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1. 发明专利

JP2005091236A Measuring method for immunologically active substance 有权
标题翻译：免疫活性物质的测量方法
公开(公告)号：JP2005091236A
公开(公告)日：2005-04-07
申请号：JP2003326829
申请日：2003-09-18
申请人： Kazuhiko Ishihara , National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所 , 一彦石原
发明人： ISHIHARA KAZUHIKO , WATANABE JUNJI , KUROSAWA SHIGERU
IPC分类号： G01N33/543
摘要： PROBLEM TO BE SOLVED: To provide a method allowing quick, easy and highly sensitive execution capable of precluding an immunologically active substance immobilized on a carrier particle from being deactivated, and capable of precluding coexisting protein in a measuring sample from being adsorbed nonspecifically on the carrier particle, in an immunological measuring method using the carrier particle immobilized with the immunologically active substance.
SOLUTION: In this measuring method for the immunologically active substance includes a process for bringing the immunologically active substance A immobilized on the particle comprising a polymer into reaction with the another immunologically active substance B in an aqueous liquid. The particle used therein is a particle of which at least the particle surface part comprises the polymer having in its side chain an aromatic group Ar having a group expressed by a general formula (1), wherein A represents an alkylene group, and R
1 , R
2 , R
3 represent alkyl groups which may have hydrogen atom or hydroxyl group, and a nonionic oxygen-containing group, and the reaction is carried out under the presence of a piezoelectric element.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种允许快速，容易和高灵敏度执行的方法，其能够阻止固定在载体颗粒上的免疫活性物质失活，并且能够排除测量样品中的共存蛋白被非特异性吸附在载体颗粒上，使用固定有免疫活性物质的载体颗粒的免疫测定方法。解决方案：在该免疫活性物质的测定方法中，包括将含有聚合物的粒子的免疫活性物质A与含水液体中的其他免疫活性物质B反应的方法。其中使用的颗粒是至少颗粒表面部分包含其侧链中具有由通式（1）表示的基团的芳族基团Ar的聚合物的颗粒，其中A表示亚烷基，R 1 ，R 2 ，R 3 表示可具有氢原子或羟基的烷基和非离子含氧基团，反应是在压电元件的存在下进行。版权所有（C）2005，JPO＆NCIPI

2. 发明专利

JP2009136201A Method for preserving biological component 审中-公开
标题翻译：保存生物成分的方法
公开(公告)号：JP2009136201A
公开(公告)日：2009-06-25
申请号：JP2007315271
申请日：2007-12-05
申请人： Kazuhiko Ishihara , Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社 , 一彦石原
发明人： KAWAMURA KENJI , ISHIHARA KAZUHIKO , KONNO TOMOHIRO
IPC分类号： C12N5/07 , C12N5/071 , C12N5/10
摘要： PROBLEM TO BE SOLVED: To provide a method for preserving a biological component immobilized without freezing in a medium consisting essentially of water under mild conditions to a biological component of normal temperature and normal pressure.
SOLUTION: The method for preserving a biological component comprises mixing a water-soluble polymer solution into which a biological component is dispersed with a water-soluble compound solution to form a three-dimensional crosslinked product and preserving the biological component in the state of the three-dimensional crosslinked product. Preferably the water-soluble polymer is a polymer containing a phosphorylcholine group and a phenylboronic acid group and the water-soluble compound is a compound containing a polyfunctional hydroxy group.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种在温和条件下将基本上由水组成的培养基中保持固定而不冷冻的生物成分与常温常压生物成分相比较的方法。解决方案：保存生物成分的方法包括将其中分散有生物成分的水溶性聚合物溶液与水溶性化合物溶液混合以形成三维交联产物并将该生物成分保持在该状态的三维交联产物。优选地，水溶性聚合物是含有磷酸胆碱基团和苯基硼酸基团的聚合物，并且水溶性化合物是含有多官能羟基的化合物。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2007314736A Polymer composition immobilizing biological component and three-dimensional cross-linked body 有权
标题翻译：聚合物组合物固定生物组分和三维交联体
公开(公告)号：JP2007314736A
公开(公告)日：2007-12-06
申请号：JP2006168036
申请日：2006-05-23
申请人： Kazuhiko Ishihara , 一彦石原
发明人： ISHIHARA KAZUHIKO , KONNO TOMOHIRO
IPC分类号： C08L57/06 , C07K17/08 , C08F230/06 , C12N11/08 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a polymer composition immobilizing a biological component at normal temperature under atmospheric pressure without carrying out a chemical treatment thereof and to provide a three-dimensional cross-linked body utilizing the polymer composition.
SOLUTION: The three-dimensional cross-linked body insoluble in water is formed as follows. A polymer having a phosphorylcholine group and a boronic acid group at the same time effectively produces reversible covalent bonds with a compound having polyhydric hydroxy groups. Furthermore, a protein, a nucleic acid, a cell or a tissue can be immobilized by a treatment at normal temperature under atmospheric pressure in an aqueous solvent in an ultrashort time. The biological component is entrapped and immobilized in a hydrogel network by producing a polymer network in a medium consisting essentially of water under conditions mild for the biological component such as normal temperature and atmospheric pressure without utilizing a chemical reaction or a physical means such as heat, light and exposure to radiation. Thereby, a high activity can be maintained by the immobilized biological component which can effectively be utilized for the bio-industry.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供在常压下在大气压下固定生物成分的聚合物组合物，而不进行化学处理，并提供利用该聚合物组合物的三维交联体。
解决方案：不溶于水的三维交联体如下形成。具有磷酸胆碱基和硼酸基的聚合物同时有效地与具有多羟基的化合物产生可逆共价键。此外，蛋白质，核酸，细胞或组织可以通过在常压下在大气压下在水溶剂中在超短时间内进行固定。通过在基本上由水组成的介质中生成聚合物网络，生物成分被捕获并固定在水凝胶网络中，该介质在生物成分温和的条件下，例如常温和大气压，而不用化学反应或诸如热，光和暴露于辐射。由此，能够有效地利用于生物工业的固定化生物成分能够维持高活性。版权所有（C）2008，JPO＆INPIT

