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1. 发明专利

JP2011231029A Enzyme inhibitor and method for producing the same 审中-公开
标题翻译：酶抑制剂及其生产方法
公开(公告)号：JP2011231029A
公开(公告)日：2011-11-17
申请号：JP2010100945
申请日：2010-04-26
申请人： Ikeda Shokken Kk , 池田食研株式会社
发明人： MANSO MITSUMASA , SATO FUMI , NISHIOKA KATSUYUKI
IPC分类号： A61K31/575 , A23L1/30 , A61K8/63 , A61P17/00 , A61P37/08 , A61P43/00 , A61Q19/08 , C07J9/00 , C12N9/99
摘要： PROBLEM TO BE SOLVED: To provide an enzyme inhibitor using cholesterol-highly unsaturated fatty acid ester obtained by combining cholesterol with highly unsaturated fatty acid as an effective component, a method for producing the enzyme inhibitor, and skin care preparations, cosmetics, foods, medicines or the like containing the enzyme inhibitor.SOLUTION: The enzyme inhibitor includes cholesterol-highly unsaturated fatty acid ester obtained by combining cholesterol; and one or more kinds of highly unsaturated fatty acids selected from docosahexaenoic acid, eicosapentaenoic acid and docosapentaenoic acid as an effective component. The enzyme inhibitor is incorporated into skin care preparations, cosmetics, foods, medicines or the like.
摘要翻译：待解决的问题：提供一种使用通过将胆固醇与高度不饱和脂肪酸组合作为有效成分获得的胆固醇 - 高度不饱和脂肪酸酯的酶抑制剂，用于制备酶抑制剂的方法，以及护肤品，化妆品，含有酶抑制剂的食品，药物等。解决方案：酶抑制剂包括通过组合胆固醇获得的胆固醇 - 高度不饱和脂肪酸酯; 和选自二十二碳六烯酸，二十碳五烯酸和二十二碳五烯酸的一种或多种高度不饱和脂肪酸作为有效成分。将酶抑制剂掺入护肤品，化妆品，食品，药物等中。版权所有（C）2012，JPO＆INPIT

2. 发明专利

JP2000014392A PRODUCTION OF GLYCERIDE CONTAINING HIGHLY UNSATURATED FATTY ACID 失效
公开(公告)号：JP2000014392A
公开(公告)日：2000-01-18
申请号：JP19172398
申请日：1998-07-07
申请人： IKEDA SHOKKEN KK
发明人： AOKI HIDEYUKI , NISHIOKA KATSUYUKI , MANSO MITSUMASA , FUJIMOTO KENSHIRO
IPC分类号： C12P7/64 , C12N1/14 , C12R1/785
摘要： PROBLEM TO BE SOLVED: To efficiently obtain the subject compound having an inhibitory action on blood coagulation, antihyperlipemic action, etc., useful for a food, a medicine, a cosmetic, a feed, etc., by culturing a filamentous fungus in a medium comprising an oil and fat mixture containing highly unsaturated fatty acids. SOLUTION: In this method for producing a glyceride containing a highly unsaturated fatty acid, a filamentous fungus [e.g. Mucor hiemalis HA-30 (FERM P-16858) or the like] is cultured in a medium comprising an oil and fat mixture containing at least one or more of highly unsaturated fatty acids such as α- linolenic acid, γ-linolenic acid, octadecatetraenoic acid, dihomo-γ-linolenic acid, arachidonic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid, etc., and one or more of the highly constituting fatty acids are accumulated in a high purity in the filamentous fungus to give the objective glyceride containing a highly unsaturated fatty acid at a low cost and efficiently.

3. 发明专利

JPH11209785A PURIFICATION OF LOWER ALCOHOL ESTER OF HIGHLY PURIFIED AND HIGHLY UNSATURATED FATTY ACID 失效
公开(公告)号：JPH11209785A
公开(公告)日：1999-08-03
申请号：JP987698
申请日：1998-01-21
申请人： IKEDA SHOKKEN KK
发明人： NISHIOKA KATSUYUKI , AOKI HIDEYUKI , MANSOU MITSUMASA
IPC分类号： C07C67/54 , C07C67/56 , C07C69/587 , C11C1/08 , C11C1/10
摘要： PROBLEM TO BE SOLVED: To provide a method for purifying a lower alcohol ester of a highly purified and highly unsaturated fatty acid capable of industrially and inexpensively producing a lower alcohol ester of a highly purified EPA(eicosapentaenoic acid) or DHA (docosahexaenoic acid) without inducing heat-denaturation thereof, and to provide an apparatus therefor. SOLUTION: This method for purifying a lower alcohol ester of a highly purified and highly unsaturated fatty acid purifies a lower alcohol ester of a highly purified and highly unsaturated fatty acid from a lower alcohol ester mixture of an unsaturated fatty acid. The purification method comprises a process of preliminarily extracting the lower alcohol ester component of the highly unsaturated fatty acid by molecular distillation of the lower alcohol ester mixture of the unsaturated fatty acid, a process of extracting the lower alcohol ester concentrated component of the highly unsaturated fatty acid by vacuum distillation of the lower alcohol ester component of the extracted highly unsaturated fatty acid, and a process of differentially purifying the lower alcohol ester of the highly purified and highly unsaturated fatty acid by subjecting the lower alcohol ester of the extracted highly unsaturated fatty acid to a high-performance liquid chromatography by using a filler of a reverse phase partition system.

