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1. 发明专利

JP2005060410A Suppressant for cell adhesion 有权
标题翻译：抑制细胞粘附
公开(公告)号：JP2005060410A
公开(公告)日：2005-03-10
申请号：JP2004351584
申请日：2004-12-03
申请人： Kao Corp , 花王株式会社
发明人： HASE TADASHI , MURASE TAKATOSHI , SUZUKI YASUTO , HORI KIMIHIKO , YADA YUKIHIRO , IMOKAWA GENJI
IPC分类号： A61P9/10 , A61K31/167 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P25/00 , A61P29/00 , A61P37/08 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a highly stable excellent anti-inflammatory agent based on a suppressant for cell adhesion.
SOLUTION: The suppressant for cell adhesion and the anti-inflammatory agent contain benzanilides represented by formula I (R
1 is t-butyl; and R
2 is H or a 1-5C alkyl) or a salt thereof as an active ingredient.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供基于细胞粘附抑制剂的高度稳定的优异的抗炎剂。解决方案：细胞粘附抑制剂和抗炎剂含有由式I表示的苯甲酰苯胺（R 1 是叔丁基; R 2 SP 2是H或 1-5C烷基）或其盐作为活性成分。版权所有（C）2005，JPO＆NCIPI

2. 发明专利

JP2004083844A Allergen-reducing agent 有权
公开(公告)号：JP2004083844A
公开(公告)日：2004-03-18
申请号：JP2003101611
申请日：2003-04-04
申请人： Kao Corp , 花王株式会社
发明人： NONOMURA MASAMI , HORI KIMIHIKO , NOJIRI HIROSHI
IPC分类号： A61K8/00 , A61K8/02 , A61K8/06 , A61K8/73 , C09K3/00 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To provide an allergen-reducing agent without having an ill effect to a human body and having no problem of discoloring, etc. SOLUTION: This allergen-reducing agent is a polysaccharide derivative having cellulose ether or starch ether as a main chain and is characterized by containing the polysaccharide derivative a part of or whole of which hydrogen atoms of hydroxy group is substituted by a group expressed by general formula (1): E 1 -(OA) n -E 2 -R [wherein, E 1 is a 1-6C alkylene which may be substituted by hydroxy or oxo; (n) is 0-50 number; nA are each the same or different and a 1-6C alkylene; E 2 is ether bond or oxycarbonyl; and R is a 4-30C alkyl which may be substituted by hydroxy, a 1-5C sulfoalkyl which may be substituted by hydroxy or its salt] as an active ingredient. COPYRIGHT: (C)2004,JPO

3. 发明专利

JP2004081840A Wipe sheet 有权
公开(公告)号：JP2004081840A
公开(公告)日：2004-03-18
申请号：JP2003189798
申请日：2003-07-01
申请人： Kao Corp , 花王株式会社
发明人： NONOMURA MASAMI , HORI KIMIHIKO , NOJIRI HIROSHI , YANAGIDA HIROYUKI , OKUDA FUMIKO
IPC分类号： A47L13/17
摘要： PROBLEM TO BE SOLVED: To provide a wipe sheet reducing allergen existing on a surface of an object by wiping operation. SOLUTION: This wipe sheet includes an allergen reducing agent in a sheet member 2. The allergen reducing agent is a polysaccharide derivative having cellulose ether or starch ether on its main chain, and constituted of the polysaccharide derivative whose part or all of hydrogen atoms of its hydroxy group is substituted by a group represented by formula (1) : -E 1 -(OA) n -E 2 -R. In the formula, E 1 is 1-6C alkylene group which is may be substituted by hydroxy group or oxo group, n is the number of 0-50, n pieces of A is each the same or different 1-6C alkylene group, E 2 is ether bond or oxycarbonyl group, and R is 4-30C alkyl group which is may be substituted by hydroxy group, or 1-5C sulfoalkyl group or its salt, which is may be substituted by hydroxy group. COPYRIGHT: (C)2004,JPO