4. 发明专利

JP2007202965A Low abrasion sliding member and artificial joint using it 有权
标题翻译：低磨损会员和使用它的人工关节
公开(公告)号：JP2007202965A
公开(公告)日：2007-08-16
申请号：JP2006028529
申请日：2006-02-06
申请人： Kazuhiko Ishihara , Japan Medical Materials Corp , Hiroshi Kawaguchi , Tomohiro Konno , Toru Moro , Kozo Nakamura , Yoshio Takatori , 耕三中村 , 浩川口 , 日本メディカルマテリアル株式会社 , 一彦石原 , 徹茂呂 , 智浩金野 , 吉雄高取
发明人： KYOMOTO MASAYUKI , MORO TORU , ISHIHARA KAZUHIKO , KONNO TOMOHIRO , NAKAMURA KOZO , TAKATORI YOSHIO , KAWAGUCHI HIROSHI , TAKATAMA HIROAKI , KONDO MAKOTO , YAMAWAKI NOBORU
IPC分类号： A61F2/32 , A61F2/38 , A61F2/40 , A61F2/42 , A61F2/44 , A61L27/00
摘要： PROBLEM TO BE SOLVED: To provide a sliding member which can maintain abrasion resistance over long periods and is excellent in durability. SOLUTION: The sliding member is the low abrasion sliding member 10 which is employed under a wetting environment, the sliding member 10 contains a base material 12 formed from a polymer material having a methylene group and a polymer membrane 30 which covers the sliding face 16 of the base material 12, the polymer membrane 30 is composed of a polymer chain containing a phosphorylcholine group which is graft connected to the sliding face 16, and a phosphoric acid index (the peak intensity of the phosphate group of infrared spectroscopic analysis spectrum/the peak intensity of a methylene group) of the sliding face 16 is 0.28 or more. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：解决的问题：提供能够长时间保持耐磨性并且耐久性优异的滑动构件。滑动构件是在润湿环境下使用的低磨损滑动构件10，滑动构件10包含由具有亚甲基的聚合物材料形成的基材12和覆盖滑动件的聚合物膜30 基材12的表面16，聚合物膜30由含有与滑动面16接触的磷酸胆碱基的聚合物链构成，磷酸指数（红外光谱分析光谱的磷酸基的峰强度 /亚甲基的峰强度）为0.28以上。版权所有（C）2007，JPO＆INPIT

