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1. 发明专利

JPH11246545A TERPHENYL DERIVATIVE AND USE THEREOF 失效
公开(公告)号：JPH11246545A
公开(公告)日：1999-09-14
申请号：JP4949398
申请日：1998-03-02
申请人： KANEBO LTD
发明人： SAKAI SHINGO , SAYO TETSUYA , INOUE SHINTARO , KAWAGISHI HIROKAZU , MURAKAMI HIROAKI
IPC分类号： C07D307/91 , A61K8/00 , A61K8/49 , A61K8/96 , A61K8/97 , A61K31/34 , A61K31/343 , A61K36/07 , A61P17/00 , A61P43/00 , A61Q1/00 , A61Q1/02 , A61Q11/00 , A61Q17/00 , A61Q19/00 , A61Q19/10 , A61K7/00 , A61K7/48 , A61K35/84
摘要： PROBLEM TO BE SOLVED: To obtain a cosmetic which can be expected to have effects for preventing and treating xeroderma, psoriasis, chapped skin, etc., where the degradation of hyaluronic acid is physiologically exasperated than that in a normal state, by adding the extract of Boletopsis Leucomelas as a component or an active ingredient. SOLUTION: This cosmetic contains an extract of Boletopsis Leucomelas or a terphenyl derivative of the formula (R1 -R4 are each OH or acetyl). The extract is obtained, for example, by immersing the lyophilized and ground product of the fruit bodies of Boletopsis Leucomelas, a mushroom originated from the family Thelephoraceae, in 5-30 times weight of an extraction solvent (especially water, ethanol, methanol or the like) usually at a temp. of 15-50 deg.C for 24 hr to 1 week, and subsequently removing impurities by a filtration method, a centrifugal separation method, etc.

2. 发明专利

JP2002017203A SKIN AGING ACCELERATION MODEL ANIMAL AND METHOD FOR PRODUCING THE SAME ACCELERATION 失效
公开(公告)号：JP2002017203A
公开(公告)日：2002-01-22
申请号：JP2000203488
申请日：2000-07-05
申请人： KANEBO LTD
发明人： SAKAI SHINGO , SAYO TETSUYA , OZAWA NAHOKO , INOUE SHINTARO , TAGAMI HACHIRO
IPC分类号： A01K67/027 , A61B5/00
摘要： PROBLEM TO BE SOLVED: To obtain a hairless model animal for skin aging acceleration, suitable for ready measurement of skin properties in a short period of time. SOLUTION: This method for preparing a skin aging acceleration model animal is achieved by administering streptozotocin or alloxan to a hairless animal.

3. 发明专利

JPH08225447A HYALURONIC ACID DECOMPOSITION INHIBITOR AND THERAPEUTIC AGENT FOR DISEASE INVOLVED IN HYALURONIC ACID DECOMPOSITION 失效
公开(公告)号：JPH08225447A
公开(公告)日：1996-09-03
申请号：JP34448095
申请日：1995-12-04
申请人： KANEBO LTD
发明人： SAKAI SHINGO , SAYO TETSUYA , KAMIO MICHIKO , INOUE SHINTARO
IPC分类号： A61K8/49 , A61K8/00 , A61K8/30 , A61K8/41 , A61K31/135 , A61K31/44 , A61K31/495 , A61K31/54 , A61P1/02 , A61P1/16 , A61P7/00 , A61P9/10 , A61P13/02 , A61P15/00 , A61P17/00 , A61P29/00 , A61P35/00 , A61P43/00 , A61Q11/00 , A61Q19/00 , A61Q19/10 , A61K7/00 , A61K7/16 , A61K7/48 , A61K7/50
摘要： PURPOSE: To provide an inhibitor inhibiting hyaluronic acid decomposition through acting on the cells present in human connective tissue, and to provide a therapeutic agent containing this inhibitor. CONSTITUTION: This hyaluronic acid decomposition inhibitor containing, as active ingredient, a histamine H1 -antagonist (salt) such as an ethanolamine-type diphenhydramine, ethylenediamine-type pyrilamine or tripelennamine, alkylamine- type chlorpheniramine or brompheniramine, piperazine-type cyclizine, or phenothiazine-type promethazine. The therapeutic agent for diseases involved in hyaluronic acid decomposition contains this inhibitor.

