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1. 发明专利

JP2009186356A Analytical method using magnetic particle 有权
标题翻译：使用磁性粒子的分析方法
公开(公告)号：JP2009186356A
公开(公告)日：2009-08-20
申请号：JP2008027551
申请日：2008-02-07
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： KANDA TAKAYUKI , IMAI KYOKO
IPC分类号： G01N33/543 , G01N33/53 , G01N33/553
摘要： PROBLEM TO BE SOLVED: To provide an analytical method using magnetic particles, which has a high performance of magnetic separation and has improved reactivity.
SOLUTION: The method which analyzes a test substance by simultaneously using two particles dispersed in a solution is characterized in that a substance interacting with the test substance is fixed on a first magnetic particle, and the particle size of a second magnetic particle is large in comparison with the first magnetic particle.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种使用具有高磁性分离性和反应性改善的磁性颗粒的分析方法。解决方案：通过同时使用分散在溶液中的两种颗粒分析测试物质的方法的特征在于将与测试物质相互作用的物质固定在第一磁性颗粒上，并且第二磁性颗粒的粒度为与第一磁性颗粒相比较大。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2008051765A Autoanalyzer and automatic analysis method 有权
标题翻译：自动分析和自动分析方法
公开(公告)号：JP2008051765A
公开(公告)日：2008-03-06
申请号：JP2006230727
申请日：2006-08-28
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： USUI SHINOBU , IMAI KYOKO , ORIHASHI TOSHIHIDE
IPC分类号： G01N35/00
摘要： PROBLEM TO BE SOLVED: To prevent automatic analysis from being carried out, based on a calibration curve which has not been calibrated, and to improve the reliability of analysis data which is to be acquired.
SOLUTION: A control computer 30 includes an analytical parameter setting section 310 for setting the analytical parameters for analysis items; a calibration necessity determining section 311 for determining whether calibrating of the calibration curve is necessary, based on the analysis parameter; and a teaching message display section 312 for displaying a teaching message prompting calibrating operation, when calibration operation of the calibration curve is determined as being necessary. Furthermore, the control computer 30 stores a calibration invalid flag in a calibration invalid flag memory section 360, which is set, when the calibration operation of the calibration curve is determined as being necessary, and which is reset, when the calibration operation is carried out; and then the control computer 30 will not perform analysis about analysis items where the calibration invalid flag is set and appends a data error to the analysis data of the analysis items, regarding the analysis items which have not been performed.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：为了防止进行自动分析，基于未校准的校准曲线，并提高要获取的分析数据的可靠性。解决方案：控制计算机30包括分析参数设置部分310，用于设置分析项目的分析参数; 基于分析参数，确定是否需要校准校准曲线的校准必要性确定部311; 以及当校准曲线的校准操作被确定为必要时，用于显示提示校准操作的示教消息的示教消息显示部分312。此外，当校准曲线的校准操作被确定为需要时，控制计算机30将校准无效标志存储在校准无效标志存储器部分360中，校准无效标志存储器部分360被设置，并且当进行校准操作时，控制计算机30被复位 ; 然后控制计算机30将不执行关于校准无效标志被设置的分析项目的分析，并且对于尚未执行的分析项目，对分析项目的分析数据附加数据错误。版权所有（C）2008，JPO＆INPIT

