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1. 发明专利

JPH11221260A BEAUTY METHOD 失效
公开(公告)号：JPH11221260A
公开(公告)日：1999-08-17
申请号：JP2554498
申请日：1998-02-06
申请人： KAO CORP
发明人： NAGASHIMA YOSHINAO , YADA YUKIHIRO , KATOU YUURI
IPC分类号： A61H7/00 , A61K8/44 , A61K8/67 , A61K8/81 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To enable to obtain large massage effect and larger beauty effect to be realized by massaging along the direction of corium strand. SOLUTION: When an upper arm part a is massaged, since the direction of corium fiber in the upper arm part a is around the arm as shown by arrow marks, a part from the elbow to the shoulder is massaged repeatedly rubbing in the direction around so as to rub up from the elbow to the shoulder. Same as for the fore arm part b, a part from the wrist to the elbow is massaged by rubbing in the direction around the arm so as to rub up from the wrist to the elbow. The femoral region c is massaged by repeatedly rubbing in the direction around the leg so as to rub up from the knee to the crotch for massaging. The crus part d is massaged by repeatedly rubbing a part from the ankle to the knee part in the direction around the leg. The abdominal part e is massaged by repeatedly rubbing in the direction around the abdominal part so as to rub up from the lower abdominal part to the pit of the stomach. The hip part is massaged by repeatedly rubbing in the direction around the waist so as to rub up from the lower hip part to the upper hip part.

2. 发明专利

JPH09308619A METHOD AND DEVICE FOR ANALYZING SKIN SURFACE 失效
公开(公告)号：JPH09308619A
公开(公告)日：1997-12-02
申请号：JP15321996
申请日：1996-05-23
申请人： KAO CORP
发明人： OSANAI TSUKASA , YADA YUKIHIRO , AKASAKI SHUICHI
IPC分类号： A61B5/00 , A61B5/107 , G06K9/00
摘要： PROBLEM TO BE SOLVED: To extremely shorten the time required for providing the analyzed result of a skin surface state by performing image analysis through a learning type image measuring system using a self-correlation mask pattern. SOLUTION: A base sheet 1, onto which horny cells are copied, is produced, its image is picked up by an image pickup means 2, the provided image is differentiated by an image differentiation filter 3 and the contrast of the image is improved. Next, the image is analyzed by executing the learning type image measuring system through an image analytic means 4 so that the overlap degree, flatness degree and area degree of cells can be discriminated and based on the overlap degree, flatness degree and area degree of cells, the growing degree of cells is discriminated by a surface state analytic means 5. On the other hand, a transmitted light quantity measuring means 6 measures the quantity of transmitted light in the case of irradiating the base sheet 1, onto which the horny cells are copied, with the prescribed quantity of light and based on this quantity of transmitted light, the surface state analytic means 5 discriminates the strength of release in the case of releasing the cells from the surface of the skin.

3. 发明专利

JPH09154832A SKIN SURFACE SHAPE JUDGING METHOD AND DEVICE 失效
公开(公告)号：JPH09154832A
公开(公告)日：1997-06-17
申请号：JP34687095
申请日：1995-12-12
申请人： KAO CORP
发明人： MONMA TOMOHARU , OSANAI TSUKASA , YADA YUKIHIRO
IPC分类号： A61B5/107 , G06T1/00 , G06T7/00
摘要： PROBLEM TO BE SOLVED: To easily and quickly measure and evaluate a shape such as texture of a skin surface by automatically discriminating a classifying class of a transmitted image of a transmission type replica of an optional skin surface by a classifying rule generated by statistically analyzing characteristic information and the classifying class. SOLUTION: First of all, a transmitted image of a transmission type replica of a skin surface is formed by a transmitted image forming means 1 in order to evaluate a skin surface shape. This transmitted image directly and accurately reflects recess-projection information such as texture of the skin surface. Therefore, an image can be highly accurately analyzed more than usual by using the transmitted image as an analutical object. In order to analyze an image of the transmitted image of the transmission type replica, first of all, characteristic information on the transmitted image is extracted by a characteristic information extracting means 2. The characteristic information extracted by this characteristic information extracting means 2 is automatically discriminated by a classifying class discriminating means 4 by a classifying rule of the skin corresponding to its transmitted image on the basis of the classifying rule generated by a classifying rule generating means 3.

