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1. 发明专利

JP2009170238A Mass spectrometer and mass spectrometry 有权
标题翻译：质谱仪和质谱仪
公开(公告)号：JP2009170238A
公开(公告)日：2009-07-30
申请号：JP2008006372
申请日：2008-01-16
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： SUGIYAMA MASUYUKI , HASHIMOTO YUICHIRO , HASEGAWA HIDEKI , TAKADA YASUAKI
IPC分类号： H01J49/42 , G01N27/62 , H01J49/40
CPC分类号： H01J49/0045
摘要： PROBLEM TO BE SOLVED: To solve the problem that a conventional MS/MS method cannot compatibly attain throughput and precursor ion mass resolution.
SOLUTION: This mass spectrometer includes an ion trap for discharging ions in a specified mass range, a collision dissociation part for dissociating the ions discharged from the ion trap, and a mass spectrometric part for performing the mass spectrometry of the ions discharged form the collision dissociation part. It resonantly discharges the ions introduced and accumulated into the iron trap in a mass selective manner. It measures the precursor ions in the conditions that incident energy into the collision dissociation part is low, and acquires a set of the profile of the precursor ions at the mass axis of the ion trap part and the profile thereof at the mass spectrometric part. Then, it measures the precursor ions in the conditions that incident energy into the collision dissociation part is high, and replaces the profile at the mass axis of the mass spectrometric part with the profile of the precursor ions of the obtained two-dimensional mass spectrum at the mass axis of the iron trap part. In this method, m/z of each of the precursor ions and fragment ions can be determined with high mass resolution.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了解决常规MS / MS方法不能兼容地获得通过量和前体离子质量分辨率的问题。解决方案：该质谱仪包括用于在特定质量范围内排出离子的离子阱，用于解离从离子阱排出的离子的碰撞解离部分和用于进行离子排出形式的质谱的质谱部分碰撞解离部分。它以质量选择的方式谐振地放出引入并累积到铁捕集器中的离子。它在入射到碰撞解离部分的能量较低的条件下测量前体离子，并且在离子阱部分的质量轴和质谱部分的轮廓获取一组前体离子的轮廓。然后，在入射到碰撞解离部分的能量高的条件下，测量前体离子，并将所得二维质谱的前体离子的轮廓替换在质谱部分的质心轴处的轮廓铁陷阱部分的质量轴。在该方法中，可以以高质量分辨率确定每个前体离子和碎片离子的m / z。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2009117388A Mass spectroscope 有权
标题翻译：质谱仪
公开(公告)号：JP2009117388A
公开(公告)日：2009-05-28
申请号：JP2009040516
申请日：2009-02-24
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： HASHIMOTO YUICHIRO , HASEGAWA HIDEKI , BABA TAKASHI , WAKE IZUMI
IPC分类号： H01J49/42 , G01N27/62 , H01J49/06
CPC分类号： H01J49/427 , H01J49/067 , H01J49/4225
摘要： PROBLEM TO BE SOLVED: To provide a mass spectroscope in which a linear trap having a high exhaust efficiency, a high mass resolution and a low exhaust energy is achieved. SOLUTION: The mass spectroscope, in which a linear trap having a high exhaust efficiency, a high mass resolution and a low exhaust energy is achieved, is provided with a quadrupole rod electrode which introduces ion generated by an ion source and has an entrance and an exit and in which a high frequency voltage is impressed. At lease a part of the ion is trapped by a trap potential formed on a central axis of the quadrupole potential and the part of the trapped ion vibrates in an intermediate direction of a neighboring quadrupole rod, and the vibrating ion is exhausted through an extracting electric field, and the exhausted ion is detected or is introduced to another detecting process. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种质量分析器，其中实现了具有高排气效率，高质量分辨率和低排放能量的线性阱。解决方案：实现了具有高排气效率，高质量分辨率和低排放能量的线性阱的质谱仪具有引入由离子源产生的离子的四极杆电极，并具有入口和出口，并且施加高频电压。至少一部分离子被形成在四极电位的中心轴上的陷阱电位捕获，并且被捕获的离子的一部分在相邻的四极棒的中间方向上振动，并且振动离子通过提取电场，并且检测出耗尽的离子，或将其引入另一检测过程。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2009063389A Analyzer 有权
标题翻译：分析仪
公开(公告)号：JP2009063389A
公开(公告)日：2009-03-26
申请号：JP2007230903
申请日：2007-09-06
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： HASHIMOTO YUICHIRO , HASEGAWA HIDEKI , SUGIYAMA MASUYUKI , TAKADA YASUAKI
IPC分类号： G01N27/62 , H01J49/10
CPC分类号： H01J49/0036
摘要： PROBLEM TO BE SOLVED: To provide a method and means for performing accurate quantification by neither reducing measuring throughput nor adding a multicomponent standard compound.
