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1. 发明专利

JPWO2016068266A1 生分解性ポリマーを用いた３次元培養方法、及び細胞移植を可能にする培養基材审中-公开
公开(公告)号：JPWO2016068266A1
公开(公告)日：2017-09-14
申请号：JP2016556642
申请日：2015-10-30
申请人：国立大学法人京都大学 , グンゼ株式会社
发明人：謙一郎亀井 , 謙一郎亀井 , 劉　莉 , 莉劉 , 憲夫中辻 , 憲夫中辻 , 勇陳 , 勇陳 , 佐藤　秀樹 , 秀樹佐藤 , 昌和鈴木 , 昌和鈴木
IPC分类号： C12M3/00 , A61K35/545 , A61L27/38 , C12N5/0735 , C12N5/074 , C12N5/10
CPC分类号： A61L27/3834 , A61L27/00 , A61L27/3895 , A61L27/58 , A61L2300/64 , A61L2400/18 , C12M25/14 , C12N1/00 , C12N5/0606 , C12N11/08 , C12N2513/00 , C12N2533/40 , C12N2533/54 , C12N2537/10
摘要：本発明は、生分解性ポリマーからなる支持体上に、生分解性ポリマーからなるナノファイバーを含有してなる、細胞の培養用基材を提供する。また、該基材上に細胞を播種し、該細胞を静置培養することを特徴とする、細胞の培養方法を提供する。さらに、該基材と、該基材上で培養した細胞とを含んでなる、細胞移植療法剤を提供する。

2. 发明专利

JP4707227B2 Biological duct stent 有权
公开(公告)号：JP4707227B2
公开(公告)日：2011-06-22
申请号：JP2000398962
申请日：2000-12-27
申请人：グンゼ株式会社
发明人：晶二郎松田 , 義人筏 , 孝司西山 , 昌和鈴木
IPC分类号： A61F2/90 , A61M29/02

3. 发明专利

JP4143784B2 Automatic suturing device attached prosthetic material for 有权
公开(公告)号：JP4143784B2
公开(公告)日：2008-09-03
申请号：JP12910799
申请日：1999-05-10
申请人：グンゼ株式会社 , 株式会社京都医療設計
发明人：敬二伊垣 , 恭裕佐藤 , 雅文川村 , 昌俊森 , 昌和鈴木
IPC分类号： A61B17/08 , A61L17/00
摘要： PROBLEM TO BE SOLVED: To obtain a suture prosthetic material improving a cutting property, a flexibility, and an affixing property by forming a unwoven cloth which has a surface smoother than other surface and is formed of a raw material of a high polymer resolvable and absorptive in a living body of which ventilation degree is controlled less than a fixed value. SOLUTION: A suture prosthetic material for an automatic suture device is used affixing to a staple acting section and is positioned as a suture prosthetic at a staple section, and an nonwoven cloth formed of a raw material resolvable and absorptive in a living body in an acting area from a staple to a cutter and manufactured by melt blow method. Corresponding with a usage of the automatic suture device, the unwoven cloth is cut in a proper size, one surface for attaching to the staple acting section is formed relatively rough in order to be easily permeated by an adhesive, and the other surface is formed flat without a catch in such a way that the prosthetic is not torn off at an operation. A ventilation degree measured by a method of JISL1018 is controlled less than 0.30 cc/cm2/sec., preferably, 0.05 cc/cm2/sec.

4. 发明专利

JP3548873B2 Sutures and their preparation for surgery 失效
公开(公告)号：JP3548873B2
公开(公告)日：2004-07-28
申请号：JP15259695
申请日：1995-05-25
申请人：グンゼ株式会社
发明人：郁夫佐々木 , 賢司富畑 , 昌和鈴木
IPC分类号： A61L17/00 , A61L17/10 , A61L17/12
CPC分类号： A61L17/12 , A61L17/105
摘要： The invention relates to a surgical suture comprising a copolymer as an essential component, the copolymer consisting of lactic acid (lactide) and epsilon -caprolacton as repeating unit, wherein shrinkage ratio of said surgical suture is 5% or less after heat treatment at 60 DEG C for 20 hours and method for production thereof.

5. 发明专利

JP3540208B2 Piezoelectric material and its manufacturing method 有权
公开(公告)号：JP3540208B2
公开(公告)日：2004-07-07
申请号：JP23623099
申请日：1999-08-24
申请人：グンゼ株式会社
发明人：直秀富田 , 義人筏 , 昌和鈴木
IPC分类号： A61L15/00 , A61L27/00 , D02J1/20 , H01L41/09 , H01L41/193 , H01L41/22 , H01L41/33
摘要： PROBLEM TO BE SOLVED: To produce a piezoelectric material capable of producing piezoelectric properties by a tension applied in the axial direction by applying specific twists in the axial direction to a fibrous material comprising a piezoelectric polymer. SOLUTION: Twists are applied through a driving unit 1 to a fiber yarn continuously delivered from a yarn tube 2 and comprising a piezoelectric polymer such as polylactic acid in the same direction or alternately with the opposite direction or in the direction randomly at a twisting angle within the range of 10-60 deg. from the axial direction and the yarn is then passed through a dry heating bath 3 and a roller bath 4 and wound with a winder 5 to produce a piezoelectric material.