3. 发明专利

JP2014035229A Method and device for detecting biomolecule, and device for analysis 有权
标题翻译：用于检测生物分子的方法和装置，以及用于分析的装置
公开(公告)号：JP2014035229A
公开(公告)日：2014-02-24
申请号：JP2012175572
申请日：2012-08-08
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： SAITO TOSHIRO , IMAI KENTA , IMAI KYOKO , IMAI KAZUNARI , YANAGI ITARU , YANAGAWA YOSHIMITSU , ANDO MASAHIKO , ITABASHI NAOSHI
IPC分类号： G01N27/02 , G01N27/00 , G01N33/543 , G01N37/00
CPC分类号： G01N27/4145 , G01N27/4148 , G01N33/48721 , G01N33/543 , G01N33/54306 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a method and a device for detecting biomolecule in a wide dynamic range with high sensitivity and high throughput without requiring density adjustment of a sample in advance.SOLUTION: A charge holding body is specifically connected to biomolecule of a detection object, current changes generated when their composite passes through a fine pore are measured, and the biomolecule of the detection object is detected one by one. Detection of a biomolecule sample becomes possible with high throughput by arranging a detection part in array.
摘要翻译：要解决的问题：提供一种用于在具有高灵敏度和高产量的宽动态范围内检测生物分子的方法和装置，而不需要预先对样品进行密度调节。解决方案：电荷保持体特异性地连接到检测的生物分子测量其复合体通过细孔时产生的当前变化，并逐个检测检测对象的生物分子。通过将检测部件布置在阵列中，可以以高产量检测生物分子样品。

4. 发明专利

JP2009222451A Automatic analyzer 审中-公开
标题翻译：自动分析仪
公开(公告)号：JP2009222451A
公开(公告)日：2009-10-01
申请号：JP2008065069
申请日：2008-03-14
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： ISHIZAWA MASAHITO , IMAI KYOKO
IPC分类号： G01N35/00
摘要： PROBLEM TO BE SOLVED: To improve a management work for comparing an ordinary measuring item with measurement results of a management specimen, namely, an accuracy management work flow by an inspection engineer, which often becomes inefficient in present device operation; to easily achieve a statistical accuracy management work which has been difficult hitherto in the comparison work; and to thereby contribute to reliability improvement of the accuracy management work.
SOLUTION: In order to apply this invention, an application software for controlling an operation screen of an automatic analyzer is improved, and the specific number of management specimen measurement results are displayed simultaneously with the measurement results of the ordinary measuring item.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：为了改进通常的测量项目与管理样本的测量结果的比较的管理工作，即由检验工程师进行的精度管理工作流程，这在当前的设备操作中经常变得低效; 以便在比较工作中难以实现统计精度管理工作; 从而有助于精度管理工作的可靠性提高。解决方案：为了应用本发明，改进了用于控制自动分析仪的操作画面的应用软件，并且与普通测量项目的测量结果同时显示管理样本测量结果的具体数量。版权所有（C）2010，JPO＆INPIT

5. 发明专利

JP2004028933A Automatic analyzer 有权
公开(公告)号：JP2004028933A
公开(公告)日：2004-01-29
申请号：JP2002189016
申请日：2002-06-28
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： MATSUBARA SHIGEKI , TAMURA TERUMI , IMAI KYOKO , MIMURA TOMONORI
IPC分类号： G01N35/00 , G01N35/02 , G01N35/04
CPC分类号： G01N35/0092 , G01N35/00603 , G01N35/026 , G01N2035/00326
摘要： PROBLEM TO BE SOLVED: To provide an automatic analyzer having a plurality of analyzing units and for continuing analysis operation as an analyzer system as a whole with the electric power to specific analyzing units turned off for maintenance work.
SOLUTION: The automatic analyzer is provided with a specimen insertion part 101; a transfer part 102; and the plurality of analyzing units 103. When failure occurs in one analyzing unit or more, from a screen of an operating part 106, the analyzing units can be set in mode capable of turning off the power. Since the analyzing units set in the mode capable of turning off the power turned into a state separated from both the operation of the analyzer and an information network within the analyzer, it is possible to continue analysis operation as the analyzer as a whole with the individual power of the analyzing units turned off.
COPYRIGHT: (C)2004,JPO

