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1. 发明专利

JP2009136201A Method for preserving biological component 审中-公开
标题翻译：保存生物成分的方法
公开(公告)号：JP2009136201A
公开(公告)日：2009-06-25
申请号：JP2007315271
申请日：2007-12-05
申请人： Kazuhiko Ishihara , Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社 , 一彦石原
发明人： KAWAMURA KENJI , ISHIHARA KAZUHIKO , KONNO TOMOHIRO
IPC分类号： C12N5/07 , C12N5/071 , C12N5/10
摘要： PROBLEM TO BE SOLVED: To provide a method for preserving a biological component immobilized without freezing in a medium consisting essentially of water under mild conditions to a biological component of normal temperature and normal pressure.
SOLUTION: The method for preserving a biological component comprises mixing a water-soluble polymer solution into which a biological component is dispersed with a water-soluble compound solution to form a three-dimensional crosslinked product and preserving the biological component in the state of the three-dimensional crosslinked product. Preferably the water-soluble polymer is a polymer containing a phosphorylcholine group and a phenylboronic acid group and the water-soluble compound is a compound containing a polyfunctional hydroxy group.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种在温和条件下将基本上由水组成的培养基中保持固定而不冷冻的生物成分与常温常压生物成分相比较的方法。解决方案：保存生物成分的方法包括将其中分散有生物成分的水溶性聚合物溶液与水溶性化合物溶液混合以形成三维交联产物并将该生物成分保持在该状态的三维交联产物。优选地，水溶性聚合物是含有磷酸胆碱基团和苯基硼酸基团的聚合物，并且水溶性化合物是含有多官能羟基的化合物。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2007314736A Polymer composition immobilizing biological component and three-dimensional cross-linked body 有权
标题翻译：聚合物组合物固定生物组分和三维交联体
公开(公告)号：JP2007314736A
公开(公告)日：2007-12-06
申请号：JP2006168036
申请日：2006-05-23
申请人： Kazuhiko Ishihara , 一彦石原
发明人： ISHIHARA KAZUHIKO , KONNO TOMOHIRO
IPC分类号： C08L57/06 , C07K17/08 , C08F230/06 , C12N11/08 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a polymer composition immobilizing a biological component at normal temperature under atmospheric pressure without carrying out a chemical treatment thereof and to provide a three-dimensional cross-linked body utilizing the polymer composition.
SOLUTION: The three-dimensional cross-linked body insoluble in water is formed as follows. A polymer having a phosphorylcholine group and a boronic acid group at the same time effectively produces reversible covalent bonds with a compound having polyhydric hydroxy groups. Furthermore, a protein, a nucleic acid, a cell or a tissue can be immobilized by a treatment at normal temperature under atmospheric pressure in an aqueous solvent in an ultrashort time. The biological component is entrapped and immobilized in a hydrogel network by producing a polymer network in a medium consisting essentially of water under conditions mild for the biological component such as normal temperature and atmospheric pressure without utilizing a chemical reaction or a physical means such as heat, light and exposure to radiation. Thereby, a high activity can be maintained by the immobilized biological component which can effectively be utilized for the bio-industry.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供在常压下在大气压下固定生物成分的聚合物组合物，而不进行化学处理，并提供利用该聚合物组合物的三维交联体。
解决方案：不溶于水的三维交联体如下形成。具有磷酸胆碱基和硼酸基的聚合物同时有效地与具有多羟基的化合物产生可逆共价键。此外，蛋白质，核酸，细胞或组织可以通过在常压下在大气压下在水溶剂中在超短时间内进行固定。通过在基本上由水组成的介质中生成聚合物网络，生物成分被捕获并固定在水凝胶网络中，该介质在生物成分温和的条件下，例如常温和大气压，而不用化学反应或诸如热，光和暴露于辐射。由此，能够有效地利用于生物工业的固定化生物成分能够维持高活性。版权所有（C）2008，JPO＆INPIT

3. 发明专利

JP2007202965A Low abrasion sliding member and artificial joint using it 有权
标题翻译：低磨损会员和使用它的人工关节
公开(公告)号：JP2007202965A
公开(公告)日：2007-08-16
申请号：JP2006028529
申请日：2006-02-06
申请人： Kazuhiko Ishihara , Japan Medical Materials Corp , Hiroshi Kawaguchi , Tomohiro Konno , Toru Moro , Kozo Nakamura , Yoshio Takatori , 耕三中村 , 浩川口 , 日本メディカルマテリアル株式会社 , 一彦石原 , 徹茂呂 , 智浩金野 , 吉雄高取
发明人： KYOMOTO MASAYUKI , MORO TORU , ISHIHARA KAZUHIKO , KONNO TOMOHIRO , NAKAMURA KOZO , TAKATORI YOSHIO , KAWAGUCHI HIROSHI , TAKATAMA HIROAKI , KONDO MAKOTO , YAMAWAKI NOBORU
IPC分类号： A61F2/32 , A61F2/38 , A61F2/40 , A61F2/42 , A61F2/44 , A61L27/00
摘要： PROBLEM TO BE SOLVED: To provide a sliding member which can maintain abrasion resistance over long periods and is excellent in durability. SOLUTION: The sliding member is the low abrasion sliding member 10 which is employed under a wetting environment, the sliding member 10 contains a base material 12 formed from a polymer material having a methylene group and a polymer membrane 30 which covers the sliding face 16 of the base material 12, the polymer membrane 30 is composed of a polymer chain containing a phosphorylcholine group which is graft connected to the sliding face 16, and a phosphoric acid index (the peak intensity of the phosphate group of infrared spectroscopic analysis spectrum/the peak intensity of a methylene group) of the sliding face 16 is 0.28 or more. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：解决的问题：提供能够长时间保持耐磨性并且耐久性优异的滑动构件。滑动构件是在润湿环境下使用的低磨损滑动构件10，滑动构件10包含由具有亚甲基的聚合物材料形成的基材12和覆盖滑动件的聚合物膜30 基材12的表面16，聚合物膜30由含有与滑动面16接触的磷酸胆碱基的聚合物链构成，磷酸指数（红外光谱分析光谱的磷酸基的峰强度 /亚甲基的峰强度）为0.28以上。版权所有（C）2007，JPO＆INPIT

