专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

JP2002145752A SKIN CARE PREPARATION AND COMPOSITION FOR SKIN CARE PREPARATION 失效
公开(公告)号：JP2002145752A
公开(公告)日：2002-05-22
申请号：JP2000335689
申请日：2000-11-02
申请人： KOSE CORP , SHIRATORI PHARM
发明人： SAKATA OSAMU , HOSHINO HIROSHI , HIGUCHI YOSHIHIRO
IPC分类号： A61K8/00 , A61K8/19 , A61K8/29 , A61K8/30 , A61K8/33 , A61K8/34 , A61K8/35 , A61K8/37 , A61K8/40 , A61K8/46 , A61K8/49 , A61K8/55 , A61K8/58 , A61K8/60 , A61K8/63 , A61K8/67 , A61K8/73 , A61K8/96 , A61K8/97 , A61K8/98 , A61K36/18 , A61K36/23 , A61K36/25 , A61K36/28 , A61K36/42 , A61K36/48 , A61K36/53 , A61K36/60 , A61K36/71 , A61K36/73 , A61K36/75 , A61K36/896 , A61K36/899 , A61P17/00 , A61P17/16 , A61Q1/00 , A61Q1/12 , A61Q19/00 , A61K7/48 , A61K7/00 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a skin care preparation and a composition for skin care preparation having excellent bleaching/beautifying effect to the skin such as propbylactic for pigmentation by including an extract of a specific plant. SOLUTION: This skin care preparation is blended with extract of a plant belonging to Hypoxidaceae.

2. 发明专利

JP2001302665A METHOD FOR PRODUCING L-BIOPTERIN OR D-NEOPTERIN 失效
公开(公告)号：JP2001302665A
公开(公告)日：2001-10-31
申请号：JP2000118180
申请日：2000-04-19
申请人： SHIRATORI PHARM
发明人： SAKAI HIDEAKI
IPC分类号： C07D475/04
摘要： PROBLEM TO BE SOLVED: To recover L-biopterin from hitherto discarded optical isomer mixture of (6R)-tetrahydro-L-biopterin and (6S)-tetrahydro-L-biopterin in high purity and yield. SOLUTION: The objective method for the production of L-biopterin or D- neopterin (2) comprises the oxidation of tetrahydro-L-biopterin or tetrahydro-D- neopterin (1) under acidic condition of pH 0-5 according to the following reaction formula (R is group of formula (3) or formula (4)).

3. 发明专利

JP2000198775A CYCLIC GUANIDINE AND ITS PRODUCTION 失效
公开(公告)号：JP2000198775A
公开(公告)日：2000-07-18
申请号：JP197199
申请日：1999-01-07
申请人： SHIRATORI PHARM
发明人： ISOBE TOSHIO , FUKUDA KEIKO
IPC分类号： C07D233/48 , C07B53/00 , C07D487/04
摘要： PROBLEM TO BE SOLVED: To obtain a new compound useful as an asymmetric synthesis reagent or the like in an industrially advantageous way under mild conditions without any environmental problem. SOLUTION: This new compound is a compound of formula I (R1 is an alkyl, aryl, or the like, R2 is H, an alkyl, or the like; R3 is an alkyl or aralkyl; R4 is an alkyl, aryl, or the like), e.g.(3S)-3-benzyl-(7S,8S)-7,8-diphenyl-6- ethoxycarbonyl-1,4,6-triazabicyclo[3.3.0]oct-4-ene. The compound of formula I is obtained by reaction of a compound of formula II e.g. (4S,5S)-4,5-diphenyl-1- ethoxycarbonyl-2-[(1S)-1-benzyl-2-hydroxyethylimino]imidazolidine} with a compound of formula III (R5 and R6 are each an alkyl; X is a halogen; (n) is 2 or 3) (e.g. 2-chloro-1,3-dimethylimidazolinium chloride) in the presence of a base such as triethylamine.

4. 发明专利

JPH11292850A OPTICALLY ACTIVE 4,5-DIPHENYL-1,3-DIALKYL-2-(2-HYDROXYETHYL) IMINOIMIDAZOLIDINE DERIVATIVE 失效
公开(公告)号：JPH11292850A
公开(公告)日：1999-10-26
申请号：JP9720898
申请日：1998-04-09
申请人： SHIRATORI PHARM
发明人： ISOBE TOSHIO , FUKUDA KEIKO
IPC分类号： C07D233/48 , C07B53/00
摘要： PROBLEM TO BE SOLVED: To provide a new compound useful as an asymmetric synthesis reagent for the selective production of an optically active compound in high yield. SOLUTION: The objective compound is expressed by formula I (R and R are each an alkyl; R is an alkyl or the like; R is H or the like; the mark *represents the position of asymmetric carbon), e.g. (4S,5S)-4,5-diphenyl-2-[(1 S)-1-benzyl-2-hydroxyethyl]imino-1,3-dimethylimidazolidine. The compound of formula I can be produced from an optically active 1,2-diphenyl-1,2- ethanediamine by successively carrying out a cyclization reaction using urea and water, a reaction with an alkyl halide and a reaction with a halogenation agent and reacting the obtained compound of formula II (X is a halogen) [e.g. (4S,5S)-2-chloro-4,5-diphenyl-1,3-dimethylimidazolinium chloride] with an amino alcohol of formula III (e.g. S-phenylalaninol).

