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    • 3. 发明专利
    • Method for producing lactam compound
    • 生产乳酸酯化合物的方法
    • JP2008156277A
    • 2008-07-10
    • JP2006346628
    • 2006-12-22
    • Daicel Chem Ind Ltdダイセル化学工業株式会社
    • SHIBAMOTO AKIHIROIWAHAMA TAKAHIRONAKANO TATSUYA
    • C07D225/02C07B61/00
    • C07D201/04C07D225/02
    • PROBLEM TO BE SOLVED: To provide an industrial method for producing an 8-15C lactam compound in high efficiency at a low cost by allowing the rearrangement reaction of a cyclic oxime compound to proceed without generating a large amount of by-products such as ammonium sulfate.
      SOLUTION: The method for producing a lactam compound expressed by formula (2) (m is an integer of 7-14) comprises the rearrangement reaction of a cyclic oxime compound of formula (1) (m is same as defined above) in a non-polar solvent B in the presence of an aromatic compound A having a leaving group bonded to a carbon atom constituting the aromatic ring and containing a heteroatom or a carbon atom bonded with an electron attractive group as an atom constituting the aromatic ring.
      COPYRIGHT: (C)2008,JPO&INPIT
    • 待解决的问题:提供一种通过使环状肟化合物的重排反应进行而不产生大量的副产物,从而以低成本高效生产8-15C内酰胺化合物的工业方法, 作为硫酸铵。 解决方案:由式(2)表示的内酰胺化合物的制备方法(m为7-14的整数)包括式(1)的环状肟化合物的重排反应(m与上述相同) 在非极性溶剂B中,在具有与构成芳环的碳原子键合的离去基团并且含有与吸电子基团键合的杂原子或碳原子作为构成芳香环的原子的芳香族化合物A的存在下进行。 版权所有(C)2008,JPO&INPIT
    • 6. 发明专利
    • Lactone compound and method for producing lactone compound
    • LACTONE化合物和生产Lactone化合物的方法
    • JP2006248965A
    • 2006-09-21
    • JP2005066739
    • 2005-03-10
    • Daicel Chem Ind Ltdダイセル化学工業株式会社
    • ISHII YASUTAKAIWAHAMA TAKAHIRO
    • C07D493/04C07B61/00C07D307/33C07D307/58C07D307/68
    • Y02P20/55
    • PROBLEM TO BE SOLVED: To obtain a new lactone compound and to provide a method for efficiently producing a lactone compound by a simple means. SOLUTION: The lactone compound is represented by formula (1) (R a , R a ', R b and R b ' are the same or different and are each a hydrogen atom, a halogen atom, a hydrocarbon group which may contain a substituent group, a heterocyclic group which may contain a substituent group, a carboxy group, a substituted oxycarbonyl group, a substituted or nonsubstituted carbamoyl group, a cyano group, an acyl group, a nitro group, a sulfur acid group, a sulfur acid ester group, a hydroxy group, a substituted oxy group, a mercapto group, a substituted thio group or a substituted or nonsubstituted amino group; the carboxy group, the sulfur acid group, the hydroxy group and the mercapto group each may be protected with a protecting group; R a and R b and R a ' and R b ' may be mutually bonded with an adjacent carbon atom, respectively to form a ring). COPYRIGHT: (C)2006,JPO&NCIPI
    • 要解决的问题:获得新的内酯化合物并提供通过简单的方法有效地制备内酯化合物的方法。 解决方案:内酯化合物由式(1)表示(R 1 SP 1,R SP 1,R 2,SP 2,R SP, > b“相同或不同,各自为氢原子,卤素原子,可以含有取代基的烃基,可以含有取代基的杂环基,羧基,取代的氧羰基 基团,取代或未取代的氨基甲酰基,氰基,酰基,硝基,硫酸基,硫酸酯基,羟基,取代的氧基,巯基,取代的硫基或 取代或未取代的氨基;羧基,硫酸基,羟基和巯基各自可以用保护基保护; R a 和R SP SP 并且R a '和R b '可以分别与相邻的碳原子相互键合以形成环)。 版权所有(C)2006,JPO&NCIPI
