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31. 发明专利

JPS61213671A METHOD FOR MEASURING HUMAN PLASMIN-ALPHA2-PLASMIN INHIBITOR COMPOUND BODY 失效
公开(公告)号：JPS61213671A
公开(公告)日：1986-09-22
申请号：JP5420885
申请日：1985-03-20
申请人： TEIJIN LTD
发明人： WASHIMI YOSHIHIKO , KOIKE YUKIYA , ICHIKAWA YATARO , YOSHIDA NOBUHIKO , AOKI NOBUO
IPC分类号： G01N33/53 , C07K16/40 , C12Q1/56 , G01N33/543 , G01N33/577 , G01N33/86
摘要： PURPOSE:To make possible exact and quick measurement by conjugating a monoclonal antibody which conjugates specifically with a human alpha2-plasmin inhibitor, an antibody to the human plasmin and a labeling antibody to a blood- plasma specimen. CONSTITUTION:The antibody to, for example, the human plasmin is fixed to an insoluble carrier (plastic, etc.). The liquid mixture composed of the material prepd. by conjugating the labeling antibody to the monoclonal antibody which can conjugate specifically with the position of the human alpha2-plasmin inhibitor where the fibrinolysis of plasmin is to be inhibited and the blood-plasma is then brought into contact therewith. The human plasma-alpha2-plasmin inhibitor compound body in the specimen is conjugated with the antibody of the plasmin fixed to the carrier and further the monoclonal antibody is conjugated with the alpha2-plasmin inhibitor. The labeling of such antibody is measured and the human plasmin-alpha2-plasmin inhibitor compound body is detected. Since the monoclonal antibody conjugating specifically therewith is used, the exact measurement is made possible without receiving the influence of extraneous materials.

32. 发明专利

JPS6139951B2 失效
公开(公告)号：JPS6139951B2
公开(公告)日：1986-09-06
申请号：JP11537176
申请日：1976-09-28
申请人： TEIJIN LTD
发明人： ONO SHOJI , SUGYAMA TAKASHI , KAWAKAMI YOSHIKO , ICHIKAWA YATARO , SUZUKI YOJI , OOMORI HITOSHI , AZUMA AKIKO
IPC分类号： C07D499/68 , A61K31/43 , A61P31/04 , C07D499/64

33. 发明专利

JPS6128647B2 失效
公开(公告)号：JPS6128647B2
公开(公告)日：1986-07-01
申请号：JP12505084
申请日：1984-06-20
申请人： TEIJIN LTD
发明人： ICHIKAWA YATARO , TSURUTA HIDEKI , KATO KENICHI , YAMANAKA YOSHUKI , YAMAMOTO AOI
IPC分类号： C07C7/152 , C07C1/00 , C07C15/08 , C07C67/00

34. 发明专利

JPS61133861A Measurement of human protein c activity 失效
标题翻译：人类蛋白C活性的测定
公开(公告)号：JPS61133861A
公开(公告)日：1986-06-21
申请号：JP25497884
申请日：1984-12-04
申请人： Teijin Ltd
发明人： WAKABAYASHI KENJI , WASHIMI YOSHIHIKO , ICHIKAWA YATARO , MIMURO ATSUSHI , AOKI NOBUO
IPC分类号： G01N33/53 , G01N33/577 , G01N33/86
CPC分类号： G01N33/86
摘要： PURPOSE:To measure the activity of human protein C simply and accurately, by employing amonoclonal antibody that does not recognize human protein C without the existence of calcium ion while does under the existence thereof. CONSTITUTION:A sample containing human protein C to be measured is rought into contact under the existence of calcium ion with an dsorbent in which a monoclonal antibody against human protein C that does recognize human protein C without the existence of calcium ion while does human protein C specifically under the existence of calcium ion jointed on the surface of a non-soluble carrier. Then, a thrombin-thrombomodulin composite is added to the mixture, then, thrombin is inactivated to measure the activity of human protein C on the adsorbent using a synthetic substrate. Thus, when the monoclonal antibody recognizes the human protein C, the activity will not be blocked.
摘要翻译：目的：通过使用在不存在钙离子的情况下不识别人蛋白C的Amonoclonal抗体，可以简单准确地测量人C蛋白的活性。构成：含有待测量的人蛋白C的样品在钙离子存在下与吸附剂粗糙接触，其中针对人蛋白C的单克隆抗体识别人蛋白C而不存在钙离子，而人蛋白C 特别是在不可溶性载体表面附着钙离子的存在下。然后，向混合物中加入凝血酶 - 血栓调节蛋白复合物，然后使用合成底物使凝血酶失活以测量吸附剂上人蛋白C的活性。因此，当单克隆抗体识别人蛋白C时，活性不会被阻断。