5. 发明专利

JPH09268178A OPTICALLY ACTIVE 4,5-DIPHENYL-2-IMIDAZOLIDINONE DERIVATIVE 失效
公开(公告)号：JPH09268178A
公开(公告)日：1997-10-14
申请号：JP7868496
申请日：1996-04-01
申请人： SHIRATORI PHARM
发明人： ISOBE TOSHIO , FUKUDA KEIKO , OOKAWA MAYU
IPC分类号： G01R33/28 , C07B57/00 , C07D233/38 , G01N24/08
摘要： PROBLEM TO BE SOLVED: To obtain an optically active 4, 5-dipheny1-2-imidazolidinone derivative useful as a reagent for analyzing an optical purity, especially the optical purity of amines havnig asymmetric carbons. SOLUTION: This optically active 4,5-diphenyl-2-imidazolidinone derivative is represented by formula I [R is an alkyl; R is an alkylene; (1) is 0 or 1; (*) represents a position of an asymmetric carbon] and obtained by reacting a compound represented by formula II (X is a halogen) with a metal thiocyanate represented by the formula MSCN (M is an alkali metal). Optical purities of amines having asymmetric carbons are accurately analyzed and determined by a simple method of condensing the amines and the compound of formula I, forming into thiourea derivatives as diastereomers and analyzinz the resultant thiourea derivatives by a nuclear electromagnetic resonance spectrography.

6. 发明专利

JPH09208514A PRODUCTION OF OPTICALLY ACTIVE CARBOXYLIC ACIDS 失效
公开(公告)号：JPH09208514A
公开(公告)日：1997-08-12
申请号：JP1725096
申请日：1996-02-02
申请人： SHIRATORI PHARM
发明人： ISOBE TOSHIO , FUKUDA KEIKO
IPC分类号： C07D233/38 , C07B53/00 , C07C51/06 , C07C51/087 , C07C53/00 , C07C57/30 , C07D333/24 , C07D409/06
摘要： PROBLEM TO BE SOLVED: To selectively produce optically active carboxylic acids of high optical purity useful in industrial fields such as medicines, agrochemicals, perfumes, food additives and electronics in high yield. SOLUTION: An optically active 4,5-diphenyl-2-imidazolidinone derivative represented by formula II (R is an alkyl, etc.; R is a dialkoxyphosphoryl or a halogen; * indicates the position of asymmetric carbon) is reacted with an aldehyde represented by the formula R CHO (R is an organic group) to afford an α,β-unsaturated acyl compound represented by formula III. The Michael addition reaction or Michael type addition reaction of the resultant α,β-unsaturated acyl compound represented by formula III is then carried out by using a reagent having an organic group R different from R to provide a diastereomer represented by formula IV (R is the organic group different from R ), which is then hydrolyzed to afford optically active carboxylic acids represented by formula I, e.g. (4S,5S)-1-cinnamoyl-4,5-diphenyl-3-methyl-2-imidazolidinone.

7. 发明专利

JPH09124621A OPTICALLY ACTIVE 1,3-OXAZOLIDINE-2-THIONE DERIVATIVE 失效
公开(公告)号：JPH09124621A
公开(公告)日：1997-05-13
申请号：JP28482495
申请日：1995-11-01
申请人： SHIRATORI PHARM
发明人： ISOBE TOSHIO , FUKUDA KEIKO , TAKASHI YOSHIHO
IPC分类号： C07D263/16
摘要： PROBLEM TO BE SOLVED: To obtain a new 5,5-di-substituted 1,3-oxazolidine-2-thione derivative useful for determining the optical purity of a carboxylic acid containing an asymmetric carbon atom. SOLUTION: This optically active 5,5-di-substituted 1,3-oxazolidine-2-thione derivative is shown by formula I (R and R are the same or different lower alkyl, aryl or aralkyl; * is an asymmetric carbon atom) such as (4S)-4- benzyl-5,5-dimethyl-1,3-oxazolidine-2-thione. The compound of formula I is obtained by reacting an L- or D-α-amino acid of formula II (Y is H or a lower alkyl) or its ester with a Grignard reagent of the formula R MgX' (X' is a halogen) to give an optically active amino-alcohol of formula III and reacting the compound with carbon disulfide. The compound of formula I is reacted with a carboxylic acid of formula IV (R is an organic group containing an asymmetric carbon atom; X is hydroxyl or a halogen) to give an acyl derivative of formula V (diastereomer).

