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41. 发明专利

JP2001061418A PURIFICATION OF ACTIVE INGREDIENT IN ROYAL JELLY 失效
公开(公告)号：JP2001061418A
公开(公告)日：2001-03-13
申请号：JP24237499
申请日：1999-08-30
申请人： POLA CHEM IND INC
发明人： KAMAKURA MASAKI , FUKUDA TOSHIYUKI , MITANI MAKOTO , MIYAZAKI HIROTAKA , FUKUSHIMA MAKOTO
IPC分类号： A23L1/30 , A23L21/20 , A23L1/076
摘要： PROBLEM TO BE SOLVED: To obtain royal jelly wherein the concentration of an active ingredient is increased and anti-fatigue effect is improved, by adding an aqueous solution of a short-chain alcohol with low concentration to royal jelly, eliminating solubles therefrom, and then treating the resultant under specific conditions. SOLUTION: This method for purifying royal jelly comprises the following steps: (A) adding an aqueous solution of a short-chain alcohol with low concentration to royal jelly and eliminating solubles using an ultra-filtration membrane for 5,000 to 20,000 molecular weight; (B) adding an excess of water to the resultant solution to eliminate the resultant precipitates, (C) obtaining a filtrate by filtering the resultant aqueous solution through an ultra-filtration membrane for 70,000 to 150,000 molecular weight, and further (D) eliminating filtered ingredients from the thus obtained filtrate using an ultra-filtration membrane for 18,000 to 22,000 molecular weight to concentrate the above filtrate. It is desirable to prepare an anti-fatigue composition by including the thus obtained purified royal jelly.

42. 发明专利

JP2015040839A 身体機能の推定方法有权
标题翻译：物理函数估计方法
公开(公告)号：JP2015040839A
公开(公告)日：2015-03-02
申请号：JP2013173629
申请日：2013-08-23
申请人：ポーラ化成工業株式会社 , Pola Chem Ind Inc
发明人： MITANI MAKOTO , MATSUMOTO TAKESHI
IPC分类号： G01N33/48
摘要：【課題】簡便で新規な身体機能の推定方法を提供する。【解決手段】見た目年齢と身体機能値である血管老化度又は血中脂質濃度、血管老化得点又は血中酸化LDL濃度の相関関係を示す単回帰式又は重回帰式を用いて、被験者の身体機能値から該被験者の見た目年齢を算出し、該被験者の身体機能を推定する。見た目年齢と、身体機能値との相関関係を示す身体機能値相関データを記憶する記憶手段と、被験者の見た目年齢を、前記記憶手段に記憶された身体機能値相関データと照合して、前記被験者の身体機能値を算出する身体機能値算出手段と、を備える、身体機能推定装置、及び被験物質の見た目年齢の改善効果を指標として、被験物質の身体機能値の改善効果を評価することを特徴とする、身体機能値を改善する物質の評価方法を含む。【選択図】図1
摘要翻译：要解决的问题：提供一种简单和新的物理功能的估计方法。解决方案：根据受试者的身体功能值计算受试者的表观年龄，并使用单个回归公式估计受试者的身体功能或显示血液老化点，血液老化程度，作为身体功能值的血脂浓度与血液老化点评分或氧化LDL浓度在血液中的相关关系的多元回归公式。物理功能估计装置包括：存储装置，用于存储表示表观年龄和身体功能值之间的相关关系的物理功能值相关数据; 以及物理功能值计算装置，用于通过将对象的表观年龄与存储在存储装置中的物理功能值相关数据进行对照来计算被摄体的物理功能值，并且还包括评估物质以改善身体功能的方法其特征在于，使用被检物质的表观年龄的改善效果作为指标，评价被检物质的物理功能值的改善效果的特征。

43. 发明专利

JP2014133749A Autonomic nerve activator 审中-公开
标题翻译：自动神经激活器
公开(公告)号：JP2014133749A
公开(公告)日：2014-07-24
申请号：JP2014077273
申请日：2014-04-03
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： MITANI MAKOTO , NAKANISHI RUIKO , MATSUMOTO TAKESHI
IPC分类号： A61K36/00 , A23L1/30 , A61K36/73 , A61P25/02 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide an excellent autonomic nerve activator which is suitable as an oral administration composition and acts immediately in vivo.SOLUTION: It is found that activities of an autonomic nerve, such as a sympathetic nerve, a parasympathetic nerve, and a sympathetic nerve involved in a heat production, are enhanced with time by taking a capsule containing an extract of the plant body of Cupressaceae Juniperus communis. There is provided the oral administration composition, such as a tablet, drink formulation, containing these.
摘要翻译：要解决的问题：提供适合作为口服给药组合物并且立即在体内作用的优异的自主神经激活剂。解决方案：发现自主神经如交感神经，副交感神经和参与热产生的交感神经随着时间的推移，通过服用含有葫芦科植物体提取物的胶囊而增强。提供了含有这些的口服给药组合物，例如片剂，饮料制剂。