6. 发明专利

JPWO2006022018A1 骨治療用具の製造方法及び骨治療用具审中-公开
公开(公告)号：JPWO2006022018A1
公开(公告)日：2008-05-08
申请号：JP2006531181
申请日：2004-08-27
申请人：グンゼ株式会社
发明人：偉志島本 , 偉志島本 , 佳丈高橋 , 佳丈高橋 , 昌和鈴木 , 昌和鈴木
IPC分类号： A61B17/58 , A61L31/00
CPC分类号： A61B17/866 , A61B17/00 , A61B2017/00004 , A61B2017/00526 , A61L27/446
摘要：本発明は、生分解性ポリマーとバイオセラミックスとの複合材料からなり、強度等の機械的特性に優れた骨治療用具の製造方法及び該製造方法を用いてなる骨治療用具を提供することを目的とする。本発明は、生分解性ポリマーからなるマトリックス中にバイオセラミックス微粒子が分散している複合材料からなる骨治療用具の製造方法であって、少なくとも、前記バイオセラミックス微粒子の表面に前記生分解性ポリマーからなるコート層を形成する工程1と、前記コート層が形成されたバイオセラミックス微粒子と前記生分解性ポリマーとを前記生分解性ポリマーの融点以上の温度で混練して混練物を調製する工程2と、前記混練物から成形物を得る工程3とを有する骨治療用具の製造方法である。

7. 发明专利

JP3667812B2 Aquaculture network 失效
公开(公告)号：JP3667812B2
公开(公告)日：2005-07-06
申请号：JP8064995
申请日：1995-02-28
申请人：グンゼ株式会社
发明人：郁夫佐々木 , 基也奥野 , 昌和鈴木
IPC分类号： A01K61/00 , A01K63/00 , A01K75/00 , C08L67/00 , C08L67/04
CPC分类号： Y02A40/81 , Y02A40/82 , Y02A40/822
摘要： PURPOSE: To obtain a net for culture suitable for culturing bivalves without requiring its removal during harvesting, comprising a blend polymer of a biodegradable polycaprolactone and a poly(β-hydroxyalkonoate). CONSTITUTION: This net for culture is obtained by blending a polycaprolactone of the structural formula (R is each independently H, an alkyl, a halogen or an alkoxy; A is oxy; (x) is an integer of 1-4; (y) is an integer of 1-4; (z) is 0 or 1; x+y+z is 4-7; the total number of Rs except hydrogen is not larger than 3) with a poly(β-hydroxyalkonoate) so as to prolong the strength retention period of the prepared net for culture for a relatively long period of time. Algae hardly stick to the net for culture and it has no environmental pollution due to an antifungal agent, etc.

8. 发明专利

JP3664367B2 Suture prosthesis 有权
公开(公告)号：JP3664367B2
公开(公告)日：2005-06-22
申请号：JP37571198
申请日：1998-11-26
申请人：グンゼ株式会社
发明人：郁夫佐々木 , 恭裕佐藤 , 昌和鈴木
IPC分类号： A61B17/08 , A61L17/00
摘要： PROBLEM TO BE SOLVED: To improve cuttabilily and flexibility of sutural prosthesis material lesed in an automatic sutural device in surgical operation by forming at least a part of the material from a non-woven fabric manufacted from an vivo decom posable and absorbable material by a melt blow method. SOLUTION: In a soft tissue prosthesis material, especially cylindrical sutural prosthesis material installed in an automatic sutural device to be used, at least a part of the material is formed from non-woven fabric manufactured from in vivo decomposing and absorbing raw material by a melt blow method. At this time, METSUKE is set 10 g/m2-100 g/m2, non-woven fabric is paralleled in one direction and at least one side is subjected to thermo compression bonding or pressure pressing. A smooth face is provided, the in vivo decomposing and absorbing raw material is polyglycol acid, and a cylindrical shape is taken, both ends being hot sealed to form a cylinder. Thus, retrial due to defective cutting or damage to the human body tissue can be suppressed, and the material is left as it is in the body to keep its function.

9. 发明专利

JP3362218B2 Coating agent to improve the strength nodules absorbable monofilament sutures 有权
公开(公告)号：JP3362218B2
公开(公告)日：2003-01-07
申请号：JP27675198
申请日：1998-09-30
申请人：グンゼ株式会社
发明人：郁夫佐々木 , 賢司富畑 , 昌和鈴木
IPC分类号： A61L17/00
摘要： PROBLEM TO BE SOLVED: To improve the affinity with a yarn body of a coating material and synergistically improve the nodus strength by including a homopolymer of ε- caprolactone or a copolymer consisting of ε-caprolactone and another absorptive monomer and calcium stearate. SOLUTION: A coating material contains ε-caprolactone as an essential component, and it may be formed of a homopolymer of ε-caprolactone or a copolymer of ε-caprolactone and another absorptive monomer. A preferred copolymer consists of a copolymer having ε-caprolactone and a lactic acid such as lactide as repeat units. This absorptive monofilament suture preferably consists of the copolymer of lactic acid and ε-caprolactone because the compatibility with the coating material is more satisfactory. The ratio of lactide: ε- caprolactone is more preferably (70-80):(30-20) mole%. In order to improve the operation operability or the rupture strength of nodus strength measurement, a higher fatty acid salt such as calcium stearate is used.

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