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1. 发明专利

JPS61212539A METHOD OF OPTICAL RESOLUTION OF ALPHA-CHLOROPROPIONIC ACID 失效
公开(公告)号：JPS61212539A
公开(公告)日：1986-09-20
申请号：JP5203985
申请日：1985-03-15
申请人： DAICEL CHEM
发明人： ICHIDA AKITO , OKAMOTO ICHIRO , SHIBATA TORU
IPC分类号： C07B57/00 , C07B31/00 , C07C67/00 , C07C67/56 , C07C69/63 , C07C231/00 , C07C231/12 , C07C231/20 , C07C233/05 , C07C233/06 , C07C233/07 , C07C325/00 , C07C327/22
摘要： PURPOSE:To subject a mixture of enantiomorph of alpha-chloropropionic acid to optical resolution, by carrying out the optical resolution by liquid chromatography using a specific resolving agent as an optically active stationary phase. CONSTITUTION:A mixture of enantiomorph of alpha-chloropropionic acid shown by the formula [A is O, or N; S is R is (substituted)aromatic group, cycloalkyl, or alkyl; * is asymmetic carbon atom] such as alpha-chloropropionic acid anilide, etc. is subjected to optical resolution by liquid chromatography having adsorbed a resolving agent comprising a polysaccharide or its derivative as an active ingredient, preferably supported on a carrier. Any of synthetic polysaccharide, naturally occurring polysaccharide and modified naturally occurring polysaccha ride may be used as the polysaccharide, optically active homoglycan having high regularity is preferable, and cellulose tribenzoate, cellulose triacetate, etc., having fixed bond style are preferable. EFFECT:Analysis of optical purity can be performed simply and accurately.

2. 发明专利

JPH0261932B2 失效
公开(公告)号：JPH0261932B2
公开(公告)日：1990-12-21
申请号：JP18996383
申请日：1983-10-13
申请人： DAICEL CHEM
发明人： ICHIDA AKITO
IPC分类号： C07C69/712 , C07C69/54 , C08F20/00 , C08F20/10 , C08F20/18

3. 发明专利

JPH02101035A ALKOXYLATION OF 2,2'-DIHYDROXY-1,1'-DINAPHTHTYL COMPOUND 失效
公开(公告)号：JPH02101035A
公开(公告)日：1990-04-12
申请号：JP25330588
申请日：1988-10-07
申请人： AGENCY IND SCIENCE TECHN , DAICEL CHEM
发明人： ICHIDA AKITO , TACHIBANA KOZO , SHINPO TOSHIO , YAMAGUCHI TOMOHIKO
IPC分类号： B01J27/232 , B01J27/24 , B01J31/02 , C07B61/00 , C07C41/00 , C07C41/16 , C07C43/20 , C07C43/215 , C07C67/00
摘要： PURPOSE:To enable industrially advantageous alkoxylation of the title compound in the shortened reaction time, easily in low costs, by selecting the solvent in case of a specific aprotic solvent in the presence of a potassium base, especially potassium carbonate. CONSTITUTION:In the presence of at least one base selected from potassium bases of K-R (R is 1 to 4 C alkoxy, -NH2, H), preferably a potassium alkoxide, and potassium carbonate, the compound of formula I is alkoxylated with an alkoxylating agent of the formula: R -X (X is Cl, Br, I) such as methyl chloride in the aprotic solvent which has O or N atoms in its molecule and boils over 65 deg.C (preferably tetrahydrofuran and N-N-dimethylformamide or dimethyl sulfoxide are employed, when potassium carbonate is used as a base) to give a compound of formula II (R is 1 to 18C hydrocarbon group).