    • 7. 发明专利
    • Method of purifying organic compound
    • 净化有机化合物的方法
    • JP2009179620A
    • 2009-08-13
    • JP2008022449
    • 2008-02-01
    • Daicel Chem Ind Ltdダイセル化学工業株式会社
    • IWAHAMA TAKAHIROKUBO TAKASHI
    • C07C67/60C07C69/675C07D307/33C07D309/30
    • PROBLEM TO BE SOLVED: To provide a method of purifying an organic compound which can simply and efficiently remove (meth)acrylic anhydride from a mixture containing an organic compound easy to decompose by a base and (meth)acrylic anhydride as an impurity while inhibiting the decomposition of the organic compound. SOLUTION: The method of purifying an organic compound comprises a step of subjecting a mixture containing an organic compound easy to decompose by a base and (meth)acrylic anhydride to hydrolysis treatment under the conditions of pH 2.2-7 to decompose the (meth)acrylic anhydride. The hydrolysis treatment is preferably carried out in the presence of an organic base or its salt. In that case, as the organic base, a nitrogen-containing aromatic heterocyclic compound is preferred. COPYRIGHT: (C)2009,JPO&INPIT
    • 待解决的问题:提供一种纯化有机化合物的方法,其可以从含有易于被碱分解的有机化合物和(甲基)丙烯酸酐作为杂质的混合物中简单有效地除去(甲基)丙烯酸酐。 同时抑制有机化合物的分解。 解决方案:有机化合物的纯化方法包括使含有有机化合物的混合物通过碱和(甲基)丙烯酸酐分解的水溶液在pH 2.2-7的条件下进行水解处理以分解( 甲基)丙烯酸酐。 水解处理优选在有机碱或其盐的存在下进行。 在这种情况下,作为有机碱,优选含氮芳香族杂环化合物。 版权所有(C)2009,JPO&INPIT
    • 10. 发明专利
    • Method for producing lactam
    • 生产乳酸菌的方法
    • JP2008179605A
    • 2008-08-07
    • JP2007295092
    • 2007-11-14
    • Daicel Chem Ind Ltdダイセル化学工業株式会社
    • ISHII YASUTAKASHIBAMOTO AKIHIROIWAHAMA TAKAHIRONAKANO TATSUYA
    • C07D223/10C07B61/00C07D225/02
    • C07D201/04C07D201/10Y02P20/52Y02P20/55
    • PROBLEM TO BE SOLVED: To provide a method for commercially and efficiently manufacturing a lactam from a cycloalkane at a high yield using a catalyst being friendly to the environment. SOLUTION: The method for manufacturing a lactam comprising a process A of synthesizing a corresponding cycloalkanone oxime by causing a cycloalkane and a nitrous acid ester to react with each other in the presence of a nitrogen-atom-containing cyclic compound (a) comprising a skeleton represented by formula (i) [wherein X represents an oxygen atom or an -OR group (R represents a hydrogen atom or a protective group of a hydroxy group)] as a component constituting the ring thereof and a process B of converting the resulting cycloalkanone oxime obtained in the process A to form a corresponding lactam by virtue of the Beckmann rearrangement, and also comprises a process of removing the nitrogen-atom-containing cyclic compound (a) in the midst of the process A and/or after completing the process A. COPYRIGHT: (C)2008,JPO&INPIT
    • 待解决的问题:提供使用对环境友好的催化剂以高产率从环烷烃商业上有效地制造内酰胺的方法。 解决方案:制备内酰胺的方法,其包括通过使环烷烃和亚硝酸酯在含氮原子的环状化合物(a)的存在下相互反应来合成相应的环烷酮肟的方法A, 包含由式(i)表示的骨架[其中X表示氧原子或-OR基团(R表示氢原子或羟基的保护基)]作为构成环的组分和转化 在方法A中获得的所得环烷酮肟由于Beckmann重排而形成相应的内酰胺,并且还包括在方法A和/或之后除去含氮原子的环状化合物(a)的方法 完成过程A.版权所有(C)2008,JPO&INPIT