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1. 发明专利

JP2011010653A Method for induction of cell differentiation 审中-公开
标题翻译：诱导细胞分化的方法
公开(公告)号：JP2011010653A
公开(公告)日：2011-01-20
申请号：JP2010112992
申请日：2010-05-17
申请人： Kumamoto Univ , Katsumi Mochidate , 国立大学法人熊本大学 , 克身持立
发明人： KUME SHOEN , SHIRAKI NOBUAKI , HIGUCHI YUICHIRO , UMEDA KAOKO , KUME KAZUHIKO , YAMANE KEITARO , MOCHIDATE KATSUMI
IPC分类号： C12N5/0735 , C12N5/071 , C12Q1/02
CPC分类号： C12N5/067 , C12N5/0676 , C12N2506/02 , C12N2506/45 , C12N2533/90 , G01N33/5073
摘要： PROBLEM TO BE SOLVED: To provide a new method for inducing differentiation of an ES cell or an iPS cell, which can induce the differentiation of an ES cell or an iPS cell into an endoderm system without requiring the use of any supporting cell.SOLUTION: There is disclosed the method for inducing the differentiation of an ES cell or an iPS cell into a pancreatic or hepatic cell, which comprises culturing a mammal-derived ES cell or iPS cell on a biosynthetic basal membrane culture substrate in the presence of a growth factor.
摘要翻译：要解决的问题：提供用于诱导ES细胞或iPS细胞分化的新方法，其可以诱导ES细胞或iPS细胞分化成内胚层系统而不需要使用任何支持细胞。解决方案：公开了将ES细胞或iPS细胞分化为胰腺或肝细胞的方法，其包括在生长因子存在下在生物合成基底膜培养基底上培养哺乳动物来源的ES细胞或iPS细胞。

2. 发明专利

JP2006087396A Cell culture substrate and method for producing the same 审中-公开
标题翻译：细胞培养基底及其制造方法
公开(公告)号：JP2006087396A
公开(公告)日：2006-04-06
申请号：JP2004279893
申请日：2004-09-27
申请人： Katsumi Mochidate , National Institute For Environmental Studies , Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社 , 克身持立 , 独立行政法人国立環境研究所
发明人： MOCHIDATE KATSUMI , KAWAMURA KENJI , TAKADA WATARU
IPC分类号： C12N5/10 , A61L27/00 , C07K14/475 , C07K14/78 , C12N5/07 , C12N5/071
摘要： PROBLEM TO BE SOLVED: To provide a new cell culture substrate able to solidify two or more peptides on the surface of the substrate in an amount of arbitrarily controlled introduction and controlling adhesion, growth, proliferation, and the like, of cells by combining a plurality of kinds of peptides and provide a method for producing the same. SOLUTION: The method for producing the cell culture substrate has a process for coating a peptide-introduced polymer, in which single kind of peptide is introduced into a hydrophobically bonded adsorbing polymer, onto the surface of the substrate for culturing two or more kinds of cells. Preferably, the hydrophobically bonded adsorbing polymer has, in the molecule, a hydrophobic straight chain carbon skeleton and functional groups able to react with peptides in the molecule. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种新的细胞培养基质，其能够以任意控制的量引导和控制细胞的粘附，生长，增殖等，使基底表面上的两种或更多种肽固化组合多种肽并提供其制备方法。解决方案：细胞培养基质的制造方法具有将单体肽引入到疏水键合的吸附性聚合物中的肽导入性聚合物的涂布于基材的表面上进行培养2次以上的方法细胞种类优选地，疏水键合的吸附聚合物在分子中具有疏水性直链碳骨架和能够与分子中的肽反应的官能团。版权所有（C）2006，JPO＆NCIPI