4. 发明专利

JPS6314730A OPTICAL RESOLUTION OF ALPHA-SUBSTITUTED ACETIC ACID ESTER 失效
公开(公告)号：JPS6314730A
公开(公告)日：1988-01-21
申请号：JP15755386
申请日：1986-07-04
申请人： DAICEL CHEM
发明人： TAKEUCHI YOSHIO , KOIZUMI TORU , ICHIDA AKITO
IPC分类号： C07B57/00 , C07B31/00 , C07C67/00 , C07C67/56 , C07C69/78 , C07C313/00 , C07C319/28 , C07C323/52 , C07C323/56 , C07C323/62 , C07D209/48
摘要： PURPOSE:To enable the optical resolution of an enantiomeric mixture of an acetic acid ester having asymmetric carbon at alpha-site and an electron attracting group at alpha-site by chromatographic means, by using a separation agent containing a polysaccharide derivative as an active component. CONSTITUTION:An enantiomeric mixture of a compound of formula [X, Y and Z are different substituted groups and at least one of them is electron attracting group (e.g. halogen, CN, NO2, alkoxycarbonyl, etc); R is alkyl, (substituted) aromatic group or (substituted) heteroaromatic group; * represents asymmetric carbon] is subjected to optical resolution by chromatographic means using a separation agent consisting of a polysaccharide derivative supported on a porous organic carrier (e.g. polystyrene, polyacrylamide, etc.) or porous inorganic carrier (e.g. silica, alumina, etc.). The polysaccharide derivative is preferably cellulose, amylose, beta-1,4-chitosan, chitin, etc., wherein >=85% of hydrogen atom of hydroxyl group is substituted with other atomic group.

5. 发明专利

JPS5933245A Halogen-containing methacrylic ester compound 失效
标题翻译：含卤素甲基丙烯酸酯化合物
公开(公告)号：JPS5933245A
公开(公告)日：1984-02-23
申请号：JP14385182
申请日：1982-08-19
申请人： Daicel Chem Ind Ltd
发明人： ICHIDA AKITO , OKAMOTO ICHIROU
IPC分类号： C07C69/653 , C08F20/00 , C08F20/22
摘要： NEW MATERIAL:A halogen-containing methacrylic ester compound shown by the formula I (R
1 , R
2 , and R
3 have aromatic group or substitutent group, and at least one of them is halogen-containing phenyl group shown by the formula II; A is halogen; P is number of halogen group and 1W5).
EXAMPLE: Tri(4-fluorophenyl)methylmethacrylate.
USE: Having optical activity, useful as an optical resolving agent for racemic modifications and a raw material for synthesizing polymers and copolymers. For example, ionic polymerization is carried out using an anionic catalyst as a polymerization initiator, to give an optical active polymer.
PROCESS: For example, silver methacrylate is reacted with Cl-Cr
1 R
2 R
3 in an ether to give a compound shown by the formula I .
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：新材料：由式I表示的含卤素的甲基丙烯酸酯化合物（R 1，R 2和R 3）具有芳基或取代基，并且其中至少一个是含卤素的苯基由式II表示; A是卤素; P是卤素基团数目和1-5）。实施例：三（4-氟苯基）甲基丙烯酸甲酯。用途：具有光学活性，可用作外消旋体改性的光学拆分剂和用于合成聚合物和共聚物的原料。例如，使用阴离子催化剂作为聚合引发剂进行离子聚合，得到光学活性聚合物。方法：例如，将甲基丙烯酸银与Cl-Cr 1 R 2 R 3在醚中反应，得到式I所示的化合物。

6. 发明专利

JP2004231522A Method for synthesizing 3-bromo-5-nitrotoluene 审中-公开
公开(公告)号：JP2004231522A
公开(公告)日：2004-08-19
申请号：JP2003018300
申请日：2003-01-28
申请人： Daicel Chem Ind Ltd , ダイセル化学工業株式会社
发明人： ICHIDA AKITO
IPC分类号： C07C201/12 , C07C205/12 , C07C263/10 , C07C265/12
摘要： PROBLEM TO BE SOLVED: To provide a method for synthesizing 3-bromo-5-nitrotoluene by which the synthetic time is shortened.
SOLUTION: The method for synthesizing the 3-bromo-5-nitrotoluene is carried out as follows. 2-Methyl-4-nitroaniline is reacted with bromine in acetic acid to provide 2-bromo-4-nitro-6-methylaniline. The resultant 2-bromo-4-nitro-6-methylaniline is then subjected to a deamination reaction.
COPYRIGHT: (C)2004,JPO&NCIPI

