加使得滋补组分能够以调整的速率持续地喂入皮肤。此外，作为经皮渗透促进剂的低级链烷醇或二醇的添加，显着提高了滋养滋养效果。

6. 发明专利

JPS58201710A Anti-inflammatory paste preparation for oral cavity 失效
标题翻译：用于口腔的抗炎药物制剂
公开(公告)号：JPS58201710A
公开(公告)日：1983-11-24
申请号：JP8457382
申请日：1982-05-18
申请人： Meiji Seika Kaisha Ltd
发明人： KITSUKOUJI TOSHIYASU , IKEDA TADAMASA , ITOU MASAYUKI , KAJII KENZOU , OKADA AKIO , KOBAYASHI TOSHIYUKI , WATANABE TADAO
IPC分类号： A61K9/06 , A61K31/19 , A61P1/02 , A61P29/00
摘要： PURPOSE: An amfenac preparation that contains at least one selected from magnesium oxide, basic magnesium carbonate and calcium carbonate in such an amount as the compound causes no effect on the amfenac salt, thus causing no discoloration and decomposition with time.
CONSTITUTION: A salt such as sodium, potassium or alkaline earth metal salt of amfenac, its chemical name is 2-amino-3-benzoylbenzeneacetate, is combined with at least one selected from magnesium oxide, basic magnesium carbonate or calcium carbonate in such an amount as the salt causes no effect on the amfenac, e.g., about 0.1W1 time the amount of the amfenac to give the objective paste. The addition of magnesium oxide or the like causes no color change of the amfenac from yellow to orangish red and decomposition into 7-benzoyl-2- oxyindole to give a stabilized preparation.
COPYRIGHT: (C)1983,JPO&Japio
摘要翻译：目的：含有选自化合物中的至少一种选自氧化镁，碱式碳酸镁和碳酸钙的氨苯酸盐制剂对所述氨芬酸盐没有影响，因此不会随时间而变色和分解。构成：盐酸盐，其化学名称为2-氨基-3-苯甲酰苯乙酸钠的钠，钾或碱土金属盐，与选自氧化镁，碱式碳酸镁或碳酸钙中的至少一种盐相混合，因为盐对阿芬卡酸没有影响，例如，给予目的糊剂的阿芬酸酸的量的大约0.1-1倍。加入氧化镁等不会导致氨芬酸从黄色变成橙色红色并分解成7-苯甲酰基-2-氧吲哚，得到稳定的制剂。

7. 发明专利

JPS63251086A PRODUCTION OF IMMOBILIZED FUNGUS 失效
公开(公告)号：JPS63251086A
公开(公告)日：1988-10-18
申请号：JP8753387
申请日：1987-04-08
申请人： MEIJI SEIKA KAISHA
发明人： TAKEBE HIDEAKI , NAMIKI ATSUSHI , SATO ATSUYUKI , WATANABE TADAO , FUKATSU SHUNZO , ENDO TAKESHI
IPC分类号： C12N11/08
摘要： PURPOSE:To immobilize fungi under a mild environmental condition sterilely and stably, by swelling a hydrophilic crosslinked polymer in a medium, adsorbing and immobilizing bacteria to the polymer and repeating multiplication of fungi. CONSTITUTION:In a process where a water-insoluble water-swelling resin having water absorbing ability, so-called water-absorbing resin, is treated in a medium for fungi and fungi are repeatedly multiplied, the fungi are adsorbed and immobilized to the water-absorbing resin. A resin having about 10-1,500 times as much water absorbing ratio as dry weight is preferable as the water-absorbing resin and a resin having about 20-1,000 times as much water absorbing ratio is more preferable. The amount of the water-absorbing resin used is preferably about 0.05-10wt.% based on the weight of the medium when the immobilized fungi are produced in a liquid and preferably about 0.05-100wt.% when the immobilized fungi are produced in a solid phase. Fungi belonging to the genus Penicillium or Cephalosporium may be cited as the fungi to be used.