5. 发明专利

JP2006275769A Solid-phase carrier for immobilizing peptide and usage method thereof 有权
标题翻译：用于固定肽的固相载体及其使用方法
公开(公告)号：JP2006275769A
公开(公告)日：2006-10-12
申请号：JP2005095367
申请日：2005-03-29
申请人： Kazuhiko Ishihara , Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社 , 一彦石原
发明人： ISHIHARA KAZUHIKO , IGARASHI KOTA
IPC分类号： G01N33/543 , C07K17/06 , G01N21/78 , G01N33/53 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a solid-phase carrier for immobilizing peptide that is evaluated easily and quickly, and also to provide a method for using the solid-phase carrier. SOLUTION: The solid-phase carrier for immobilizing peptide is a solid-phase carrier used when immobilizing the peptide onto a solid-phase surface, operating a physiological active substance specifically reacting with the immobilized peptide, and detecting the physiological active substance specifically reacting with the peptide or the specifically reacting peptide by using fluorescence, emission, or color development. The carrier has a polymer substance having a phosphorylcholine group and an active ester group on the solid-phase surface, while a solid-phase material is made of plastic. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供一种用于固定肽的固相载体，其被容易且快速地评估，并且还提供使用该固相载体的方法。解决方案：固定肽的固相载体是将肽固定在固相表面上时使用的固相载体，操作与固定肽特异性反应的生理活性物质，特异性地检测生理活性物质通过使用荧光，发射或显色来与肽或特异性反应的肽反应。载体在固相表面具有磷酸胆碱基团和活性酯基的聚合物物质，而固相材料由塑料制成。版权所有（C）2007，JPO＆INPIT

6. 发明专利

JP2006201091A Micro particle for capture beads, capture beads using same, and biochip 有权
标题翻译：用于捕获珠粒的微粒，使用相同的珠粒和生物体
公开(公告)号：JP2006201091A
公开(公告)日：2006-08-03
申请号：JP2005014753
申请日：2005-01-21
申请人： Kazuhiko Ishihara , Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社 , 一彦石原
发明人： ISHIHARA KAZUHIKO , YOKOYAMA KANEHISA , FUNAOKA SOUHEI
IPC分类号： G01N33/543 , C12M1/00 , C12N15/09 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide capture beads having a high reaction efficiency between a physiologically active material immobilized to its surface and a physiologically active material to be detected in a specimen solution and capable of easily moving through channels without interruption and being easily filled in the channels. SOLUTION: The surfaces of the capture beads are coated with a high polymer containing both a first unit having a phosphoryl choline group and a second unit having a carboxylic acid derivative group in which an electron-attractive substituent binds to a carbonyl group. The carboxylic acid derivative group reacts with a capture material for capturing a physiologically active material to form covalent binding, and the capture material for capturing the physiologically active material is immobilized. The physiologically active material in a test liquid is treated through the use of the capture beads. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供在固定在其表面上的生理活性物质和待检测的生理活性物质之间具有高反应效率的捕获珠，并且能够容易地通过通道而不中断地移动，并且容易填入渠道。解决方案：捕获珠粒的表面用含有磷酰胆碱基团的第一单元和具有电子吸引取代基与羰基结合的羧酸衍生基团的第二单元的高聚物包被。羧酸衍生物基团与用于捕获生理活性物质的捕获材料反应以形成共价结合，并且用于捕获生理活性物质的捕获材料被固定。通过使用捕获珠处理测试液体中的生理活性物质。版权所有（C）2006，JPO＆NCIPI

7. 发明专利

JP2006177803A Liquid discharge method and microarray manufacturing method 审中-公开
标题翻译：液体放电方法和微波制造方法
公开(公告)号：JP2006177803A
公开(公告)日：2006-07-06
申请号：JP2004372029
申请日：2004-12-22
申请人： Kazuhiko Ishihara , Seiko Epson Corp , セイコーエプソン株式会社 , 一彦石原
发明人： TAKAGI FUMIO , ISHIHARA KAZUHIKO
IPC分类号： G01N33/53 , G01N33/543 , G01N37/00
CPC分类号： B01L3/0268 , B01J2219/00378 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01L2300/161
摘要： PROBLEM TO BE SOLVED: To provide a liquid discharge method, capable of improving discharge stability at the discharge of biological matter, even at repeated use, and to provide a microarray manufacturing method that uses it.
SOLUTION: In the method for discharging liquids containing biological matter, a polymer, made of an unsaturated compound unit containing a phosphorylcholine group as a discharge stabilizer or a copolymer containing this, is added to a liquid containing biological matter, and the liquid containing the biological matter is discharged by an ink-jet method. It is preferable that the copolymer contain an unsaturated compound unit (a1) that contains a phosphorylcholine group and a (meta) acrylic ester unit (a2) as a constituting unit.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：解决的问题：提供即使在重复使用时也能够提高生物物质排出时的放电稳定性的液体排出方法，并且提供使用它的微阵列制造方法。解决方案：在含有生物物质的液体的排出方法中，将含有磷酸胆碱基的不饱和化合物单元作为排出稳定剂或含有该共聚物的共聚物制成的聚合物添加到含有生物物质的液体中，通过喷墨法排出含有生物物质的物质。优选共聚物含有含有磷酸胆碱基的不饱和化合物单元（a1）和作为构成单元的（间位）丙烯酸酯单元（a2）。版权所有（C）2006，JPO＆NCIPI