8. 发明专利

JPH07206833A PRODUCTION OF 1,3,4-OXADIAZOLE COMPOUND 失效
公开(公告)号：JPH07206833A
公开(公告)日：1995-08-08
申请号：JP369794
申请日：1994-01-18
申请人： SHIRATORI PHARM
发明人： ISOBE TOSHIO , HOSOGAI AKIHIKO
IPC分类号： C07D271/10
摘要： PURPOSE:To efficiently obtain a 1,3,4-exazole a compound in high yield in an industrially advantageous way under nearly neutral, mild conditions by dehydrating an 1,2-diacylhydrazine compound with a specific haloiminium salt. CONSTITUTION:This compound, a 1,3,4-oxadiazole compound of formula III can be obtained by reaction of an 1,2-diacylhydrazine compound of formula I (R and R are each an organic group) with a haloiminium salt of formula II (R and R are each a lower alkyl; X is a halogen; n is 2 or 3). The haloiminium salt of formula II can easily be produced by reaction of e.g. a compound of formula TV known as a readily available solvent with a halogenating agent such as oxalyl halogenide. By this method, the objective compound can be obtained in one-pot from a monoacylhydrazine compound and a carboxylic acid compound without the need for isolating the 1,2- diacylhydrazine compound. The compound of formula III is useful as a medicine, agrochemical, dye, ultraviolet light absorber, fluorescent agent, scintillator, etc., or e.g. a raw material for thermally stable resins.

9. 发明专利

JPH0789926A PRODUCTION OF UREA COMPOUNDS OR SEMICARBAZIDE COMPOUNDS 失效
公开(公告)号：JPH0789926A
公开(公告)日：1995-04-04
申请号：JP23447093
申请日：1993-09-21
申请人： SHIRATORI PHARM
发明人： ISOBE TOSHIO , HOSOGAI AKIHIKO
IPC分类号： B01J31/02 , C07B61/00 , C07C273/18 , C07C275/28 , C07C281/06
摘要： PURPOSE:To obtain the compound in a high yield under almost neutral and mild conditions by reacting a hydroxamic acid compound with a specific haloiminium salt in the presence of a base and subsequently reacting the reaction product with an amine or hydrazine compound. CONSTITUTION:A hydroxamic acid compound of formula 2 (R is organic group) is reacted with a haloiminium salt of formula 1 (R , R are lower alkyl; X is halogen; n is 2, 3) in the presence of a base of formula 4, and subsequently with an amine or hydrazine compound of formula 3 (R , R are H, organic group; Y is N, hydrazine bond) to obtain an urea or semicarbazide compound of formula 5. The method can industrially and advantageously provide the compound without being affected with the natures of the raw materials and without requiring to heat the raw materials at a high temperature. The resultant urea compound can be used in the fields of dyestuffs, fertilizers, antiparasitics, plastics, fibers, etc. The produced semicarbazide compound is important as a reagent for detecting aldehydes or ketones, and furthermore useful as a raw material for synthesizing heterocyclic compounds.

10. 发明专利

JPH05239088A 失效
公开(公告)号：JPH05239088A
公开(公告)日：1993-09-17
申请号：JP4137092
申请日：1992-02-27
申请人： SHIRATORI PHARM , AMANO PHARMA CO LTD
发明人： ISOBE TOSHIO , IMAI YUTAKA , SAITO MASAAKI , MURATA SHINYA , NAGAO TAKASHI , TSURUMI CHIHO
IPC分类号： A61K31/56 , A61P25/28 , C07J53/00
摘要： PURPOSE:To obtain the subject new compound useful as an ameliorant of cerebral function for treating motor dysfunction, intelligent dysfunction, etc., caused by cerebral hemorrhage, cerebral infarction, subarachnoidal hemorrhage, transient cerebral ischemic attack, etc., due to its manifestation of excellent antihypoxic action. CONSTITUTION:The objective compound of formula I [R is residue of monosaccharides, disaccharides, etc., or R CO (R is dialkylamino, alkoxy, etc.)] or its salt, e.g. 3-cycloartenyl ethyl carbonate. This compound is obtained by a method for subjecting, e.g. a carboxylic acid of the formula R COOH (R is R other than alkylamino) and cycloartenol of formula II to esterifying reaction in the presence of a base such as pyridine or reacting phosgene of the formula COCl2 or trichloromethyl formate of the formula ClCOOCCl2 with the cycloartenol of formula II in the presence of a base such as pyridine, then reacting the produced cycloartenyl chloroformate with an alcohol or an amine of the formula R H (R is alkoxy, alkylamino, etc.), etc.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式