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1. 发明专利

JP2006087396A Cell culture substrate and method for producing the same 审中-公开
标题翻译：细胞培养基底及其制造方法
公开(公告)号：JP2006087396A
公开(公告)日：2006-04-06
申请号：JP2004279893
申请日：2004-09-27
申请人： Katsumi Mochidate , National Institute For Environmental Studies , Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社 , 克身持立 , 独立行政法人国立環境研究所
发明人： MOCHIDATE KATSUMI , KAWAMURA KENJI , TAKADA WATARU
IPC分类号： C12N5/10 , A61L27/00 , C07K14/475 , C07K14/78 , C12N5/07 , C12N5/071
摘要： PROBLEM TO BE SOLVED: To provide a new cell culture substrate able to solidify two or more peptides on the surface of the substrate in an amount of arbitrarily controlled introduction and controlling adhesion, growth, proliferation, and the like, of cells by combining a plurality of kinds of peptides and provide a method for producing the same. SOLUTION: The method for producing the cell culture substrate has a process for coating a peptide-introduced polymer, in which single kind of peptide is introduced into a hydrophobically bonded adsorbing polymer, onto the surface of the substrate for culturing two or more kinds of cells. Preferably, the hydrophobically bonded adsorbing polymer has, in the molecule, a hydrophobic straight chain carbon skeleton and functional groups able to react with peptides in the molecule. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种新的细胞培养基质，其能够以任意控制的量引导和控制细胞的粘附，生长，增殖等，使基底表面上的两种或更多种肽固化组合多种肽并提供其制备方法。解决方案：细胞培养基质的制造方法具有将单体肽引入到疏水键合的吸附性聚合物中的肽导入性聚合物的涂布于基材的表面上进行培养2次以上的方法细胞种类优选地，疏水键合的吸附聚合物在分子中具有疏水性直链碳骨架和能够与分子中的肽反应的官能团。版权所有（C）2006，JPO＆NCIPI

2. 发明专利

JP2009229351A Method of detecting physiologically active substance, and measurement kit 有权
标题翻译：检测生理活性物质的方法和测量试剂盒
公开(公告)号：JP2009229351A
公开(公告)日：2009-10-08
申请号：JP2008077237
申请日：2008-03-25
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： TAKADA WATARU
IPC分类号： G01N33/547 , G01N33/53 , G01N33/545
摘要： PROBLEM TO BE SOLVED: To provide a method of detecting an antibody-binding physiologically active substance preventing nonspecific adsorption of a physiologically active substance, such as protein out of the purpose and serving as the purpose, without blocking operations, and a measurement kit used for the detection method.
SOLUTION: This method of detecting the antibody-binding physiologically active substance includes a process to bind an antibody on an insoluble carrier having on the surface a high molecular substance made by copolymerizing (A) an ethylene-based unsaturated polymeric monomer having an alkylene glycol residual group and (B) an ethylene-based unsaturated polymeric monomer having a crosslinkable functional group by solving the antibody which specifically binds the physiologically active substance into a high-concentration phosphate buffer solution into contact with the solution, and a process to make contact with a specimen and to specifically bind the antibody-binding physiologically active substance in the specimen with the antibody on the insoluble carrier.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供一种检测抗体结合生理活性物质的方法，其防止非特异性吸附生理活性物质如蛋白质的目的并作为目的而不进行阻断操作，并且测量用于检测方法的试剂盒。检测抗体结合生理活性物质的方法包括将抗体结合在具有表面的不溶性载体上的方法，该高分子物质是通过共聚合（A）乙烯类不饱和聚合单体，其具有亚烷基二醇残基和（B）具有可交联官能团的乙烯类不饱和聚合单体，通过将将生理活性物质特异性结合到高浓度磷酸盐缓冲溶液中的抗体与溶液接触，制备方法与样品接触并将抗体结合生理活性物质与抗体结合在不溶性载体上。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2008215894A Detection method of protein and detecting method of peptide 审中-公开
标题翻译：蛋白质的检测方法及其检测方法
公开(公告)号：JP2008215894A
公开(公告)日：2008-09-18
申请号：JP2007050889
申请日：2007-03-01
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： TAKADA WATARU
IPC分类号： G01N33/547 , G01N33/53 , G01N33/543 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a detection method of a protein or a peptide having high sensitivity and high throughput, having few noises originated in nonspecific adsorption, capable of immobilizing an antibody on an optional position on a substrate surface, and capturing simultaneously a plurality of kinds of target proteins or peptides in a specimen.
SOLUTION: This detection method of a protein or a peptide by immobilizing the antibody on the substrate surface, and by capturing specifically the protein or the peptide in the specimen by an interaction with the antibody includes (a) a process for applying a polymer having a phosphorylcholine group on the substrate surface or a polymer acquired by polymerizing ethylene-based unsaturated polymeric monomers having respectively an alkylene glycol residue, (b) a process for immobilizing the antibody on the polymer, (c) a process for labeling the protein or the peptide in the specimen, (d) a process for allowing the specimen acquired in the process (c) and a water-soluble polymer to coexist in the same system, and (e) a process for bringing the specimen acquired in the process (d) into contact with the substrate acquired in the process (b).
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：为了提供具有高灵敏度和高通量的蛋白质或肽的检测方法，具有很少的非特异性吸附产生的噪音，能够将抗体固定在基材表面上的可选位置上，并且捕获同时在样本中同时存在多种靶蛋白或肽。解决方案：通过将抗体固定在底物表面上，通过与抗体的相互作用特异性捕获样品中的蛋白质或肽，蛋白质或肽的检测方法包括（a）应用在基材表面上具有磷酸胆碱基团的聚合物或通过聚合具有亚烷基二醇残基的乙烯类不饱和聚合单体获得的聚合物，（b）将抗体固定在聚合物上的方法，（c）标记蛋白质的方法或试样中的肽，（d）允许在方法（c）中获得的样品和水溶性聚合物在同一系统中共存的方法，和（e）使在该方法中获得的样品的方法（d）与方法（b）中获得的基材接触。版权所有（C）2008，JPO＆INPIT