8. 发明专利

JP2006011381A Ocular lens material and method for producing the same 有权
标题翻译：眼镜片材及其制造方法
公开(公告)号：JP2006011381A
公开(公告)日：2006-01-12
申请号：JP2005136845
申请日：2005-05-10
申请人： Kazuhiko Ishihara , Shiseido Co Ltd , 株式会社資生堂 , 一彦石原
发明人： SUMIDA YUKIMITSU , MIYAZAWA KAZUYUKI , ISHIHARA KAZUHIKO
IPC分类号： G02C7/04 , A61F2/16 , A61L27/28 , C08J7/04 , C08J7/12 , C08L101/00 , G02B1/04
CPC分类号： C08J7/12 , A61F2/16 , A61F2002/1699 , A61L27/28 , G02B1/043
摘要： PROBLEM TO BE SOLVED: To provide an ocular lens material which prevents protein adsorption, and to provide a method for producing the material.
SOLUTION: The method for producing an ocular lens material includes a step of reacting and covalently bonding a compound having a phosphorylcholine group expressed by Formula (1) with the surface of an ocular lens material having a hydroxyl group, wherein a compound expressed by Formula (2) is reacted with an ocular lens material in an organic solvent, whereby being covalently bonded thereto through an ester bond. In the Formula (2), n is a natural number of 1 to 18.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种防止蛋白质吸附的眼用透镜材料，提供该材料的制造方法。解决方案：眼用透镜材料的制造方法包括使具有由式（1）表示的磷酸胆碱基的化合物与具有羟基的眼晶状体材料的表面反应并共价键合的工序，其中表达的化合物通过式（2）与眼用透镜材料在有机溶剂中反应，由此通过酯键与其共价键合。在式（2）中，n为1〜18的自然数。版权所有（C）2006，JPO＆NCIPI

9. 发明专利

JP2006011380A Ocular lens material and method for producing the same 有权
标题翻译：眼镜片材及其制造方法
公开(公告)号：JP2006011380A
公开(公告)日：2006-01-12
申请号：JP2005136844
申请日：2005-05-10
申请人： Kazuhiko Ishihara , Shiseido Co Ltd , 株式会社資生堂 , 一彦石原
发明人： SUMIDA YUKIMITSU , MIYAZAWA KAZUYUKI , ISHIHARA KAZUHIKO
IPC分类号： G02C7/04 , A61F2/16 , C07F7/18 , C08J7/12 , C08L33/00 , C08L83/00 , G02B1/04
CPC分类号： G02B1/043 , C08J7/12
摘要： PROBLEM TO BE SOLVED: To provide a contact lens which prevents protein adsorption, and to provide a method for producing the contact lens.
SOLUTION: The ocular lens material is characterized in that a phosphorylcholine group of a specified structure is covalently bonded to the surface of an ocular lens material, through a post-treatment wherein a phosphorylcholine group-containing compound is reacted with the ocular lens material.
COPYRIGHT: (C)2006,JPO&NCIPI

10. 发明专利

JP2005255969A Method for producing biodegradable polymer and application thereof 有权
标题翻译：生产可生物降解聚合物的方法及其应用
公开(公告)号：JP2005255969A
公开(公告)日：2005-09-22
申请号：JP2004113646
申请日：2004-03-12
申请人： Kazuhiko Ishihara , Yasuhiko Iwasaki , 泰彦岩崎 , 一彦石原
发明人： IWASAKI YASUHIKO , AKIYOSHI KAZUNARI , ISHIHARA KAZUHIKO
IPC分类号： A61K47/34 , A61L27/00 , C08F289/00 , C08G79/04 , C08L101/16
摘要： PROBLEM TO BE SOLVED: To obtain a polyphosphoric acid compound with a branched structure being an essential material in producing an amphiphilic material excellent in biodegradability. SOLUTION: The subject method is for producing the polyphosphoric acid compound expressed by formula(1), where A is an alkyl chain, or the like; B is an organic group; R 1 and R 2 are each hydrogen, or the like; X is a halogen atom; and M is a radically polymerizable compound. COPYRIGHT: (C)2005,JPO&NCIPI

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