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1. 发明专利

JP2006290802A New diagnostic method for constitution and counseling method using the diagnosis 审中-公开
标题翻译：使用诊断的组织和辅助方法的新诊断方法
公开(公告)号：JP2006290802A
公开(公告)日：2006-10-26
申请号：JP2005113972
申请日：2005-04-11
申请人： Kanebo Cosmetics Inc , Kanebo Ltd , カネボウ株式会社 , 株式会社カネボウ化粧品
发明人： TANNO OSAMU , SUMIDA YASUSHI , TAKEDA REIKO , MATSUMOTO MASAYUKI , INOUE SHINTARO , YOMODA SATOSHI , TAKAHASHI RYUJI
IPC分类号： A61K45/06 , A23L1/30 , A61B19/00 , A61K8/96 , A61K36/00 , A61K36/18 , A61K36/23 , A61K36/28 , A61K36/42 , A61K36/48 , A61K36/53 , A61K36/71 , A61K36/73 , A61K36/75 , A61K36/899 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a composition for improving constitutional balance by easily judging the constitutional balance of an individual and supplementing the balance, more particularly, a constitutional balance improving composition composed of (a) a congenital constitution supplementing component and (b) an acquired constitution supplementing molecular species and provide a method for counseling the constitutional balance improvement by using the composition. SOLUTION: The constitutional balance improving composition contains (a) a congenital constitution supplementing component composed of an outer constitution supplementing component or an inner constitution supplementing component and (b) one kind of acquired constitution supplementing component selected from hot wet constitution supplementing component, hot dry constitution supplementing component, cold wet constitution supplementing component and cold dry constitution supplementing component. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：通过容易地判断个人的宪法平衡和补充余额来提供一种用于提高宪法平衡的组合物，更具体地说，提供一种由（a）先天性构成补充成分和（ b）补充分子物种的获得性宪法，并提供一种通过使用组合物来辅导宪法平衡改进的方法。解决方案：构成平衡改善组合物包含（a）由外部构成补充成分或内部构成补充成分构成的先天性构成补充成分和（b）从热湿补充成分中选择的一种获得性构成补充成分热干燥构成补充成分，冷湿构成补充成分和冷干构成补充成分。版权所有（C）2007，JPO＆INPIT

2. 发明专利

JP2003012684A New galactosyl ceramide analog and use thereof 有权
标题翻译：新型胶体蛋白模拟物及其用途
公开(公告)号：JP2003012684A
公开(公告)日：2003-01-15
申请号：JP2001196016
申请日：2001-06-28
申请人： Kanebo Ltd , カネボウ株式会社
发明人： UEMATSU SUESHIGE , NAKAJIMA FUMIO , YOSHIDA MASAHIRO , FUKUNAGA KYOKO , HARA MARIKO , INOUE SHINTARO , NISHIMURA SHINICHIRO
IPC分类号： C07H15/04 , A61K8/00 , A61K8/02 , A61K8/60 , A61K8/68 , A61K31/7028 , A61L15/40 , A61P17/16 , A61P43/00 , A61Q19/00 , C07H15/14 , A61K7/00 , A61K7/48
CPC分类号： C07H15/14 , A61K8/602 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide an easily available β-glucocerebrosidase activation agent and a skin care preparation effective for improving the formation of a cuticle layer transmission barrier by the activation of β-glucocerebrosidase and accordingly expectable to have an effect for ameliorating roughened skin.
SOLUTION: The galactosylceramide analog is expressed by general formula (1) or (2) (X and Y are each S or O; R
1 and R
2 are each a 9-35C alkyl or alkenyl; and R
3 is a 2-30C alkyl or alkenyl).
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：提供一种容易获得的β-葡糖脑苷脂酶活化剂和一种通过β-葡萄糖脑苷脂酶活化来改善角质层传播阻挡层形成的皮肤护理制剂，因此预期具有改善粗糙皮肤的作用。解决方案：半乳糖神经酰胺类似物由通式（1）或（2）表示（X和Y各自为S或O; R 1和R 2各自为9-35C烷基或烯基; R 3为 >是2-30C烷基或烯基）。

