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1. 发明专利

JP2004344027A Method for culturing cordyceps sinensis sacc. mycelium, and composition comprising the same 有权
公开(公告)号：JP2004344027A
公开(公告)日：2004-12-09
申请号：JP2003142665
申请日：2003-05-20
申请人： Hokuto Corp , Nitto Denko Corp , ホクト株式会社 , 日東電工株式会社
发明人： SAHASHI HIROKO , TSUJIKURA YOSHIKO , INATOMI SATOSHI , ENOKI RYOSUKE
IPC分类号： A01G1/04 , A23L1/28 , A23L1/30 , A61K35/64 , A61K36/06 , A61P25/00 , C12N1/14 , C12R1/645 , A61K35/70
摘要： PROBLEM TO BE SOLVED: To provide a method for culturing Cordyceps sinensis Sacc. mycelia efficiently and stably having pharmacological activities and pharmacological components and a method for enhancing the pharmacological activities of the same. SOLUTION: The method for culturing Cordyceps sinensis Sacc. mycelia comprises inoculating fungi of Cordyceps sinensis Sacc., and continuously or intermittently irradiating the fungi with light having a peak in a wavelength range of 350-550 mn. COPYRIGHT: (C)2005,JPO&NCIPI

2. 发明专利

JP2005320307A New sesquiterpene compound and method for producing the same and composition 有权
标题翻译：新的SESQUITERPENE化合物及其生产方法和组合物
公开(公告)号：JP2005320307A
公开(公告)日：2005-11-17
申请号：JP2004141648
申请日：2004-05-11
申请人： Hokuto Corp , Nitto Denko Corp , ホクト株式会社 , 日東電工株式会社
发明人： OSHIMA YOSHITERU , KIKUCHI HARUHISA , INATOMI SATOSHI , ENOKI RYOSUKE , SAHASHI HIROKO , TSUJIKURA YOSHIKO
IPC分类号： A23L1/30 , A61K31/352 , A61K36/06 , A61P35/00 , C07D311/00 , A61K35/70
摘要： PROBLEM TO BE SOLVED: To provide a new compound having a proliferation inhibitory activity for cancer cells, and to provide a method for producing the same and a medicinal composition or a food composition comprising the compound. SOLUTION: The new sesquiterpene compound is represented by formula (I). The compound is collected from a cultivated body of Cordyceps sinensis Sacc. or obtained by synthesis from a known substance 4-acetyl-12,13-epoxy-9-trichothecene-3,15-diol. The medicinal composition or the food composition comprises the resultant compound. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供具有对癌细胞的增殖抑制活性的新化合物，并提供其制备方法以及包含该化合物的药物组合物或食品组合物。解决方案：新的倍半萜烯化合物由式（I）表示。该化合物从冬虫夏草的栽培体中收集。或通过从已知的物质4-乙酰基-12,13-环氧-9-单端三烯-3,15-二醇合成得到。药物组合物或食品组合物包含所得化合物。版权所有（C）2006，JPO＆NCIPI