4. 发明专利

JP2000212588A PRODUCTION OF HIGHLY UNSATURATED FATTY ACID-CONTAINING GLYCERIDE 失效
公开(公告)号：JP2000212588A
公开(公告)日：2000-08-02
申请号：JP1257599
申请日：1999-01-21
申请人： IKEDA SHOKKEN KK
发明人： NORINOBU SEIJI , SATO FUMI , NISHIOKA KATSUYUKI , MANSO MITSUMASA
IPC分类号： C11B7/00 , C11C3/10
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a highly unsaturated fatty acid- containing glyceride by which the glyceride containing both eicosapentaenoic acid and docosahexaenoic acid concentrated so as to be highly pure is produced at a low cost with high efficiency. SOLUTION: This method for producing a glyceride containing >=30% eicosapentaenoic acid and >=20% docosahexaenoic acid comprises using an oil and fat containing >=20% eicosapentaenoic acid and >=10% docosahexaenoic acid, obtained by mixing an oil and fat derived from a shellfish containing >=30% eicosapentaenoic acid, and an oil and fat derived from a fish containing >=20% docosahexaenoic acid in an arbitrary rate.

5. 发明专利

JP2000212587A PRODUCTION OF EICOSAPENTAENOIC ACID-CONTAINING GLYCERIDE 失效
公开(公告)号：JP2000212587A
公开(公告)日：2000-08-02
申请号：JP1257999
申请日：1999-01-21
申请人： IKEDA SHOKKEN KK
发明人： SATO FUMI , NORINOBU SEIJI , NISHIOKA KATSUYUKI , MANSO MITSUMASA
IPC分类号： C11B7/00
摘要： PROBLEM TO BE SOLVED: To efficiently produce an eicosapentaenoic acid-containing glyceride useful for a food, a cosmetic, a medicine or the like in high purity and high yield by using a scallop oil containing the eicosapentaenoic acid in a prescribed value or more as a raw material. SOLUTION: A scallop oil obtained by using a scallop residue containing >=30%, preferably >=40% eicosapentaenoic acid as a raw material, or an internal organ such as hepatopancreas in the scallop residue as the raw material, hydrolyzing the raw material, for example, by using a lipase derived from microorganisms belonging to the genus Alkaligenes or the like (the use thereof is 50-600 units per gram oil and fat), within the range of pH 6.0-10.0 at 25-50 deg.C reaction temperature, to provide the objective eicosapentaenoic acid-containing glyceride. The hydrolyzing reaction is preferably carried out in a nitrogen gas atmosphere to prevent deterioration of the fatty acid.

6. 发明专利

JPH11225696A PRODUCTION OF FERMENTED SOYBEAN FOOD 失效
公开(公告)号：JPH11225696A
公开(公告)日：1999-08-24
申请号：JP2961798
申请日：1998-02-12
申请人： IKEDA SHOKKEN KK
发明人： NISHIOKA KATSUYUKI , ODA KEIICHI
IPC分类号： A23L11/00 , A23L11/20 , C12N1/14 , C12R1/845 , A23L1/20 , A23L1/202
摘要： PROBLEM TO BE SOLVED: To obtain a fermented soybean food not generating black spores, having 1 white brilliant appearance, having excellent block strength, physiological activity and quality and useful for health, etc., by roasting soybeans of raw material, adding the spores of a mold belonging to the genus Rhizopus to the roasted soybeans and subsequently fermenting the soybeans. SOLUTION: This method for producing a fermented soybean food comprises roasting soybeans of raw material, immersing the roasted soybeans of raw material in a diluted acid solution, adding the spores of a mold belonging to the genus Rhizopus to the swollen soybeans, gradually reducing the concentration of oxygen, fermenting the soybeans in an oxygen concentration of

7. 发明专利

JPH11209786A PURIFICATION OF LOWER ALCOHOL ESTER OF HIGHLY PURIFIED AND HIGHLY UNSATURATED FATTY ACID AND APPARATUS THEREFOR 失效
公开(公告)号：JPH11209786A
公开(公告)日：1999-08-03
申请号：JP14339798
申请日：1998-05-25
申请人： IKEDA SHOKKEN KK
发明人： NISHIOKA KATSUYUKI , AOKI HIDEYUKI , MANSOU MITSUMASA
IPC分类号： C07C67/54 , C07C67/56 , C07C69/587 , C11C1/08 , C11C1/10
摘要： PROBLEM TO BE SOLVED: To provide a purifying method capable of industrially and inexpensive ly producing a lower alcohol ester of e.g. highly purified EPA(eicosapentaenoic acid) or DHA(docosahexaenoic acid) from a mixture without inducing heat denaturation, and an apparatus therefor. SOLUTION: This purification method comprises (1) a process of preliminary extraction by subjecting an unsaturated fatty acid lower alcohol ester mixture to a molecular distillation under Torr at 80-85 deg.C, (2) a process of extracting a concentrated component by subjecting the preliminarily extracted component to a vacuum distillation under Torr at

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