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11. 发明专利

JP2007045794A Antifatigue peptide derived from edible meat protein 有权
标题翻译：从食用蛋白质衍生的抗生素肽
公开(公告)号：JP2007045794A
公开(公告)日：2007-02-22
申请号：JP2005234407
申请日：2005-08-12
申请人： Kitasato Gakuen , Prima Meat Packers Ltd , プリマハム株式会社 , 学校法人北里学園
发明人： ARIHARA KEIZO , TOMITA KOHEI , ISHIKAWA SHINICHI , ITO MAKOTO , AKIMOTO MASANOBU , SAMEJIMA TAKASHI
IPC分类号： A61K38/00 , A23L1/305 , A61K36/06 , A61P3/00 , C07K5/103 , C07K5/113
摘要： PROBLEM TO BE SOLVED: To provide an antifatigue agent effective for preventing fatigue and recovering from the fatigue and safe, and to provide a functional food. SOLUTION: This antifatigue agent contains a peptide-containing fraction which is given by treating a suspension of actomyosin existing in muscle (skeletal muscle) of an animal in a large amount with a protease, such as papain, and then removing insoluble matter therefrom, wherein the peptide-containing fraction is found to have high antifatigue activity and Asp-Leu-Tyr-Ala, Ser-Leu-Tyr-Ala, and Val-Trp of which the each is a peptide having the antifatigue activity are purified/identified from the peptide-containing fraction having the high antifatigue activity. Further, the peptides having an antifatigue effect are obtained by being purified from a decomposition product of the actomyosin or chemically synthesized based on information about sequences thereof. Furthermore, the food having the antifatigue effect is obtained by adding the peptides having the antifatigue effect to a food. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种有效预防疲劳和疲劳恢复的抗疲劳剂，并提供功能性食品。解决方案：该抗疲劳剂含有含肽部分，其通过用诸如木瓜蛋白酶的蛋白酶大量处理存在于动物肌肉（骨骼肌）的肌动蛋白的悬浮液，然后除去不溶物发现其中含有肽的级分具有高的抗疲劳活性，并且其中各自为具有抗疲劳活性的肽的Asp-Leu-Tyr-Ala，Ser-Leu-Tyr-Ala和Val-Trp被纯化/ 从具有高抗疲劳活性的含肽级分鉴定。此外，通过从肌动球蛋白的分解产物纯化或基于其序列的信息化学合成获得具有抗疲劳作用的肽。此外，具有抗疲劳效果的食品通过将具有抗疲劳作用的肽加入到食物中而获得。版权所有（C）2007，JPO＆INPIT

12. 发明专利

JP2006347937A HYPOTENSIVE PEPTIDE DERIVED FROM PROTEIN OF MEAT OF DOMESTIC ANIMAL 审中-公开
公开(公告)号：JP2006347937A
公开(公告)日：2006-12-28
申请号：JP2005175085
申请日：2005-06-15
申请人： PRIMA MEAT PACKERS LTD
发明人： ARIHARA KEIZO , ISHIKAWA SHINICHI , ITO MAKOTO , AKIMOTO MASANOBU , NAKAJIMA YASUYOSHI , KANAI SATOSHI
IPC分类号： C07K7/06 , A23L1/305 , A23L33/17 , A23L33/18 , A61K35/34 , A61K38/00 , A61K38/01 , A61K38/06 , A61K38/08 , A61K38/12 , A61K38/17 , A61P9/04 , A61P9/12 , A61P43/00 , C07K5/08 , C12N9/99 , C12P21/06
摘要： PROBLEM TO BE SOLVED: To provide new peptides given from edible meat which is situated in an important position among foods and having hypotensive action or angiotensin I converting enzyme inhibiting activity, and to provide a pharmaceutical composition containing the peptides as an active ingredient. SOLUTION: A peptide composition containing a pentapeptide having a structure of Ile-Arg-Val-Val-Glu and tripepides having structures of Val-Trp-Ile, Val-Gly-Arg, and Ile-Lys-Ile is obtained by hydrolyzing a protein of the edible meat, or myosin or actin of which the each is an important protein of the edible meat by action of a protease, such as Amano S (trade name). The peptides have the angiotensin I converting enzyme inhibiting activity and the hypotensive action, so as to be used as an angiotensin I converting enzyme inhibitor. Further, the peptides are highly safe and applied to a food for preventing hypertension and ameliorating a symptom thereof. COPYRIGHT: (C)2007,JPO&INPIT

