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1. 发明专利

JP2014020802A Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：JP2014020802A
公开(公告)日：2014-02-03
申请号：JP2012156740
申请日：2012-07-12
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： YAMASHITA YOSHIHIRO , SAKAZUME TAKU
IPC分类号： G01N35/02
摘要： PROBLEM TO BE SOLVED: To suppress the extension of an inspection time, and to suppress increase in the usage amounts of a detection object.SOLUTION: A control section 119 of an automatic analyzer 100 preliminarily plans a first process of performing the analysis of a 400-power diluted sample as first analysis; a second process of performing the analysis of an undiluted solution sample as second analysis; a third process of performing the analysis of a 4000-power diluted sample; and a fourth process of performing the analysis of a 40000-power diluted sample as third analysis in the case of performing the analysis of a sample. Furthermore, when a detection object in the sample is accurately detected by the first analysis, the preliminarily planned second analysis and third analysis are abandoned. In each analysis, the diluted sample is held on an incubator disk 104 without being abandoned until the analytic result is obtained. The control section 119 starts the control of the operation of each mechanism for executing an analytic operation on the basis of the created plan.
摘要翻译：要解决的问题：抑制检查时间的延长，并且抑制检测对象的使用量的增加。自动分析装置100的控制部119预先进行400的分析的第一处理作为第一次分析的稀释样品; 进行未稀释溶液样品的分析的第二过程作为第二分析; 执行4000功率稀释样品分析的第三个过程; 以及在进行样品分析的情况下，进行40000-功率稀释样品的分析的第四过程作为第三分析。此外，当通过第一次分析准确地检测到样品中的检测对象时，放弃了预先规划的第二分析和第三分析。在每个分析中，将稀释的样品保持在培养箱盘104上，而不被放弃，直到获得分析结果。控制部分119基于所创建的计划开始对用于执行分析操作的每个机构的操作的控制。

2. 发明专利

JP2013088164A Automatic analyzer 审中-公开
标题翻译：自动分析仪
公开(公告)号：JP2013088164A
公开(公告)日：2013-05-13
申请号：JP2011226617
申请日：2011-10-14
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： HARADA YUJI , YAMASHITA YOSHIHIRO , SAKAZUME TAKU
IPC分类号： G01N35/02
摘要： PROBLEM TO BE SOLVED: To provide an automatic analyzer in which a capture magnetic field strength in B/F separation can be changed in accordance with the kind of a substance to be measured and a high-precision stable measurement result can be obtained regardless of the kind of the substance to be measured.SOLUTION: A B/F separation mechanism 10 comprises a reaction vessel 11 in which a liquid sample containing magnetic particles is accommodated, a reaction vessel holder 12 which holds the reaction vessel 11, a reaction vessel holder temperature adjusting mechanism 13 which adjusts a temperature of the reaction vessel holder 12, a reaction vessel stirring mechanism which stirs the liquid sample in the reaction vessel, and a magnetic field generating mechanism 15 which is disposed along the outer periphery of the reaction vessel. The magnetic field generating mechanism 15 includes a plurality of magnetic field generation members 15a which are disposed symmetrically to the reaction vessel 11 and a magnetic field strength adjusting mechanism which adjusts the strength of a magnetic field which is generated within the reaction vessel 11 by the magnetic field generation members 15a.
摘要翻译：要解决的问题：提供一种自动分析器，其中可以根据待测物质的种类改变B / F分离中的捕获磁场强度并且可以获得高精度稳定的测量结果不管要测量的物质的种类。解决方案：AB / F分离机构10包括其中容纳含有磁性颗粒的液体样品的反应容器11，保持反应容器11的反应容器保持器12，反应容器保持器温度调节机构13，其调节反应容器保持器12的温度，搅拌反应容器中的液体样品的反应容器搅拌机构，以及沿着反应容器的外周配置的磁场产生机构15。磁场产生机构15包括多个对应于反应容器11设置的磁场产生部件15a和磁场强度调节机构，该磁场强度调节机构通过磁场调节在反应容器11内产生的磁场的强度场产生部件15a。版权所有（C）2013，JPO＆INPIT