7. 发明专利

JPH0859702A SEPARATING AGENT FOR OPTICAL ISOMER AND ITS PRODUCTION 失效
公开(公告)号：JPH0859702A
公开(公告)日：1996-03-05
申请号：JP13721494
申请日：1994-06-20
申请人： DAICEL CHEM
发明人： MURAKAMI TATSUFUMI , ICHIDA AKITO
IPC分类号： B01J20/291 , B01J20/281 , B01J20/283 , B01J20/32 , C07B57/00 , C08B37/00 , G01N30/88 , G01N30/48
摘要： PURPOSE: To obtain a separating agent, excellent in solvent resistance and optimal for optical resolution by mutually cross-linking only polysaccharide derivatives on a carrier and immobilizing the polysaccharide derivatives thereon. CONSTITUTION: This separating agent for optical isomers is obtained by mutually cross-linking only polysaccharide derivatives on a carrier and immobilizing the polysaccharide derivatives thereon. The carrier is a silica gel having the surface inactivated to reaction and 1μm to 10mm grain diameter. The polysaccharide derivatives before the cross-linking are ester or carbamate derivatives of cellulose or amylose having >=0.1 unreacted hydroxyl group or reactive functional group based on the glucose unit in an introduced group. The cross-linking is carried out by mutually cross-linking only the polysaccharide derivatives on the carrier with a polyfunctional cross-linking agent (a diisocyanate derivative or an acid chloride derivative, a diepoxy derivative or a divinyl derivative of a dicarboxylic acid). The hydroxyl groups at the 6-position of the cellulose or amylose are mutually selectively cross-linked. The resultant separating agent is used as a separating agent for thin-layer and gas chromatographies, especially liquid chromatography.

8. 发明专利

JPH0316940B2 失效
公开(公告)号：JPH0316940B2
公开(公告)日：1991-03-06
申请号：JP14385182
申请日：1982-08-19
申请人： DAICEL CHEM
发明人： ICHIDA AKITO , OKAMOTO ICHIRO
IPC分类号： C07C69/653 , C08F20/00 , C08F20/22

9. 发明专利

JPH038364B2 失效
公开(公告)号：JPH038364B2
公开(公告)日：1991-02-05
申请号：JP14385282
申请日：1982-08-19
申请人： DAICEL CHEM
发明人： ICHIDA AKITO , OKAMOTO ICHIRO
IPC分类号： C08F4/00 , C08F4/42 , C08F4/46 , C08F4/50 , C08F20/00 , C08F20/22

10. 发明专利

JPH01305037A OPTICAL RESOLUTION OF COMPOUND HAVING TWO AROMATIC GROUPS ON ASYMMETRIC CENTER 失效
公开(公告)号：JPH01305037A
公开(公告)日：1989-12-08
申请号：JP13488588
申请日：1988-06-01
申请人： DAICEL CHEM
发明人： ICHIDA AKITO , MATSUMOTO YOSHITAKA
IPC分类号： C07C213/10 , C07B57/00 , C07C67/00 , C07C213/00 , C07C215/30 , C07C217/10 , C07C319/28 , C07C323/25 , C07D213/30 , C07D295/00 , C07D295/08 , G01N30/88
摘要： PURPOSE:To easily and accurately perform optical resolution of a mixture of enantiomers of a compound having two aromatic groups on the asymmetric center by using a separation agent containing a polysaccharide derivative as an active component. CONSTITUTION:A mixture of enantiomers of a compound of formula I or II (Ar and Ar' are different 5-14C unsubstituted or substituted aromatic groups; R1 is H or OH; R2 and R3 are 1-5C alkyl; X is O or S; m is 1-5; R4 is 1-10C chain alkyl; n and p are 1-5; * represents asymmetric carbon atom) is subjected to optical resolution with a separation agent containing a polysaccharide derivative as an active component. The polysaccharide derivative is preferably cellulose, amylose, beta-1,4-chitosan, chitin, etc., which are easily available in the form of high-purity polysaccharide. It is generally supported on a porous carrier having particle diameter of 1-300mum and average pore diameter of 50-10,000Angstrom . The optical resolution is carried out by chromatography and the obtained compound is used as pharmaceuticals.

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