4. 发明专利

JP2007130020A Agent for ameliorating swelling, and slimming agent 审中-公开
标题翻译：用于改善破裂和滑动剂的代理
公开(公告)号：JP2007130020A
公开(公告)日：2007-05-31
申请号：JP2006326526
申请日：2006-12-04
申请人： Kao Corp , 花王株式会社
发明人： CHIBA HIROE , FUKUDA YUKO , KITAHARA TAKASHI , HORI KIMIHIKO
IPC分类号： A23L1/30 , A61K31/7048 , A61P7/10
摘要： PROBLEM TO BE SOLVED: To provide a skin cosmetic, a quasi-drug for skin external use, a health food, a food for medical application, a food for a medicine and a food for improving a cosmetic, effective for reducing spontaneous swelling of legs or the like caused by a standing posture and a sitting posture for a long time, and slimming of the belly or the like. SOLUTION: The skin cosmetic, the quasi-drug for skin external use, the health food, the food for the medical application, the food for the medicine and the cosmetic for ameliorating the swelling contain α-glycosylated rutin as an active ingredient. A tablet (including a chewing tablet), a granule, a powder, a drinkable preparation, and a processed food such as a cookie, a biscuit, a cake and a bread are used as the oral dosage form. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种皮肤美容品，用于皮肤外用的准药物，保健食品，医疗应用食品，用于药物的食品和用于改善化妆品的食品，有效减少自发的长时间站立姿势，坐姿引起的腿等肿胀，腹部等变瘦。
解决方案：皮肤化妆品，皮肤外用准准药，保健食品，医疗用食品，药物食品和改善肿胀的化妆品含有α-糖基化芦丁作为活性成分。作为口服剂型，使用片剂（包括咀嚼片），颗粒剂，粉剂，饮料制剂，加工食品如饼干，饼干，蛋糕和面包。版权所有（C）2007，JPO＆INPIT

5. 发明专利

JP2002370998A Ceramide production promoter 有权
标题翻译：陶瓷生产促销
公开(公告)号：JP2002370998A
公开(公告)日：2002-12-24
申请号：JP2002164130
申请日：2002-06-05
申请人： Kao Corp , 花王株式会社
发明人： OKUBO KOJI , TAKAGI YUTAKA , TAKATOKU HIROKO , HORI KIMIHIKO , KUSUOKU HIROSHI , SHIBUYA YUSUKE
IPC分类号： A61K36/18 , A61K36/00 , A61K36/25 , A61K36/28 , A61K36/48 , A61K36/60 , A61K36/73 , A61K36/896 , A61K36/899 , A61P17/00 , A61P17/16 , A61P43/00 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To increase the amount of ceramides decreased in the horny layer and to restore the barrier function and moisturizing function of the skin by restoring a ceramide producing mechanism inherent in the living body to the healthy state. SOLUTION: This ceramide production promoter comprises a plant selected from Eucalyptus globules Labill., Humulus lupulus L., Zingiber officinale Roscoe, Uncaria gambir Roxburgh, Rosa multifolia Thunberg, Aesculus hippocastanum Linne, Lilium candidum, Coix lacryma-jobi Linne var. ma-yuen Stapf, Typha angustifolia Linne, Eriobotrya japonica Lindley, Gardenia jasminoides Ellis, Panax ginseng C.A. Meyer, Saponaria officinalis Linne, Betula pendula Roth., Hydrangea serrata Seringe var. thunbergii Sugimoto (or Hydrangea macrophylla Seringe var. thunbergii Makino), Syzygium aromaticum Merrill et Perry (or Eugenia caryophyllata Thunberg), Carthamus tinctorius Linne, Sanguisorba officinalis Linne, Iris florentina L., etc., and Sophora flavescens Aiton or an extract, a steam distilled product or a pressed product thereof. The plant or the extract, steam distilled product or pressed product thereof is used for preparing the ceramide production promoter.
摘要翻译：要解决的问题：通过将生物体固有的神经酰胺生产机制恢复到健康状态，增加角质层中神经酰胺的量减少并恢复皮肤的屏障功能和保湿功能。解决方案：该神经酰胺生产促进剂包含选自桉树ules ill，，，，，，e e，，，burgh，，，，，um um um um，，。。。。。。。。。。。。。。。。。。。。马en en f，olia olia olia Garden Garden Garden Garden Garden Garden Garden Garden。。。。。。。。。。。 Meyer，Saponaria officinalis Linne，Betula pendula Roth。，绣球花Serrata Seringe var。（或八仙花），，，ry ry ry ry ry，，un un un a a a a a a a a a a a a a a a a a a a a a a a a a a a a a a a a a a a a a a a a a 蒸汽蒸馏产品或其压制产品。用于制备神经酰胺生产促进剂的植物或提取物，蒸汽蒸馏产物或其压制产物。