3. 发明专利

JP2006311803A Method for purifying nucleic acid and tool for purifying nucleic acid 审中-公开
标题翻译：净化核酸的方法和净化核酸的工具
公开(公告)号：JP2006311803A
公开(公告)日：2006-11-16
申请号：JP2005134728
申请日：2005-05-06
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： YAMASHITA YOSHIHIRO , SAKURAI TOMOYA
IPC分类号： C12N15/09 , C12M1/00
CPC分类号： C12N15/1006
摘要： PROBLEM TO BE SOLVED: To provide a technique for purifying an RNA from a nucleic acid-containing sample by safe and simple operation.
SOLUTION: As a result of intensive studies, it is found that a DNA is insolubilized and the RNA maintains a soluble state when an organic solvent is added to a mixture liquid of the sample containing the DNA and RNA with a chaotropic agent. A method for purifying the nucleic acid comprises mixing the nucleic acid-containing sample with the chaotropic agent and organic solvent, insolubilizing the DNA, separating the resultant insolubilized material from the mixture liquid and purifying the RNA from the residual liquid. The RNA can be bound to the solid phase containing silica by bringing the residual liquid into contact with the solid phase containing the silica even without adding a reagent, etc., to the residual liquid. Furthermore, the DNA can be purified from the insolubilized material. The high-purity RNA can be purified from the sample containing the DNA and RNA by the safe and simple operation. The RNA and DNA can simultaneously be purified from the single sample.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供通过安全且简单的操作从含核酸样品中纯化RNA的技术。解决方案：作为深入研究的结果，发现当使用离液剂将有机溶剂加入到含有DNA和RNA的样品的混合液中时，DNA不溶解，并且RNA保持可溶性状态。纯化核酸的方法包括将含核酸的样品与离液剂和有机溶剂混合，使DNA不溶解，从混合液中分离得到的不溶化物质并从残余液中纯化RNA。通过使剩余液体与含有二氧化硅的固相接触，即使不向剩余液体中添加试剂等，也可以将RNA与含有二氧化硅的固相结合。此外，可以从不溶物质中纯化DNA。可以通过安全，简单的操作从含有DNA和RNA的样品中纯化高纯度RNA。可以从单个样品中同时纯化RNA和DNA。版权所有（C）2007，JPO＆INPIT

4. 发明专利

JP2013190400A Autoanalyzer 审中-公开
标题翻译：自动加油
公开(公告)号：JP2013190400A
公开(公告)日：2013-09-26
申请号：JP2012058848
申请日：2012-03-15
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： HARADA YUJI , YAMASHITA YOSHIHIRO , SAKAZUME TAKU
IPC分类号： G01N35/00
摘要： PROBLEM TO BE SOLVED: To provide an autoanalyzer capable of suppressing deterioration of analysis efficiency by shortening time to stabilization of reagent temperature.SOLUTION: An autoanalyzer includes: a reagent constant temperature part 6a of a reagent constant temperature mechanism 6 which holds a reagent container 5 under predetermined fixed temperature environment; and a reagent temperature control part 21 which is provided in the reagent constant temperature mechanism 6, and holds the reagent container 5 under changeable temperature environment. The autoanalyzer conveys the reagent container 5 inside the reagent constant temperature mechanism 6 including the reagent temperature control part 21 by a reagent container conveyance mechanism 22, and controls temperature environment for holding the reagent container 5 of the reagent temperature control part 21 on the basis of a measurement result of a reagent temperature measurement mechanism 30.
摘要翻译：要解决的问题：提供能够通过缩短试剂温度稳定化的时间来抑制分析效率的劣化的自动分析仪。自动分析仪包括：试剂恒温机构6的试剂恒温部分6a，其保持试剂容器5 在预定的固定温度环境下; 以及试剂温度控制部21，其设置在试剂恒温机构6中，并且在可变温度环境下保持试剂容器5。自动分析器通过试剂容器搬运机构22将试剂容器5输送到包含试剂温度控制部21的试剂恒温机构6内，并且基于试剂温度控制部21的试剂容器5的保持温度环境试剂温度测定机构30的测定结果。