4. 发明专利

JP2003306409A Terphenyl derivative and application 有权
标题翻译：泰勒衍生物和应用
公开(公告)号：JP2003306409A
公开(公告)日：2003-10-28
申请号：JP2003148687
申请日：2003-05-27
申请人： Kanebo Ltd , カネボウ株式会社
发明人： SAKAI SHINGO , SAYO TETSUYA , INOUE SHINTARO , KAWAGISHI HIROKAZU , MURAKAMI HIROAKI
IPC分类号： A61K8/49 , A61K8/00 , A61K8/02 , A61K8/06 , A61K31/343 , A61P17/16 , A61Q11/00 , A61K7/00 , A61K7/16
摘要： PROBLEM TO BE SOLVED: To obtain a hyaluronic acid decomposition inhibitor and a therapeutic agent, a rough skin or dry skin inhibitor having preventive and therapeutic effect to diseases more physiologically accelerated in decomposition of hyaluronic acid than that in normal state such as xeroderma, psoriasis, rough skin, dry skin and the like and provide a cosmetic effective for preventing wrinkles, improving flexibility and so forth.
SOLUTION: The cosmetic, the hyaluronic acid decomposition inhibitor, the rough skin or dry skin inhibitor and a therapeutic agent for anomalous decomposition of hyaluronic acid contain an extract of Boletopsis leucomelas or a terphenyl derivative expressed by formula 1 (wherein R
1 to R
4 express each OH or acetyl).
COPYRIGHT: (C)2004,JPO
摘要翻译：待解决的问题：为了获得透明质酸分解抑制剂和治疗剂，对透明质酸分解中比在正常状态如透皮质中分解更加生理上加速的疾病具有预防和治疗效果的粗糙皮肤或干性皮肤抑制剂牛皮癣，皮肤粗糙，皮肤干燥等，并提供有效防止皱纹，提高柔韧性等的化妆品。解决方案：化妆品，透明质酸分解抑制剂，粗糙皮肤或干性皮肤抑制剂和用于透明质酸异常分解的治疗剂含有Boletopsis leucomelas或由式1表示的三联苯衍生物的提取物（其中R 1 至R SB 表示每个OH或乙酰基）。版权所有（C）2004，JPO

5. 发明专利

JP2001002551A AGENT FOR INCREASING HYALURONIC ACID CONTENT OF HORNY LAYER 失效
公开(公告)号：JP2001002551A
公开(公告)日：2001-01-09
申请号：JP17241599
申请日：1999-06-18
申请人： KANEBO LTD
发明人： SAKAI SHINGO , SAYO TETSUYA , YASUDA SUESHIGE , INOUE SHINTARO
IPC分类号： A61K8/00 , A61K8/60 , A61K8/73 , A61K8/96 , A61Q19/00 , A61K7/48 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To obtain the subject agent which can increase the hyaluronic acid content of the horny layer to optimize the water environment and hardness of the horny layer, allows to expect an effect for preventing rough skins and wrinkles, is stable in preparations, and is useful for skin cosmetics, by including N-acetylglucosamine. SOLUTION: This agent for increasing the hyaluronic acid content of a horny layer comprises N-acetylglucosamine. The agent is preferably added to a skin cosmetic preferably in an amount of 0.001 to 10%, especially preferably 0.01 to 5%, based on the total amount of the cosmetic composition. The agent may preferably further be compounded with a polyhydric alcohol such as 1,3-butylene glycol, a vitamin derivative such as an ascorbic acid phosphoric acid ester salt, an anionic surfactant such as N-stearoyl-L-glutamic acid salt, and so on.

