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1. 发明专利

JP2011067174A Target detector and method for producing the same 审中-公开
标题翻译：目标检测器及其制造方法
公开(公告)号：JP2011067174A
公开(公告)日：2011-04-07
申请号：JP2009222878
申请日：2009-09-28
申请人： Fujitsu Ltd , 富士通株式会社
发明人： ARINAGA KENJI
IPC分类号： C12M1/00 , C12N15/09 , C12Q1/68 , G01N21/78 , G01N33/53 , G01N33/542 , G01N37/00
CPC分类号： G01N27/3276 , B01J2219/00612 , B01J2219/0063 , B01J2219/00637 , B01J2219/00653 , B01J2219/00722
摘要： PROBLEM TO BE SOLVED: To provide a target detector detecting a target nucleic acid with high accuracy and in a short time, and to provide a method for producing the detector.
SOLUTION: The target detector includes a substrate, and a plurality of probes in which one end thereof is bonded onto the substrate, wherein the probes each include, in a part thereof, a label which functions as the label when separated from the substrate and are capable of forming double strands together with the target nucleic acid. The plurality of probes are arranged in such positions that, when the probes form double strands together with the target nucleic acid, steric hindrance occurs between one double strand and another double strand adjacent to the one double strand so as to separate the label from the substrate.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供以高精度和短时间检测目标核酸的靶标检测器，并提供一种检测器的制造方法。解决方案：目标检测器包括基板和多个探针，其中一个端部结合到基板上，其中探针的一部分包括当与其分离时用作标签的标签并且能够与靶核酸一起形成双链。多个探针排列成这样的位置，即当探针与靶核酸一起形成双股时，在一条双股与另一条双股相邻的另一条双股之间发生位阻，从而将标记与基质分开。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2010091394A Method for applying potential to working electrode in electrolyte and device for controlling potential working electrode 有权
标题翻译：在电解槽中施加电极电位的方法及用于控制潜在工作电极的装置
公开(公告)号：JP2010091394A
公开(公告)日：2010-04-22
申请号：JP2008261300
申请日：2008-10-08
申请人： Fujitsu Ltd , 富士通株式会社
发明人： ARINAGA KENJI
IPC分类号： G01N27/416 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a technology to easily apply desired potential to an electrode specific to a solution. SOLUTION: Three electrodes are soaked in an electrolyte, one of which is a working electrode and the other two of which are auxiliary electrodes. Potential is applied across the working electrode and one of the auxiliary electrodes, and between the auxiliary electrodes independently. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种技术，以容易地将特定于溶液的电极的期望电位应用于电极。解决方案：三个电极浸泡在电解质中，其中一个是工作电极，另外两个电极是辅助电极。在工作电极和辅助电极之间以及辅助电极之间独立地施加电位。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2009180513A Target evaluating method and device 有权
标题翻译：目标评估方法和设备
公开(公告)号：JP2009180513A
公开(公告)日：2009-08-13
申请号：JP2008017133
申请日：2008-01-29
申请人： Fujitsu Ltd , 富士通株式会社
发明人： ARINAGA KENJI
IPC分类号： G01N21/78 , G01N33/533 , G01N33/543
摘要： PROBLEM TO BE SOLVED: To provide a technology for evaluating a target with low noise and high selectivity, without applying decoration to the target. SOLUTION: When evaluating the target in a sample, the target is a singularly bondable substance itself being a substance singularly bondable to a certain affinity probe or a substance directly or indirectly bondable to the singularly bondable substance. An affinity probe labelled with a specific cyanine fluorochrome is used as the affinity probe. A treated object is provided by treating the sample by the affinity probe, and the existence, a difference or its quantity of the target are evaluated from the existence of a change, a difference or a degree of the change in light emitting fluorescent intensity of a fluorochrome after treatment to the light emitting fluorescent intensity of the fluorochrome before the treatment. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供用于评估低噪声和高选择性的目标的技术，而不对目标进行装饰。解决方案：当评估样品中的目标物时，目标物是单一可键合的物质，本身就是与特定亲和探针或直接或间接与单一可键合物质结合的物质单独结合的物质。使用用特定花青荧光染料标记的亲和探针作为亲和探针。通过用亲和探针对样品进行处理来提供处理对象，并且根据存在变化的差异或者目标的发光荧光强度的变化程度处理后的荧光染料在处理前的荧光染料的发光荧光强度。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2006098169A Device and method for quantitatively determining analyte 审中-公开
标题翻译：用于定量分析的定量和方法
公开(公告)号：JP2006098169A
公开(公告)日：2006-04-13
申请号：JP2004283245
申请日：2004-09-29
申请人： Fujitsu Ltd , 富士通株式会社
发明人： ARINAGA KENJI , RANT ULRICH , FUJIWARA KENJI , FUJITA SHOZO
IPC分类号： G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a technique for quantitatively determining an analyte, which can quantitatively determine the analyte over a wide range without lowering its detection sensitivity and can significantly improve the performance of the quantitative determination for the analyte. SOLUTION: A device is provided with an analyte detecting unit for capturing and detecting the analyte; and a quantitative measurement unit for quantitatively determining the analyte. In the device, a signal which is generated when the analyte is detected by the analyte detecting unit, is divided into a plurality of parts in the direction of the flow in a flow channel for processing by the quantitative measurement unit. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种用于定量测定分析物的技术，其可以在不降低其检测灵敏度的情况下定量测定分析物的范围，并且可以显着提高分析物的定量测定的性能。解决方案：设备具有用于捕获和检测分析物的分析物检测单元; 以及用于定量测定分析物的定量测量单元。在该装置中，当通过分析物检测单元检测到分析物时产生的信号，在由定量测量单元进行处理的流路中沿流动方向分成多个部分。版权所有（C）2006，JPO＆NCIPI

