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1. 发明专利

JP2010241832A Adiponectin decrease inhibitor 审中-公开
标题翻译： ADIPONECTIN降解抑制剂
公开(公告)号：JP2010241832A
公开(公告)日：2010-10-28
申请号：JP2010162948
申请日：2010-07-20
申请人： Kao Corp , 花王株式会社
发明人： OSAKI NORIKO , MATSUO NOBORU , TOKIMITSU ICHIRO , MEGURO SHINICHI
IPC分类号： A61K31/22 , A61P1/16 , A61P3/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P29/00 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide medicines or foods which inhibit the decrease of adiponectin in the blood and exhibit a liver fibrillation-inhibiting effect.
SOLUTION: The adiponectin decrease inhibitors, which contain a diacylglycerol as an effective ingredient, improve hepatic function and inhibit liver fibrillation effectively.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供抑制血液中脂连蛋白降低的药物或食品，并具有肝纤维化抑制作用。
解决方案：含有二酰基甘油作为有效成分的脂联素降低抑制剂可有效改善肝功能，抑制肝纤维颤动。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2008013460A Improver for endurance 有权
标题翻译：改善耐力
公开(公告)号：JP2008013460A
公开(公告)日：2008-01-24
申请号：JP2006184447
申请日：2006-07-04
申请人： Kao Corp , 花王株式会社
发明人： HARAMIZU SATOSHI , FUKUOKA DAISUKE , SHIMOTOYOTOME REI , MEGURO SHINICHI , MURASE TAKATOSHI
IPC分类号： A61K31/718 , A23L1/30 , A61P3/02 , A61P3/06
摘要： PROBLEM TO BE SOLVED: To provide a pharmaceutical, a quasi drug and a food using materials having excellent endurance improving effect, anti-fatigue action, etc., a high safety and a wide coverage. SOLUTION: The invention relates to the improver for endurance, anti-fatigue agent, lipid combustion promoter comprising hydroxypropylated starch as an active ingredient. The invention relates to the food characterized by comprising the hydroxypropylated starch and having the endurance improving effect, and indicating that the food is used for improving endurance. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供具有优异的耐久性改善效果，抗疲劳作用等的药物，准药物和食品，具有高安全性和广泛的覆盖范围。解决方案：本发明涉及包含羟丙基淀粉作为活性成分的耐久性，抗疲劳剂，脂质燃烧促进剂的改良剂。本发明涉及包含羟丙基淀粉并具有耐久性改善效果的食品，并表明该食品用于提高耐力。版权所有（C）2008，JPO＆INPIT

3. 发明专利

JP2002326932A BODY FAT COMBUSTION PROMOTER 审中-公开
公开(公告)号：JP2002326932A
公开(公告)日：2002-11-15
申请号：JP2001304244
申请日：2001-09-28
申请人： KAO CORP
发明人： MURASE TAKATOSHI , WATANABE HIROYUKI , OSAKI NORIKO , MEGURO SHINICHI , HASE TADASHI , TOKIMITSU ICHIRO
IPC分类号： A23L2/52 , A23F3/30 , A23L1/30 , A61K31/353 , A61P1/16 , A61P3/04 , A61P43/00 , C07D311/62
摘要： PROBLEM TO BE SOLVED: To provide a body fat combustion promoter, capable of promoting combustion of deposit body fat, promoting combustion of alimentary fat and promoting expression of liver β-oxidation gene by taking non-polymeric catechins and useful in health maintenance of body. SOLUTION: This deposit body fat combustion promoter comprises non- polymeric catechins.