6. 发明专利

JPH11106396A ERGOSTEROL GLYCOSIDE DERIVATIVE AND USE 失效
公开(公告)号：JPH11106396A
公开(公告)日：1999-04-20
申请号：JP28440597
申请日：1997-09-30
申请人： KANEBO LTD
发明人： SAKAI SHINGO , SAYO TETSUYA , INOUE SHINTARO , KAMIO MICHIKO , KAWAGISHI HIROKAZU , HOSOKAWA SATOSHI
IPC分类号： C12N9/99 , A61K8/00 , A61K31/575 , A61P17/00 , A61Q11/00 , C07J17/00
摘要： PROBLEM TO BE SOLVED: To obtain the subject new derivative useful for a preventive/ therapeutic agent for diseases observed to have hyaluronic acid abnormal decomposition and decomposition accentuation, an inhibitor against hyaluronic acid decomposition, a preventive for chapped skin and dried skin, a cosmetic, etc., comprising a specific ergosterol glycoside. SOLUTION: This new ergosterol glycoside derivative is shown by the formula, is expected to have preventing and treating effects on diseases followed by abnormal decomposition of hyaluronic acid and gingivitis, xeroderma, chapped skin, dried skin, etc., in which hyaluronic acid decomposition is more aggravated than a physiologically normal state and is useful as a medicine composition directly acting on fibroblast, an inhibitor against hyaluronic acid decomposition, a preventive for chapped skin and dried skin, a cosmetic, etc. The glycoside is obtained by extracting a lyophilized substance of a fruit body of Naemaroloma sublateritium a mushroom derived from the family Strophariaceae with an extraction solvent such as water, methanol, etc., filtering or centrifuging the extraction solution to remove impurities, concentrating the filtrate under reduced pressure, reextracting the concentrate with ethyl acetate and drying the extracted essence by lyophilization, etc.

7. 发明专利

JPH09176037A HYALURONIC ACID DECOMPOSITION-INHIBITING AGENT, COSMETIC, FOOD, MEDICINE COMPOSITION AND MEDICINE FOR TREATING ABNORMALITY HYALURONIC ACID-DECOMPOSING DISEASE 失效
公开(公告)号：JPH09176037A
公开(公告)日：1997-07-08
申请号：JP35392095
申请日：1995-12-27
申请人： KANEBO LTD
发明人： SAYO TETSUYA , YASUDA SUESHIGE , KAMIO MICHIKO , SAKAI SHINGO , INOUE SHINTARO , KAWAGISHI HIROKAZU
IPC分类号： A23L1/30 , A61K8/00 , A61K8/96 , A61K8/97 , A61K36/06 , A61K36/07 , A61P1/02 , A61P17/00 , A61P25/04 , A61P29/00 , A61P31/04 , A61P43/00 , A61Q11/00 , A61Q19/00 , A61Q19/08 , C12N9/99 , A61K35/84 , A61K7/00 , A61K7/48
摘要： PROBLEM TO BE SOLVED: To obtain the above inhibiting agent containing the extract of Naematoloma sublateritium, directly acting on human connective tissue- originated cells to inhibit the decomposition of hyaluronic acid, and useful for the therapy of abnormally hyaluronic acid-decomposing diseases, etc. SOLUTION: This agent for inhibiting the decomposition of hyaluronic acid contains the extract of Naematoloma sublateritium as an active ingredient. The extract is preferably obtained by extracting the Naematoloma sublateritium belonging to the genus Naematoloma in the family Stropharia with ethanol or its mixed solvents as an extraction solvent. The extract is preferably added to a cosmetic, food or medicine composition in a dry amount of 0.0001-0.5wt.%, preferably 0.001-0.1wt.%, based on the whole amount of the composition.

