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1. 发明专利

JP2007230882A Plasminogen activator inhibitor-i inhibitor and food composition compounded therewith 有权
标题翻译： PLASMINOGEN激活剂抑制剂-I抑制剂和食品组合物
公开(公告)号：JP2007230882A
公开(公告)日：2007-09-13
申请号：JP2006051414
申请日：2006-02-28
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： FUKUDA TOSHIYUKI , MITANI MAKOTO
IPC分类号： A61K36/18 , A23L1/03 , A23L1/30 , A61K31/122 , A61K36/00 , A61P7/02 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a technique for inhibiting a plasminogen activator inhibitor(PAI) by a plant ingredient that can be taken in as a food. SOLUTION: The technique comprises using an extract from a plant belonging to Zingiberaceae family such as Curcuma zedoaria ROSC., Crucuma longa L. or Zingiber officinale ROSC. as a PAI-1 inhibitor. In this technique, the plant extract is obtained preferably by removing a polar portions from the hydrous ethanol extract, and among the steps 1 to 3 described below, is obtained preferably by the step 2 or 3: (step 1) The plant body of the above plant is subjected to extraction with a 50-80% ethanol aqueous solution followed by concentration. (step 2) The product obtained by the step 1 is subjected to liquid-liquid extraction with n-hexane and water to obtain a n-hexane phase. (step 3) Ethyl acetate is added to the aqueous phase obtained by the step 2 followed by adding water as desired and then conducting a liquid-liquid extraction to obtain an ethyl acetate phase. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供通过可以作为食物摄入的植物成分来抑制纤溶酶原激活物抑制剂（PAI）的技术。解决方案：该技术包括使用来自属于姜科（Zeriberaceae）家族的植物的提取物，例如姜黄（Curcuma zedoaria ROSC），葫芦科植物（Crucuma longa L.）或姜属植物化学（Zingiber officinale ROSC）。作为PAI-1抑制剂。在该技术中，优选通过从含水乙醇提取物中除去极性部分而获得植物提取物，优选通过步骤2或3获得下述步骤1〜3 :(步骤1）将上述植物用50-80％乙醇水溶液萃取，然后浓缩。（步骤2）将由步骤1得到的产物用正己烷和水进行液 - 液萃取，得到正己烷相。（步骤3）将乙酸乙酯加入到通过步骤2获得的水相中，然后根据需要加入水，然后进行液 - 液萃取以获得乙酸乙酯相。版权所有（C）2007，JPO＆INPIT

2. 发明专利

JP2003292952A Antioxidant composition 有权
标题翻译：抗氧化剂组合物
公开(公告)号：JP2003292952A
公开(公告)日：2003-10-15
申请号：JP2002103523
申请日：2002-04-05
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： FUKUDA TOSHIYUKI , YOSHIDA TAKASHI , ITO HIDEYUKI
IPC分类号： A23L3/349 , A61K8/49 , A61K8/60 , A61K31/7024 , A61P17/00 , A61P39/06 , C09K15/08 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To provide a new antioxidant component.
SOLUTION: The antioxidant composition contains at least two of glycosides of α-D-glucose-2,3-cyclic (4,4',5,5',6,6'-hexahydroxydifenate or 4,4',5,5',6,6'- hexahydroxydifenate saccharides, e.g. pedunculagin or the like. The composition for antioxidant is produced by defatting the edible parts of nuts, e.g. walnuts or pecan nuts, extracting the defatted edible parts with a polar or neutral solvent and concentrating the extract. The antioxidant composition is useful in food and as a preparation for external use for skin.
COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供新的抗氧化成分。解决方案：抗氧化剂组合物含有至少两种α-D-葡萄糖-2,3-环状（4,4'，5,5'，6,6'-六羟基靛红或4,4'，5 抗氧化剂组合物是通过将坚果的可食用部分（例如核桃或山核桃仁）脱脂而制成的，用极性或中性溶剂萃取脱脂食用部分，浓缩提取物，抗氧化剂组合物可用于食品和外用皮肤制剂。版权所有（C）2004，JPO