6. 发明专利

JP2014032101A Immunity analysis method and immunity analysis device 有权
标题翻译：免疫分析方法和免疫分析装置
公开(公告)号：JP2014032101A
公开(公告)日：2014-02-20
申请号：JP2012172483
申请日：2012-08-03
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： IMAI KYOKO , SAITO TOSHIRO , IMAI KAZUNARI
IPC分类号： G01N33/543 , G01N21/64 , G01N33/552 , G01N33/553 , G01N37/00
CPC分类号： G01N33/54386 , G01N21/6428 , G01N21/6452 , G01N33/54326 , G01N33/54366
摘要： PROBLEM TO BE SOLVED: To provide a high-sensitivity immunity analysis method and an analysis device.SOLUTION: There are provided an immunity analysis method and an analysis device which are configured to subject a component to be measured and an acquisition component singularly reacting therewith to reaction so that when the component to be measured is further present, a reactant is marked, to arrange the marked reactant at a spatially separated predetermined position, and to analyze the component to be measured with sensitivity and resolution of one molecule by detecting the mark of the marked reactant.
摘要翻译：要解决的问题：提供高灵敏度的免疫分析方法和分析装置。解决方案：提供了一种免疫分析方法和分析装置，其被配置为使被测量的成分和单独反应的获取成分与反应，使得当进一步存在待测量的组分时，标记反应物，以将标记的反应物排列在空间分离的预定位置，并通过检测一分子的标记来分析具有灵敏度和分辨率的待分析成分标记的反应物。

7. 发明专利

JP2007085804A Data processing method equipped with checking function for integration-type data operation method 有权
标题翻译：具有检查功能的数据处理方法用于集成型数据操作方法
公开(公告)号：JP2007085804A
公开(公告)日：2007-04-05
申请号：JP2005273048
申请日：2005-09-21
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： SAKAZUME TAKU , IMAI KYOKO , SUZUKI KANTARO
IPC分类号： G01N35/00
摘要： PROBLEM TO BE SOLVED: To provide an automatic analyzer for acquiring measurement data of higher reliability by detecting a measurement error factor if it occurs. SOLUTION: This automatic analyzer is equipped with a means for giving a trigger from outside a system, a detection means for detecting a light signal arising from inside the system based on the trigger, and a recording means for recording, with time, the intensity of the light signal arising from inside the system. This automatic analyzer is further equipped with a comparison means for comparing the time-position of a peak in the light signal with a previously set time-position, and a storage means for therein storing an evaluation result associated with information in a measured light signal based on a comparison result obtained by the comparison means. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种通过检测测量误差因子（如果发生）来获取具有更高可靠性的测量数据的自动分析器。解决方案：该自动分析仪装备有用于从系统外部提供触发的装置，用于基于触发来检测从系统内部产生的光信号的检测装置，以及用于随时间记录的记录装置，光信号强度由系统内部产生。该自动分析仪还配备有比较装置，用于将光信号中的峰值的时间位置与预先设定的时间位置进行比较，以及存储装置，用于存储与测量的光信号中的信息相关联的评估结果通过比较装置得到的比较结果。版权所有（C）2007，JPO＆INPIT

8. 发明专利

JP2007071554A Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：JP2007071554A
公开(公告)日：2007-03-22
申请号：JP2005255803
申请日：2005-09-05
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： MAEDA NORIKO , IMAI KYOKO , SAKAZUME TAKU , TOKIWA YUKIE , SUZUKI KANTARO
IPC分类号： G01N35/00 , G01N35/10
CPC分类号： G06F17/00 , G01N35/00594 , G01N35/00603 , G01N35/00663 , G01N2035/00881 , Y10T436/11 , Y10T436/115831
摘要： PROBLEM TO BE SOLVED: To avoid a trouble of data abnormality caused by consumables, and to estimate a countermeasure, by discriminating using a measurement result acquired by measurement by an analyzer and each identifier of a specimen, a reagent and a consumable member used for measurement, and by storing correlatively. SOLUTION: An automatic analyzer and an automatic analysis system have characteristics, wherein the specimen, the reagent and members used in common for measurement of at least two or more measuring objects: a system reagent (buffer solution), a sensor component, a probe, a nozzle, a chip, a dispensation cup, a tube, an ISE electrode, a detector, pure water, waste liquid or the like which are used for the analyzer are discriminated and managed unitary together with the measurement result. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题为了避免由消耗品引起的数据异常的问题，并且通过区分使用由分析仪进行的测量获得的测量结果和样本，试剂和消耗部件的每个标识符来估计对策用于测量，并通过相关存储。解决方案：自动分析仪和自动分析系统具有以下特征，其中样品，试剂和用于测量至少两个或更多个测量对象的共同使用的试剂和试剂：体系试剂（缓冲溶液），传感器组分，用于分析器的探针，喷嘴，芯片，分配杯，管，ISE电极，检测器，纯水，废液等与测量结果一并被统一和管理。版权所有（C）2007，JPO＆INPIT