35. 发明专利

JPS61132185A Base sequence of promotor dna and gene fragment 失效
标题翻译：引物DNA和基因片段的基因序列
公开(公告)号：JPS61132185A
公开(公告)日：1986-06-19
申请号：JP25197184
申请日：1984-11-30
申请人： Teijin Ltd
发明人： KUDO AKIRA , NISHIMURA YUJI , ICHIKAWA YATARO , WATANABE TAKESHI
IPC分类号： C12N15/09 , C07H21/04 , C12N15/00 , C12N15/85
CPC分类号： C12N15/85
摘要： PURPOSE:A base sequence for promotor DNA which is confirmed to be in the intron between the leading zone and the V zone of the H-chain in human anatibody gene and a gene fragment consisting of said sequence and protein gene. CONSTITUTION:The title base sequence of promotor DNA is confirmed to exist in the intron between the leading zone and the V zone in the H-chain of human antibody gene and the base sequence contains formula I (A is deoxyadenosine-5t- phosphoric acid; C is deoxycytidine-5t-phosphoric acid; G is deoxyguanoisine-5'- phosphoric acid; T is deoxythymidine-5'-phosphoric acid) or base sequence containing formula I and formual II and/or formula III and its complementary sequence. Further, a gene fragment is obtained from the base sequence and protein gene.
摘要翻译：目的：确认在人类抗体基因的H链的前导区和V区的内含子中的启动子DNA的碱基序列和由所述序列和蛋白质基因组成的基因片段。构成：确认启动子DNA的标题碱基序列存在于人抗体基因的H链中的前导区与V区之间的内含子中，碱基序列含有式I（A为脱氧腺苷-5t-磷酸; C是脱氧胞苷-5t-磷酸; G是脱氧维吾宁-5'-磷酸; T是脱氧胸苷-5'-磷酸）或碱基序列，其含有式I和式Ⅱ和/或式Ⅲ及其互补序列。此外，从碱基序列和蛋白质基因获得基因片段。

36. 发明专利

JPS6192563A Cultivation of microorganism 失效
标题翻译：微生物的培养
公开(公告)号：JPS6192563A
公开(公告)日：1986-05-10
申请号：JP21430184
申请日：1984-10-15
申请人： Teijin Ltd
发明人： ICHIKAWA YATARO , HAMAMOTO KIMIHIKO , TOKASHIKI MICHIYUKI
IPC分类号： C12N1/00
摘要： PURPOSE: A fluorocarbon containing oxygen dissolved therein is fed into a suspension of microorganisms to enable high-density cultivation.
CONSTITUTION: To a culture medium in which a microorganism is cultured in a suspension state, is added a fluorocarbon in which oxygen is dissolved at a rate of 0.1l of oxygen per 1l of the culture medium per hour. Thus, oxygen is fed in a mild state to enable high-efficiency proliferation of the microorganism through stabilized operations.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：目的：将含有溶解氧的含氟碳氟化合物加入到微生物悬浮液中以实现高密度培养。构成：向其中以悬浮状态培养微生物的培养基中，以每1升培养基每小时0.1升氧气的比例加入氧气。因此，氧气以温和状态进料，以通过稳定的操作实现微生物的高效增殖。

37. 发明专利

JPS6165845A Beta,gamma-unsaturated carboxylic acid, herbicide and plant growth regulator comprising it as active ingredient 失效
标题翻译：硫酸铵，不饱和羧酸，除草剂和植物生长调节剂，将其作为活性成分
公开(公告)号：JPS6165845A
公开(公告)日：1986-04-04
申请号：JP18810784
申请日：1984-09-10
申请人： Teijin Ltd
发明人： AZUMA SHIZUO , HIRAMATSU TOSHIYUKI , YAMAJI TEIZO , ICHIKAWA YATARO
IPC分类号： A01N37/36 , A01N37/48 , C07C67/00 , C07C69/712 , C07C69/73 , C07C201/00 , C07C205/37 , C07C205/38 , C07C213/00 , C07C217/78 , C07C229/30 , C07C253/00 , C07C255/23 , C07C255/54 , C07C313/00 , C07C323/12 , C07C323/20 , C07C323/52 , C07C323/54 , C07C323/60 , C07C325/00 , C07C327/22
摘要： NEW MATERIAL:A compound shown by the formula I {R is group shown by the formula II [Ar is (halogen-, cyano, nitro-substituted) aromatic hydrocarbon group; R
6 and R
7 are H, halogen, cyano, nitro, lower alkyl, etc.; n is 1W10]; R
1 WR
4 are H, halogen, cyano, nitro, 1W25C alkyl, etc.; R
5 is -OR
11 (R
11 is H, or 1W15C hydrocarbon which may contain O, S, or N), or -SR
11 , etc.}, and its acid addition salt.
EXAMPLE: Ethyl 2-(2,4-dichloro-phenoxyacetylthio)-3-methyl-3-butenate.
USE: A herbicide and a plant growth regulator. Showing improved herbicidal effects on various plants, exhibiting improved herbicidal effects, etc. even before or after germination of plants.
PREPARATION: A compound shown by the formula III is reacted with a compound shown by the formula IV to give an epoxy compound shown by the formula V, which is subjected to ring opening reaction in the presence of neutral aluminum to give a compound shown by the formula VI, which is condensed with an acid chloride compound to give a compound shown by the formula I.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：新材料：由式I表示的化合物{R是式II所示的基团[Ar是（卤素，氰基，硝基取代的）芳族烃基; R 6和R 7是H，卤素，氰基，硝基，低级烷基等; n为1-10]; R 1 -R 4是H，卤素，氰基，硝基，1-25C烷基等; R 5为-OR 11（R 11为H或可含有O，S或N的1-15C烃）或-SR 11等}及其酸加成盐。实施例：2-（2,4-二氯 - 苯氧基乙酰硫基）-3-甲基-3-丁烯酸乙酯。用途：除草剂和植物生长调节剂。显示出对各种植物的除草效果的改善，即使在植物发芽前后也表现出改善的除草效果。制备：将式III化合物与式IV化合物反应，得到式V所示的环氧化合物，其在中性铝存在下进行开环反应，得到式VI，其与酰氯化合物缩合，得到式I所示的化合物。