3. 发明专利

JP2009000013A Method for culturing plant cell mass 有权
标题翻译：培养植物细胞质量的方法
公开(公告)号：JP2009000013A
公开(公告)日：2009-01-08
申请号：JP2007161865
申请日：2007-06-19
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： SAHASHI HIROKO , TSUJIKURA YOSHIKO
IPC分类号： C12N5/04
摘要： PROBLEM TO BE SOLVED: To provide an excellent method for culturing plant cell masses, which can solve a problem of proliferation failure caused in scaling up the culture of the plant cell masses. SOLUTION: This method for culturing the plant cell masses in a liquid culture medium comprises culturing the plant cell masses so that the content of crushed plant cell masses is ≤20%, and the content of precipitated plant cell masses is ≤20%, at the seventh day after the start of the culture. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供用于培养植物细胞块的优良方法，其可以解决在放大植物细胞群的培养中引起的增殖失败的问题。解决方案：这种在液体培养基中培养植物细胞团的方法包括培养植物细胞团，使破碎的植物细胞团的含量≤20％，沉淀的植物细胞团的含量≤20％在文化开始后的第七天。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2005312323A Method for subculture of ginseng callus 有权
标题翻译：金山调查组织培养方法
公开(公告)号：JP2005312323A
公开(公告)日：2005-11-10
申请号：JP2004131678
申请日：2004-04-27
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： TSUJIKURA YOSHIKO , SAHASHI HIROKO
IPC分类号： C12N5/04
摘要： PROBLEM TO BE SOLVED: To provide a method for the subculture of ginseng callus, enabling the change in the properties of seed stocks to be suppressed to a minimum even if a long-term subculture is performed, enabling the activity of seed stocks to be maintained at high levels, as a result, capable of suppressing such problems as to decrease in the harvest of a ginseng callus-cultured product after subculture and/or decrease in the content of secondary metabolites such as saponins produced inside of the ginseng callus-cultured product. SOLUTION: The method for the subculture of ginseng callus comprises alternately repeating a liquid culture under conditions A and that under conditions B, wherein the conditions B are such that, as compared to the conditions A, the amount of a medium to be used is 110-200 vol.% of that in the conditions A and the concentration of an auxin in the liquid medium is 1/7 to 1/2 time that in the conditions A. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为了提供人参愈伤组织亚文化的方法，即使进行长期亚文化，能够将种子库的性质变化抑制至最小，使得种子库的活动维持在高水平，结果能够抑制继代培养后人参愈伤组织培养产物的收获减少和/或次要代谢物如在人参愈伤组织内产生的皂苷的含量降低的问题文化产品。解决方案：人参愈伤组织的传代培养方法包括在条件A下和在条件B下交替重复液体培养，其中条件B使得与条件A相比，培养基的量在条件A中为110-200体积％，液体培养基中生长素浓度为条件A中的1/7至1/2倍。（C）2006，JPO＆NCIPI

5. 发明专利

JP2004290082A Method for culturing ginseng callus 审中-公开
公开(公告)号：JP2004290082A
公开(公告)日：2004-10-21
申请号：JP2003086887
申请日：2003-03-27
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： TSUJIKURA YOSHIKO , SAHASHI HIROKO
IPC分类号： C12N5/04
摘要： PROBLEM TO BE SOLVED: To provide a method for culturing callus of Ginseng origin for maintaining the characteristics of the callus as seed strain for a long period through solving the problems of decline in the yield of the cultured product thereof in its subculture and proliferative culturing steps and decline in the content of a secondary metabolite produced in the cultured product. SOLUTION: The method for culturing Ginseng callus comprises the subculture step in a liquid medium followed by the proliferative culture step in a liquid medium. In this method, culture vessels for the subculture step and the proliferative culture step are the same in shape, and the amount of the liquid medium in the subculture step is 55-90 vol% of that in the proliferative culture step. COPYRIGHT: (C)2005,JPO&NCIPI

6. 发明专利

JP2007000064A NEW VEGETATIVE WASP STRAIN 审中-公开
公开(公告)号：JP2007000064A
公开(公告)日：2007-01-11
申请号：JP2005183162
申请日：2005-06-23
申请人： NITTO DENKO CORP , HOKUTO CORP
发明人： SAHASHI HIROKO , TSUJIKURA YOSHIKO , INATOMI SATOSHI , ENOKI RYOSUKE , ISHII MAKOTO
IPC分类号： C12N1/14 , A23L1/30 , A61K36/06 , A61P9/04 , A61P25/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/04 , A61P43/00 , C12N15/09 , C12R1/645
摘要： PROBLEM TO BE SOLVED: To provide vegetative wasp strain and its culture product and extract which can be stably artificially cultured and stably maintain useful physiological activity or the like. SOLUTION: The strain of Cordyceps takaomontana represents light yellow color to dark orange color of mycelium in a process of vegetative propagation. COPYRIGHT: (C)2007,JPO&INPIT

7. 发明专利

JP2000032952A ANTIALLERGIC FOOD 失效
公开(公告)号：JP2000032952A
公开(公告)日：2000-02-02
申请号：JP20296098
申请日：1998-07-17
申请人： NITTO DENKO CORP
发明人： TANAKA HOZUMI , TSUJIKURA YOSHIKO , SAHASHI HIROKO , HIBINO TAKESHI
IPC分类号： A23L1/30 , A23L1/304 , A23L19/00 , A23L1/212
摘要： PROBLEM TO BE SOLVED: To obtain an antiallergic food orally takable with ease for the mitigation and prevention of allergic diseases such as atopic dermatitis. SOLUTION: Panax ginseng extract obtained by extracting Panax ginseng with water and a calcium ion donor are compounded as essential components. The Panax ginseng extract is preferably extracted from a tissue-cultured product and the calcium ion donor is preferably calcium lactate or calcium gluconate. The compounding amount of the calcium ion donor is preferably 0.2-5 pts.wt. in terms of calcium ion based on 1 pt.wt. of the Panax ginseng extract.

