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1. 发明专利

JP2011010653A Method for induction of cell differentiation 审中-公开
标题翻译：诱导细胞分化的方法
公开(公告)号：JP2011010653A
公开(公告)日：2011-01-20
申请号：JP2010112992
申请日：2010-05-17
申请人： Kumamoto Univ , Katsumi Mochidate , 国立大学法人熊本大学 , 克身持立
发明人： KUME SHOEN , SHIRAKI NOBUAKI , HIGUCHI YUICHIRO , UMEDA KAOKO , KUME KAZUHIKO , YAMANE KEITARO , MOCHIDATE KATSUMI
IPC分类号： C12N5/0735 , C12N5/071 , C12Q1/02
CPC分类号： C12N5/067 , C12N5/0676 , C12N2506/02 , C12N2506/45 , C12N2533/90 , G01N33/5073
摘要： PROBLEM TO BE SOLVED: To provide a new method for inducing differentiation of an ES cell or an iPS cell, which can induce the differentiation of an ES cell or an iPS cell into an endoderm system without requiring the use of any supporting cell.SOLUTION: There is disclosed the method for inducing the differentiation of an ES cell or an iPS cell into a pancreatic or hepatic cell, which comprises culturing a mammal-derived ES cell or iPS cell on a biosynthetic basal membrane culture substrate in the presence of a growth factor.
摘要翻译：要解决的问题：提供用于诱导ES细胞或iPS细胞分化的新方法，其可以诱导ES细胞或iPS细胞分化成内胚层系统而不需要使用任何支持细胞。解决方案：公开了将ES细胞或iPS细胞分化为胰腺或肝细胞的方法，其包括在生长因子存在下在生物合成基底膜培养基底上培养哺乳动物来源的ES细胞或iPS细胞。

2. 发明专利

JP2012016292A Method for producing endodermal cell 审中-公开
标题翻译：生产内膜细胞的方法
公开(公告)号：JP2012016292A
公开(公告)日：2012-01-26
申请号：JP2010153907
申请日：2010-07-06
申请人： Kumamoto Univ , Tsuchiya Rubber Co Ltd , つちやゴム株式会社 , 国立大学法人熊本大学
发明人： KAI HIROFUMI , KUME SHOEN , SHIRAKI NOBUAKI , KOGA TOMIAKI , YANO SHUICHIRO , KURATA YUHEI
IPC分类号： C12N5/071 , C12N5/0735 , C12N5/10
摘要： PROBLEM TO BE SOLVED: To provide a more efficient method for producing a pancreatic precursor cell.SOLUTION: There are provided a method for producing an endodermal cell including a step of applying a micro-pulse current and heat to an undifferentiated endodermal cell induced from an embryonic stem cell or an induced pluripotent stem cell; the method for producing the pancreatic precursor stem cell including a step of applying the micro-pulse current and heat in the presence of activin and a basic fibroblastic growth factor (bFGF); and the method in which the pancreatic precursor cell is a Pdx1-expressing cell.
摘要翻译：要解决的问题：提供一种更有效的胰腺前体细胞的制备方法。提供了一种生产内胚层细胞的方法，其包括对从胚胎干细胞或诱导多能干细胞诱导的未分化内胚层细胞施加微脉冲电流和加热的步骤; 包括在活化素和碱性成纤维细胞生长因子（bFGF）的存在下施加微脉冲电流和加热的步骤的胰前体干细胞的制备方法。以及胰腺前体细胞为Pdx1表达细胞的方法。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2008241703A Detecting method of pancreas stem cell, lung villus cell, liver stem cell or pancreatic cancer 有权
标题翻译：胰腺癌细胞，肺癌细胞，肝细胞癌或胰腺癌的检测方法
公开(公告)号：JP2008241703A
公开(公告)日：2008-10-09
申请号：JP2008045507
申请日：2008-02-27
申请人： Kumamoto Univ , 国立大学法人熊本大学
发明人： KUME SHOEN , YOSHIDA SATORU , SHIRAKI NOBUAKI , KUME KAZUHIKO , MATSUO AKIRA
IPC分类号： G01N33/574 , C12N5/07 , C12N5/095 , C12Q1/02
摘要： PROBLEM TO BE SOLVED: To provide a method for identifying a marker molecule of a pancreas stem cell, and detecting the pancreas stem cell by utilizing it, and a method for isolating the pancreas stem cell.
SOLUTION: This method for detecting the pancreas stem cell, a lung villus cell, a liver stem cell or pancreatic cancer includes detection of manifestation of an epiplakin 1 (EPPK1) gene.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种用于鉴定胰腺干细胞的标志物分子的方法，以及通过利用胰腺干细胞的检测方法，以及分离胰腺干细胞的方法。
解决方案：这种检测胰腺干细胞，肺绒毛细胞，肝干细胞或胰腺癌的方法包括检测表皮蛋白1（EPPK1）基因的表现。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2011115161A Method for inducing differentiation of cell 审中-公开
标题翻译：诱导细胞分化的方法
公开(公告)号：JP2011115161A
公开(公告)日：2011-06-16
申请号：JP2010248665
申请日：2010-11-05
申请人： Kumamoto Univ , 国立大学法人熊本大学
发明人： KUME SHOEN , SHIRAKI NOBUAKI , KUME KAZUHIKO
IPC分类号： C12N5/0735 , C12N5/071 , C12N5/10 , C12N15/09 , C12Q1/02
摘要： PROBLEM TO BE SOLVED: To provide a new method for inducing differentiation of an ES (embryonic stem) cell or an iPS (induced pluripotent stem) cell by which the differentiation of the ES cell or iPS cell into an endoderm system, a mesoderm system and an ectoderm system can be induced without using a supporting cell. SOLUTION: The method for inducing the differentiation from the ES cell or iPS cell into the endoderm system, mesoderm system or ectoderm system includes culturing the ES cell or iPS cell derived from a mammal on a matrix composed of nano-size fibers or particles or a positively charged matrix. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：为了提供一种诱导ES（胚胎干）细胞或iPS（诱导多能干细胞）分化的新方法，通过该细胞将ES细胞或iPS细胞分化成内胚层系统，可以在不使用支持细胞的情况下诱导中胚层系统和外胚层系统。诱导从ES细胞或iPS细胞分化为内胚层系统，中胚层系统或外胚层系统的方法包括在由纳米尺寸纤维构成的基质上培养源自哺乳动物的ES细胞或iPS细胞，或颗粒或带正电的基质。版权所有（C）2011，JPO＆INPIT