44. 发明专利

JP2010180166A Body-slimming composition 审中-公开
标题翻译：身体组合物
公开(公告)号：JP2010180166A
公开(公告)日：2010-08-19
申请号：JP2009025513
申请日：2009-02-06
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： MITANI MAKOTO , FUKUDA TOSHIYUKI , NAKANISHI RUIKO
IPC分类号： A61K31/12 , A23L1/30 , A61K8/35 , A61P3/04 , A61Q19/06
摘要： PROBLEM TO BE SOLVED: To provide a body-slimming composition comprising a compound represented by a specific acetophenone derivative and/or a salt thereof. SOLUTION: The body-slimming composition comprises a compound represented by general formula (1), particularly 2'-hydroxy-4', 6'-dimethoxyacetophenone as an effective ingredient. In the formula, R 1 is an alkyl group; and R 2 , R 3 and R 4 are each a hydrogen atom or an alkyl group. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供一种减肥组合物，其包含由特定的苯乙酮衍生物和/或其盐表示的化合物。解决方案：减肥组合物包含由通式（1）表示的化合物，特别是2'-羟基-4'，6'-二甲氧基苯乙酮作为有效成分。在该式中，R SB 1是烷基; R SB 3，R SB 3和R SB 4各自为氢原子或烷基。版权所有（C）2010，JPO＆INPIT

45. 发明专利

JP2003113100A CALORIGENIC PROTEIN-EXPRESSING PROMOTER AND COMPOSITION CONTAINING THE SAME 审中-公开
公开(公告)号：JP2003113100A
公开(公告)日：2003-04-18
申请号：JP2001304853
申请日：2001-10-01
申请人： POLA CHEM IND INC
发明人： MITANI MAKOTO , FUKUDA TOSHIYUKI , KAMAKURA MASAKI
IPC分类号： A23L1/30 , A61K8/02 , A61K8/06 , A61K8/96 , A61K8/97 , A61K36/18 , A61P3/00 , A61P3/04 , C11B1/10 , C11B9/00 , C11B9/02 , A61K35/78 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To provide a promoter for promoting expression of a calorigenic protein in brown adipose cell, promoting surplus fat accumulation suppression, and to provide a diet composition for medicines, foods and cosmetics. SOLUTION: The polar solvent extract from kernels of seeds of Nymphacaccac and Nelumbonaccae belonging to the genus Nelumbo, Euryale ferox Salish and Victria amazonica promotes expression of carorigenic protein having 32 k dalton molecular weight in mitochondrial inner membrane in brown cell to suppress accumulation of surplus fat and, thereby, a composition having antiobestic effect is provided by compounding the extract into medicines, foods and cosmetics.

46. 发明专利

JP2003061648A Protein kinase b activator 审中-公开
标题翻译：蛋白激酶B激活剂
公开(公告)号：JP2003061648A
公开(公告)日：2003-03-04
申请号：JP2001259187
申请日：2001-08-29
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： KAMAKURA MASAKI , FUKUDA TOSHIYUKI , MITANI MAKOTO , MIYAZAKI HIROTAKA
IPC分类号： A23L1/30 , A61K35/64 , A61K38/55 , A61P1/16 , A61P43/00 , C07K14/435 , C12N9/00
摘要： PROBLEM TO BE SOLVED: To provide a protein kinase B activator capable of being used as a liver-protecting agent for improving and recovering a liver function disorder, etc. SOLUTION: This protein kinase B activator comprises royal jelly. A glycoprotein which is contained in the royal jelly and has a molecular weight of 57 kDa accelerates activation of the protein kinase B like a growth factor and controls a series of phenomena of cascade reaction starting with phosphorylation following the activation. Further, the glycoprotein brings about liver cell growth-accelerating action and liver-protecting action. Therefore, a medicine or food compounded with the glycoprotein is used as the excellent liver-protecting agent for improving and recovering the liver function disorder, etc.
摘要翻译：要解决的问题：提供能够用作肝脏保护剂以改善和恢复肝功能障碍等的蛋白激酶B激活剂。解决方案：该蛋白激酶B活化剂包括蜂王浆。包含在蜂王浆中并具有57kDa分子量的糖蛋白加速了蛋白激酶B的活化，如生长因子，并控制一系列从激活后磷酸化开始的级联反应现象。此外，糖蛋白引起肝细胞生长促进作用和肝保护作用。因此，使用与糖蛋白复合的药物或食品作为改善和恢复肝功能障碍等的优良的肝保护剂。