8. 发明专利

JPH04290811A HAIR-CULTURING AGENT 失效
公开(公告)号：JPH04290811A
公开(公告)日：1992-10-15
申请号：JP5439691
申请日：1991-03-19
申请人： NITTO DENKO CORP
发明人： OBA TOSHIJI , TANAKA HOZUMI , ODA HIROHIKO , TSUJIKURA YOSHIKO , SATO SUSUMU
IPC分类号： A61K8/00 , A61K8/97 , A61K36/25 , A61P17/00 , A61Q5/00 , A61Q7/00
摘要： PURPOSE:To provide a safe hair-culturing agent having a high pharmacological activity by employing the tissue-cultured product of Panax Japonicas. CONSTITUTION:Panax Japonicas is subjected to a tissue culture, and from the resultant tissue culture products a tissue culture product containing a saponin, especially the saponin having oleanolic acid as an aglycone, is selected. The selected tissue culture product or an extract thereof is employed as an active ingredient for hair-culturing agents. The hair-culturing agent containing the cultured product exhibits an excellent trichogenous activity.

9. 发明专利

JPH0420280A GASEOUS PHASE CULTIVATION APPARATUS 失效
公开(公告)号：JPH0420280A
公开(公告)日：1992-01-23
申请号：JP12457990
申请日：1990-05-15
申请人： NITTO DENKO CORP
发明人： INOUE SHOZO , SATO SUSUMU , ODA HIROHIKO , OBA TOSHIJI , TANAKA HOZUMI , TSUJIKURA YOSHIKO
IPC分类号： C12M3/00
摘要： PURPOSE:To provide a gaseous phase cultivation apparatus easy to sterilize the inner space and enabling long-term cultivation by using a perforated holding device to hold a cultivation object and a cultivation tank placed below the holding device, furnished with a cultivation-liquid holding means and an atomizing means and capable of keeping the inside in air-tight state. CONSTITUTION:A thermal sterilization and temperature-controlling means 11 is placed outside a cultivation tank 1 to enable the thermal sterilization and the temperature control in the tank 1. An implantation hole 100 for charging a cultivation object 14 and an aeration hole 101 are formed at the upper part of the cultivation tank 1 and the bottom of the tank 1 is provided with a cultivation liquid holding part 12. One or more stages of holding devices 13 are placed in the gaseous phase above the holding part to enable the stable cultivation of a plant tissue, etc., over a long period.

10. 发明专利

JPH03127955A GANODERMA LUCIDUM JELLY AND PRODUCTION THEREOF 失效
公开(公告)号：JPH03127955A
公开(公告)日：1991-05-31
申请号：JP26729989
申请日：1989-10-13
申请人： NITTO DENKO CORP
发明人： TSUJIKURA YOSHIKO , HIGUCHI TOSHIO
IPC分类号： A23L21/10 , C12N1/14 , C12R1/645
摘要： PURPOSE:To easily obtain the title jelly without requiring much labor by making a liquid culture of Ganoderma lucidum mycelia in a medium containing, as the essential ingredients, maltose and corn steep liquor. CONSTITUTION:The objective jelly can be obtained by liquid culture of Ganoderma lucidum mycelia in the medium mentioned above. In this case, it is preferable that the maltose content and corn steep liquor content in the medium be 1-5w/v% and 0. 5-1. 5w/v%, respectively. Where appropriate, this medium may contain inorganic salts. grain germs, rice bran, nutritive ingredients like vitamins etc. For the incubation, in general, 300cc of a liquid medium is put into a Meyer flask with a capacity of 1l, and ca. 10-20mg of seed mycelia is incubated using a rotary shaking incubator at 25-30 deg.C for 3-12 days. After incubation, the resultant culture solution is in the form of highly viscous polysaccharide gel, which is then cooled at 5 deg.C for 3-5hr and solidified either directly or after its sterilization, thus obtaining the objective Ganoderma lucidum jelly.

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