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1. 发明专利

JPH01282144A TRICALCIUM PHOSPHATE SINTERED BODY AND PRODUCTION THEREOF 失效
公开(公告)号：JPH01282144A
公开(公告)日：1989-11-14
申请号：JP10994288
申请日：1988-05-06
申请人： OLYMPUS OPTICAL CO , AGENCY IND SCIENCE TECHN
发明人： HAKAMAZUKA KOJI , IRIE HIROYUKI , KAWAMURA MOTOZO , TORIYAMA MOTOHIRO
IPC分类号： A61L27/00 , C04B35/00 , C04B35/447
摘要： PURPOSE:To easily improve high strength and biological affinity by adding and mixing both SiO2 powder and Al2O3 powder to/with calcium phosphate powder which is specified in Ca/P ratio and has been synthesized by a mechanochemical method and sintering the mixture. CONSTITUTION:CaCO3 and CaHPO4.2H2O are mixed together with pure water at a molar ratio of (1.02-1.10):2 so that Ca/P is regulated to 1.51-1.55 and the mixture is pulverized with a ball mill and subjected to mechanochemical reaction to obtain slurry (A). Then after dehydrating and drying the component A, calcium phosphate (B) is obtained by calcining it at about 750 deg.C. Thereafter a mixture (C) is obtained by mixing crystalline SiO2 powder which has been obtained by crystallizing SiO2 powder with Al2O3 powder at weight ratio of 3:1. A mixture (D) is obtained by adding both 8-12wt.% component C and an ammonium polyacrylate-base deflocculant to the component B and mixing them to obtain a mixture (D). Then a tricalcium phosphate sintered body is produced by sintering the component D at 1200-1400 deg.C.

2. 发明专利

JPH05310595A 失效
公开(公告)号：JPH05310595A
公开(公告)日：1993-11-22
申请号：JP7720291
申请日：1991-03-18
申请人： AGENCY IND SCIENCE TECHN , OLYMPUS OPTICAL CO
发明人： SUZUKI TAKAHIRO , KAWAMURA MOTOZO , TORIYAMA MOTOHIRO , YOKOGAWA YOSHIYUKI , KAWAMOTO YUKARI , HAKAMAZUKA KOJI , IRIE HIROYUKI
IPC分类号： A61K9/00 , A61K38/45 , A61K47/02 , A61P7/02 , C12N11/14 , A61K37/52
摘要： PURPOSE:To obtain the subject complex capable of keeping the activity of a plasminogen activator(PA) effect and effective as a thrombolytic agent for the treatment of cerebral thrombosis, etc., by bonding PA to a porous material composed of a calcium phosphate through covalent bond. CONSTITUTION:A toluene solution of aminopropyltriethoxysilane, etc., is added to a porous carrier (beta-TCP carrier) composed of a calcium phosphate (e.g. beta-tricalcium phosphate) and heated at 110 deg.C for 6hr under refluxing. The treated beta-TCP carrier is washed with toluene and dried. The obtained beta-TCP carrier having introduced amino groups is filled in a column and a 0.1M phosphoric acid buffer solution (pH7) containing glutaraldehyde is circulated through the column. Thereafter, a 0.1M phosphoric acid buffer solution containing a plasminogen activator (e.g. urokinase) is circulated through the column to bond the plasminogen activator to the carrier through covalent bond and the unreacted materials are removed by washing to obtain the objective complex of the plasminogen activator and the porous carrier.

3. 发明专利

JPH03228811A PRODUCTION OF CALCIUM PHOSPHATE 失效
公开(公告)号：JPH03228811A
公开(公告)日：1991-10-09
申请号：JP30463390
申请日：1990-11-09
申请人： AGENCY IND SCIENCE TECHN , OLYMPUS OPTICAL CO
发明人： HAKAMAZUKA KOJI , IRIE HIROYUKI , KAWAMURA MOTOZO , TORIYAMA MOTOHIRO
IPC分类号： A61L27/00 , C01B25/32 , C04B35/00 , C04B35/447
摘要： PURPOSE:To obtain calcium phosphate powder showing excellent biological safeness by effecting the mechanochemical reaction of calcium carbonate and calcium hydrogen phosphate in a water slurry state, pulverizing the reaction product and then calcinating this powder. CONSTITUTION:The starting material is prepared by weighing the powder of calcium hydrogen phosphate or its dihydrate and the powder of high purity calcium carbonate, preferably having =30 deg.C, and is made to react mechanochemically in a ball mill, preferably for 24 hours. This slurry is then dried at 80 deg.C, preferably for 8 hours. The dried sample is pulverized and calcined, preferably at 720-1150 deg.C for 1-10 hours or longer to provide the objective calcium phosphate as a porous or dense body.