5. 发明专利

JP2012021778A Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：JP2012021778A
公开(公告)日：2012-02-02
申请号：JP2010157436
申请日：2010-07-12
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： MATSUOKA SHINYA , SAKAZUME TAKU , YAMASHITA YOSHIHIRO
IPC分类号： G01N35/02 , G01N35/10
摘要： PROBLEM TO BE SOLVED: To provide a washing tank which can generate a chaotic flow of water and washing liquid in it without using driving means such as a motor.SOLUTION: An automatic analyzer comprises an agitating rod for agitating a reagent, a washing liquid for washing the agitating rod, and a washing tank for containing the washing liquid, the agitating rod being washed with the washing liquid contained in the washing tank. The washing tank is connected with a discharge mechanism for discharging the washing liquid, and a plurality of discharge ports are provided between the washing tank and the discharge mechanism.
摘要翻译：要解决的问题：提供一种可以在不使用诸如电动机的驱动装置的情况下产生混乱的水流和洗涤液体的洗涤槽。解决方案：自动分析仪包括用于搅拌试剂的搅拌棒，用于洗涤搅拌棒的洗涤液和用于容纳洗涤液的洗涤槽，搅拌棒用洗涤槽中所含的洗涤液洗涤。洗涤槽与排出洗涤液的排出机构连接，在洗涤槽与排出机构之间设有多个排出口。版权所有（C）2012，JPO＆INPIT

6. 发明专利

JP2011247617A Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：JP2011247617A
公开(公告)日：2011-12-08
申请号：JP2010118166
申请日：2010-05-24
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： YAMASHITA YOSHIHIRO , MATSUOKA SHINYA , SUZUKI KANTARO , SAKASHITA TAKAMICHI , SAKAZUME TAKU
IPC分类号： G01N35/08
摘要： PROBLEM TO BE SOLVED: To provide an automatic analyzer which is capable of suppressing the influence of a phenomenon caused by mixture of gas and liquid in a flow path, on pressure transmission from a syringe to a nozzle.SOLUTION: The automatic analyzer includes: a nozzle 17 for sucking/discharging a liquid or gas; a syringe 32 for generating pressure which makes the nozzle 17 suck/discharge the liquid or gas; a drain 39 for ejecting an object; a flow path comprising a first flow path 20 for connecting the nozzle 17 and a branch portion 23, a second flow path 21 for connecting the drain 39 and the branch portion 23, and a third flow path 22 for connecting the syringe 32 and the branch portion 23; a first on-off valve 30 for opening/closing the first flow path; a second on-off valve 31 for opening/closing the second flow path; and a gas-liquid separating mechanism 33 which is provided at the portion of the second flow path 21 which is on the drain 39 side of the second on-off valve 31, and makes a mixture of gas and liquid to be sent to the drain 39 pass therethrough to separately remove the gas.
摘要翻译：要解决的问题：提供一种自动分析装置，其能够抑制从流路中的气体和液体的混合引起的现象对从注射器到喷嘴的压力传递的影响。解决方案：自动分析仪包括：用于吸取/排出液体或气体的喷嘴17; 用于产生使喷嘴17吸出/排出液体或气体的压力的注射器32; 用于喷射物体的排水口39; 流路，其包括用于连接喷嘴17和分支部23的第一流路20，用于连接排水口39和分支部23的第二流路21，以及用于连接注射器32和分支部分23; 用于打开/关闭第一流路的第一开关阀30; 用于打开/关闭第二流路的第二开关阀31; 以及气体分离机构33，其设置在第二流路21的位于第二开闭阀31的排水口39侧的部分，并且将气体和液体的混合物送至排水管 39通过其分开除去气体。版权所有（C）2012，JPO＆INPIT