5. 发明专利

JP2003282924A Photo detector and method of manufacturing the same 有权
标题翻译：相片检测器及其制造方法
公开(公告)号：JP2003282924A
公开(公告)日：2003-10-03
申请号：JP2002082494
申请日：2002-03-25
申请人： Fujitsu Ltd , 富士通株式会社
发明人： ARINAGA KENJI
IPC分类号： G01J1/02 , C01B31/02 , H01L27/14 , H01L31/08
摘要： PROBLEM TO BE SOLVED: To provide a novel photo detector of a simple configuration which has a high quantum efficiency, and also to provide a method of manufacturing the same.
SOLUTION: Either carbon nanotubes 6 and 7, each of which has a band gap corresponding to a photosensitive wavelength of specific light, or a combination of the carbon nanotubes 6 and 7 and other components are used as a light receiving section.
COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供一种具有高量子效率的简单配置的新型光电检测器，并且还提供一种其制造方法。解决方案：使用具有对应于特定光的感光波长的带隙的碳纳米管6和7，或者碳纳米管6和7的组合等组分用作光接收部分。版权所有（C）2004，JPO

6. 发明专利

JP2010127804A Method for evaluating target molecule 有权
标题翻译：评估目标分子的方法
公开(公告)号：JP2010127804A
公开(公告)日：2010-06-10
申请号：JP2008303621
申请日：2008-11-28
申请人： Fujitsu Ltd , Technische Univ Muenchen , テクニッシェウニヴェルシテートミュンヘン , 富士通株式会社
发明人： ARINAGA KENJI , RANT ULRICH , PRINGSHEIM ERIKA , KAISER WOLFGANG , KNEZEVIC JELENA
IPC分类号： G01N33/543 , G01N21/64 , G01N21/78 , G01N27/00 , G01N27/327 , G01N37/00
CPC分类号： B82Y15/00 , G01N21/6428 , G01N27/3275 , G01N33/5438 , G01N2021/6432
摘要： PROBLEM TO BE SOLVED: To provide a new method for evaluating a physical property value of target molecules having high selectivity and few noises. SOLUTION: In this method for evaluating a target molecule bonded to a probe molecule including a marker, an AC voltage is applied between a substrate electrode provided on a substrate and a counter electrode, and by using a signal obtained from the marker included on the probe molecule bonded to the substrate electrode when a frequency of the AC voltage is varied, or an average value of the signal, at least some one is determined, between a Stokes radius or molecular weight of the target molecule, a bonding rate between the probe molecule and the target molecule, and a bonding rate constant therebetween, a dissociation rate therebetween, and a dissociation rate constant therebetween. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于评价具有高选择性和少量噪声的目标分子的物理性质值的新方法。解决方案：在用于评估与包括标记的探针分子结合的靶分子的方法中，在设置在基板上的基板电极和对电极之间施加AC电压，并且通过使用从包括的标记获得的信号当交流电压的频率变化时，在探针分子上结合的探针分子，或者在靶分子的斯托克斯半径或分子量之间确定至少一个信号的平均值，信号的平均值之间的键合速率，探针分子和靶分子，以及它们之间的键合速率常数，它们之间的解离速率和它们之间的解离速率常数。版权所有（C）2010，JPO＆INPIT