3. 发明专利

JP2007003408A Cell biosensor 审中-公开
标题翻译：细胞生物传感器
公开(公告)号：JP2007003408A
公开(公告)日：2007-01-11
申请号：JP2005185135
申请日：2005-06-24
申请人： Kyushu Institute Of Technology , Katsumi Mochidate , National Institute For Environmental Studies , 国立大学法人九州工業大学 , 克身持立 , 独立行政法人国立環境研究所
发明人： HARUYAMA TETSUYA , MOCHIDATE KATSUMI , ASAKAWA MASA
IPC分类号： G01N27/416 , C12M1/34 , C12M1/40
摘要： PROBLEM TO BE SOLVED: To provide a cell biosensor imparted with performance and a function bonded while a cell keeps normal cell activity, on a sensor surface, so as to detect efficiently a produced molecule in the cell produced by chemical stimulation. SOLUTION: This cell biosensor of the present invention is constituted of a sensor matrix imparted with a cell bonding activity, and a detection device. A complex of a cell bonding molecule, for example, a cell bonding peptide and a polymer containing a polypeptide chain, and a sensor matrix, for example, a polyion complex, is mentioned as the sensor matrix imparted with a cell bonding activity. The biosensor of the present invention is used, for example, as a cell biosensor for measuring an NO molecule. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供在细胞保持正常细胞活性的同时赋予性能和功能的细胞生物传感器在传感器表面上，以便有效地检测由化学刺激产生的细胞中产生的分子。解决方案：本发明的细胞生物传感器由赋予细胞粘合活性的传感器矩阵和检测装置构成。提及细胞结合分子的复合物，例如细胞结合肽和含有多肽链的聚合物，以及传感器基质，例如聚离子络合物，作为赋予细胞结合活性的传感器基质。本发明的生物传感器例如用作测定NO分子的细胞生物传感器。版权所有（C）2007，JPO＆INPIT

4. 发明专利

JP2009002677A Surface acoustic wave device biosensor 审中-公开
标题翻译：表面声波设备生物传感器
公开(公告)号：JP2009002677A
公开(公告)日：2009-01-08
申请号：JP2007161312
申请日：2007-06-19
申请人： Hirosaki Univ , Katsumi Mochidate , River Eletec Kk , リバーエレテック株式会社 , 国立大学法人弘前大学 , 克身持立
发明人： MOCHIDATE KATSUMI , FURUYA YASUBUMI , HOSOKAWA NAOHIRO , HAYASHI YOSHIYUKI , SAEGUSA YASUTAKA , KON HIROTAKE
IPC分类号： G01N29/00
摘要： PROBLEM TO BE SOLVED: To provide a surface acoustic wave device biosensor capable of detecting a process of propagation-growth-injury repairing of a cell, which is observed conventionally only by an optical microscope, by measuring it as a surface acoustic wave (SAW) propagation characteristic due to physical and chemical changes of the cell formed on an SAW propagation route, using an SAW generated on a piezoelectric substrate.
SOLUTION: A high-frequency current or voltage is applied/impressed to an IDT 23 joined to the piezoelectric substrate 22, the SAW 25 is generated in the vicinity of a surface of the piezoelectric substrate 22, and the physical and chemical changes of the cell of the SAW are detected based on the propagation characteristic of the SAW 25, in this SAW device biosensor 21 of the present invention. In this SAW device biosensor 21, SiO
2 is film-formed onto the IDT 23, a pseudo-matrix 27 is coating-treated thereafter on the piezoelectric substrate 22, the SAW propagation route 24 comprising a culture cell 28 is formed to be constituted into dual channels, a change caused by a temperature and a solution mass is corrected in one of the channels, and the physical and chemical changes of the cell are detected in the other one channel.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够检测细胞的传播生长损伤修复过程的表面声波装置生物传感器，其通过仅通过光学显微镜观察到，通过将其测量为表面声波（SAW）传播特性，由于在SAW传播路径上形成的单元的物理和化学变化，使用在压电基板上产生的SAW。解决方案：向连接到压电基片22的IDT 23施加/加压高频电流或电压，在压电基片22的表面附近产生SAW 25，物理和化学变化在本发明的SAW器件生物传感器21中，基于SAW 25的传播特性来检测SAW的单元。在该SAW器件生物传感器21中，在IDT23上成膜形成SiO 2，然后在压电基板22上对其进行涂敷处理，SAW传播路径24包括培养池 28形成为双通道，在一个通道中校正由温度和溶液质量引起的变化，并且在另一个通道中检测电池的物理和化学变化。版权所有（C）2009，JPO＆INPIT

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