5. 发明专利

JP2011072231A Method for detecting endoderm cell, intestinal tract cell or pancreatic cell 有权
标题翻译：检测内源细胞，细胞因子细胞或胰腺细胞的方法
公开(公告)号：JP2011072231A
公开(公告)日：2011-04-14
申请号：JP2009225758
申请日：2009-09-30
申请人： Kumamoto Univ , 国立大学法人熊本大学
发明人： KUME SHOEN , HARADA KIYOKO , SHIRAKI NOBUAKI , KUME KAZUHIKO
IPC分类号： C12Q1/68 , C12N5/10 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide a method for detecting endoderm cells, intestinal tract cells or pancreatic cells by identifying the marker molecules of the endoderm cells, intestinal tract cells or pancreatic cells and utilizing them, and also a method for separating the endoderm cells, intestinal tract cells and pancreatic cells. SOLUTION: This method for detecting and separating the endoderm cells, intestinal tract cells or pancreatic cells is provided by including the detection of expression of at least one of a gene selected from among a decay-accelerating factor [DAF, CD55] gene, Tmem184a gene, Akr1c19 gene, 3300001A09Rik gene, Aebp2 gene, AI464131 gene, Foxp4 gene, Hipk2 gene, Lass4 gene, Pbxip1 gene, Pcbd1 gene and Pcdh1 gene. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供通过鉴定内胚层细胞，肠道细胞或胰腺细胞的标记分子并利用它们来检测内胚层细胞，肠道细胞或胰腺细胞的方法，以及分离内胚层细胞，肠道细胞和胰腺细胞。检测和分离内胚层细胞，肠道细胞或胰腺细胞的方法是通过包括检测选自加速衰老因子[DAF，CD55]基因中的至少一种的基因的表达来提供的，Tmem184a基因，Akr1c19基因，3300001A09Rik基因，Aebp2基因，AI464131基因，Foxp4基因，Hipk2基因，Lass4基因，Pbxip1基因，Pcbd1基因和Pcdh1基因。版权所有（C）2011，JPO＆INPIT

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