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1. 发明专利

JPH10218777A SWELLING IMPROVER AND SLIMMING AGENT 失效
公开(公告)号：JPH10218777A
公开(公告)日：1998-08-18
申请号：JP2266797
申请日：1997-02-05
申请人： KAO CORP , HAYASHIBARA BIOCHEM LAB , TOYO SUGAR REFINING
发明人： CHIBA HIROE , FUKUDA YUKO , KITAHARA TAKASHI , HORI KIMIHIKO , MATSUO NOBORU , TAKIZAWA MINORU , MIYAKE TOSHIO , YUMOTO TAKASHI
IPC分类号： C07H17/07 , A61K8/00 , A61K8/37 , A61K8/60 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P3/00 , A61P3/04 , A61P17/00 , A61Q19/00 , A61K7/00 , A61K7/48
摘要： PROBLEM TO BE SOLVED: To obtain a swelling improver and a slimming agent capable of manifesting excellent suppressing actions on spontaneous swelling and excellent slimming actions and further effects thereof for external use for skin even by an oral route by including an α-glucosylated hesperidine as an active ingredient. SOLUTION: This swelling improver comprises (A) an α-glucosylated hesperidine represented by the formula (one or more of R to R are each a monosaccharide or an oligosaccharide residue and the others are H) as an active ingredient. The agent is formulated into a skin preparation for external use, e.g. an ointment, a milky lotion or a toilet lotion or further an oral administration form such as a tablet, a granule or a processed food, e.g. a biscuit, a cake or bread and administered in a daily dose of preferably 0.01-10g expressed in terms of the amount of the ingredient A for an adult in the case of oral administration.

2. 发明专利

JP2003180288A ORAL MATERIAL WITH IMPROVED TASTE, METHOD FOR IMPROVING TASTE OF THE SAME, AND METHOD FOR USING ENZYME-TREATED GINKGO LEAVES EXTRACT 审中-公开
公开(公告)号：JP2003180288A
公开(公告)日：2003-07-02
申请号：JP2001386603
申请日：2001-12-19
申请人： TOYO SUGAR REFINING , HAYASHIBARA BIOCHEM LAB
发明人： YUMOTO TAKASHI , MIYAKE TOSHIO
IPC分类号： A23L2/02 , A21D2/36 , A21D13/08 , A23F3/14 , A23L1/30 , A23L2/00 , A23L2/60 , A23L5/41 , A23L27/00 , A23L27/30 , A61K47/10 , A61K47/26 , A61K47/42 , A61K47/46 , A23L1/22 , A23L1/236 , A23L1/272
摘要： PROBLEM TO BE SOLVED: To provide an oral material containing a high-sweetness sweetener, such as a food/drink, crude drug-containing food/drink or dentifrice, ameliorated in bitterness and aftersweetness, and increased in sweetness body in the case of containing a sugar alcohol. SOLUTION: This oral material such as a citrus drink, vegetable drink, tea drink, crude drug-containing food/drink, coffee, cacao product or dentifrice, improved in taste, is obtained by incorporating sweetener(s) which is (are) prepared by formulating the high-sweetness sweetener and/or sugar alcohol with enzyme-treated ginkgo leaves extract. This oral material is ameliorated in grassy smell, bitterness and astringency and prevented from oxidation and color fading; wherein the high-sweetness sweetener is preferably at least one of sucralose, asesulfame K, aspartame, stevia, enzyme-treated stevia and glycyrrhizin. COPYRIGHT: (C)2003,JPO

3. 发明专利

JPH10323196A PRODUCTION OF ALPHA-MONOGLUCOSYLHESPERIDIN HIGH-CONTENT SUBSTANCE 失效
公开(公告)号：JPH10323196A
公开(公告)日：1998-12-08
申请号：JP6339698
申请日：1998-03-13
申请人： HAYASHIBARA BIOCHEM LAB , TOYO SUGAR REFINING
发明人： MIYAKE TOSHIO , YUMOTO TAKASHI
IPC分类号： C12P19/60 , A61K8/60 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P3/02 , A61P9/14 , C07H17/07
摘要： PROBLEM TO BE SOLVED: To easily obtain the subject compound that is useful in pharmacuticals or cosmetics by treating a solution containing α-glucosylhesperidin and hesperidin with glucoamylase and α-L-rhamnosidase and separating the product by precipitation. SOLUTION: Glucoamylase and α-L-rhamnosidase are simultaneously or in turn, at first either of them, added to a solution containing α-glucohesperidin represented by formula I (G is glucose; n is 1-20) and hesperidin thereby allowing them to react each other. Then, the reaction mixture is precipitated in a lower alcohol to separate a substance containing the α-monoglucosylhesperidin in high content. This substance contains more than 85 wt.% of α- monoglucosylhesperidin represented by formula II and scarcely includes hesperidin, β-monoglucosylhesperetin, hesperetin and the like thereby readily obtaining the objective substance of high content of α-monoglucosylhesperidin that is markedly excellent in solubility in water.