9. 发明专利

JP2008209339A Automatic analysis apparatus 审中-公开
标题翻译：自动分析仪
公开(公告)号：JP2008209339A
公开(公告)日：2008-09-11
申请号：JP2007048388
申请日：2007-02-28
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： WATANABE ATSUSHI , NISHIDA MASAHARU , MATSUBARA SHIGEKI , IMAI KYOKO
IPC分类号： G01N35/10
摘要： PROBLEM TO BE SOLVED: To prevent samples from being thinned by aqueous droplets adhering to a fractionation nozzle during the fractionating operation of the samples. SOLUTION: The automatic analysis apparatus is provided with both a sample fractionation mechanism provided with nozzles for fractionating samples from sample containers and dispensing the samples to reaction containers and a nozzle moving mechanism for moving the nozzles between the sample containers and the reaction containers. The automatic analysis apparatus is provided with a cleaning mechanism control mechanism provided with a plurality of types of nozzle cleaning mechanisms to control the selective use of the nozzle cleaning mechanisms according to the amount of samples fractionated by the nozzles. COPYRIGHT: (C)2008,JPO&INPIT

10. 发明专利

JP2007047038A Liquid dispensing apparatus 有权
标题翻译：液体分配装置
公开(公告)号：JP2007047038A
公开(公告)日：2007-02-22
申请号：JP2005232286
申请日：2005-08-10
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： TOKIWA YUKIE , SAKAZUME TAKU , IMAI KYOKO , SUZUKI KANTARO
IPC分类号： G01N35/10
摘要： PROBLEM TO BE SOLVED: To reduce carryovers between samples and between reagents by efficiently cleaning proteins contained in a liquid to be dispensed adsorbed to a dispensing probe. SOLUTION: After the dispensing probe 1 constituted of an insulator material is immersed in a solution in a cleaning tank 15 and a solution for electrophoresis is absorbed by the dispensing probe 1, a voltage is applied across both an electrode 27 in the probe 1 and an electrode 26 in the cleaning tank 15 by a power supply unit 28 for electrophoresis. Since the total charge of proteins becomes negative by the alkali solution and electrically repels a negative charge of the charged surfaces of inside walls of the probe 1 and the outer wall of its tip, the surface of the dispensing probe 1 hardly adsorbs the proteins. The voltage application to the electrodes 26 and 27 is terminated in a prescribed time, and the probe 1 is elevated to open a valve 8, feed a purified water, and extrude the solution for electrophoresis outside the probe 1. A valve 16 is opened to rinse the outer-wall tip of the dispensing probe 1 immersed in the solution for electrophoresis by the purified water supplied from a purified water supply nozzle 17 and wash away the solution. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：通过有效地清洗吸附在分配探针上待分配的待分配液体中的蛋白质来减少样品之间和试剂之间的滞留。解决方案：将由绝缘体材料构成的分配探头1浸入清洗槽15中的溶液中，并且用于电泳的溶液被分配探针1吸收，在探针中的电极27两端施加电压 1和通过用于电泳的电源单元28在清洁槽15中的电极26。由于蛋白质的总电荷通过碱溶液变为负电，并且电斥出了探针1的内壁的电荷表面和其尖端的外壁的负电荷，所以分配探针1的表面几乎不吸附蛋白质。电极26和27的电压施加在规定的时间内终止，探针1被升高以打开阀8，供给净化水，并在探针1外挤出电泳溶液。阀16打开至冲洗溶解在溶液中的分配探针1的外壁尖端，用纯化水供给喷嘴17供给的净化水进行电泳，并洗去溶液。版权所有（C）2007，JPO＆INPIT

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