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21. 发明专利

JPH0773597B2 失效
公开(公告)号：JPH0773597B2
公开(公告)日：1995-08-09
申请号：JP11695888
申请日：1988-05-16
IPC分类号： C07D307/62 , A61L9/01 , B01D53/38 , B01D53/77 , C01G45/00 , C07C51/00 , C07C51/41 , C07C59/245 , C07C59/265 , C07C67/00 , C07F13/00

22. 发明专利

JPH0672945A PRODUCTION OF D-MALIC ACID 失效
公开(公告)号：JPH0672945A
公开(公告)日：1994-03-15
申请号：JP13633191
申请日：1991-06-07
申请人： MITSUBISHI PETROCHEMICAL CO
发明人： TERASAWA MASATO , NARA SHOICHI , YAMAGATA HISASHI , YUGAWA HIDEAKI
IPC分类号： C07C59/245 , C12P7/46
摘要： PURPOSE:To produce D-malic acid from inexpensive DL-malic acid in high efficiency. CONSTITUTION:A reaction liquid containing DL-malic acid is treated with a microbial cell having fumarase activity or aspartase activity or with a treated product of the cell. L-malic acid is converted to L-aspartic acid by the above enzymatic process an the remaining D-malic acid is separated from the reaction product.

23. 发明专利

JPH05271147A 失效
公开(公告)号：JPH05271147A
公开(公告)日：1993-10-19
申请号：JP6825792
申请日：1992-03-26
IPC分类号： C07B57/00 , C07C51/487 , C07C59/245 , C12P7/46 , C12P13/20
摘要： PURPOSE:To collect high-purity D-malic acid simply and in high yield by treating a mixed aqueous solution of D-malic acid and L-aspartic acid with a strongly acidic ion exchange resin. CONSTITUTION:In expensive D-malic acid as a raw material is treated with cells of microorganism having fumarase activity and aspartase activity or its treated material in an aqueous solution. L-malic acid is converted to fumaric acid by action fumarase and further converted to L-aspartic acid by action of aspartase. A mixed solution of L-aspartic acid and unreacted D-malic acid thus obtained is passed through a strongly acidic cation exchange resin and treated. Consequently, D-malic acid is collected, separated and recovered. For example, 'Diaion SK-IB' H type (manufactured by MITSUBISHI KASEI KK) is preferable as the strongly acidic ion exchange resin. The passing condition is preferably about 1-3ml/ml resin hr space velocity at room temperature to about 50 deg.C. D-Malic acid is useful as an intermediate raw material for medicines, agricultural chemicals, etc.

24. 发明专利

JPH03108490A PHOSPHOLIPASE A2 INHIBITOR 失效
公开(公告)号：JPH03108490A
公开(公告)日：1991-05-08
申请号：JP14800790
申请日：1990-06-06
申请人： SHIONOGI & CO
发明人： YOSHIDA TADASHI , ITAZAKI HIROSHI , ARITA HITOSHI , KAWAMURA YOSHIMI , MATSUMOTO KOICHI
IPC分类号： C12P7/44 , A61K31/19 , A61K31/215 , A61K31/365 , A61P7/02 , A61P43/00 , C07C59/245 , C07C59/42 , C07C69/675 , C07C69/732 , C07D307/33 , C07D493/10 , C12N9/99 , C12P7/42 , C12P7/64 , C12P17/02 , C12P17/04 , C12P17/18 , C12R1/645
摘要： NEW MATERIAL:A compound shown by formula I [R to R are each -COOR , -COOR or -COOR (R to R are H, lower alkyl, etc.); W is -OH; X, Y and Z are H or -OH; broken line is existence of double bond]. EXAMPLE:A compound shown by formula II. USE:A phospholipase A2 inhibitor. PREPARATION:A fungus [e.g. Circinotrichum falcatisporum RF-641 (FERM P-275A)] belonging to the genus Circinotrichum, capable of producing a compound shown by formula I, is cultured and the compound shown by formula I is collected from the culture solution.

28. 发明专利

JPS6334857B2 失效
公开(公告)号：JPS6334857B2
公开(公告)日：1988-07-12
申请号：JP13202880
申请日：1980-09-22
申请人： SUMITOMO CHEMICAL CO
发明人： KATSURA TADASHI , YAMACHIKA HIROSHI
IPC分类号： C07C59/245 , C07B57/00 , C07C51/00 , C07C51/42 , C07C51/487 , C07C67/00 , C07C209/00 , C07C211/27

29. 发明专利

JPS62142150A NEUTRAL L-ARGININE-L-MALATE CRYSTAL AND PRODUCTION THEREOF 失效
公开(公告)号：JPS62142150A
公开(公告)日：1987-06-25
申请号：JP28488086
申请日：1986-11-28
申请人： TANABE SEIYAKU CO
发明人： SENHATA ICHIRO , WASHIMI AKIHIKO , ITO HIROSHI , OTSUKI OSAMU , IZUTSU NOZOMI
IPC分类号： C07C59/245 , C07C67/00 , C07C239/00 , C07C279/14
摘要： NEW MATERIAL:Neutral L-arginine L-malate crystals. USE:An additive for enriching nutriment and medicine. High-purity crystals, stable to moisture in a crystal state, having very high solubility in water and most suitable for oral administration because of no taste and odor. PREPARATION:Two mol L-arginine and 1mol L-malic acid are subjected to neutralization reaction in an aqueous solvent by adjusting pH to 6.0-8.5, prefer ably 6.5-7.5 to give a neutral salt. The titled compound is then deposited from the aqueous solution containing the neutral salt by a method for adding a hydrophilic organic solvent, e.g. methanol, etc., or supplying seed crystals, The concentration of the aqueous solution containing the neutral salt to be used for the depositing operation is preferably 50-70%.

30. 发明专利

JPS60166643A PREPARATION OF DISODIUM DL-MALATE HYDRATE 失效
公开(公告)号：JPS60166643A
公开(公告)日：1985-08-29
申请号：JP2083884
申请日：1984-02-09
申请人： TAIYO KAGAKU KOGYO CO LTD
发明人： OGATA TOMEZOU , TAKANAMI RIYOUICHI , MATSUO KAZUHIKO , SHIOMITSU TADAO
IPC分类号： C07C59/245 , C07C51/00 , C07C51/41 , C07C67/00
摘要： PURPOSE:To obtain a granular or particulate material of the titled compound having improved fluidity, by neutralizing dl-malic acid with sodium carbonate in a specific proportion to a specific neutralization degree, and neutralizing the resultant slurry mixture with an aqueous solution of caustic soda. CONSTITUTION:dl-Malic acid is mixed with a carbonate to give 45-75mol% carbonate and 25-55mol% caustic soda in the total sodium required to neutralize the dl-malic acid. An aqueous solution of caustic soda and if necessary water are added to the mixture to give 80-90% neutralization degree. The resultant slurry mixture is aged until no gaseous carbon dioxide is evolved. The remaining aqueous solution of caustic soda is then added thereto under agitation not to dissolve the slurry. The resultant mixture is heated with the heat of neutralization or if necessary heated to 55-65 deg.C to evaporate moisture. The formed wet powdery material is then heated to 70-130 deg.C to afford the aimed powdery or granular material of the disodium dl-malate hydrate with

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