4. 发明专利

JPH1070994A ENZYME-TREATED HESPERIDIN AND ITS PRODUCTION AND USAGE 失效
公开(公告)号：JPH1070994A
公开(公告)日：1998-03-17
申请号：JP10427297
申请日：1997-04-22
申请人： HAYASHIBARA BIOCHEM LAB , TOYO SUGAR REFINING
发明人： MIYAKE TOSHIO , YUMOTO TAKASHI
IPC分类号： A23L2/02 , A23B7/154 , A23L1/275 , A23L2/44 , A23L2/58 , A23L2/70 , A23L3/3544 , A23L5/41 , C07H17/07 , C09B67/00 , C12P19/14 , C12P19/60
摘要： PROBLEM TO BE SOLVED: To obtain the subject compound high in solubility to water, and useful for preventing canned mandarin oranges from getting cloudy and natural coloring matter from discoloration, by making α-L-rhamnosidase act on a solution containing α-glucosylhesperidin and hesperidin. SOLUTION: This enzyme-treated hesperidin high in solubility to water, not getting cloudy even after preserved for a long period and useful for preventing canned mandarin oranges from getting cloudy and natural coloring matter from discoloration is obtained by making an α-L-rhamnosidase activity- bearing exogenous enzyme (e.g. hesperidinase) on a solution containing α- glucosylhesperidin of formula I and hesperidin of formula II to convert the hesperidin to β-monoglucosylhesperetin. This enzyme-treated hesperidin contains the α-glucosylhesperidin,

5. 发明专利

JP2002199896A 3"-alpha-MONOGLYCOSYLNARINGIN CONTAINING COMPOSITION, METHOD FOR PRODUCING THE SAME AND USE THEREOF 失效
公开(公告)号：JP2002199896A
公开(公告)日：2002-07-16
申请号：JP2001160817
申请日：2001-05-29
申请人： HAYASHIBARA BIOCHEM LAB , TOYO SUGAR REFINING
发明人： MIYAKE TOSHIO , YUMOTO TAKASHI
IPC分类号： A23L33/15 , A23L3/3562 , A23L27/00 , A23L27/20 , A61K8/60 , A61K47/26 , C12P19/18 , A23L1/22 , A23L1/226 , A23L1/302 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To obtain a composition which has a high content of 3"-α- monoglycosylnaringin and improved characteristics of naringin such as an antioxidant, bitterness, water solubility, cloudiness causing of naringin and is added to a food and a beverage, a medicine, a cosmetic, and used. SOLUTION: This 3"-α-monoglycosylnaringin-containing composition comprises >=60 wt.% of 3"-α-monoglycosylnaringin in the total amount of naringenin glycoside. Preferably the 3"-α-monoglycosylnaringin-containing composition comprises 10 wt.% to 30 wt.% of naringin based on the naringenin glycoside and