4. 发明专利

JPH09278732A AMIDE DERIVATIVE AND AGENT COMPOSITION FOR EXTERNAL USE CONTAINING THE SAME 失效
公开(公告)号：JPH09278732A
公开(公告)日：1997-10-28
申请号：JP23643196
申请日：1996-09-06
申请人： KAO CORP
发明人： SUGAI YOSHIYA , YOSHINO KOJI , YAMAMURO AKIRA , ARAI YOICHI , MEGURO SHINICHI
IPC分类号： A61K8/30 , A61K8/00 , A61K8/42 , A61Q19/00 , C07C235/08 , C07C237/22 , A61K7/00 , A61K7/48
摘要： PROBLEM TO BE SOLVED: To obtain a new amide derivative expressed by specific formula, having effect of essentially improving (maintaining, reinforcing) the horny layer barrier function, good in the solubility and stability to basal agent, and useful as e.g. a preparation for external use for skin. SOLUTION: This new amide derivative is expressed by formula I [R is a 1-40C hydrocarbon; R is a 1-6C alkylene; R is H, hydroxyl or a (substituted) 1-12C alkoxy; R is a 1-39C divalent hydrocarbon; R is formula II (R is H or a 1-6C hydrocarbon; R is a 1-40C hydrocarbon), etc.]. The compound is obtained, pref. for example, by reaction of (A) an aminoalcohol derivative of formula III prepared from (i) glycidyl ether and (ii) an amine with (B) an amidocarboxylic acid derivative of formula IV prepared from (iii) an aminocorboxylic acid derivative and (iv) a carboxylic acid derivative or an acid chloride, in the presence of a dehydrating agent or a base catalyst.

5. 发明专利

JPH0565213A HAIR GROWTH AGENT 失效
公开(公告)号：JPH0565213A
公开(公告)日：1993-03-19
申请号：JP22921091
申请日：1991-09-09
申请人： KAO CORP
发明人： KIDENA HIDEFUMI , HIRAYAMA NORIKO , HOTTA MITSUYUKI , MEGURO SHINICHI , YOSHIZUKA NAONOBU , NISHIZAWA YOSHINORI
IPC分类号： A61K8/00 , A61K8/97 , A61Q5/00 , A61Q7/00
摘要： PURPOSE:To obtain a hair growth agent, capable of promoting hair growth regardless of symptoms or physical constitution and effective against various alopecias. CONSTITUTION:A hair growth agent is obtained by blending carrageenan moss or its extract, especially an extract prepared by, grinding the whole alga of the carrageenan moss or part thereof and extracting with water, a lower alcohol, hydrocarbons or esters, then treating the extracted phase with active carbon, etc., eluting an adsorbed active ingredient with methanol, etc., and distilling away the solvent as the active ingredient at a concentration of preferably 0.0001-50wt.%, especially 0.001-10wt.% expressed in terms of a dry substance (0.01-10wt.% when the dosage form is a liquid such as a suspension or a paste such as an ointment) in using the extract and preferably 0.001-50wt.%, especially 0.01-20wt.% in using the carrageenan moss itself with other ingredients. The resultant hair growth agent has the above-mentioned effects. Furthermore, the dosage form is not especially limited if the hair growth agent is used as a medicine for external use. The dosage form is preferably a liniment such as an ointment, a lotion, a tonic, a spray, a suspension or an emulsion.

6. 发明专利

JPH04112826A CORNIFICATION IMPROVING AGENT 失效
公开(公告)号：JPH04112826A
公开(公告)日：1992-04-14
申请号：JP23422390
申请日：1990-09-04
申请人： KAO CORP
发明人： YADA YUKIHIRO , MEGURO SHINICHI , KIDENA HIDEFUMI , HATTORI MICHIHIRO
IPC分类号： C07D307/91 , A61K31/34 , A61K31/343 , A61P17/16
摘要： PURPOSE:To obtain a cornification improving agent promoting the differentiation-induction of epidermic cell, exhibiting excellent cornification improving action and effective against psoriasis, seborrheic dermatitis, dandruff, etc., by using an active component comprising usnic acid existing widely in lichen and having high safety. CONSTITUTION:Usnic acid which is a component of lichen and expressed by formula is used as an active component of the objective cornification improving agent. The amount of usnic acid is especially 0.01-10wt.%, more desirably 0.1-5wt.% in the cornification improving agent. The agent has influence on the differentiation-inducing process of epidermic cell and exhibits excellent cornification improving action.