6. 发明专利

JPH1192353A SKIN PREPARATION FOR EXTERNAL USE FOR INHIBITING SEBUM SYNTHESIS 失效
公开(公告)号：JPH1192353A
公开(公告)日：1999-04-06
申请号：JP25502997
申请日：1997-09-19
申请人： KAO CORP
发明人： OUCHI ATSUSHI , HOTTA MITSUYUKI , KANAZAWA SATOSHI , NISHIZAWA YOSHINORI , HORI KIMIHIKO
IPC分类号： A61K8/96 , A61K8/00 , A61K8/97 , A61K36/00 , A61K36/18 , A61P3/06 , A61P17/00 , A61Q19/00 , A61K7/48 , A61K7/00 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To prepare the subject preparation for external use, capable of continuously inhibiting the secretion of sebum on skin or scalp, hardly causing side effects and high in safety by formulating an extract of Echinacea angustifolia and E.purpurea, and/or Tropaeolum majus as an active ingredient. SOLUTION: The objective preparation for external use is obtained by formulating 0.01-10 wt.%, preferably 0.5-5 wt.% extract obtained by carrying out an extraction treatment of pulverized material of root or whole plant of Echinacea angustifolia and E.purpurea, and/or leaf of Tropaeolum majus with one or mixture of two or more kinds of ethanol, propylene glycol, 1,3-butylene glycol and water at 3-70 deg.C, in terms of the dried weight based on the amount of the preparation for the external use as an active ingredient.

7. 发明专利

JPH1192339A HAIR-RESTORING AND GROWING MATERIAL 失效
公开(公告)号：JPH1192339A
公开(公告)日：1999-04-06
申请号：JP25503097
申请日：1997-09-19
申请人： KAO CORP
发明人： OUCHI ATSUSHI , HOTTA MITSUYUKI , KANAZAWA SATOSHI , NISHIZAWA YOSHINORI , HORI KIMIHIKO , NISHIJIMA AYUMI
IPC分类号： A61K8/00 , A61K8/97 , A61K36/00 , A61K36/18 , A61P17/00 , A61P43/00 , A61Q5/00 , A61Q7/00 , A61K7/06
摘要： PROBLEM TO BE SOLVED: To obtain a hair-restoring and growing material, e.g. a lotion and a hair tonic, which shows excellent hair-growing activity against various alopecia in spite of symptoms and individual differences and is safe to the living body by formulating extracts from Echinacea angustifolia, Echinacea purpurea and/or Tropaeolum majus as active ingredients. SOLUTION: This material is obtained by formulating extracts from (A) Echinacea angustifolia, Echinacea purpurea and/or (B) Tropaeolum majus preferably in amounts of 0.01-1 wt.% based on the whole weight in the dry weight. On the above-stated extracts, roots or whole grasses of Echinacea angustifolia or Echinacea purpurea are used as the component A and leaves of Tropaeolum majus are used as the component B. These ground pieces are extracted with a solvent, e.g. an aqueous solution of propylene glycol and the like, preferably at an ordinary temperature of 3-70 deg.C to obtain the material. It is preferable that this hair-restoring and growing agent is used as a solution such as a shampoo and a rinse.