7. 发明专利

JP2010066271A Device and method for determining quantity of an analyte 有权
标题翻译：用于确定分析数量的装置和方法
公开(公告)号：JP2010066271A
公开(公告)日：2010-03-25
申请号：JP2009254600
申请日：2009-11-06
申请人： Fujitsu Ltd , 富士通株式会社
发明人： ARINAGA KENJI , RANT ULRICH , FUJIWARA KENJI , FUJITA SHOZO
IPC分类号： G01N35/08 , G01N21/78 , G01N27/28 , G01N27/327 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a technology for determining the quantity of an analyte by which the quantity of the analyte can be determined in a wide range without causing the deterioration of detection sensitivity and the capability of determining the quantity of the analyte can be remarkably improved. SOLUTION: In a device for determining the quantity of an analyte including a flow channel, an analyte detecting section for catching and detecting the analyte, and a quantity metering section for determining the quantity of the analyte, a signal that is generated when the analyte detecting section detects the analyte is processed by the quantity metering section dividing it into a plurality of signals along a direction of a flow of the flow channel. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供用于确定分析物的量的技术，通过该技术可以在宽范围内确定分析物的量，而不会导致检测灵敏度的降低和确定分析物的量的能力可以显着提高。解决方案：在用于确定包括流动通道的分析物的量的装置中，用于捕获和检测分析物的分析物检测部分和用于确定分析物的量的量计量部分，分析物检测部分检测分析物被量计量部分处理，该数量计量部分沿着流动通道的流动方向将其分成多个信号。版权所有（C）2010，JPO＆INPIT

8. 发明专利

JP2009288201A Flow velocity determination method of analyte, analyte evaluation method using the method, and design method of analyte evaluation device 有权
标题翻译：分析仪的流速测定方法，使用方法的分析评估方法和分析仪评估装置的设计方法
公开(公告)号：JP2009288201A
公开(公告)日：2009-12-10
申请号：JP2008143849
申请日：2008-05-30
申请人： Fujitsu Ltd , Univ Nagoya , 国立大学法人名古屋大学 , 富士通株式会社
发明人： AKI MASAHIKO , ARINAGA KENJI , BABA YOSHINOBU , TOKESHI MANABU , KACHI NORIMASA
IPC分类号： G01N33/543 , G01N21/64 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To enable rational flow velocity determination, when evaluating an analyte by means of fluorescence emission. SOLUTION: The analyte or a material other than the analyte which is a material, capable of changing intensity of fluorescence emission from a fluorescence-labeled substance by being coupled with the fluorescence-labeled substance, is allowed to flow during light reception onto the fluorescence-labeled substance capable of changing intensity of fluorescence emission, by being coupled with the analyte during light reception, to be brought into contact with the fluorescence-labeled substance, and flow velocity to be used for evaluating the analyte is determined from the relation between a time constant and the flow velocity, determined by standardizing a gradient of the rises time or the fall time change of the fluorescence intensity from the fluorescence labeled substance. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：当通过荧光发射评估分析物时，能够确定合理的流速。解决方案：允许通过与荧光标记物质偶联，能够改变荧光标记物质的荧光发射强度的分析物或分析物以外的材料，该分析物是能够在光接收期间流过荧光标记物质的荧光发射强度，荧光标记的物质能够通过与受光时的分析物结合而与荧光标记的物质接触，并且可以从用于评价分析物的流速来改变荧光发射强度通过标准化来自荧光标记物质的荧光强度的上升时间或下降时间变化的梯度来确定时间常数和流速之间的关系。版权所有（C）2010，JPO＆INPIT