7. 发明专利

JP2012032216A Method for screening lipid consumption control agent 审中-公开
标题翻译：筛选脂肪消耗控制剂的方法
公开(公告)号：JP2012032216A
公开(公告)日：2012-02-16
申请号：JP2010170506
申请日：2010-07-29
申请人： Kao Corp , 花王株式会社
发明人： HASUMURA TAKAHIRO , MEGURO SHINICHI
IPC分类号： G01N33/15 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a method for screening a substance for increasing or suppressing consumption of lipid.SOLUTION: A method for screening a substance for increasing or suppressing consumption of body lipid includes the following steps of: dyeing the body lipid by a dye pigment and dosing a test substance to a sample selected from embryos, larvae, and fry of teleost fish; isolating the dyed body lipid from the sample; quantitating a pigment amount in the isolated lipid and determining an amount of the body lipid based on the pigment amount; and evaluating a capability of increasing or suppressing the consumption of the body lipid of the test substance based on the amount of the lipid.
摘要翻译：待解决的问题：提供一种用于筛选增加或抑制脂质消耗的物质的方法。解决方案：用于筛选用于增加或抑制体脂消耗的物质的方法包括以下步骤：用染料颜料染色身体脂质并将测试物质给予选自胚胎，幼虫和鱼苗的样品硬骨鱼从样品中分离染色体脂质; 定量分离的脂质中的颜料量，并基于颜料量确定人体脂质的量; 并且基于脂质的量来评估增加或抑制被检物质的体脂消耗的能力。版权所有（C）2012，JPO＆INPIT

8. 发明专利

JP2008145136A Method for evaluating obesity control agent 有权
标题翻译：评估肥胖控制剂的方法
公开(公告)号：JP2008145136A
公开(公告)日：2008-06-26
申请号：JP2006329637
申请日：2006-12-06
申请人： Kao Corp , 花王株式会社
发明人： SHIMOTOYOTOME REI , SUZUKI JUNKO , SUGINO NANAMI , FUKUOKA DAISUKE , MIZUNO TOMOHITO , MEGURO SHINICHI
IPC分类号： G01N33/50 , G01N33/15
CPC分类号： G01N33/74 , C07K14/62 , G01N33/5085 , G01N2333/62 , G01N2500/00 , G01N2800/042 , G01N2800/044
摘要： PROBLEM TO BE SOLVED: To provide a method of evaluating or selecting efficiently an obesity control substance, a blood insulin control substance, or a blood sugar control substance.
SOLUTION: In the method for evaluating or selecting the obesity control substance, a carbohydrate and lipid are administered to an animal to evaluate or select a substance of decreasing or increasing the secretion of insulin.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供一种有效地评价或选择肥胖控制物质，血液胰岛素对照物质或血糖控制物质的方法。解决方案：在用于评估或选择肥胖控制物质的方法中，将碳水化合物和脂质施用于动物以评估或选择降低或增加胰岛素分泌的物质。版权所有（C）2008，JPO＆INPIT

9. 发明专利

JP2007290989A Gip(gastric inhibitory polypeptide) secretion inhibitor 有权
标题翻译： GIP（GASTRIC抑制多肽）分泌抑制剂
公开(公告)号：JP2007290989A
公开(公告)日：2007-11-08
申请号：JP2006119048
申请日：2006-04-24
申请人： Kao Corp , 花王株式会社
发明人： SUGINO NANAMI , SHIMOTOYOTOME REI , MEGURO SHINICHI
IPC分类号： A61K31/215 , A23L1/30 , A23L2/52 , A61P1/14 , A61P43/00
CPC分类号： A23K20/158 , A23L33/115 , A23V2002/00 , A61K31/215 , A23V2200/32 , A23V2250/192
摘要： PROBLEM TO BE SOLVED: To provide a GIP secretion inhibitor useful in the form of a pharmaceutical or food. SOLUTION: The postcibal GIP secretion inhibitor comprises a monoacylglycerol as active ingredient. Drinks/foods are also provided, each containing the monoacylglycerol, being characterized in having the effect of promoting digestion or ameliorating a dull feeling in the stomach, and labeled with the fact indicating that it is to be used for promoting digestion or ameliorating a dull feeling in the stomach. COPYRIGHT: (C)2008,JPO&INPIT

10. 发明专利

JP2011236239A Gip secretion inhibitor 审中-公开
标题翻译： GIP分泌抑制剂
公开(公告)号：JP2011236239A
公开(公告)日：2011-11-24
申请号：JP2011164350
申请日：2011-07-27
申请人： Kao Corp , 花王株式会社
发明人： SHIMOTOYOTOME REI , SUGINO NANAMI , MEGURO SHINICHI
IPC分类号： A61K31/718 , A23L1/30 , A61P1/14 , A61P43/00 , C08B31/12
摘要： PROBLEM TO BE SOLVED: To provide a GIP (gastric inhibitory polypeptide) secretion inhibitor useful for medicines or foods.SOLUTION: A postprandial GIP secretion inhibitor having a hydroxypropylated starch as an active ingredient is provided.

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