3. 发明专利

JP2003306409A Terphenyl derivative and application 有权
标题翻译：泰勒衍生物和应用
公开(公告)号：JP2003306409A
公开(公告)日：2003-10-28
申请号：JP2003148687
申请日：2003-05-27
申请人： Kanebo Ltd , カネボウ株式会社
发明人： SAKAI SHINGO , SAYO TETSUYA , INOUE SHINTARO , KAWAGISHI HIROKAZU , MURAKAMI HIROAKI
IPC分类号： A61K8/49 , A61K8/00 , A61K8/02 , A61K8/06 , A61K31/343 , A61P17/16 , A61Q11/00 , A61K7/00 , A61K7/16
摘要： PROBLEM TO BE SOLVED: To obtain a hyaluronic acid decomposition inhibitor and a therapeutic agent, a rough skin or dry skin inhibitor having preventive and therapeutic effect to diseases more physiologically accelerated in decomposition of hyaluronic acid than that in normal state such as xeroderma, psoriasis, rough skin, dry skin and the like and provide a cosmetic effective for preventing wrinkles, improving flexibility and so forth.
SOLUTION: The cosmetic, the hyaluronic acid decomposition inhibitor, the rough skin or dry skin inhibitor and a therapeutic agent for anomalous decomposition of hyaluronic acid contain an extract of Boletopsis leucomelas or a terphenyl derivative expressed by formula 1 (wherein R
1 to R
4 express each OH or acetyl).
COPYRIGHT: (C)2004,JPO
摘要翻译：待解决的问题：为了获得透明质酸分解抑制剂和治疗剂，对透明质酸分解中比在正常状态如透皮质中分解更加生理上加速的疾病具有预防和治疗效果的粗糙皮肤或干性皮肤抑制剂牛皮癣，皮肤粗糙，皮肤干燥等，并提供有效防止皱纹，提高柔韧性等的化妆品。解决方案：化妆品，透明质酸分解抑制剂，粗糙皮肤或干性皮肤抑制剂和用于透明质酸异常分解的治疗剂含有Boletopsis leucomelas或由式1表示的三联苯衍生物的提取物（其中R 1 至R SB 表示每个OH或乙酰基）。版权所有（C）2004，JPO

4. 发明专利

JP2002029979A HISTAMINE H2 RECEPTOR ANTAGONISTIC AGENT AND SKIN CARE PREPARATION 失效
公开(公告)号：JP2002029979A
公开(公告)日：2002-01-29
申请号：JP2000210881
申请日：2000-07-12
申请人： KANEBO LTD
发明人： TAKAHASHI YASUTO , YAMAGUCHI SAYURI , INOUE SHINTARO , YOSHIDA MASAKI
IPC分类号： A61K8/96 , A61K8/00 , A61K8/97 , A61K36/18 , A61K36/73 , A61P1/04 , A61P17/00 , A61P43/00 , A61Q19/00 , A61Q19/02 , A61K35/78 , A61K7/00 , A61K7/48
摘要： PROBLEM TO BE SOLVED: To provide a histamine H2 receptor antagonistic agent highly safe to the human body and capable of specifically and effectively inhibiting gastric acid secretion and melanogenesis due to the excitation of histamine released in skin inflammation caused by ultraviolet radiation or the like. SOLUTION: This histamine H2 receptor antagonistic agent is characterized by comprising, as the active ingredient, an extract from at least one plant selected from the group consisting of white birch, loquat, cranesbill, quina, hamamelis, Cercidiphyllum japonicum, herbaceous peony and eucalyptus.