4. 发明专利

JPS63134672A FORMATION OF CALCIUM PHOSPHATE FILM AND MEMBER TO BE IMPLANTED IN LIVING BODY 失效
公开(公告)号：JPS63134672A
公开(公告)日：1988-06-07
申请号：JP28016086
申请日：1986-11-25
申请人： OLYMPUS OPTICAL CO , AGENCY IND SCIENCE TECHN
发明人： HAKAMAZUKA KOJI , KAWAMURA MOTOZO , TORIYAMA MOTOHIRO
IPC分类号： C04B41/87 , A61F2/00 , A61L27/00 , A61L27/32 , C04B41/52 , C04B41/89 , C23C22/03
摘要： PURPOSE:To form a rigid film having superior biocompatibility by coating the surface of a base material with a slurry of fine phosphate glass powder and further coating it with a slurry of fine calcium phosphate powder synthesized by a mechanochemical process. CONSTITUTION:The surface of a base material of ceramics or a metal is coated with a slurry of fine phosphate glass powder consisting of CaO, Na2O, P2O5 and Al2O3, and the slurry is dried and heat treated to form a binder layer. The surface of the base material having the binder layer is then coated with a slurry prepd. by mixing fine calcium phosphate powder synthesized by a mechanochemical process with a deflocculating agent such as ammonium polyacrylate and water, and the slurry is dried and heat treated to form a calcium phosphate film. This film is dense and uniform and has high adhesion to the base material. The base material having the film is poisonless and can be utilized as a material to be implanted in a living body such as an artificial dental root or an artificial bone.

5. 发明专利

JP2003320011A Living tissue filling material, living tissue filling body, method of manufacturing living tissue filling body, and device of manufacturing living tissue filling body 审中-公开
标题翻译：生活组织填充材料，生活组织填充体，制造生活组织填充体的方法，以及制造生活组织填充体的装置
公开(公告)号：JP2003320011A
公开(公告)日：2003-11-11
申请号：JP2002129266
申请日：2002-04-30
申请人： Olympus Optical Co Ltd , オリンパス光学工業株式会社
发明人： HIBINO HIROKI , INOUE AKIRA , HAKAMAZUKA KOJI , ADACHI HIDEYUKI
IPC分类号： C12M3/00 , A61L27/00 , C12N5/07 , C12N5/06
摘要： PROBLEM TO BE SOLVED: To provide a living tissue filling material, a living tissue filling body, and a method and device of manufacturing the living tissue filling body into which cells can be sufficiently infiltrated within a limited period of time. SOLUTION: A cell-including humor is filtered with the living tissue filling material 1 and required cells are collected to obtain the living tissue filling body 30. COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供活组织填充材料，活组织填充体，以及制造生物体组织填充体的方法和装置，其中细胞可以在有限的时间内充分渗入细胞内。解决方案：用生物体组织填充材料1过滤包含细胞的幽默物质，并收集所需的细胞以获得活组织填充体30.版权所有（C）2004，JPO

6. 发明专利

JPH05192354A MANUFACTURE OF DENTAL PROSTHESIS 失效
公开(公告)号：JPH05192354A
公开(公告)日：1993-08-03
申请号：JP741292
申请日：1992-01-20
申请人： OLYMPUS OPTICAL CO
发明人： HAKAMAZUKA KOJI
IPC分类号： A61C5/77 , A61C13/20
摘要： PURPOSE:To provide a method for manufacturing a dental prosthesis capable of preventing the breakage of a dental prosthesis resulted from a scratch generated at the time of cutting and polishing the sprue line of a casted material. CONSTITUTION:A sprue line 12 is planted on the cheek side surface 13 of a wax pattern 11. A casting mold is formed by use of the wax pattern 11. Into the obtained casting mold, glass ceramics is casted. Thereafter, heating treatment is conducted with determined temperature and time, and the glass ceramics is crystallized to provide a casted material having a wax pattern part having the form corresponding to the wax pattern 11 and a sprue line part having the form corresponding to the sprue line 12. After the sprue line part of the casted material is cut and polished, porcelain having a thermal expansion coefficient nearly equal to that of the glass ceramics is baked so as to cover the surface area of the wax pattern part to which the sprue line part is connected, and a dental prosthesis is provided.