13. 发明专利

JPH11346718A MEAT PROCESSED FOOD USING ENZYME 失效
公开(公告)号：JPH11346718A
公开(公告)日：1999-12-21
申请号：JP16544598
申请日：1998-06-12
申请人： PRIMA MEAT PACKERS LTD
发明人： YAMANAKA HIROYUKI , AKIMOTO MASANOBU , KANAI SATOSHI
IPC分类号： A23L13/70 , A23L1/318
摘要： PROBLEM TO BE SOLVED: To provide a method for rapidly and safely producing a meat processed food which solves problems of energy, problems of safety and hygiene, etc., has the same aging taste as that of a meat product aged for a long period of time and has an excellent taste. SOLUTION: An enzyme having 0.01-10 u/g, preferably 0.05-2 u/g protease activity in salted meat is dissolved in a pickle solution. The enzyme-containing solution is injected into meat to increase the content of free amino acid in the meat. An acidic protease having the optimum pH at 2-4, an alkali protease having the optimum pH at pH 9-12 and an enzyme having essentially low enzyme activity can be cited as the enzyme to be used.

14. 发明专利

JP2009244277A Detection method of wheat allergen 有权
标题翻译：小麦过敏原检测方法
公开(公告)号：JP2009244277A
公开(公告)日：2009-10-22
申请号：JP2009170624
申请日：2009-07-21
申请人： Prima Meat Packers Ltd , プリマハム株式会社
发明人： AKIMOTO MASANOBU , KATO SHIGESHIRO , NAMIOKA MAKOTO
IPC分类号： G01N33/53 , C07K16/16 , C07K16/18 , C12P21/08 , G01N33/543 , G01N33/577 , G01N33/68
CPC分类号： C07K16/16 , C07K16/18 , G01N33/5308 , G01N33/68 , G01N2333/4731 , Y10S530/85 , Y10S530/868
摘要： PROBLEM TO BE SOLVED: To provide an immunological detection method of high sensitivity capable of detecting a wheat allergen even in a state that the wheat allergen is modified/unmodified in food containing the wheat allergen, and a detection kit used therein.
SOLUTION: In the detection method of the wheat allergen using two kinds of monoclonal antibodies for recognizing unmodified and modified wheat allergens, gliadin being wheat principal protein is set to an index.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供即使在小麦变应原食物中的小麦变应原被修饰/未修饰的状态下也能够检测小麦变应原的高灵敏度的免疫学检测方法和其中使用的检测试剂盒。解决方案：在使用两种单克隆抗体识别未修饰和修饰的小麦过敏原的小麦过敏原的检测方法中，将麦醇溶蛋白作为小麦主要蛋白质设置为指标。版权所有（C）2010，JPO＆INPIT

15. 发明专利

JP2008241704A New stress biomarker and its application 有权
标题翻译：新应用生物标记及其应用
公开(公告)号：JP2008241704A
公开(公告)日：2008-10-09
申请号：JP2008046643
申请日：2008-02-27
申请人： Prima Meat Packers Ltd , Shizuokaken Koritsu Daigaku Hojin , プリマハム株式会社 , 静岡県公立大学法人
发明人： AKIMOTO MASANOBU , NAMIOKA MAKOTO , KATO AYAKO , NAKAYAMA TSUTOMU , OHASHI NORIO , NAITO HIROYOSHI
IPC分类号： G01N27/447 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/573
摘要： PROBLEM TO BE SOLVED: To provide a screening method of a stress inhibitor substance or stress fortifier substance utilizing a new stress biomarker, how to determine stress, and a stress diagnostic kit.
SOLUTION: In this method, serum of a rat with stress loaded through water-submersion arresting is tested to two-dimensional electrophoresis. The two-dimensional electrophoretic images of before and after stress load are compared, using any one of proteins such as apolipoprotein H, fetuin β, actin β, or enolase β after stress load as a marker. For example, when detected quantity of the actin β, enolase β, apolipoprotein H, or fetuin β is varying compared with the case of serum sampled from healthy mammal, the mammal intended for evaluation is determined to undergo stress.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供使用新的应激生物标志物的应激抑制物质或应激强化剂物质的筛选方法，如何确定应激和应激诊断试剂盒。解决方案：在这种方法中，测试通过水 - 浸没阻滞加载的应力的大鼠血清进行二维电泳。比较应激负荷前后的二维电泳图像，使用任何一种蛋白质，如载脂蛋白H，胎球蛋白β，肌动蛋白β或烯醇化酶β作为标记。例如，当检测到的肌动蛋白β，烯醇化酶β，载脂蛋白H或胎球蛋白β的量与从健康哺乳动物取样的血清的情况相比变化时，要评价的哺乳动物被测定为经受应激。版权所有（C）2009，JPO＆INPIT