4. 发明专利

JP2006132944A Biochip and its manufacturing method 有权
标题翻译：生物及其制造方法
公开(公告)号：JP2006132944A
公开(公告)日：2006-05-25
申请号：JP2004318753
申请日：2004-11-02
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： TAKADA WATARU , YOKOYAMA KANEHISA
IPC分类号： G01N33/53 , G01N33/545 , G01N33/552 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a biochip of high sensitivity and high throughput which fixes an antibody to the surface of a substrate at an arbitrary position without coating the substrate with an adsorption inhibitor, suppresses the adsorption and bonding an unnecessary physiologically active material to a part other than the arbitrary position and can detect a physiologically active material, and its manufacturing method.
SOLUTION: In the biochip constituted by fixing the antibody to the surface of the substrate, the surface of the substrate is coated with a polymer having a phosphoryl chlorine group and the antibody is fixed on the polymer.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为了提供高灵敏度和高通量的生物芯片，其在任意位置固定抗体到基底表面，而不用吸附抑制剂涂覆基底，抑制吸附和结合不必要的生理活性材料到任意位置以外的部分，并且可以检测生理活性物质及其制造方法。解决方案：在通过将抗体固定在基材表面构成的生物芯片中，用具有磷酰氯基团的聚合物涂覆基材的表面，并将抗体固定在聚合物上。版权所有（C）2006，JPO＆NCIPI

5. 发明专利

JP2009128093A Method of detecting physiological active substance 审中-公开
标题翻译：检测生理活性物质的方法
公开(公告)号：JP2009128093A
公开(公告)日：2009-06-11
申请号：JP2007301275
申请日：2007-11-21
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： TAKADA WATARU
IPC分类号： G01N33/547 , G01N33/53 , G01N33/543 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a physiological active substance detection method which is easily operated and capable of measurements in a visible region.
SOLUTION: An ethylene-based unsaturated polymerizable monomer having an alkylene glycol residue, an ethylene-based unsaturated polymerizable monomer having a functional group for immobilizing physiological active substances, and an ethylene-based unsaturated polymerizable monomer having a crosslinkable functional group are copolymerized to form a high-molecular substance, and an insoluble carrier has the high-molecular substance in its surface. An antibody is immobilized in the insoluble carrier to bring a biologically active substance to be an antigen into reaction with the antibody. An enzyme is introduced to a reacted antibody-antigen complex to make a color-developing substrate develop a color by the action of the enzyme. The contained situation of the physiological active substance in an object to be detected is determined on the basis of the degree of color development in the physiological active substance detection method.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供易于操作并且能够在可见区域中进行测量的生理活性物质检测方法。解决方案：具有亚烷基二醇残基的乙烯类不饱和可聚合单体，具有用于固定生理活性物质的官能团的乙烯类不饱和可聚合单体和具有交联性官能团的乙烯类不饱和可聚合单体共聚合以形成高分子物质，并且不溶性载体在其表面具有高分子物质。将抗体固定在不溶性载体中，使生物活性物质成为抗原与抗体反应。将酶引入反应的抗体 - 抗原复合物中，以通过酶的作用使显色底物显色。基于生理活性物质检测方法中的显色程度来确定被检测物中的生理活性物质的含有情况。版权所有（C）2009，JPO＆INPIT