6. 发明专利

JP2007039349A HESPERETIN-7-β-MALTOSIDE AND METHOD FOR PRODUCING THE SAME AND USE THEREOF 有权
标题翻译： HESPERETIN-7-β-MALTOSIDE及其生产方法及其用途
公开(公告)号：JP2007039349A
公开(公告)日：2007-02-15
申请号：JP2005222955
申请日：2005-08-01
申请人： Hayashibara Biochem Lab Inc , Toyo Seito Kk , 東洋精糖株式会社 , 株式会社林原生物化学研究所
发明人： MIYAKE TOSHIO , YUMOTO TAKASHI
IPC分类号： C07H17/07 , A23L33/15 , A61K8/60 , A61K47/26 , C12P19/44
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a hesperetin-7-β-maltoside and to provide uses thereof. SOLUTION: The method for producing the hesperetin-7-β-maltoside is characterized as follows. Hesperidin is reacted with an enzyme having an α-1,6-rhamnosidase activity to remove rhamnose. The resultant 7-β-D-monoglucosyl hesperetin is reacted with a glycosyltransferase in the presence of starch or dextrin to add one or more α-D-glucoses. A method for producing a hesperetin glycoside composition containing the hesperetin-7-β-maltoside is characterized as follows. The resultant addition product is reacted with a hydrolase to reduce the average number of added glucoses. Thereby, the average number of added glucoses is regulated to 1.5-3.0 based on the 7-β-D-monoglucosyl hesperetin. A method for improving the water solubility of a sparingly water-soluble substance comprises making the sparingly water-soluble substance selected from the hesperidin, the 7-β-D-monoglucosyl hesperetin, hesperetin, rutin, naringin and isoflavone coexist with the hesperetin-7-β-maltoside. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供一种制备橙皮素-7-β-麦芽糖苷的方法并提供其用途。解决方案：产生橙皮素-7-β-麦芽糖苷的方法的特征如下。橙皮苷与具有α-1-1 - 鼠李糖苷酶活性的酶反应以除去鼠李糖。在淀粉或糊精的存在下，所得的7-β-D-单葡萄糖基橙皮素与糖基转移酶反应以加入一种或多种α-D-葡萄糖。含有橙皮素-7-β-麦芽糖苷的橙皮素糖苷组合物的制造方法的特征如下。所得加成产物与水解酶反应以减少平均加入的葡萄糖数。因此，基于7-β-D-单糖基橙皮素将平均加入的葡萄糖数量调节至1.5-3.0。提高微溶水性物质的水溶性的方法包括制备选自橙皮苷，7-β-D-单糖基橙皮素，橙皮素，芦丁，柚皮苷和异黄酮的少量水溶性物质与橙皮素-7 -β-麦芽糖。版权所有（C）2007，JPO＆INPIT

7. 发明专利

JP2003073279A Oral nutritional supplement containing flavonoid glycoside having immediate effect and persistency 有权
标题翻译：含有具有立即效果和持久性的氟氯氰菊酯的口服营养补充剂
公开(公告)号：JP2003073279A
公开(公告)日：2003-03-12
申请号：JP2001264448
申请日：2001-08-31
申请人： Hayashibara Biochem Lab Inc , Toyo Seito Kk , 東洋精糖株式会社 , 株式会社林原生物化学研究所
发明人： FUJITA RIEISHI , SHIMOI KAYOKO , KINAE NAOHIDE , SATO HIDEO , YUMOTO TAKASHI , MIYAKE TOSHIO
IPC分类号： A23L1/30 , A61K31/352 , A61K31/7048 , A61P3/02
摘要： PROBLEM TO BE SOLVED: To provide an oral nutritional supplement containing a water-soluble quercetin glycoside or a water-soluble hesperetin glycoside by which both of immediate effect and persistency of rutins or hesperidins are attained after oral ingestion. SOLUTION: This oral nutritional supplement containing the water-soluble quercetin glycoside or the water-soluble hesperetin glycoside comprises monoglucosylrutin and isoqueritrin, or α-monoglucosylhesperidin and β- monogluocosylhesperetin, and as necessary rutin or hesperidin in a molar ratio of 1: (0.1 to 0.4):(0.001 to 0.4). In quercetin (or hesperetin) conjugate, a ratio C8 /C0.5 of blood concentration C8 after 8 hr of oral ingestion to blood concentration C0.5 after 0.5 hr of oral ingestion is kept within the range of 0.2-0.9.
摘要翻译：要解决的问题：提供一种含有水溶性槲皮素糖苷或水溶性橙皮苷糖苷的口服营养补充剂，其在口服摄取后可以获得芦丁或橙皮苷的立即作用和持续性。解决方案：含有水溶性槲皮素糖苷或水溶性橙皮素糖苷的口服营养补充剂含有单葡糖基润蛋白和异喹啉酮，或α-单葡糖苷酶和β-单葡糖苷酶，根据需要，芦丁或橙皮苷的摩尔比为1：（0.1〜 0.4）:( 0.001〜0.4）。在槲皮素（或橙皮素）缀合物中，口服摄入8小时后的血液浓度C8的比例C8 / C0.5与口服摄入0.5小时后的血液浓度C0.5保持在0.2-0.9的范围内。