16. 发明专利

JP2007084533A Immune response-modulating composition and food with the same as active ingredient 审中-公开
标题翻译：免疫反应调节组合物和食物作为活性成分
公开(公告)号：JP2007084533A
公开(公告)日：2007-04-05
申请号：JP2006227564
申请日：2006-08-24
申请人： National Agriculture & Food Research Organization , Prima Meat Packers Ltd , プリマハム株式会社 , 独立行政法人農業・食品産業技術総合研究機構
发明人： AKIMOTO MASANOBU , TAKUBO RITSUKO , DEN BIRAN , MIZUMACHI ISAKO , AOKI REIJI , KURISAKI JUNICHI
IPC分类号： A61K38/00 , A23L1/30 , A23L1/305 , A61K35/74 , A61P37/02
摘要： PROBLEM TO BE SOLVED: To provide an immune response-modulating composition and food containing the same useful for treating/preventing various immunological diseases including food allergy. SOLUTION: The immune response-modulating composition comprises at least one substance selected from the group consisting of protein having immunomodulating function such as albumen ovomucoid, the protein's split product having immunomodulating function and chemically modified product thereof having immunomodulating function and lactic acid bacteria selected from the microorganism group belonging to the genera Lactobacillus, Bifidobacterium and Enterococcus and enabling immunomodulating function to be improved via synergistic action with the above-mentioned chemical substance(s) through inducing Th1-type cytokine(e.g. IL-12, IFN-γ) and Th2-type cytokine(e.g. IL-6, IL-10). The food with the above composition as active ingredient is also provided. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供免疫应答调节组合物和含有可用于治疗/预防各种免疫疾病（包括食物过敏）的食物。解决方案：免疫应答调节组合物包含至少一种选自具有免疫调节功能的蛋白质，例如白蛋白类粘蛋白，具有免疫调节功能的蛋白质分裂产物和具有免疫调节功能的化学修饰产物和乳酸菌中的至少一种物质选自属于乳杆菌属，双歧杆菌属和肠球菌属的微生物组，并且通过诱导Th1型细胞因子（例如IL-12，IFN-γ）通过与上述化学物质的协同作用来改善免疫调节功能，和Th2型细胞因子（如IL-6，IL-10）。还提供了具有上述组合物作为活性成分的食物。版权所有（C）2007，JPO＆INPIT

17. 发明专利

JP2001327266A METHOD FOR PRODUCING MEAT-SUSPENDED DISPERSION 失效
公开(公告)号：JP2001327266A
公开(公告)日：2001-11-27
申请号：JP2000292250
申请日：2000-09-26
申请人： PRIMA MEAT PACKERS LTD
发明人： AKIMOTO MASANOBU , KANAI SATOSHI , YAMANAKA HIROYUKI
IPC分类号： A23G3/00 , A23G3/34 , A23G9/32 , A23G9/44 , A23G9/52 , A23L2/66 , A23L9/10 , A23L13/70 , A23L23/00 , A23L1/318 , A23G9/02 , A23L1/187 , A23L1/39
摘要： PROBLEM TO BE SOLVED: To obtain food as the subject dispersion including liquid meat and gel-like enzyme-treated meat high in dispersibility in the form of a solution, easily takable even for elderly persons, infants or sick persons feeling difficult to chew or swallow food, having flavor inherent in meat and high in dispersibility. SOLUTION: This meat-suspended dispersion is produced by the following process: ground meat is subjected to an endo-type protease and/or exo-type protease and then heat-treated at 85-95 deg.C for 20-45 min to deactivate the protease, the resultant gelled product is suspended in water so as to be 10 wt.% in concentration and give such a dispersibility as to be >=80% in floating rate after left to stand for 4 h; wherein the above protease treatment comprises performing an enzymatic reaction until the breaking stress of the gelled product after the above heat treatment comes to 33-67% of the protease-untreated reference. When this meat-suspended dispersion is to be used as a food, it is preferable that this dispersion is put to filtration treatment in advance to remove contaminants such as hair and bones.