6. 发明专利

JP2006170717A Detection method of protein and peptide 有权
标题翻译：蛋白和肽的检测方法
公开(公告)号：JP2006170717A
公开(公告)日：2006-06-29
申请号：JP2004361677
申请日：2004-12-14
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： TAKADA WATARU , YOKOYAMA KANEHISA
IPC分类号： G01N33/53 , G01N33/566 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a high throughput protein and peptide detecting method of high sensitivity constituted so as to immobilize a physiologically active substance on the surface of a substrate at an arbitrary position without coating the substrate with an adsorption inhibitor to simultaneously capture a plurality of kinds of target proteins or peptides in a specimen.
SOLUTION: The detection method of protein and peptide is constituted so as to immobilize the physiologically active substance on the surface of the substrate to specifically capture the proteins or peptides in the specimen by the interaction with the physiologically active substance and includes a process (a) for coating the surface of the substrate with a polymer having a phosphorycholine group, a process (b) for immobilizing the physiologically active substance on the polymer, a process (c) for labelling the proteins or peptides in the specimen and a process (d) for bringing the specimen obtained in the process (c) into contact with the substrate obtained in the process (b).
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供高灵敏度的高通量蛋白质和肽检测方法，其构成为在任意位置将生理活性物质固定在基材表面上，而不用同时用吸附抑制剂涂覆底物在样本中捕获多种靶蛋白或肽。解决方案：构建蛋白质和肽的检测方法，以将生理活性物质固定在底物的表面上，以通过与生理活性物质的相互作用特异性捕获样品中的蛋白质或肽，并且包括方法（a）用具有磷酸胆碱基团的聚合物涂覆基材的表面，用于将生理活性物质固定在聚合物上的方法（b），用于标记样品中的蛋白质或肽的方法（c）（d）使在工序（c）中得到的试样与在工序（b）中得到的基材接触。版权所有（C）2006，JPO＆NCIPI

7. 发明专利

JP2012032260A Sugar chain array 审中-公开
标题翻译：糖链阵列
公开(公告)号：JP2012032260A
公开(公告)日：2012-02-16
申请号：JP2010171561
申请日：2010-07-30
申请人： Hokkaido Univ , Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社 , 国立大学法人北海道大学
发明人： NISHIMURA SHINICHIRO , MATSUSHITA TAKAHIKO , SHIMAOKA HIDEYUKI , TAKADA WATARU , IGARASHI KOTA , ABE MIDORI , ABE HIROKI , FUKUSHIMA MASAO
IPC分类号： G01N33/53 , G01N33/543 , G01N37/00
CPC分类号： G01N33/5308 , G01N33/54393 , G01N33/569 , G01N33/66 , G01N2333/42
摘要： PROBLEM TO BE SOLVED: To provide a sugar chain array, to which a sugar chain is fixed, and which is useful for detection of coupling between a substance to be detected and the sugar chain, and to provide the sugar chain array to which the sugar chain is fixed, which can suppress nonspecific adsorption, coupling of the substance to be detected without coating an adsorption prevention agent.SOLUTION: It is discovered that the sugar chain array, which is developed by inventors, and to which a specific sugar chain is fixed is useful for the detection of the coupling between the substance such as a pathogen of an infection disease and its secretion to be detected. It is further discovered that, when a base material coated by a high molecular compound containing a unit having a primary amino group, a unit for holding hydrophilicity, and a unit having a hydrophobic group is used in the sugar chain array, the sugar chain can be efficiently fixed, and the nonspecific adsorption, coupling of the substance to be detected can be effectively suppressed.
摘要翻译：待解决的问题：提供糖链固定的糖链阵列，其可用于检测待检测物质与糖链之间的偶联，并提供糖链阵列糖链固定，可以抑制非特异性吸附，待被检物质的偶联而不涂覆吸附防止剂。解决方案：发现由发明人开发并且特定糖链固定的糖链阵列可用于检测物质如感染疾病的病原体与其之间的偶联分泌物检测。进一步发现，当在糖链阵列中使用由含有具有伯氨基单元的高分子化合物，保持亲水性单元和具有疏水基团的单元包覆的基材时，糖链可以有效地固定，并且可以有效地抑制待检测物质的非特异性吸附，偶联。版权所有（C）2012，JPO＆INPIT