4. 发明专利

JP2004175752A Solid pharmaceutical composition and method for producing the same 有权
公开(公告)号：JP2004175752A
公开(公告)日：2004-06-24
申请号：JP2002345912
申请日：2002-11-28
申请人： Kazuhiko Ishihara , Nof Corp , 日本油脂株式会社 , 一彦石原
发明人： ISHIHARA KAZUHIKO , KONNO TOMOHIRO , SAKAGUCHI KOJI , YASUKOCHI TORU , KITANO SHIGERU
IPC分类号： A61K47/34 , A61K9/14 , A61K9/70 , A61K31/337
摘要： PROBLEM TO BE SOLVED: To obtain a solid pharmaceutical composition having improved resolubility in administration, especially a solid pharmaceutical composition of powder form or film form, and to provide a method for producing the composition.
SOLUTION: The solid pharmaceutical composition contains a medicinal agent and a copolymer having a constitutional unit (I) based on 2-methacryloyloxyethyl phosphorylcholine and a constitutional unit (II) based on a hydrophobic monomer at an I/II molar ratio of 2/8 to 6.5/3.5. This invention further provides a method for the production of the composition.
COPYRIGHT: (C)2004,JPO

5. 发明专利

JP2003310649A Artificial joint member made of high polymer material 有权
标题翻译：高分子材料的人工接头成员
公开(公告)号：JP2003310649A
公开(公告)日：2003-11-05
申请号：JP2003041037
申请日：2003-02-19
申请人： Kazuhiko Ishihara , Kobe Steel Ltd , Kozo Nakamura , 耕三中村 , 株式会社神戸製鋼所 , 一彦石原
发明人： ISHIHARA KAZUHIKO , MORO TORU , NAKAMURA KOZO , TAKATORI YOSHIO , KAWAGUCHI HIROSHI , KONNO TOMOHIRO , MATSUSHITA TOMIHARU , KUSUMOTO SHUJI
IPC分类号： A61F2/30
摘要： PROBLEM TO BE SOLVED: To provide an artificial joint member made of a high polymer material capable of favorably maintaining a lubricated state of a sliding portion throughout a long period. SOLUTION: A sliding face of the artificial joint member formed by a high polymer substance comprises a high polymer having a phosphorylcholine group. COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供一种能够在长时间内有利地保持滑动部分的润滑状态的由高分子材料制成的人造关节构件。解决方案：由高分子物质形成的人造关节部件的滑动面包含具有磷酸胆碱基团的高分子。版权所有（C）2004，JPO

6. 发明专利

JP2008148850A Low-wear sliding member and artificial joint making use of the same 有权
标题翻译：低滑动成员和人工接合使用它们
公开(公告)号：JP2008148850A
公开(公告)日：2008-07-03
申请号：JP2006338601
申请日：2006-12-15
申请人： Kazuhiko Ishihara , Japan Medical Materials Corp , Hiroshi Kawaguchi , Tomohiro Konno , Toru Moro , Kozo Nakamura , Yoshio Takatori , 耕三中村 , 浩川口 , 日本メディカルマテリアル株式会社 , 一彦石原 , 徹茂呂 , 智浩金野 , 吉雄高取
发明人： KYOMOTO MASAYUKI , FUTATSUKA TAKESHI , ISHIHARA KAZUHIKO , KONNO TOMOHIRO , NAKAMURA KOZO , KAWAGUCHI HIROSHI , TAKATORI YOSHIO , MORO TORU , HASHIMOTO MASAMI
IPC分类号： A61L27/00 , A61F2/32 , A61F2/38 , A61F2/40 , A61F2/42 , A61F2/44
摘要： PROBLEM TO BE SOLVED: To provide a sliding member that maintains its wear resistance over a prolonged period of time, excelling in durability. SOLUTION: The low-wear sliding member 10 is used in a wet environment, and the sliding member 10 includes a base material 12 molded from a polymer material having a methylene group and a polymer film 30 covering the sliding surface 16 of the base material 12. The polymer film 30 is constituted of a polymer chain having a phosphorylcholine group graft-bonded to the sliding surface 16, and the thickness of the polymer film is 10 to 200 nm. COPYRIGHT: (C)2008,JPO&INPIT

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