9. 发明专利

JP2009085636A Method and apparatus for evaluating target molecule 审中-公开
标题翻译：评估目标分子的方法和装置
公开(公告)号：JP2009085636A
公开(公告)日：2009-04-23
申请号：JP2007252550
申请日：2007-09-27
申请人： Fujitsu Ltd , 富士通株式会社
发明人： AKI MASAHIKO , ARINAGA KENJI
IPC分类号： G01N21/64 , G01N33/543 , G01N33/551
CPC分类号： G01N33/5438 , G01N21/66 , G01N21/68 , G01N21/69 , G01N2021/6439
摘要： PROBLEM TO BE SOLVED: To provide a novel technique for enabling the evaluation or the like of the comparing judgment of an evaluation target, the judgment of the kind of the evaluation target, the quantification of the evaluation target, the determination of the dissociation constant of the evaluation target and the separation of the objective evaluation target and an impure substance in a label free state. SOLUTION: In a case that AC potential is applied across a substrate electrode and a counter electrode to evaluate the target molecule bonded to the probe molecule bonded on the substrate electrode, for example, at least either one of signal intensity, which is obtained by formula 1: signal intensity=fluorescence intensity at time of application of potential 1-fluorescence of background, and the signal amplitude, which is obtained by formula 2: signal amplitude=ä(fluorescence intensity at time of application of potential 1-fluorescence intensity at time of application of potential 2)/(fluorescence intensity at time of application of potential 2-fluorescence intensity of background)}×100, is measured to evaluate the target molecule. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了提供评价对象的评价等的新颖的技术，评价对象的种类的判断，评价对象的量化，评价对象的判定评估目标的解离常数和客观评估目标的分离以及不标示物质的不纯物质。解决方案：在跨越衬底电极和对电极施加交流电势以评估与结合在衬底电极上的探针分子结合的靶分子的情况下，例如，信号强度，即通过公式1获得：信号强度=应用背景的电位1-荧光时的荧光强度和由公式2获得的信号幅度：信号幅度=ä（施加电位1-荧光时的荧光强度应用电位时的强度2）/（应用电位2荧光强度背景时的荧光强度）}×100，以评估靶分子。版权所有（C）2009，JPO＆INPIT

10. 发明专利

JP2004132848A Target capturing body and target detection apparatus 有权
公开(公告)号：JP2004132848A
公开(公告)日：2004-04-30
申请号：JP2002297941
申请日：2002-10-10
申请人： Fujitsu Ltd , 富士通株式会社
发明人： FUJIWARA KENJI , FUJITA SHOZO , TAKEISHI SHUNSAKU , ARINAGA KENJI , YAMAGUCHI YOSHITAKA , USUKI TATSUYA
IPC分类号： G01N21/64 , C12M1/00 , C12M1/34 , C12N15/09 , G01N21/77 , G01N21/78 , G01N33/483 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide a target detection apparatus or the like capable of effectively detecting various targets such as proteins without labeling of fluorescence, etc.
SOLUTION: The target detection apparatus comprises a target capturing body which includes an area interacting with a conductive material in at least a part thereof and can be coupled with a target, and which enables light emission upon receiving light irradiation when not being interacting with the conductive material; a means for discharging the target capturing body from the conductive material by releasing the interaction between the conductive material and the target capturing body; a means for irradiating light toward the conductive material; and a means for detecting light emitted from the target capturing body upon receiving light irradiated from the light irradiation means. The target capturing body comprises: an interaction part including an area interactive with conductive material in at least a part thereof; a target capturing part capable of capturing a target; and a light emission part capable of emitting light upon receiving light irradiation when the area of the interaction part is not interacted with the conductive material.
COPYRIGHT: (C)2004,JPO

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