8. 发明专利

JPS58201726A Preparation of stable pharmaceutical 失效
标题翻译：制备稳定的药物
公开(公告)号：JPS58201726A
公开(公告)日：1983-11-24
申请号：JP8457482
申请日：1982-05-18
申请人： Meiji Seika Kaisha Ltd
发明人： KAJII KENZOU , OKADA AKIO , KITSUKOUJI TOSHIYASU , IKEDA TADAMASA , ITOU MASAYUKI , KOBAYASHI TOSHIYUKI , WATANABE TADAO
IPC分类号： A61K31/19 , A61K31/195 , A61K47/00 , A61K47/02 , A61P29/00
摘要： PURPOSE: To obtain the titled amfenac pharmaceutical, useful as a nonsteroid anti-inflammatory and analgesic agent, and stable with time, by adding a small amount of a specific additive capable of exhibiting the efficacy to the amfenac and amfenac calcium.
CONSTITUTION: At least one selected from magnesium oxide, basic magnesium carbonate and calcium carbonate in an amount of 0.1W1 of amfenac and amfenac calcium is added to the amfenac and amfenac calcium to give the aimed substance. This invention provides the aimed pharmaceutical without change in appearance due to the formation of a decomposition product, e.g. color change of a capsule from the yellow contents unique to the amfenac sodium to a light red, the yellow surface of a tablet to red, and the yellow powder of the power to light red, and discoloration on storage under room temperature conditions for one year.
COPYRIGHT: (C)1983,JPO&Japio
摘要翻译：目的：为了获得一种有用的非甾体抗炎镇痛药，并且随时间稳定，通过加入少量能够显示出对amfenac和amfenac钙的功效的特定添加剂。构成：将至少一种选自氧氟化物，碱式碳酸镁和碳酸钙的量为0.1-1的安非那定和氨苯达克钙加入到阿芬酸和氨苯达克钙中以得到目标物质。本发明提供了由于形成分解产物而导致的外观改变的目标药物，例如，胶囊的颜色变化由琥珀酸钠特有的黄色内容变为淡红色，片剂的黄色表面为红色，黄色粉末的电源为浅红色，并在室温条件下储存变色一年。

9. 发明专利

JPS6368528A PERCUTANEOUS ABSORPTION PREPARATION 失效
公开(公告)号：JPS6368528A
公开(公告)日：1988-03-28
申请号：JP21144586
申请日：1986-09-10
申请人： MEIJI SEIKA KAISHA
发明人： SATO TOYOMI , ODAGIRI TAKAHIRO , KOBAYASHI TOSHIYUKI , WATANABE TADAO
IPC分类号： A61K9/00 , A61K9/70 , A61K47/00 , A61K47/14 , A61K47/26 , A61K47/30
摘要： PURPOSE:The titled preparation useful as a sustained release preparation, raising drug releasability, containing a drug compound having percutaneous absorption, blended with a fatty acid ester, etc., as an active ingredient and a silicone elastomer as a maintaining carrier for the active ingredient. CONSTITUTION:A percutaneous absorption preparation containing a drug compound having percutaneous absorption so an active ingredient and a silicone elastomer as a maintaining carrier for the active ingredient. The drug compound is blended with a fatty acid ester or a sugaralcohol or both to raise drug releasability. Penicillin, aspirin, diazepam, vitamin, etc., maybe cited as the drug compound. Propylene glycol caprate, etc., may be used as the fatty acid ester. Since the preparation has high drug releasability and a necessary and sufficient amount of the drug is absorbed through the skin, application is easy and side effects can be suppressed.

10. 发明专利

JPS6368521A ORAL SUSTAINED RELEASE PHARMACEUTICAL FORMULATION BY RESINATE 失效
公开(公告)号：JPS6368521A
公开(公告)日：1988-03-28
申请号：JP21144686
申请日：1986-09-10
申请人： MEIJI SEIKA KAISHA
发明人： SATO TOYOMI , ODAGIRI TAKAHIRO , ITO MASAYUKI , KOBAYASHI TOSHIYUKI , WATANABE TADAO
IPC分类号： A61K9/56 , A61K47/00 , A61K47/32
摘要： PURPOSE:A pharmaceutical formulation, obtained by coating particles of an ion exchange resin containing a pharmaceutical compound-resin complex with a water permeable diffusion barrier membrane and capable of continuously and sustainedly releasing the pharmaceutical compound for a given long period. CONSTITUTION:A pharmaceutical formulation obtained by adsorbing and ionizable pharmaceutical compound, e.g. amfenac, miokamycin or phosphomycin, on particles of an ion exchange resin (reaction by ionic bonding also occurs) to give ion exchange resin particles containing a pharmaceutical compound-resin complex, thoroughly washing the resultant particles with deionized water, drying the washed particles in a fluidized bed dryer, forming acrylate-methacrylate copolymer films in a fluidized bed coating device to provide an oral sustained release formulation. The above-mentioned formulation is preferably produced from a composition within the range containing 5-10pts.wt. pharmaceutical compound, 40-95pts.wt. ion exchange resin and 2-20pts.wt. diffusion barrier coating material.

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