5. 发明专利

JP2002017203A SKIN AGING ACCELERATION MODEL ANIMAL AND METHOD FOR PRODUCING THE SAME ACCELERATION 失效
公开(公告)号：JP2002017203A
公开(公告)日：2002-01-22
申请号：JP2000203488
申请日：2000-07-05
申请人： KANEBO LTD
发明人： SAKAI SHINGO , SAYO TETSUYA , OZAWA NAHOKO , INOUE SHINTARO , TAGAMI HACHIRO
IPC分类号： A01K67/027 , A61B5/00
摘要： PROBLEM TO BE SOLVED: To obtain a hairless model animal for skin aging acceleration, suitable for ready measurement of skin properties in a short period of time. SOLUTION: This method for preparing a skin aging acceleration model animal is achieved by administering streptozotocin or alloxan to a hairless animal.

6. 发明专利

JPH101410A SKIN COSMETIC 失效
公开(公告)号：JPH101410A
公开(公告)日：1998-01-06
申请号：JP17418996
申请日：1996-06-12
申请人： KANEBO LTD
发明人： MATSUI TADASHI , TOKUNAGA KAZUNOBU , KITAMURA NOBUO , INOUE SHINTARO
IPC分类号： A61K8/19 , A61K8/00 , A61K8/25 , A61K8/30 , A61K8/41 , A61K8/44 , A61K8/49 , A61K8/64 , A61K8/68 , A61K8/96 , A61Q19/00 , A61Q19/08 , A61K7/00 , A61K7/48
摘要： PROBLEM TO BE SOLVED: To prepare the subject cosmetic containing the fibroblast collagen production-stimulating substance and an epidermal cell ceramide synthesis- stimulating substance and excellent in a skin ageing-preventing effect. SOLUTION: This skin cosmetic contains (A) a fibroblast collagen production- stimulating substance and (B)0 an epidermal cell ceramide synthesis-stimulating substance. The component A preferably comprises one or more kinds of compounds selected from the group consisting of serine (derivatives) and ethanolamine (derivatives) or one or more kinds of substances selected from the group consisting of a silk fiber sulfuric acid hydrolyzate having a mol.wt. of

7. 发明专利

JPH09157175A GERMICIDAL AGENT 失效
公开(公告)号：JPH09157175A
公开(公告)日：1997-06-17
申请号：JP28299196
申请日：1996-10-03
申请人： KANEBO LTD
发明人： INOUE YOSHIFUMI , INOUE SHINTARO , TONOMURA MIKIO
IPC分类号： A61L2/16 , A01N59/12 , A01N59/16 , A61K33/18 , A61K33/32 , A61P17/00
摘要： PROBLEM TO BE SOLVED: To obtain the subject germicidal agent little in foaming property, easily removable by washing, having little unpleasant smell attributable to iodine molecule in a practical working range of concentration and excellent in germicidal effect by adjusting the pH of an acidic aqueous solution containing both iodide ion and manganese ion. SOLUTION: This germicidal agent is obtained by preparing an acidic aqueous solution containing (A) iodide ion and (B) manganese ion, and adding an alkali (e.g. sodium hydroxide) to the aqueous solution to adjust pH to 2.5-7.0. Further, it is preferable that the weight ratio of the component B to the component A is 10:1 to 1:30, and the component B is manganese sulfate or manganese chloride and the component A is an alkali metal salt, e.g. potassium iodide or sodium iodide.

8. 发明专利

JPH08225447A HYALURONIC ACID DECOMPOSITION INHIBITOR AND THERAPEUTIC AGENT FOR DISEASE INVOLVED IN HYALURONIC ACID DECOMPOSITION 失效
公开(公告)号：JPH08225447A
公开(公告)日：1996-09-03
申请号：JP34448095
申请日：1995-12-04
申请人： KANEBO LTD
发明人： SAKAI SHINGO , SAYO TETSUYA , KAMIO MICHIKO , INOUE SHINTARO
IPC分类号： A61K8/49 , A61K8/00 , A61K8/30 , A61K8/41 , A61K31/135 , A61K31/44 , A61K31/495 , A61K31/54 , A61P1/02 , A61P1/16 , A61P7/00 , A61P9/10 , A61P13/02 , A61P15/00 , A61P17/00 , A61P29/00 , A61P35/00 , A61P43/00 , A61Q11/00 , A61Q19/00 , A61Q19/10 , A61K7/00 , A61K7/16 , A61K7/48 , A61K7/50
摘要： PURPOSE: To provide an inhibitor inhibiting hyaluronic acid decomposition through acting on the cells present in human connective tissue, and to provide a therapeutic agent containing this inhibitor. CONSTITUTION: This hyaluronic acid decomposition inhibitor containing, as active ingredient, a histamine H1 -antagonist (salt) such as an ethanolamine-type diphenhydramine, ethylenediamine-type pyrilamine or tripelennamine, alkylamine- type chlorpheniramine or brompheniramine, piperazine-type cyclizine, or phenothiazine-type promethazine. The therapeutic agent for diseases involved in hyaluronic acid decomposition contains this inhibitor.