3. 发明专利

JP2003063983A Apoptosis inhibitor 审中-公开
标题翻译：杀虫剂抑制剂
公开(公告)号：JP2003063983A
公开(公告)日：2003-03-05
申请号：JP2001259649
申请日：2001-08-29
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： KAMAKURA MASAKI , FUKUDA TOSHIYUKI , MITANI MAKOTO , MIYAZAKI HIROTAKA
IPC分类号： A23L1/30 , A61K35/64 , A61K38/00 , A61P1/16 , A61P43/00 , C07K14/435
摘要： PROBLEM TO BE SOLVED: To provide a liver-protecting drug for improving and curing the functional disorders of the liver or the like. SOLUTION: Sugar protein of molecular weight of 57 kilo dalton contained in royal jelly, as a growth factor, restrains apoptosis by manifesting BcL-xL, one of the apoptosis suppressors existing in the outer membrane of mitochondria, and promotes and maintains the survival of the liver cells on a non-serum culture medium. An excellent composition for the protection of the liver cells, the liver tissues and the livers and for carrying organs to be transplanted is obtained by mixing the sugar protein concerned in medicinal drugs and food.
摘要翻译：要解决的问题：提供用于改善和治愈肝脏等功能障碍的肝保护药物。解决方案：作为生长因子，蜂王浆中分子量为57千道尔顿的糖蛋白通过表现存在于线粒体外膜中的凋亡抑制剂之一的BcL-xL来抑制细胞凋亡，并促进和维持肝细胞在非血清培养基上。通过混合药用药物和食品中的糖蛋白，可以获得保护肝细胞，肝组织和肝脏以及携带器官移植的优良组合物。

4. 发明专利

JP2010180166A Body-slimming composition 审中-公开
标题翻译：身体组合物
公开(公告)号：JP2010180166A
公开(公告)日：2010-08-19
申请号：JP2009025513
申请日：2009-02-06
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： MITANI MAKOTO , FUKUDA TOSHIYUKI , NAKANISHI RUIKO
IPC分类号： A61K31/12 , A23L1/30 , A61K8/35 , A61P3/04 , A61Q19/06
摘要： PROBLEM TO BE SOLVED: To provide a body-slimming composition comprising a compound represented by a specific acetophenone derivative and/or a salt thereof. SOLUTION: The body-slimming composition comprises a compound represented by general formula (1), particularly 2'-hydroxy-4', 6'-dimethoxyacetophenone as an effective ingredient. In the formula, R 1 is an alkyl group; and R 2 , R 3 and R 4 are each a hydrogen atom or an alkyl group. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供一种减肥组合物，其包含由特定的苯乙酮衍生物和/或其盐表示的化合物。解决方案：减肥组合物包含由通式（1）表示的化合物，特别是2'-羟基-4'，6'-二甲氧基苯乙酮作为有效成分。在该式中，R SB 1是烷基; R SB 3，R SB 3和R SB 4各自为氢原子或烷基。版权所有（C）2010，JPO＆INPIT

5. 发明专利

JP2010037247A Glutathione production promoting agent 审中-公开
标题翻译： GLUTATHIONE生产促销代理
公开(公告)号：JP2010037247A
公开(公告)日：2010-02-18
申请号：JP2008200485
申请日：2008-08-04
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： FUKUDA TOSHIYUKI , NAKANISHI RUIKO
IPC分类号： A61K31/165 , A23L1/30 , A61K8/42 , A61K8/97 , A61K36/00 , A61K36/28 , A61P1/16 , A61P3/10 , A61P9/10 , A61P9/12 , A61P15/00 , A61P17/00 , A61P17/10 , A61P27/02 , A61P37/08 , A61P39/02 , A61P43/00 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a substance which acts as a glutathione production promoter for enhancing oxidative stress protection and detoxifying functions in vivo and is suitably used as a composition for oral or transdermal administration.
SOLUTION: A specific cinnamoyl spermine derivative and/or a salt thereof has a glutathione production promoting action, and N1, N5, N10, N14-tetra-p-(E)-coumaroyl spermine is contained in extracts of genus Chrysanthemum plants belonging to Compositae family. The composition for oral or transdermal administration having the glutathione production promoting action can be applied to foods, cosmetics, glutathione production promoters, etc.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种充当用于增强体内氧化应激保护和解毒功能的谷胱甘肽生产促进剂的物质，并且适合用作口服或透皮给药组合物。解决方案：特定的肉桂酰精胺衍生物和/或其盐具有谷胱甘肽生产促进作用，而菊花植物提取物中含有N1，N5，N10，N14-四对 - （E） - 硬脂酰精胺属于菊科。具有谷胱甘肽生产促进作用的口服或透皮给药组合物可用于食品，化妆品，谷胱甘肽生产促进剂等。版权所有（C）2010，JPO＆INPIT