4. 发明专利

JPH0848621A SKIN WHITENING COSMETIC 失效
公开(公告)号：JPH0848621A
公开(公告)日：1996-02-20
申请号：JP12684295
申请日：1995-05-25
申请人： KAO CORP
发明人： SUZUKI YASUTO , OHASHI YUKIHIRO , NISHIZAWA YOSHINORI , KIMURA MITSUTOSHI , MORIZAKI NAOKO , YADA YUKIHIRO , IMOKAWA GENJI
IPC分类号： A61K8/30 , A61K8/00 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/49 , A61K31/19 , A61K31/44 , A61K31/60 , A61P3/00 , A61P17/00 , A61P43/00 , A61Q1/00 , A61Q1/04 , A61Q1/12 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C07C65/24 , C07C69/92 , A61K7/48 , A61K7/00
摘要： PURPOSE:To obtain the subject cosmetic excellent in skin whitening effect such as preventing or remedying abnormal pigmentation, and having virtually no side effects with high safety to the skin. CONSTITUTION:This skin whitening cosmetic contains, as active ingredient, a substituted benzoic acid derivative (salt) of formula I [R1 is H, OH, carboxyl, a lower alkoxyl or lower alkoxycarbonyl; R2 is a (substituted) aralkyl or aryl; R3 is H or a lower alkyl], e.g. 4-benzyloxy-2-hydroxybenzoic acid. If desired, this cosmetic may additionally contain a skin whitening agent, ultraviolet light absorber and/or keratinization-remedying agent. Among compounds of formula I, a compound of formula II (R4 is naphthyl, anthryl, carboxyphenyl, mono- or dihydroxyphenyl, pyridyl or 2,3-ethylenedloxyphenyl; R5 is the same as R1; R6 is OH or a lower alkoxyl; (n) is 1-6), e.g. 4-(4'-hydroxybenzyloxy)-2- hydroxybenzoic acid, is a new compound, esp. excellent in skin whitening activity.

5. 发明专利

JPH0770030A AMIDE DERIVATIVE AND SKIN EXTERNAL PREPARATION 失效
公开(公告)号：JPH0770030A
公开(公告)日：1995-03-14
申请号：JP21648493
申请日：1993-08-31
申请人： KAO CORP
发明人： OHASHI YUKIHIRO , KAWAMATA AKIRA , YADA YUKIHIRO , HIGUCHI KAZUHIKO , IMOKAWA GENJI
IPC分类号： A61K8/30 , A61K8/00 , A61K8/42 , A61K8/49 , A61K31/16 , A61K31/335 , A61K31/357 , A61P17/00 , A61Q19/00 , A61Q19/08 , C07C237/22 , C07D317/30 , A61K7/00 , A61K7/48
摘要： PURPOSE:To obtain a new amide derivative useful as a skin external preparation having effects to improve the barrier function of the stratum corneum, e.g. retention, restoration, reinforcement of such function. CONSTITUTION:An amide derivative of formula I [R is a 10-40C hydrocarbon; R is a 1-39C hydrocarbon; R is H or a 1-6C hydrocarbon; R is an (H- or O-contg.) 1-40C hydrocarbon (may be of cyclic structure)]. The compound of formula I can be obtained by the following method: an amine of formula II is prepared from an ethanolamine and a glycidyl ether; while an aminocarboxylic acid of formula III (R is H or a lower alkyl) or its ester is reacted with a carboxylic acid of formula IV (R is the same as R ) or an ester or an acid chloride thereof of formula V to form an amidocarboxylic acid of formula VI or an ester thereof; subsequently, the amine of formula II is reacted with the compound of formula VI in the presence of a base or a dehydrating agent.