8. 发明专利

JPH10218777A SWELLING IMPROVER AND SLIMMING AGENT 失效
公开(公告)号：JPH10218777A
公开(公告)日：1998-08-18
申请号：JP2266797
申请日：1997-02-05
申请人： KAO CORP , HAYASHIBARA BIOCHEM LAB , TOYO SUGAR REFINING
发明人： CHIBA HIROE , FUKUDA YUKO , KITAHARA TAKASHI , HORI KIMIHIKO , MATSUO NOBORU , TAKIZAWA MINORU , MIYAKE TOSHIO , YUMOTO TAKASHI
IPC分类号： C07H17/07 , A61K8/00 , A61K8/37 , A61K8/60 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P3/00 , A61P3/04 , A61P17/00 , A61Q19/00 , A61K7/00 , A61K7/48
摘要： PROBLEM TO BE SOLVED: To obtain a swelling improver and a slimming agent capable of manifesting excellent suppressing actions on spontaneous swelling and excellent slimming actions and further effects thereof for external use for skin even by an oral route by including an α-glucosylated hesperidine as an active ingredient. SOLUTION: This swelling improver comprises (A) an α-glucosylated hesperidine represented by the formula (one or more of R to R are each a monosaccharide or an oligosaccharide residue and the others are H) as an active ingredient. The agent is formulated into a skin preparation for external use, e.g. an ointment, a milky lotion or a toilet lotion or further an oral administration form such as a tablet, a granule or a processed food, e.g. a biscuit, a cake or bread and administered in a daily dose of preferably 0.01-10g expressed in terms of the amount of the ingredient A for an adult in the case of oral administration.

9. 发明专利

JPH10182468A SWELLING IMPROVING AGENT AND REDUCING AGENT 失效
公开(公告)号：JPH10182468A
公开(公告)日：1998-07-07
申请号：JP34098796
申请日：1996-12-20
申请人： KAO CORP
发明人： CHIBA HIROE , FUKUDA YUKO , KITAHARA TAKASHI , HORI KIMIHIKO
IPC分类号： A61K8/60 , A61K8/00 , A61K31/70 , A61P3/00 , A61P3/04 , A61P17/00 , A61P43/00 , A61Q19/00 , A61K7/00 , A61K7/48
摘要： PROBLEM TO BE SOLVED: To obtain the subject improving agent excellent suppressing activity on a spontaneously generated swelling and weight reducing activity, and manifesting the effectiveness either by an oral use or by an external use on a skin, by making the agent containing α-glycosylated rutin as an active ingredient. SOLUTION: This swelling improving agent contain α-glycosylated rutin e.g. expressed by the formula (at least one of R to R is a monosaccharide or an oligo saccharide residue and the rests are H) as an active ingredient. Further, in order to obtain the above rutin, e.g. preferably a glycosyl residue transferease such as a glycosidase is effected on a composition obtained by adding a partially hydrolyzed starch as a saccharide donating material to the rutin, and in the case of oral administration, 0.01-10g as the α-glycosylated rutin for an adult daily and in the case of external agent of the skin, 0.01-10wt.% were preferably blended.

10. 发明专利

JPH10167957A INTERCELLULAR ADHESION SUPPRESSING AGENT 失效
公开(公告)号：JPH10167957A
公开(公告)日：1998-06-23
申请号：JP34240696
申请日：1996-12-09
申请人： KAO CORP
发明人： NITTA HIROYUKI , WATANABE IKUO , HORI KIMIHIKO
IPC分类号： A61K8/06 , A61K8/00 , A61K8/02 , A61K8/30 , A61K8/34 , A61K31/045 , A61K31/047 , A61P17/00 , A61P43/00 , A61Q19/00 , C07C31/125 , C07C33/02 , A61K7/00 , A61K7/48
摘要： PROBLEM TO BE SOLVED: To obtain the subject suppressing agent useful for treating skin diseases and improving corneum troubles through the action on cells themselves by compounding a specific alcohol as an active component. SOLUTION: This suppressing agent is a composition containing a 15-25C terpene alcohol as an active component preferably in an amount of 0.001-20wt.%. Examples of the above terpene alcohol include a compound of formula I [a dotted line expresses a single bond or a double bond; (n)=2, 3, 4] (e.g. farnesol), a compound of formula II (e.g. geranylgeranylisopropanol), a compound of formula III [(n)=3, 4] (e.g. phytanetriol) or a compound of formula IV (e.g. isophytol). The suppressing agent can be compound with another medicinal component such as a germicidal disinfectant, an astringent agent or a skin softening agent, or an aqueous component, powder, an oil solution, a humectant, etc., which are used as a component of a cosmetic or a percutaneous medicine. The suppressing agent is preferably used as an agent for external use for skin, and ointment, milky lotion, cream, skin lotion, etc., is cited as a dosage form. When used as an agent for external use, the agent is administered 1-3 times a day at a dose of 0.1-2mg/cm on the entire application region.

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