7. 发明专利

JPH0549650A PRODUCTION OF DENTAL PROSTHETIC APPLIANCE 失效
公开(公告)号：JPH0549650A
公开(公告)日：1993-03-02
申请号：JP21497991
申请日：1991-08-27
申请人： OLYMPUS OPTICAL CO
发明人： HAKAMAZUKA KOJI
IPC分类号： A61C5/08 , A61C13/083
摘要： PURPOSE:To provide the process for production of the dental prosthetic appli ance which can produce the dental prosthetic appliance having an excellent aesthetic property and high mechanical strength. CONSTITUTION:A core material 12 formed by casting and molding castable ceramics in accordance with the conventional method, then subjecting the molding to a crystallization treatment by heating the molding at 920 deg.C is disposed on an abutment tooth pattern 11. A porcelain mixture 13 prepd. by mixing porcelain 'Bitadule-N(R)' produced by Bita Co., porcelain 'Duceram(R)' correction powder (K) produced by Ducera Co., and low fusing graze material 'Ceracom Fine Grating Stain(R)' produced by Ceracom Co., at 7:2:1 weight ratio is then built up. After this mixture is cried for minutes at 600 deg.C, the mixture is heated up to 905 deg.C at 50 deg.C ratio per minute under a reduced pressure (760mmHg). The molding is then held for 30 minutes at 905 deg.C and is slowly cooled in the atm., by which the dental prosthetic appliance 10 is obtd.

8. 发明专利

JPH0538709A RELEASING METHOD FOR MATRIX, MANUFACTURE OF CASTS AND MATRIX RELEASING SHEET USED FOR THE SAME METHOD 失效
公开(公告)号：JPH0538709A
公开(公告)日：1993-02-19
申请号：JP19799291
申请日：1991-08-07
申请人： OLYMPUS OPTICAL CO
发明人： HAKAMAZUKA KOJI
IPC分类号： B28B1/26 , B28B7/34
摘要： PURPOSE:To provide the above releasing method for a matrix from a cast simply in a short time, the manufacturing method for casts and a MATRIX releasing sheet. CONSTITUTION:A casting material is filled until wax patterns 11 and 12 disposed in a vessel 16 are hidden, and a first cast section 17 is manufactured, and a cast releasing sheet 18 composed of ceramic fiber is disposed on the first cast section 17 in a manner of not being brought into contact with wax patterns 11 and 12. A cast material is filled to the upper end of the casting vessel 16 above the sheet 18 to manufacture a second cast section 19. The cast material is cured and then heated to eliminate the wax patterns 11 and 12 and manufacture the matrix. A glass molten body is cast in the cast and cured completely, when the cast is released from the casting vessel 16. The matrix is separated by using the sheet 18 as a boundary and the second cast section 19 is removed, and then the sheet 18 is released from the first cast section 17, and the first cast section 17 is removed without damaging the cast material.

9. 发明专利

JPH04266755A SUPPORT BASE TOOTH FOR CERAMIC CROWN 失效
公开(公告)号：JPH04266755A
公开(公告)日：1992-09-22
申请号：JP5047591
申请日：1991-02-22
申请人： OLYMPUS OPTICAL CO
发明人： FUKUDA HIROSHI , HAKAMAZUKA KOJI , WATANABE KAZUHIRO , IRIE HIROYUKI
IPC分类号： A61C13/09 , A61C8/00 , A61C13/30
摘要： PURPOSE:To prevent the rupture of a ceramic crown not to cause a metal allergy by constituting a support base tooth for the ceramic crown out of ceramics or metal having large elastic modulus and excellent organism affinity. CONSTITUTION:Zirconia powder is press-molded, temporarily baked, machined into a support base tooth shape, and baked to manufacture a support base tooth 3. A crown 6 made of ceramics or metal is fitted to it. No tension is generated on the inside of the ceramic crown 6, the rupture of the ceramic crown 6 is prevented, zirconia has excellent organism affinity, then no metal allergy is caused. Either zirconia, alumina, mica-beta-spodumene crystallized glass or high-intensity beta-TCP is used for the ceramics, and either titanium, titanium alloy or gold alloy is used for the metal.

10. 发明专利

JPH041122A SUSTAINED RELEASE MATERIAL AND PRODUCTION THEREOF 失效
公开(公告)号：JPH041122A
公开(公告)日：1992-01-06
申请号：JP9964290
申请日：1990-04-16
申请人： OLYMPUS OPTICAL CO
发明人： HAKAMAZUKA KOJI , IRIE HIROYUKI
IPC分类号： A61M37/00 , A61K9/00
摘要： PURPOSE:To obtain the title material having adequate therapeutic effects with the liquid drug sustainedly releasable over a long period of time, by covering a ceramic porous part with a second ceramic porous part with its pore size and porosity smaller than those of the former part. CONSTITUTION:The objective material 1 impregnated with a specified liquid drug in advance and to sustainedly release the drug in such a slate as to be embedded near the affected sites in vivo, can be obtained by covering the first porous part (esp. a spherical porous form 2 of high porosity) made of a ceramic member (e.g. highly biocompatible beta-calcium phosphate) with the second porous form (esp. a porous form 3 of low porosity) made of a second ceramic member with its pore size and/or porosity smaller than those of the first porous part. Change in the properties of the first and second porous parts can control their liquid drug impregnation degrees and sustained release capabilities. The present material can be put to long-term therapeutic use for affected sites by sustainedly releasing a liquid drug such as antibiolic or carcinostatic.

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