47. 发明专利

JP2001240529A COSMETICS FOR SKIN CARE 失效
公开(公告)号：JP2001240529A
公开(公告)日：2001-09-04
申请号：JP2000055077
申请日：2000-03-01
申请人： POLA CHEM IND INC
发明人： KAMAKURA MASAKI , FUKUDA TOSHIYUKI , MITANI MAKOTO , MIYAZAKI HIROTAKA
IPC分类号： A61K8/00 , A61K8/02 , A61K8/06 , A61K8/63 , A61K8/64 , A61K8/96 , A61K8/98 , A61Q19/00 , C07K14/435 , A61K7/48 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To provide a technique which matures the keratinocyte and improves the skin barrier function. SOLUTION: A royal jelly characterized by containing a protein having the following properties, which constitutes 9 weight % or more with respect to the all proteins in the jelly, is contained in cosmetics; (1) a single band is formed in unmodified polyacrylamide gel electrophoresis of protein in royal jelly; (2) a molecular weight measured by SDS-polyacrylamide gel electrophoresis under reducing conditions is about 57 kDa; (3) a amino acid sequence of amino acids n: 1-8 in sequence 1 (refer to the specification) is contained.

48. 发明专利

JP2000336038A LIVER PROTECTING AGENT 失效
公开(公告)号：JP2000336038A
公开(公告)日：2000-12-05
申请号：JP34523199
申请日：1999-12-03
申请人： POLA CHEM IND INC
发明人： KAMAKURA MASAKI , FUKUDA TOSHIYUKI , MITANI MAKOTO , MIYAZAKI HIROTAKA
IPC分类号： A23L2/38 , A01N1/02 , A23L1/305 , A23L2/52 , A23L2/60 , A23L2/66 , A23L33/10 , A23L33/17 , A23L33/18 , A61K35/64 , A61K35/644 , A61K38/00 , A61K38/02 , A61P1/16
摘要： PROBLEM TO BE SOLVED: To obtain a liver protecting agent for treatment or prophylaxis of liver function failure or protection of liver for transplantation. SOLUTION: This liver protecting agent comprises a protein in royal jelly specified by the following properties as an active ingredient. (a) A single band is formed in unmodified polyacrylamide gel electrophoresis of protein in royal jelly. (b) A molecular weight measured by SDS-polyacrylamide gel under reducing conditions is about 51 kDa.

49. 发明专利

JP2000199753A EVALUATION METHOD FOR QUALITY OF ROYAL JELLY 失效
公开(公告)号：JP2000199753A
公开(公告)日：2000-07-18
申请号：JP30534999
申请日：1999-10-27
申请人： POLA CHEM IND INC
发明人： KAMAKURA MASAKI , FUKUDA TOSHIYUKI , MITANI MAKOTO , FUKUSHIMA MAKOTO
IPC分类号： A23L21/20 , A61K35/64 , A61K35/644 , G01N27/447 , G01N30/26 , G01N30/74 , G01N30/88 , G01N33/02 , A23L1/076
摘要： PROBLEM TO BE SOLVED: To obtain an evaluation method in which the quality of royal jelly can be evaluated by a method, wherein the decomposition of a protein in the royal jelly is used as an index. SOLUTION: In this evaluation method for the quality of royal jelly, the decomposition of a protein in the royal jelly is used as an index. That is to say, the constitution of the protein is analyzed through electrophoresis, chromatography or the like, the protein content which is estimated as an effective component is measured, and the quality is evaluated. When electrophoresis is performed, protein as the effective component forms a single band. When the contained component of the protein is numerous, effect such as an antifatigue action or the like is made proportionately large. Reduction in its content becomes the index of the degradation of the protein. The molecular weight of the protein as the index is, e.g. about 51 kilodatons, and modified polyacryalamide gel electrophoresist is preferable. In addition, the protein as the index of the degradation can be discriminated and quantitatively determined also by chromatography, such as gel filtration chromatography or the like. Consequently, on the basis of the analyzed result, the quality of the royal jelly can be controlled, and the effect of the royal jelly can be discriminated and evaluated.

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