7. 发明专利

JP2011153946A Analyzer 有权
标题翻译：分析仪
公开(公告)号：JP2011153946A
公开(公告)日：2011-08-11
申请号：JP2010016160
申请日：2010-01-28
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： YAMASHITA YOSHIHIRO , SAKAZUME SUGURU , SAKASHITA TAKAMICHI , TAGAMI EIJI , SUZUKI KANTARO
IPC分类号： G01N35/00 , G01N21/76 , G01N33/53 , G01N33/543
摘要： PROBLEM TO BE SOLVED: To provide an automatic analyzer for improving the accuracy and the reliability of an analysis performance, and maintaining the accuracy and the repeatability of a relative position relationship between a detection container and a magnetic particle capturing magnet adjacent to the detection container. SOLUTION: The analyzer includes the detection container for receiving a solution containing the magnetic particles, the magnet for magnetically capturing the magnetic particles within the detection container, a photoelectron multiplier for measuring the quantity of an emission derived from a light emitting material within the detection container, and the function for evaluating the relative position relationship between the detection container and the magnetic particle capturing magnet based on a change in an output signal due to an effect of an external magnetic field to the photoelectron multiplier. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：为了提供一种用于提高分析性能的精度和可靠性的自动分析仪，并且保持检测容器与邻近的检测容器和磁性粒子捕获磁体之间的相对位置关系的精度和重复性检测容器。解决方案：分析仪包括用于接收含有磁性颗粒的溶液的检测容器，用于磁性捕获检测容器内的磁性颗粒的磁体，用于测量源自发光材料的发射量的光电子倍增器检测容器，以及基于由于外部磁场对光电子倍增器的影响而导致的输出信号的变化来评价检测容器与磁性粒子捕获磁体之间的相对位置关系的功能。版权所有（C）2011，JPO＆INPIT

8. 发明专利

JP2009201444A Nucleic acid analyzer 审中-公开
标题翻译：核酸分析仪
公开(公告)号：JP2009201444A
公开(公告)日：2009-09-10
申请号：JP2008048991
申请日：2008-02-29
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： YAMAMOTO SHUHEI , SAKURAI TOMOYA , SHOJI YOSHIYUKI , HOSOIRI TAKEHIKO , YAMASHITA YOSHIHIRO , HIDA TOMOYUKI
IPC分类号： C12M1/00
CPC分类号： B01L7/52 , B01L3/50851 , B01L3/50853 , B01L2200/142 , B01L2300/1844 , B01L2300/1861 , G01N35/025
摘要： PROBLEM TO BE SOLVED: To prevent condensation occurring when reaction solutions in sealed vessels are heated in a nucleic acid analyzer for performing sequential processing in which individual reaction vessels are sequentially fed to a nucleic acid amplification unit in a given cycle.
SOLUTION: The nucleic acid analyzer includes a vessel mounting rack capable of holding the plurality of reaction vessels, wherein the reaction vessel mounted on the vessel mounting rack is heated by an adjacent noncontact heat source and air circulation from the heat source to a reaction vessel upper portion, and a temperature of the reaction vessel upper portion is kept higher than a temperature of a reaction vessel lower portion. Condensation possibly occurring on the inner wall of the sealed vessel upper portion due to heating during nucleic acid amplification can be prevented, and more accurate nucleic acid analysis is enabled.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了防止在密封容器中的反应溶液在核酸分析仪中加热以进行顺序加工，以防止在给定循环中将各个反应容器顺序加入到核酸扩增单元中的冷凝。解决方案：核酸分析仪包括能够保持多个反应容器的容器安装架，其中安装在容器安装架上的反应容器被相邻的非接触式热源加热，并且从热源到空气循环反应容器上部，反应容器上部的温度保持高于反应容器下部的温度。可以防止由于核酸扩增期间的加热而在密封容器上部的内壁上发生冷凝，能够进行更准确的核酸分析。版权所有（C）2009，JPO＆INPIT