18. 发明专利

JP2001233898A ANTIHYPERTENSIVE PEPTIDE DERIVED FROM MEAT PROTEIN 失效
公开(公告)号：JP2001233898A
公开(公告)日：2001-08-28
申请号：JP2000048143
申请日：2000-02-24
申请人： PRIMA MEAT PACKERS LTD
发明人： ARIHARA KEIZO , NAKAJIMA YASUYOSHI , ITO MAKOTO , AKIMOTO MASANOBU , SAMEJIMA TAKASHI , MOTONO KAZUO
IPC分类号： A23L1/305 , A23L33/10 , A23L33/17 , A23L33/18 , A61K35/34 , A61K38/00 , A61K38/17 , A61P9/12 , A61P43/00 , C07K5/083 , C07K5/093 , C07K5/097 , C07K7/06 , C12N9/99 , C12P21/02
摘要： PROBLEM TO BE SOLVED: To provide new peptides having antihypertensive action or angiotensin I-converting enzyme-inhibiting activity obtained from meat ranked as important food, and to provide a pharmacological composition comprising at least one of the peptides as an active component. SOLUTION: A peptide composition comprising pentapeptides having respective structures of Met-Asn-Pro-Pro-Lys and Ile-Thr-Thr-Asn-Pro is obtained by hydrolyzing meat protein or myosin of a principal meat protein by the action of a protease such thermolysin or protease K. These two pentapeptides and respective tripeptides having partial amino acid sequences Met-Asn-Pro and Pro-Pro-Lys of one of the pentapeptides have both of angiotensin I-converting enzyme-inhibiting activity and antihypertensive action. These peptides are highly safe and can be applied to food for prophylaxis of hypertension and amelioration of its symptom.

19. 发明专利

JPH04132959A QUANTITATIVE AND QUALITATIVE ANALYSIS OF EGG PROTEIN 失效
公开(公告)号：JPH04132959A
公开(公告)日：1992-05-07
申请号：JP25430390
申请日：1990-09-26
申请人： PRIMA MEAT PACKERS LTD
发明人： AKIMOTO MASANOBU , KURISAKI JUNICHI , YAMAGUCHI NAOKO
IPC分类号： G01N33/53
摘要： PURPOSE:To enable quantitative and qualitative analysis of egg protein with high specificity and good sensitivity by using ELIZA analysis with thermally stable ovomucoid used as an index. CONSTITUTION:Ovomucoid is separated from egg white to obtain purified ovomucoid, which is mixed with Freund's complete adjuvant. A rabbit is immunized by subcutaneous injection of the adjuvant, and blood is gathered according to a common method to obtain anti-ovomucoid serum. In order to confirm reaction of egg white protein with anti-ovomucoid serum, three kinds of egg white protein is made into approximately 0.01% solution (W/V) with phosphoric acid buffer solution, and reaction with the anti-ovomucoid serum is ELIZA- analyzed, wherein the anti-ovomucoid serum reacts with any of the egg white protein, from which light absorbency, it is known that any of them contains a similar amount of ovomucoid. Reaction to casein sodium and soybean separated protein is extremely low, so that the anti-ovomucoid serum is high in specificity.

20. 发明专利

JP2014066641A Method for detecting escherichia coli o157 审中-公开
标题翻译：检测食品科学O157的方法
公开(公告)号：JP2014066641A
公开(公告)日：2014-04-17
申请号：JP2012213101
申请日：2012-09-26
申请人： Prima Meat Packers Ltd , プリマハム株式会社
发明人： HOSOKAWA DAISUKE , KAMISAKI NAOKO , KATO SHIGESHIRO , TAKESHITA KAZUKO , AKIMOTO MASANOBU
IPC分类号： G01N33/569 , C07K16/12 , G01N33/531 , G01N33/543
摘要： PROBLEM TO BE SOLVED: To provide Escherichia coli O157 for immunochromatography detection kit capable of using a detection method by an immuno-chromatographic method capable of specifically and quickly detecting Escherichia coli O157 from a sample to be tested of a food product and Escherichia coli O157 for immuno-chromatographic detection kit usable for the detection method in order to efficiently eliminate contamination and infection by pathogenic Escherichia coli O157.SOLUTION: A sample to be tested is treated with a surface-active agent such as polyoxyethylene (10) octylphenyl ether and benzalkonium chloride, and an antibody for pathogenic escherichia coli O157 is made to act on this treated object so as to detect pathogenic escherichia coli O157. A monoclonal antibody for pathogenic escherichia coli O157 is preferably two kinds of monoclonal antibodies that recognize different epitopes.
摘要翻译：要解决的问题：提供能够使用能够通过免疫色谱法的检测方法的大肠杆菌O157，其能够从待测试的样品中大肠杆菌O157特异性地快速检测食品和大肠杆菌O157，用于免疫色谱检测试剂盒可用于检测方法，以有效消除致病性大肠杆菌O157的污染和感染。溶液：待测样品用表面活性剂如聚氧乙烯（10）辛基苯基醚和苯扎氯铵使病原性大肠杆菌O157的抗体作用于该处理对象，以便检测致病大肠杆菌O157。用于致病大肠杆菌O157的单克隆抗体优选是识别不同表位的两种单克隆抗体。

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