38. 发明专利

JPS6135782A Process for cell culture 失效
标题翻译：细胞培养方法
公开(公告)号：JPS6135782A
公开(公告)日：1986-02-20
申请号：JP15542484
申请日：1984-07-27
申请人： Teijin Ltd
发明人： ICHIKAWA YATARO , HAMAMOTO KIMIHIKO , TOKASHIKI MICHIYUKI
IPC分类号： C12N5/02
摘要： PURPOSE: To supply a culture system with oxygen in high efficiency, and to promote the proliferation of cells, by transferring a fluorocarbon containing dissolved oxygen through a culture tank to the outside of the tank, dissolving oxygen in the fluorocarbon, and recycling the fluorocarbon again to the culture tank.
CONSTITUTION: Cells are cultured in a culture tank in suspended state under the following conditions. (i) A fluorocarbon containing dissolved oxygen is supplied to the culture tank. (ii) The fluorocarbon is taken out of the culture tank. (iii) Oxygen is dissolved in the fluorocarbon taken out of the tank. (iv) The resultant fluorocarbon containing dissolved oxygen is circulated to the step (i). The inlet of the fluorocarbon to the suspension liquid in the culture tank may take the form of nozzle, slit, porous material, and various other forms. The fluorocarbon may be present in the suspension liquid in the form of a liquid column, liquid drop, liquid film, etc., and above all, liquid drop is preferable.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：目的：通过将含有溶解氧的碳氟化合物通过培养罐转移到罐外，将氧气溶解在碳氟化合物中，并再次使用碳氟化合物，以高效提供氧气培养系统，促进细胞增殖到文化坦克。构成：在以下条件下将细胞在悬浮状态的培养箱中培养。（i）将含有溶解氧的碳氟化合物供给至培养罐。（ii）将碳氟化合物从培养槽中取出。（iii）将氧气溶解在从罐中取出的碳氟化合物中。（iv）将含有溶解氧的所得碳氟循环至步骤（i）。碳氟化合物对培养罐中悬浮液的入口可以采取喷嘴，狭缝，多孔材料和各种其他形式的形式。碳氟化合物可以以液柱，液滴，液膜等的形式存在于悬浮液中，最重要的是液滴。

39. 发明专利

JPS612673B2 JPS612673B2 - 失效
公开(公告)号：JPS612673B2
公开(公告)日：1986-01-27
申请号：JP4740675
申请日：1975-04-21
申请人： Teijin Ltd
发明人： ICHIKAWA YATARO , NAKAGAWA KOJI , TSURUTA HIDEKI , YOSHIDA EIJI , YAMAGUCHI HISAO , KATO YOSHINORI , OOBA TAKEO , OZAWA KENJI
IPC分类号： C07D501/10 , C07D501/14

40. 发明专利

JPS6042239B2 失效
公开(公告)号：JPS6042239B2
公开(公告)日：1985-09-20
申请号：JP15808176
申请日：1976-12-29
申请人： TEIJIN LTD
发明人： YAMAGUCHI HISAO , OOBA TAKEO , OZAWA KENJI , OOMORI HITOSHI , AZUMA AKIKO , ICHIKAWA YATARO
IPC分类号： C07D499/68 , A61K31/43 , A61P31/04 , C07D499/64 , C07F9/6561

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