9. 发明专利

JP2007124952A Method and tool for purifying nucleic acid 有权
标题翻译：用于净化核酸的方法和工具
公开(公告)号：JP2007124952A
公开(公告)日：2007-05-24
申请号：JP2005320733
申请日：2005-11-04
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： YAMASHITA YOSHIHIRO , SAKURAI TOMOYA
IPC分类号： C12N15/09 , B01J20/10 , C12M1/00 , G01N30/06 , G01N30/26 , G01N30/38 , G01N30/88
CPC分类号： C07H21/00 , C12N15/1006 , Y10T436/107497 , Y10T436/173845
摘要： PROBLEM TO BE SOLVED: To separate and purify a long-chain nucleic acid and a short-chain nucleic acid from a sample containing the long-chain nucleic acid and the short-chain nucleic acid by a safe and simple operation. SOLUTION: The long-chain and short-chain nucleic acids are separated and purified from the nucleic acid-containing sample by mixing the nucleic acid-containing sample with a chaotropic agent, passing the resultant mixed liquid twice or more through the first silica-containing solid phase having a liquid-passing pores with a prescribed pore diameters, passing the obtained mixed liquid twice or more through the second silica-containing solid phase having a liquid-passing pores having pore sizes smaller than those of the first silica-containing solid phase, and collecting the nucleic acid bound to the first and the second silica-containing solid phases. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：通过安全和简单的操作从含有长链核酸和短链核酸的样品中分离并纯化长链核酸和短链核酸。解决方案：通过将含核酸的样品与离液剂混合来将含有核酸的样品分离和纯化长链和短链核酸，使得到的混合液体经过第一次含有具有规定孔径的液体通过孔的二氧化硅固相，使得到的混合液经过第二含二氧化硅的固相，通过孔径小于第一二氧化硅 - 并收集与第一和第二含二氧化硅的固相结合的核酸。版权所有（C）2007，JPO＆INPIT

10. 发明专利

JP2007074914A Method for extracting nucleic acid 审中-公开
标题翻译：提取核酸的方法
公开(公告)号：JP2007074914A
公开(公告)日：2007-03-29
申请号：JP2005263168
申请日：2005-09-12
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： YAMASHITA YOSHIHIRO , SAKURAI TOMOYA
IPC分类号： C12N15/09
CPC分类号： C12N1/066 , C12N15/1006 , C12N15/1017
摘要： PROBLEM TO BE SOLVED: To solve problems in which operation is complicated and increase of operation labor and operation time and deterioration of properties of nucleic acid accompanied by prolongation of the operation time occur, because a method for extracting nucleic acid in which solid-like biological sample is targeted uses two or more kinds of devices targeting crushing of a biological sample and extraction of nucleic acid, and the sample attached to a crushing device in crushing operation of the biological sample is not fed to nucleic acid extraction operation in the following step and nucleic acid extraction efficiency is lowered thereby. SOLUTION: A method for extracting nucleic acid comprises a step for crushing a biological sample and a nucleic acid extraction step for extracting the nucleic acid in a state isolated from the crushed sample, which are performed by a single device. Nucleic acid extraction efficiency is improved without losing the sample attached to a sample-crushing device and operability is improved by simplifying the operation. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：解决问题：为了解决操作复杂的问题，随着操作时间的延长而发生操作时间和操作时间的增加以及核酸的性质的劣化，因为提取其中固体的核酸的方法靶向的生物样品使用靶向破碎生物样品和提取核酸的两种或更多种装置，并且在生物样品的破碎操作中附着于破碎装置的样品不进入核酸提取操作随后的步骤和核酸提取效率降低。解决方案：提取核酸的方法包括用于破碎生物样品的步骤和用从单个装置进行的从破碎样品分离的状态提取核酸的核酸提取步骤。提高核酸提取效率，而不会丢失附着于样品破碎装置的样品，并且通过简化操作来提高操作性。版权所有（C）2007，JPO＆INPIT

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