8. 发明专利

JP2002045145A SWEETENER COMPOSITION AND METHOD FOR PRODUCING THE SAME 失效
公开(公告)号：JP2002045145A
公开(公告)日：2002-02-12
申请号：JP2000235148
申请日：2000-08-03
申请人： TOYO SUGAR REFINING
发明人： YUMOTO TAKASHI , IWAMOTO YUTAKA
IPC分类号： A23L27/00 , A23L1/22
摘要： PROBLEM TO BE SOLVED: To provide a sweetener composition reduced in bitterness and improved in taste, and to provide a method for producing the sweetener composition. SOLUTION: This sweetener composition is a stevia extract not subjected to crystallization, containing >=2 pts.wt. of dulcoside A based on a total of 100 pts.wt. of stevioside, rebaudioside A, rebaudioside C and dulcoside A in a β-glucosylsteviol in the stevia extract. The other objective method for producing the composition is provided. It is desirable for other versions of the composition to be obtained through the following process: making α-1,2-rhamnosidase act on a stevia extract subjected to no crystallization, hydrolyzing a rhamnose site of a dulcoside A to form rubusoside, and optionally, making α- glucosyltransferase act on the rubusoside to form an α-glucosylsteviol glycoside, and optionally, reducing the number of glucosyl groups added to the α- glucosylsteviol glycoside via α-1, 4 linkage to

9. 发明专利

JP2001158796A METHOD FOR PRODUCING ALPHA-GLUCOSYLDIOSMIN AND FLAVONOID COMPOSITION 失效
公开(公告)号：JP2001158796A
公开(公告)日：2001-06-12
申请号：JP34033899
申请日：1999-11-30
申请人： TOYO SUGAR REFINING
发明人： YUMOTO TAKASHI , SATO HIDEO , AIBA YOICHI
IPC分类号： C07H17/07 , A61K31/7042 , A61K31/7048 , A61P7/10 , A61P9/12 , A61P35/00
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a large amount of water-soluble α-glucosyldiosmin in high efficiency at a low cost and provide a flavonoid composition produced by the method. SOLUTION: The method for the production of α-glucosyldiosmin comprises the oxidative dehydrogenation reaction of α-glucosylhesperidin. The reaction is preferably carried out in a solvent in the presence of iodine preferably under acidic condition. The solvent is preferably dimethyl sulfoxide (DMSO). The acidic condition is preferably attained by the addition of sulfuric acid to the reaction system. The flavonoid composition contains 10-1,000 pts.wt. of α- glucosyldiosmin based on 100 pts.wt. of α-glucosylhesperidin.

10. 发明专利

JP2002034501A SWEETENING COMPOSITION AND LOW CALORIE DRINKS 失效
公开(公告)号：JP2002034501A
公开(公告)日：2002-02-05
申请号：JP2000218787
申请日：2000-07-19
申请人： TOYO SUGAR REFINING
发明人： YUMOTO TAKASHI , SATO HIDEO , AIBA YOICHI
IPC分类号： A23L2/02 , A23L2/00 , A23L2/60 , A23L27/00 , A23L27/30 , A23L27/40 , A23L1/22 , A23L1/236 , A23L1/237
摘要： PROBLEM TO BE SOLVED: To provide a sweetening composition having deep sweetness, brisk sweetness and almost free from nasty taste. SOLUTION: This sweetening composition includes 100 pts.wt. of at least one synthetic sweetening having high sweetness selected from a group comprising Acesulfame K, Sucralose, Aspartame and 10-900 pts.wt. of an α-glucosylated extract of stevia having average 1.0-2.4 glucosyl groups added to β-glucosyl- steviol included in the extract of stevia in an α-1,4 bonding. The preferable content of the β-glucosyl-steviol is less than 10 pts. wt.per 100 pts.wt. of the α-glucosylated the extract of stevia. Sodium chloride and an enzyme treated naringin are preferably included. This invention also includes low calorie drinks formulated with a fruits juice to the sweetening composition and the drinks preferably includes the enzyme treated naringin.

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