8. 发明专利

JP2008304427A Biodevice, manufacturing method, and biosensor 有权
标题翻译：生物装置，制造方法和生物传感器
公开(公告)号：JP2008304427A
公开(公告)日：2008-12-18
申请号：JP2007154217
申请日：2007-06-11
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： TAKADA WATARU
IPC分类号： G01N33/68 , C12M1/00
摘要： PROBLEM TO BE SOLVED: To provide a biodevice that can minimize the influence on a three-dimensional structure to fix a physiological active substance, and detect physiological active substances of high sensitivity and high throughput, and to provide its manufacturing method and a biosensor that uses the biodevice.
SOLUTION: In this biodevice, the surface of a solid-phase substrate has high-molecular compound, containing a unit having phosphorylcholine group, a unit having hydrophobic group, and a unit having primary amino group, and hydrophilic compound is bonded to the surface. Preferably, the primary amino group is an oxyl amino group and/or a hydrazide group.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供可以最小化对三维结构的影响以固定生理活性物质并检测高灵敏度和高产量的生理活性物质的生物装置，并提供其制造方法和使用生物装置的生物传感器。解决方案：在该生物装置中，固相基材的表面具有含有具有磷酸胆碱基的单元，具有疏水基的单元和具有伯氨基的单元的高分子化合物，亲水性化合物键合到表面。优选地，伯氨基是氧基氨基和/或酰肼基。版权所有（C）2009，JPO＆INPIT

9. 发明专利

JP2007285835A Plate for bioplate, manufacturing method therefor and the bioplate 审中-公开
标题翻译：生产板，生产方法和生物制品
公开(公告)号：JP2007285835A
公开(公告)日：2007-11-01
申请号：JP2006112846
申请日：2006-04-17
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： TAKADA WATARU
IPC分类号： G01N33/547 , G01N33/53 , G01N33/543 , G01N33/545 , G01N33/552
摘要： PROBLEM TO BE SOLVED: To provide a plate for a bioplate, capable of fixing a physiologically active substance to the surface of a substrate at an arbitrary position, without having to coat the substrate with an adsorption inhibitor for detecting the physiologically active substance with high sensitivity and at high throughput, and to provide its manufacturing method and the bioplate. SOLUTION: The plate for the bioplate is used for fixing the physiologically active substance on the surface of a solid phase substrate and has a polymeric substance, which contains a first unit having a phosphorylcholine group and a second unit having a carboxylic acid derivative group, formed by bonding an electron-withdrawing substituent to a carbonyl group, on its surface. The manufacturing method of the plate for the bioplate and the bioplate, where the physiologically active substance is fixed on the plate, are also disclosed. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：为了提供一种用于生物板的板，其能够在任意位置将生理活性物质固定在基材表面，而不必用用于检测生理活性物质的吸附抑制剂涂覆基材具有高灵敏度和高产量，并提供其制造方法和生物板。解决方案：用于生物板的板用于将生理活性物质固定在固相基材的表面上，并且具有聚合物质，其含有具有磷酸胆碱基团的第一单元和具有羧酸衍生物的第二单元在其表面上通过将吸电子取代基键合到羰基而形成的基团。还公开了生物活性物质固定在板上的用于生物板和生物板的板的制造方法。版权所有（C）2008，JPO＆INPIT

10. 发明专利

JP2007205753A Manufacturing method of biochip 有权
标题翻译：生物制造方法
公开(公告)号：JP2007205753A
公开(公告)日：2007-08-16
申请号：JP2006022161
申请日：2006-01-31
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： TAKADA WATARU , YOKOYAMA KANEHISA
IPC分类号： G01N33/53 , G01N33/543 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a biochip which immobilizes a protein on an optional position on the substrate surface without coating it with an adsorption prevention agent, suppresses adsorption and bonding of an unnecessary biological active substance onto a part other than the position, and performs high-throughput and high-sensitivity detection of the biological active substance, and also to provide its manufacturing method.
SOLUTION: The manufacturing method of a biochip for immobilizing a protein on the substrate surface is characterized by including processes of: (1) applying a polymer having a phosphorylcholine group onto the substrate surface; (2) spot-contacting or applying liquid acquired by dissolving or dispersing the protein in a solvent, onto the substrate surface; and (3) immobilizing the protein at a temperature of 20°C or higher.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种生物芯片，其将蛋白质固定在基材表面上的任选位置，而不用吸附防止剂涂覆，抑制不必要的生物活性物质吸附并结合到位置以外的部分，并进行生物活性物质的高通量和高灵敏度检测，并提供其制造方法。解决方案：用于将蛋白质固定在基材表面上的生物芯片的制造方法的特征在于包括以下过程：（1）将具有磷酸胆碱基团的聚合物施加到基材表面上; （2）通过将蛋白质溶解或分散在溶剂中而获得的点接触或施加液体到基底表面上; 和（3）将蛋白质固定在20℃以上的温度。版权所有（C）2007，JPO＆INPIT

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