SOLUTION: In this analyzer having means for ionizing a mixture, which is obtained by adding a specific compound to a measuring sample, to mass-analyze the formed ions and quantifying the concentration of the measuring target compound contained in the measuring sample, a database which stores the signal intensity dependence to the concentration of a certain matrix component with respect to the measuring target compound and the added compound is provided and the concentration of the measuring target compound is corrected from the signal originating from the measuring target compound obtained by the mass analyzing means and the signal originating from the added compound. A multicomponent analyzer using mass analysis of low cost and high throughput as compared with a conventional technique can be realized.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供通过既不降低测量量也不添加多组分标准化合物来进行精确定量的方法和装置。解决方案：在具有将通过向测量样品中加入特定化合物而获得的混合物离子化的装置中，对形成的离子进行质量分析并量化测量样品中包含的测量目标化合物的浓度的分析仪中，存储与相对于测定对象化合物和添加的化合物相对于特定的基质成分的浓度的信号强度依赖性的数据库，根据来自测定对象化合物的信号，由测定对象化合物的信号质量分析装置和来自添加的化合物的信号。可以实现使用与常规技术相比低成本和高吞吐量的质量分析的多组分分析仪。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2008282542A Ionic mobility analyzer and ionic mobility-separator/mass-spectroscopy composite apparatus 有权
标题翻译：离子移动分析仪和离子移动分离器/质谱复合装置
公开(公告)号：JP2008282542A
公开(公告)日：2008-11-20
申请号：JP2007122956
申请日：2007-05-08
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： HASHIMOTO YUICHIRO , HASEGAWA HIDEKI , SUGIYAMA MASUYUKI , TAKADA YASUAKI
IPC分类号： H01J49/40 , G01N27/62
CPC分类号： G01N27/622
摘要： PROBLEM TO BE SOLVED: To provide an ionic mobility separation filter of low cost and high ion transmissivity, capable of allowing ions in a specific ionic mobility range to pass at atmospheric pressure. SOLUTION: The apparatus comprises an ion source, a first drift region in which the direction of a direct current electric field is opposite to the gas low direction, a second drift region in which the direction of applying a direct current electric field is opposite to a gas flow direction different from the gas flow direction in the first drift region, an intermediate region having an electric field to proceed ions between the first and second drift regions, and a detector to detect ions passing through the first and second regions. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供低成本和高离子透射率的离子迁移率分离过滤器，其能够使特定离子迁移率范围内的离子在大气压下通过。解决方案：该装置包括离子源，直流电场的方向与气体低方向相反的第一漂移区域，施加直流电场的方向的第二漂移区域为与不同于第一漂移区域中的气体流动方向的气体流动方向相反的中间区域，具有用于在第一和第二漂移区域之间进行离子的电场的中间区域以及检测通过第一和第二区域的离子的检测器。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2004095451A Ion source and mass spectrometer 审中-公开
公开(公告)号：JP2004095451A
公开(公告)日：2004-03-25
申请号：JP2002257251
申请日：2002-09-03
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： HIRABAYASHI TSUDOI , HASHIMOTO YUICHIRO , HASEGAWA HIDEKI
IPC分类号： G01N27/62 , G01N30/72 , G01N30/88 , H01J49/04 , H01J49/10
摘要： PROBLEM TO BE SOLVED: To provide a spray ionization interface capable of preventing introduction of charged particles to a vacuum device, suitable for ionization of a low flow-volume liquid and a supersensitive mass spectrometer.
SOLUTION: The ion source is provided with a capillary 1 with its outer and inner diameter tapered toward the tip of one end and with a liquid sample introduced from the other end, a gas guide tube 6 flowing gas along an outer periphery of the one end side and spraying the liquid sample from the one end, and a gas lead-in part 5 introducing gas to the gas guide tube. At the side where the one end side is inserted, the inner diameter of the gas guide tube is formed tapered toward the one end. An ion gas generated is introduced into a vacuum part 9 from an ion take-in part inlet 7 and mass-analyzed with a mass spectrometer. The vicinity of the one tip end side of the capillary 1 is fixed inside the gas guide tube 2 with a holding member 3 and the capillary 1 is fixed inside an ion source housing with a plug 4. Charged particles are removed outside by a suction port 8.
COPYRIGHT: (C)2004,JPO

