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11. 发明专利

JP2012125197A Method for producing protein 审中-公开
标题翻译：生产蛋白质的方法
公开(公告)号：JP2012125197A
公开(公告)日：2012-07-05
申请号：JP2010280276
申请日：2010-12-16
申请人： Kyowa Hakko Kirin Co Ltd , 協和発酵キリン株式会社
发明人： KURODA KOSUKE
IPC分类号： C12P21/08 , C12N5/10 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a method for more efficiently producing proteins.SOLUTION: In the method for producing proteins, a desired protein is produced by: subjecting animal cells transformed with a DNA (RRM1 gene or RRM2 gene) encoding ribonucleotide reductase and a DNA encoding the desired protein to semibatch culture; producing and accumulating the protein in the cultured substance; and collecting the protein from the cultured substance. In the method for producing proteins, the animal cells are CHO cells and the protein is an antibody.
摘要翻译：要解决的问题：提供一种更有效地生产蛋白质的方法。解决方案：在生产蛋白质的方法中，通过以下步骤制备所需的蛋白质：将编码核糖核苷酸还原酶的DNA（RRM1基因或RRM2基因）转化的动物细胞和编码所需蛋白质的DNA进行半匹配培养; 产生和积累培养物质中的蛋白质; 并从培养物质中收集蛋白质。在生产蛋白质的方法中，动物细胞是CHO细胞，蛋白质是抗体。版权所有（C）2012，JPO＆INPIT

12. 发明专利

JP2012056948A Topiramate granule 有权
标题翻译： TOPIRAMATE GRANULE
公开(公告)号：JP2012056948A
公开(公告)日：2012-03-22
申请号：JP2011173733
申请日：2011-08-09
申请人： Kyowa Hakko Kirin Co Ltd , 協和発酵キリン株式会社
发明人： HIROTA EIICHIRO , TANIMURA SHINJI , KANEKO NAOKI , KIGOSHI MAKOTO
IPC分类号： A61K31/7004 , A61K9/16 , A61K47/26 , A61K47/32 , A61K47/38 , A61P25/08
摘要： PROBLEM TO BE SOLVED: To perform coating that gives superior taste masking and prompt release in a stomach, the coating being for taste masking of core particles containing topiramate.SOLUTION: The topiramate granules include (a) the core particles containing topiramate and (b) a masking-coating membrane to coat the core particles. The masking-coating membrane includes 15-70 wt.% of a polymer such as an ethyl acrylate/methyl methacrylate copolymer, 15-60 wt.% of an excipient such as D-mannitol based on the weight of the membrane, and a coating substrate so that the weight ratio of the coating substrate and the polymer is 0:1 to 4:1, wherein the total amount of the polymer and the excipient is 50-95 wt.% based on the weight of the masking-coating membrane. The topiramate granules or the like with the characteristics is provided.
摘要翻译：要解决的问题：为了进行在胃中具有优异的掩味和迅速释放的涂层，该涂层用于掩蔽包含托吡酯的核心颗粒的味道。托吡酯颗粒包括（a）含有托吡酯的核心颗粒和（b）涂覆核心颗粒的掩蔽涂层膜。掩蔽涂膜包括15-70重量％的聚合物，例如丙烯酸乙酯/甲基丙烯酸甲酯共聚物，15-60重量％的赋形剂如D-甘露醇，基于膜的重量，涂层使得涂布基材和聚合物的重量比为0:1至4:1，其中基于掩蔽涂膜的重量，聚合物和赋形剂的总量为50-95重量％。提供具有特征的托吡酯颗粒等。版权所有（C）2012，JPO＆INPIT

13. 发明专利

JP2011190176A Degranulation inhibitor for mast cell 审中-公开
标题翻译：用于MAST细胞的降解抑制剂
公开(公告)号：JP2011190176A
公开(公告)日：2011-09-29
申请号：JP2008177109
申请日：2008-07-07
申请人： Kyowa Hakko Kirin Co Ltd , 協和発酵キリン株式会社
发明人： YAMADA AKISHI , YOSHIDA TETSUO
IPC分类号： A61K45/00 , A61K31/713 , A61K48/00 , A61P11/00 , A61P11/06 , A61P17/02 , A61P37/08 , A61P43/00 , C12N15/09
CPC分类号： A61K31/713 , C12N15/1137 , C12N2310/14
摘要： PROBLEM TO BE SOLVED: To provide a degranulation inhibitor for a mast cell, a method for inhibiting degranulation of a mast cell, and a therapeutic agent for a disease caused by abnormality of a mast cell.
SOLUTION: The degranulation inhibitor for a mast cell comprises as an effective ingredient a substance inhibiting a process of biosynthesis of a micro-RNA from a micro-RNA precursor, for example, a substance inhibiting expression of a Dicer1 gene. There are also provided the method for inhibiting degranulation of a mast cell, and the therapeutic agent for a disease caused by abnormality of a mast cell.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种肥大细胞的脱颗粒抑制剂，抑制肥大细胞脱粒的方法和由肥大细胞异常引起的疾病治疗剂。解决方案：肥大细胞的脱粒抑制剂包括抑制微RNA前体的微RNA生物合成过程的物质，例如抑制Dicer1基因表达的物质作为有效成分。还提供了抑制肥大细胞脱粒的方法和由肥大细胞异常引起的疾病治疗剂。版权所有（C）2011，JPO＆INPIT