6. 发明专利

JPH06321766A EXTERNAL APPLICATION FOR SKIN 失效
公开(公告)号：JPH06321766A
公开(公告)日：1994-11-22
申请号：JP2018494
申请日：1994-02-17
申请人： KAO CORP
发明人： OHASHI YUKIHIRO , FUJIMORI TAKETOSHI , KAWAMATA AKIRA , TAKEMA YOSHINORI , OSU HIROYUKI , YADA YUKIHIRO , HIGUCHI KAZUHIKO , IMOKAWA GENJI , KUSUOKU HIROSHI , FUJIMURA TSUTOMU
IPC分类号： A61K8/30 , A61K8/00 , A61K8/41 , A61K31/13 , A61P17/00 , A61Q19/00 , A61K7/48 , A61K7/00
摘要： PURPOSE:To obtain a medicine for external application for skin expressing antidandruff effect and improving effect after sunburn, excellent in preventing and improving effects on plication, capable of keeping the normal function of skin by containing an amine derivative as an effective component. CONSTITUTION:This medicine contains a compound of the formula (R is 1-3C hydrocarbon or 1-5C hydrocarbon containing a hetero atom; R -R are H, 1-20C hydrocarbon capable of being substituted with OH) or its acid adduct salt as an effective component. The compounding ratio is 0.0001-5wt.% for the external medicine for skin of emulsion type and 0.0001-10wt.% for an oily external medicine for skin using a liquid hydrocarbon such as squalane, etc., as a substrate. 1-(2-Hydroxyethylamino)-3-methoxy-2-propanol is an example of a compound of the formula. The external medicine for skin controls occurrence of plication, expresses marked effect on disappearing plication, further expresses marked controlling action on parakeratosis, acanthosis, abnormal lipids metabolism, etc., and contributes to recover the normal function of skin and maintain its homeostasis.

7. 发明专利

JPH06321759A SKIN BEAUTIFYING AGENT 失效
公开(公告)号：JPH06321759A
公开(公告)日：1994-11-22
申请号：JP11048193
申请日：1993-05-12
申请人： KAO CORP
发明人： YADA YUKIHIRO , MORIZAKI NAOKO , KIMURA MITSUTOSHI , IMOKAWA GENJI
IPC分类号： A61K8/60 , A61K8/00 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P17/00 , A61Q1/00 , A61Q1/12 , A61Q19/00 , A61Q19/02 , C07H17/07 , A61K7/48 , A61K7/00
摘要： PURPOSE:To obtain a skin beautifying agent having actions to suppress melanogenesis and dissipate pigmentation formed by the stimulation with ultraviolet rays, etc., and giving a skin cosmetic having excellent skin beautifying effect and the preventing and treating effect on the spots and freckles caused by sunburn, etc. CONSTITUTION:A skin beautifying agent composed of an alpha-glucosylrutin of the formula [R is (poly)glycose residue] and a skin cosmetic containing the compound. The amount of compound of the formula to be compounded to the skin cosmetic is preferably 0.00001-10wt.%, especially 0.0001-5wt.%. This skin cosmetic includes quasi-drugs and medicines for external use, etc., as well as common skin cosmetics. It is used in various forms such as cream, milky lotion, face lotion, foundation, lotion, gel, solution or stick according to the use.

8. 发明专利

JPH06321750A SKIN BEAUTIFYING AGENT 失效
公开(公告)号：JPH06321750A
公开(公告)日：1994-11-22
申请号：JP10672593
申请日：1993-05-07
申请人： KAO CORP
发明人： YADA YUKIHIRO , KIMURA MITSUTOSHI , MORIZAKI NAOKO , IMOKAWA GENJI
IPC分类号： A61K8/30 , A61K8/00 , A61K8/33 , A61K31/11 , A61K31/19 , A61P17/00 , A61P43/00 , A61Q1/00 , A61Q1/12 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C07C65/03 , A61K7/48 , A61K7/00 , A61K7/42
摘要： PURPOSE:To obtain a skin beautifying agent having actions to suppress melanogenesis and dissipate pigmentation formed by the stimulation with ultraviolet rays, etc., and giving a skin cosmetic having excellent skin beautifying effect and the preventing and treating effect on the spots and freckles caused by sunborn, etc. CONSTITUTION:A skin beautifying agent composed of a catechol derivative of the formula (R is formyl or carboxyl) and a skin cosmetic containing the compound. The compound of the formula can be separated from the supernatent of a cultivation product obtained by the culture of an actinomycete. The amount of compound of the formula to be compounded to the skin cosmetic is preferably 0.00001-10wt.%, especially 0.0001-5wt.%. This skin cosmetic includes quasi-drugs and medicines for external use, etc., as well as common skin cosmetics. It is used in various forms such as cream, milky lotion, face lotion, foundation, pack, lotion, gel, solution or stick according to the use.