9. 发明专利

JPH06189780A HYALURONIC ACID PRODUCTION PROMOTING AGENT 失效
公开(公告)号：JPH06189780A
公开(公告)日：1994-07-12
申请号：JP17248793
申请日：1993-06-17
申请人： KANEBO LTD
发明人： KODAMA NOBUTSUGU , SHIMADA AKIYOSHI , OISHI YUICHI , SAKAI SHINGO , INOUE SHINTARO
IPC分类号： A61K8/00 , A61K8/30 , A61K8/41 , A61K8/44 , A61K31/195 , A61P17/00 , C12P19/26 , C12R1/91 , A61K7/00
摘要： PURPOSE:To provide the subject agent containing N-methyl-L-serine, ethanolamine, N-methylethanolamine or their salts, etc., acting on human- originated fibroblast cell and promoting the depressed hyaluronic acid productivity. CONSTITUTION:The objective hyaluronic acid production promoting agent having the form of cosmetic, bathing agent, pharmaceuticals, etc., acting on human- originated fibroblast cell and capable of promoting the hyaluronic acid productivity is produced by compounding one or more compounds selected from N-methyl- L-serine, ethanolamine, N-methylethanolamine and their salts in an amount of 0.001-3W/W% for N-methyl-L-serine or its salt, 0.001-1W/W% for ethanolamine or its salt and 0.00001-0.05 W/W% for N-methylethanolamine or its salt to an excipient or assistant such as petrolatum, squalane, higher alcohol, higher fatty acid lower alkyl ester and polyhydric alcohol, a surfactant such as polyethylene alkyl ether phosphate, etc.

10. 发明专利

JPH06183990A COLLAGENASE ACTIVITY INHIBITOR 失效
公开(公告)号：JPH06183990A
公开(公告)日：1994-07-05
申请号：JP27517292
申请日：1992-09-18
申请人： KANEBO LTD
发明人： OTA HIDEKO , INOUE SHINTARO , SAITO YUJI
IPC分类号： A61K8/00 , A61K8/97 , A61K9/20 , A61K9/68 , A61K36/53 , A61P1/02 , A61P43/00 , A61Q11/00 , A61K35/78 , A61K7/16
摘要： PURPOSE:To obtain the subject medicine suitable as a product for oral cavity such as food, gum, mouth washing solution, dentifrice, effective for preventing and treating periodontal disease, having inhibitory activity against collagenase derived from human, comprising essence of Schizonepeta-Herb or essence of Mentha-Herb as an active ingredient. CONSTITUTION:Schizonepeta-Herb is cut and mixed with water, heated, extracted at 100 deg.C for one hours under reflux, the extracted solution is filtered, concentrated under reduced pressure and freeze-dried to prepare dried essence powder of Schizonepeta-Herb or cut Mentha-Herb is extracted, filtered, concentrated under reduced pressure and freeze-dried by the same operation to give dried essence powder of Mentha-Herb. The dried essence powder of Schizonepeta-Herb or Mentha-Herb is blended with polyethylene glycol, silicic anhydride, magnesium stearate, talc, hydroxypropyl cellulose, mannitol, etc., and pharmaceutically manufactured to give the objective collagenase activity inhibitor useful as troche, having inhibitory activity against human-derived collagenase, being expected to prevent and treat periodontal disease.

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