6. 发明专利

JP2010001257A Oral administration composition 审中-公开
标题翻译：口腔管理组合物
公开(公告)号：JP2010001257A
公开(公告)日：2010-01-07
申请号：JP2008162188
申请日：2008-06-20
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： YOSHIDA TAKANORI , FUKUDA TOSHIYUKI
IPC分类号： A61K36/73 , A23L1/30 , A61K31/165 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a new oral administration composition for energy production improvement, which is caused by activation of a transcription factor associated with mitochondria biosynthesis. SOLUTION: The oral administration composition for energy production improvement comprises an extract of a plant of the family Rosaceae. The plant of the family Rosaceae is preferably Rosa rugosa or its allied species and preferably contains a coumaroylspermidine derivative represented by the general formula (1) (wherein R 1 , R 2 and R 3 are each independently a hydrogen atom or a coumaroyl group and at least one of R 1 , R 2 and R 3 is a coumaroyl group) and/or its salt. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供由与线粒体生物合成相关的转录因子的活化引起的用于能量产生改善的新的口服给药组合物。解决方案：用于能量生产改进的口服组合物包括家蔷薇科植物的提取物。家蔷薇科的植物优选是罗莎（Rosa rugosa）或其相关物种，优选含有由通式（1）表示的椰子酰亚胺微粒衍生物（其中R 1 ，R 2 和 R SB 3，各自独立地为氢原子或芳香酰基，R SB 1，R SB 2，R SB 3， / SB>是香豆酰基）和/或其盐。版权所有（C）2010，JPO＆INPIT

7. 发明专利

JP2007204434A Coffee oil quina acid derivative and composition including the same as an active ingredient for suppressing plasminogen activator inhibitor 有权
标题翻译：咖啡油酸衍生物和组合物，包括其作为抑制剂量激活剂抑制剂的活性成分
公开(公告)号：JP2007204434A
公开(公告)日：2007-08-16
申请号：JP2006025748
申请日：2006-02-02
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： FUKUDA TOSHIYUKI
IPC分类号： A61K31/235 , A23L1/30 , A61K36/73 , A61P7/02 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a technique for suppressing plasminogen activator inhibitor (PAI) by using a specific vegetable component. SOLUTION: The composition for suppressing plasminogen activator inhibitor includes, as active ingredients, 1-benzoyl-2-coffee oil- 4,6-dihydroxy-4-hydroxycarbonylcyclohexane and/or its salt. As the above-stated 1-benzoyl-2-coffee oil-4,6-dihydroxy-4-hydroxy-carbonylcyclohxane, is preferably cited 4-benzyl-5-coffee oil quina acid and the composition is preferably used for improving blood flow rate. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供通过使用特定的植物成分来抑制纤溶酶原激活物抑制剂（PAI）的技术。解决方案：用于抑制纤溶酶原激活物抑制剂的组合物包括作为活性成分的1-苯甲酰基-2-咖啡油-4,6-二羟基-4-羟基羰基环己烷和/或其盐。作为上述1-苯甲酰基-2-咖啡油-4,6-二羟基-4-羟基 - 羰基环己烷优选引入4-苄基-5-咖啡油喹诺酸，该组合物优选用于提高血液流速。版权所有（C）2007，JPO＆INPIT

8. 发明专利

JP2006052184A Food for inhibiting oxidation stress 审中-公开
标题翻译：食物用于抑制氧化应激
公开(公告)号：JP2006052184A
公开(公告)日：2006-02-23
申请号：JP2004236342
申请日：2004-08-16
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： FUKUDA TOSHIYUKI , YOSHIDA TAKASHI , ITO HIDEYUKI
IPC分类号： C07H13/08 , A23L1/30 , A61K31/7024 , A61P39/06
摘要： PROBLEM TO BE SOLVED: To provide a new material for protecting living bodies from oxidation stresses. SOLUTION: A polyphenol represented by general formula (I) (R1 to R26 are each independently H, a 1 to 4C alkyl or a 1 to 4C acyl) or its salt. The compound is obtained by subjecting the seed kernel of a plant belonging to Juglandaceae, Juglans to extraction with a nonpolar solvent, removing polar ingredients by a solvent extraction, and purifying by column chromatography. The compound is added to a food composition and orally administered. Thereby, a living body can be protected from oxidation stress. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种保护生物体免受氧化应激的新材料。解决方案：由通式（I）表示的多酚（R1至R26各自独立地为H，1至4C烷基或1至4C酰基）或其盐。该化合物通过使属于菊花科植物的胡萝卜属植物的种子仁用非极性溶剂进行萃取，通过溶剂萃取除去极性成分，并通过柱色谱法纯化来获得。将该化合物加入到食品组合物中并口服给药。由此，能够防止生物体的氧化应力。版权所有（C）2006，JPO＆NCIPI