6. 发明专利

JP2003331776A Ion source, mass spectroscope and mass spectrometry 审中-公开
标题翻译：离子源，质谱和质谱
公开(公告)号：JP2003331776A
公开(公告)日：2003-11-21
申请号：JP2002134841
申请日：2002-05-10
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： HIRABAYASHI TSUDOI , HASHIMOTO YUICHIRO , HASEGAWA HIDEKI
IPC分类号： G01N27/62 , H01J49/00 , H01J49/04 , H01J49/10
CPC分类号： H01J49/167 , H01J49/0404
摘要： PROBLEM TO BE SOLVED: To provide a spray ionization interface suitable for ionization of a low flow-volume liquid and a supersensitive mass spectroscope.
SOLUTION: The ion source is provided with a capillary 1 with its outer and inner diameter tapered toward the tip of one end and with a liquid sample introduced from the other end, a gas guide tube 6 flowing gas along an outer periphery of the one end side and spraying the liquid sample from the one end, and a gas lead-in part 5 introducing gas to the gas guide tube. At the side where the one end side is inserted, the inner diameter of the gas guide tube is formed tapered toward the one end. An ion gas generated is introduced into a vacuum part 9 from an ion take-in part inlet 7 and mass-analyzed with a mass spectrometer. The vicinity of the one tip end side of the capillary 1 is fixed inside the gas guide tube 2 with a holding member 3 and the capillary 1 is fixed inside an ion source housing with a plug 4. Charged particles are removed outside by a suction port 8. With this, the charged particles can be prevented from being introduced into a vacuum device.
COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供适合于低流量液体和超灵敏质谱仪电离的喷雾电离界面。解决方案：离子源设置有毛细管1，其外径和内径朝向一端的尖端逐渐变细，并且从另一端引入液体样品，气体引导管6沿着外部的外周流动气体一端侧并从一端喷射液体样品;以及气体引入部5，将气体导入导气管。在一端插入的一侧，气体导向管的内径形成为朝向一端渐缩。将所产生的离子气体从离子入口部分入口7引入真空部分9并用质谱仪进行质量分析。毛细管1的一个前端侧附近用保持部件3固定在导气管2的内部，毛细管1通过插头4固定在离子源壳体的内部。带电粒子通过吸入口由此，可以防止带电粒子被引入真空装置。版权所有（C）2004，JPO

7. 发明专利

JP2006107929A Ion mobility analyzing device and ion mobility analyzing method 有权
标题翻译：离子移动分析装置和离子移动分析方法
公开(公告)号：JP2006107929A
公开(公告)日：2006-04-20
申请号：JP2004293191
申请日：2004-10-06
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： HASHIMOTO YUICHIRO , HASEGAWA HIDEKI , WAKE IZUMI
IPC分类号： H01J49/40 , G01N27/62
CPC分类号： G01N27/622
摘要： PROBLEM TO BE SOLVED: To provide an ion mobility analyzing device separating and detecting ion with high resolution and low cost. SOLUTION: The ion mobility analyzing device is composed of an ion source 1 generating first ion, a first drift part (L1) separating the first ion depending on the flying drift time of the first ion, an ion dissociation part (Lg) generating second ion by dissociating separated first ion, and a second drift part (L2) separating the second ion depending on the flying drift time of the second ion. The first drift part, the ion dissociation part, and the second drift part are stored in a chamber in which the pressure is 10 m/Torr or higher. Ion can be separated and detected with high resolution and low cost. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供以高分辨率和低成本分离和检测离子的离子迁移率分析装置。解决方案：离子迁移率分析装置由产生第一离子的离子源1，根据第一离子的飞行漂移时间分离第一离子的第一漂移部（L1），离子离解部（Lg）通过解离分离的第一离子产生第二离子;以及第二漂移部分（L2），其根据第二离子的飞行漂移时间分离第二离子。第一漂移部分，离子解离部分和第二漂移部分储存在压力为10m /乇或更高的室中。离子可以分离和检测，分辨率高，成本低。版权所有（C）2006，JPO＆NCIPI

8. 发明专利

JP2004350693A Method and apparatus for purifying and isolating nucleic acid 有权
公开(公告)号：JP2004350693A
公开(公告)日：2004-12-16
申请号：JP2004270673
申请日：2004-09-17
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： KOJIMA KYOKO , OZAWA OSAMU , HASEGAWA HIDEKI , FUKUZONO SHINICHI , KANDA TAKAYUKI
IPC分类号： C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a method for purifying and isolating a nucleic acid stably in high yield.
SOLUTION: This method comprises the steps of (1) adding an organic solvent at -5 to 55°C to a solution containing the nucleic acid and a high-concentration salt and (2) adsorbing the nucleic acid to a carrier, thus improving the collection yield of the nucleic acid with slight variation in its collection.
COPYRIGHT: (C)2005,JPO&NCIPI