8. 发明专利

JPH1180004A INHIBITOR FOR DECOMPOSITION OF HYALURONIC ACID, AGENT FOR IMPROVING AND TREATING DISEASE CAUSING ABNORMAL DECOMPOSITION OF HYALURONIC ACID AND AGENT FOR PREVENTING GINGIVITIS AND AGENT FOR PREVENTING DRY SKIN OR ROUGH SKIN 失效
公开(公告)号：JPH1180004A
公开(公告)日：1999-03-23
申请号：JP25289497
申请日：1997-09-01
申请人： KANEBO LTD
发明人： SAKAI SHINGO , SAYO TETSUYA , INOUE SHINTARO
IPC分类号： A61K9/08 , A61K8/00 , A61K8/72 , A61K8/73 , A61K9/20 , A61K9/48 , A61K31/715 , A61P1/02 , A61P1/16 , A61P9/10 , A61P17/00 , A61P29/00 , A61P35/00 , A61P43/00 , A61Q19/10 , C08B37/10 , A61K31/725
摘要： PROBLEM TO BE SOLVED: To obtain an inhibitor for decomposition of hyaluronic acid, acting on a cell which exists in human binding tissue and inhibiting decomposition of hyaluronic acid and useful as an agent for improving and treating diseases causing abnormal decomposition of hyaluronic acid such as rheumatism, osteoarthritis and malignant tumor by including heparin. SOLUTION: This inhibitor contains heparin and/or its salt extracted according to ordinary method from intestine or the like of pig or the like, preferably in an amount of 0.001-5 g based on 100 g total amount of medicine. Daily doses of the compound is preferably 1-10 g as total amount of heparin and its salt in the case of oral administration and preferably 0.1-5 g in the case of parenteral administration. The medicine is useful as an agent for improving and treating diseases causing abnormal decomposition of hyaluronic acid, e.g. hepatitis, gingivitis and fibrosis.

9. 发明专利

JPH08163983A HYARULONIC ACID PRODUCTION PROMOTER 失效
公开(公告)号：JPH08163983A
公开(公告)日：1996-06-25
申请号：JP33399394
申请日：1994-12-15
申请人： KANEBO LTD
发明人： SAYO TETSUYA , SAKAI SHINGO , INOUE SHINTARO
IPC分类号： C12N9/50 , A61K36/06 , C12P19/26
摘要： PURPOSE: To obtain a hyarulonic acid production promoter containing, as active ingredient, yeast extract, capable of promoting the hyarulonic acid productivity in human skin fibroblast, thus useful for preventing skin aging and treating such diseases as to involve the abnormal decomposition of hyarulonic acid, and safe to the human body. CONSTITUTION: A mixture comprising cetanol, lipophilic monostearic acid glycerin-polyoxyethylene cetyl ether, liquid paraffin, methylpolysiloxane, etc., is first prepared by homogeneously mixing these components at 80 deg.C, and butyl p-oxybenzoate is added to and dissolved in the mixture. Separately, a second mixture comprising sodium N-stearoyl-L-glutamate, dipropylene glycol and water is prepared by homogeneously mixing these components at 80 deg.C, and a yeast extract is added to and dissolved in this mixture. Subsequently, the resultant two solutions are mutually mixed and then cooled to 30 deg.C under through agitation, thus obtaining the objective promoter having the above- mentioned advantages.

10. 发明专利

JPH08157321A COSMETIC 失效
公开(公告)号：JPH08157321A
公开(公告)日：1996-06-18
申请号：JP33011494
申请日：1994-12-05
申请人： KANEBO LTD
发明人： SAYO TETSUYA , SAKAI SHINGO , KAMIO MICHIKO , INOUE SHINTARO
IPC分类号： A61K8/30 , A61K8/00 , A61K8/41 , A61K8/49 , A61K31/13 , A61K31/44 , A61K31/495 , A61K31/54 , A61K45/00 , A61P17/00 , A61P43/00 , A61Q19/00 , A61K7/00 , A61K7/48
摘要： PURPOSE: To obtain a cosmetic comprising histamine H1 -antagonist(s) or salt(s) thereof, having inhibitory action on the decomposition of hyarulonic acid, thus effective for remedying the chapped skin and dried skin. CONSTITUTION: This cosmetic contains at least one kind of histamine H1 - antagonist or salt thereof, having inhibitory action on the decomposition of hyarulonic acid important for skin dampishness and firmness, therefore, can remedy chapped or dried skin. The histamine H1 -antagonist is esp. pref. chlorpheniramine, pyrilamine, diphenhydramine, tripelennamine, brompheniramine, cyclizine, or promethazine. The salt thereof is e.g. a hydrochloride, hydrobromide, sulfate, acetate, fumarate, maleate, tartrate. This cosmetic can take such a form as gel, cream, spray, cataplasm, lotion, pack, milky lotion, or powder.

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