9. 发明专利

JP2005200319A New dicarboxylic acid glycoside 有权
标题翻译：新的二羧酸甘氨酸
公开(公告)号：JP2005200319A
公开(公告)日：2005-07-28
申请号：JP2004006210
申请日：2004-01-14
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： FUKUDA TOSHIYUKI , YOSHIDA TAKASHI , ITO HIDEYUKI
IPC分类号： A23L1/30 , A61K8/96 , A61K8/97 , A61K36/18 , A61P29/00 , A61P35/00 , A61P43/00 , C07H1/08 , C07H13/04
摘要： PROBLEM TO BE SOLVED: To provide a new compound having an anti-oxidizing ability and obtained from an aqueous extract of walnut kernel. SOLUTION: Works for purifying a walnut kernel aqueous extract faction having an anti-oxidizing ability have been repeated. Consequently, a compound represented by general formula (1) (R is a sugar residue or a quinolyl group which may have a carboxy group or a 1 to 4C alkyloxycarbonyl group) is isolated by extracting the kernel of the fruit of Juglandaceae, Juglans with a water-miscible organic solvent, removing the solvent, performing a solution extraction using water and an organic solvent non-miscible with water in an arbitrary ratio, taking out the aqueous phase, and then purifying the ingredient dissolved in the aqueous phase with column chromatography filled with an ion exchange resin and using a water-lower alcohol mixture solvent as an elution solvent, while checking the elution state. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供具有抗氧化能力并由核桃仁的水提取物获得的新化合物。解决方案：重复用于纯化具有抗氧化能力的核桃仁水提取物组的工作。因此，将通式（1）表示的化合物（R是可以具有羧基或1〜4个烷氧基羰基的糖残基或喹啉基）分离，通过将菊果的果实提取出来，与水混溶的有机溶剂，除去溶剂，使用水和与水不溶的有机溶剂以任意比例进行溶液萃取，取出水相，然后用柱色谱法填充溶解在水相中的组分用离子交换树脂，并使用水 - 低级醇混合溶剂作为洗脱溶剂，同时检查洗脱状态。版权所有（C）2005，JPO＆NCIPI

10. 发明专利

JP2004217555A Polyphenol derived from walnut kernel 有权
标题翻译：从WALNUT KERNEL衍生的聚苯醚
公开(公告)号：JP2004217555A
公开(公告)日：2004-08-05
申请号：JP2003005774
申请日：2003-01-14
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： FUKUDA TOSHIYUKI , YOSHIDA TAKASHI , ITO HIDEYUKI
IPC分类号： A23L1/30 , A61K31/7024 , A61K36/18 , A61K47/26 , A61P37/08 , A61P39/06 , C07H13/08 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a new antioxidant component suitable for use in antioxidant compositions, specifically foods. SOLUTION: The new antioxidant consists of a new compound represented by the general formula(1)( wherein, R1, R2, R3, R4, R5, R6, R7, R6 and R9 are each H, a 6-15C aromatic group or 6-15C aromatic acyl group, wherein either aromatic or aromatic acyl group may be the same in base as other acyl groups, and the bond indicated by a broken line may be present or absent ), for example, granslin A, granslin B or granslin C. The compound is obtained by extraction and purification of walnut kernels. It is preferable that this compound be incorporated as an antioxidant in ordinary foods, health foods or specific health foods in the form of tablets, granules or capsules intended for health maintenance or health promotion. COPYRIGHT: (C)2004,JPO&NCIPI
摘要翻译：要解决的问题：提供适用于抗氧化剂组合物，特别是食品的新型抗氧化剂组分。解决方案：新型抗氧化剂由通式（1）表示的新化合物组成（其中，R1，R2，R3，R4，R5，R6，R7，R6和R9分别为H，6-15C芳族基团或6-15C芳族酰基，其中芳族或芳族酰基可以在碱中与其它酰基相同，并且虚线表示的键可以存在或不存在），例如，Granslin A，granslin B 或转运蛋白C.该化合物通过核桃仁的提取和纯化获得。优选将该化合物作为用于健康维护或健康促进的片剂，颗粒或胶囊形式的普通食品，保健食品或特定保健食品中的抗氧化剂。版权所有（C）2004，JPO＆NCIPI

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