9. 发明专利

JP2009037819A Mass spectrometer and mass spectrometry 有权
标题翻译：质谱仪和质谱仪
公开(公告)号：JP2009037819A
公开(公告)日：2009-02-19
申请号：JP2007200298
申请日：2007-08-01
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： SUGIYAMA MASUYUKI , HASHIMOTO YUICHIRO , HASEGAWA HIDEKI , TAKADA YASUAKI
IPC分类号： H01J49/42 , G01N27/62
CPC分类号： H01J49/0045
摘要： PROBLEM TO BE SOLVED: To solve a problem that detection sensitivity and throughput cannot be achieved at the same time in a conventional MS and MS method.
SOLUTION: The mass spectrometer has: an ion trap for discharging ions of a specific mass dimension; a collision and dissociation part for dissociating ions discharged from the ion trap; a mass spectrometry part for carrying out mass spectrometry of ions discharged from the collision and dissociation part; and a control part having a list in which measuring conditions of each ion is stored, and resonates and discharges the ions introduced and accumulated into the ion trap selectively by mass. The scan operation is composed of a repetition of an operation to discharge specific precursor ions in the collision and dissociation part direction and an operation not to discharge, and controls the output voltage of each part by referring to the information of the list. Accordingly, each ion can be measured by an optimum condition; and a mass spectrometry capable of MS and MS measurement having a high sensitivity and a high throughput is achieved.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题为了解决在常规MS和MS方法中同时无法实现检测灵敏度和吞吐量的问题。解决方案：质谱仪具有：用于排出特定质量尺寸的离子的离子阱; 用于离解从离子阱排出的离子的碰撞和解离部分; 用于进行从碰撞和解离部分排出的离子的质谱的质谱部分; 以及具有其中存储每个离子的测量条件的列表的控制部分，并且选择性地将引入并累积到离子阱中的离子进行谐振和放电。扫描操作由重复在碰撞和解离部分方向排出特定前体离子的操作和不排放的操作组成，并且通过参考列表的信息来控制每个部分的输出电压。因此，可以通过最佳条件测量每个离子; 并且实现了具有高灵敏度和高通量的能够进行MS和MS测量的质谱。版权所有（C）2009，JPO＆INPIT

10. 发明专利

JP2005183022A Mass spectroscope 有权
标题翻译：质谱仪
公开(公告)号：JP2005183022A
公开(公告)日：2005-07-07
申请号：JP2003417894
申请日：2003-12-16
申请人： Hitachi High-Technologies Corp , Hitachi Ltd , 株式会社日立ハイテクノロジーズ , 株式会社日立製作所
发明人： HASHIMOTO YUICHIRO , BABA TAKASHI , HASEGAWA HIDEKI , WAKE IZUMI
IPC分类号： G01N27/62 , H01J49/00 , H01J49/16 , H01J49/40 , H01J49/42
CPC分类号： H01J49/4225 , H01J49/004 , H01J49/401
摘要： PROBLEM TO BE SOLVED: To provide a mass spectroscope capable of analyzing a wide range of the mass number in high sensitivity and high mass accuracy. SOLUTION: The mass spectroscope is provided with an ion source 301 generating ion; an ion transport part 302 transporting the ion; a first linear trap storing the ion and discharging the ion within a specific range of the mass number; a second linear trap having an end electrode 6 at an outlet end for discharging ion, trapping the ion discharged from the first linear trap and repeatedly discharging it in a pulse state by changing relative direct current potential gradients against direct current potential of the end electrode 6; a time-of-flight mass spectrometry part accelerating and detecting the ion discharged by the second linear trap in an orthogonal direction; and a control part 101 changing pulse time widths for the ion to be discharged from the second linear trap, or delay time widths from completion of the ion discharge until the impression of accelerating voltage of the time-of-flight mass spectrometry part in accordance with the mass number range of the ion discharged from the first linear trap to the second linear trap. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供能够以高灵敏度和高质量精度分析宽范围的质量数的质谱仪。解决方案：质谱仪设置有产生离子的离子源301; 运送离子的离子迁移部302; 存储离子并将离子排出在质量数的特定范围内的第一线性阱; 第二线性陷阱，具有用于排出离子的出口端的端电极6，捕获从第一线性陷阱排出的离子，并且通过相对于端电极6的直流电位改变相对直流电位梯度，以脉冲状态重复放电 ; 飞行时间质谱部分加速和检测由第二线性捕集器在正交方向上排出的离子; 以及控制部101，其改变从第二线性陷阱排出的离子的脉冲宽度，或延迟时间从完成离子放电直到飞行时间质谱部分的加速电压根据从第一线性阱到第二线性阱的离子的质量数范围。版权所有（C）2005，JPO＆NCIPI

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