9. 发明专利

JPH06312921A SKIN-BEAUTIFYING AGENT AND SKIN COSMETIC CONTAINING THE AGENT 失效
公开(公告)号：JPH06312921A
公开(公告)日：1994-11-08
申请号：JP10563793
申请日：1993-05-06
申请人： KAO CORP
发明人： YADA YUKIHIRO , MORIZAKI NAOKO , KIMURA MITSUTOSHI , IMOKAWA GENJI
IPC分类号： A61K8/49 , A61K8/00 , A61K31/505 , A61P17/00 , A61P43/00 , A61Q1/00 , A61Q1/12 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61K7/48 , A61K7/00 , A61K7/42
摘要： PURPOSE:To provide a skin-beautifying agent and skin cosmetic containing a specific pyrimidopyrrole derivative as an essential component, exhibiting excellent preventing and ameliorating effect on pigmentation, having beautifying effect on the skin after ultraviolet irradiation and effective for preventing and treating spots and freckles caused by sunburn, etc. CONSTITUTION:A skin-beautifying agent composed of a pyrimidopyrrole derivative of formula (X is two H or NH) and a skin cosmetic containing the pyrimidopyrrole derivative of formula. The pyrimidopyrrole derivative of formula is produced by actinomycetes and has action to inhibit the phospholipid metabolism of cell. The compound of formula is preferably compounded to a skin cosmetic in an amount of 0.0001-5%. The skin cosmetic may be properly incorporated, in addition to the pyrimidopyrrole derivative of formula used as an essential component, with lubricant, humectant, thickener, antiseptic, emulsifier, pigment, powder, pH-modifier, drug active component, ultraviolet absorbent, antioxidant, flavor, etc. The skin cosmetic can be used in the form of cream, milky lotion, face lotion, foundation, pack, lotion, gel, solution, stick, etc.

10. 发明专利

JPH06312920A SKIN-BEAUTIFYING AGENT AND SKIN COSMETIC CONTAINING THE AGENT 失效
公开(公告)号：JPH06312920A
公开(公告)日：1994-11-08
申请号：JP10563693
申请日：1993-05-06
申请人： KAO CORP
发明人： YADA YUKIHIRO , MORIZAKI NAOKO , KIMURA MITSUTOSHI , IMOKAWA GENJI
IPC分类号： A61K8/60 , A61K8/00 , A61K31/70 , A61P17/00 , A61P43/00 , A61Q1/00 , A61Q1/12 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61K7/48 , A61K7/00 , A61K7/42
摘要： PURPOSE:To provide a skin-beautifying agent and skin cosmetic containing phosphoramidon having peptidase inhibiting action as an essential component, having beautifying effect on the skin after ultraviolet irradiation and effective for preventing and treating spots and freckles caused by sunburn, etc. CONSTITUTION:The objective skin-beautifying agent and skin cosmetic are composed of phosphoramidon expressed by formula. Phosphoramidon of formula exhibits excellent effect for preventing and ameliorating pigmentation and has high safety. The skin cosmetic can be used in the form of cream, milky lotion, face lotion, foundation, pack, lotion, gel, solution, stick, etc. Commercially available phosphoramidon can be used for the purpose and the content of phosphoramidon in the skin cosmetic is preferably 0.0001-5%. The skin cosmetic may be properly incorporated, in addition to the phosphoramidon used as an essential component, with lubricant, humectant, thickener, antiseptic, emulsifier, pigment, powder, pH-modifier, drug active component, ultraviolet absorbent, antioxidant, flavor, etc.

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