14. 发明专利

JP2011063627A Granule and orally disintegrable tablet containing medicine having bitterness 有权
标题翻译：含有含有药物的颗粒和ORALLY DISINTABLE TITLET
公开(公告)号：JP2011063627A
公开(公告)日：2011-03-31
申请号：JP2010293163
申请日：2010-12-28
申请人： Kyowa Hakko Kirin Co Ltd , 協和発酵キリン株式会社
发明人： MIYAMOTO YUJI , TOKUDA TAKUYA , OTA MOTOHIRO , ISHIKAWA YASUHIRO
IPC分类号： A61K31/335 , A61K9/16 , A61K9/20 , A61K31/137 , A61K31/357 , A61K47/10 , A61K47/26 , A61K47/32
CPC分类号： A61K9/5026 , A61K9/0056 , A61K9/2081 , A61K9/5015 , A61K31/137 , A61K31/335 , A61K31/357 , A61K31/55
摘要： PROBLEM TO BE SOLVED: To provide a powder, granule, orally disintegrable tablet and the like, having both conflicting properties of intraoral suppression of bitterness (suppressing the amount of elution in the oral cavity) and good eluting properties in the stomach, in the powder, granule, orally disintegrable tablet and the like containing a medicine having bitterness.
SOLUTION: The medicine-containing granule includes (a) a core particle comprising a medicine having bitterness and (b) a masking film to coat the core particle. The masking film is characterized by including at least one polymer selected from a methacrylic acid copolymer S, methacrylic acid copolymer L, methacrylic acid-ethyl acrylate copolymer, and ethyl acrylate-methyl methacrylate copolymer, and at least one excipient selected from D-mannitol, lactose, trehalose, xylitol, maltitol and erythritol. The orally disintegrable tablet containing the granule is also provided.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：为了提供口腔内抑制苦味（抑制口腔洗脱量）和胃中良好洗脱性质的粉末，颗粒，口腔崩解片等，在含有具有苦味的药物的粉末，颗粒，口腔崩解片等中。含药颗粒包括（a）包含具有苦味的药物的核心颗粒和（b）用于包覆核心颗粒的掩蔽膜。掩模膜的特征在于包括至少一种选自甲基丙烯酸共聚物S，甲基丙烯酸共聚物L，甲基丙烯酸 - 丙烯酸乙酯共聚物和丙烯酸乙酯 - 甲基丙烯酸甲酯共聚物的聚合物和至少一种选自D-甘露糖醇，乳糖，海藻糖，木糖醇，麦芽糖醇和赤藓糖醇。还提供了含有颗粒的口腔崩解片。版权所有（C）2011，JPO＆INPIT

15. 发明专利

JP2011042655A Compound inhibiting in vivo phosphorus transport and medicine containing the same 审中-公开
标题翻译：血液中磷酸盐运输的化合物抑制和含有它的药物
公开(公告)号：JP2011042655A
公开(公告)日：2011-03-03
申请号：JP2010205973
申请日：2010-09-14
申请人： Kyowa Hakko Kirin Co Ltd , 協和発酵キリン株式会社
发明人： ETO NOBUAKI , NAGAO RIKA , MIYAZAKI TETSUKO
IPC分类号： C07C251/80 , A61K31/167 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/4375 , A61K31/438 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/443 , A61K31/4465 , A61K31/4535 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/498 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/551 , A61P3/06 , A61P3/10 , A61P5/00 , A61P7/00 , A61P7/06 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P13/12 , A61P15/00 , A61P17/04 , A61P19/00 , A61P19/02 , A61P21/00 , A61P25/00 , A61P27/02 , A61P37/04 , A61P43/00 , C07D207/335 , C07D209/14 , C07D209/34 , C07D211/22 , C07D211/40 , C07D211/46 , C07D213/53 , C07D213/70 , C07D213/81 , C07D213/82 , C07D231/04 , C07D239/76 , C07D241/44 , C07D243/08 , C07D249/12 , C07D257/04 , C07D261/18 , C07D307/38 , C07D307/52 , C07D307/56 , C07D307/71 , C07D333/22 , C07D333/38 , C07D333/68 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D471/04 , C07D471/14 , C07D491/10 , C07D491/113 , C07D495/04
CPC分类号： C07C323/60 , C07C251/86 , C07C255/66 , C07C259/10 , C07C317/44 , C07C323/25 , C07C323/66 , C07C2601/14 , C07D209/14 , C07D209/34 , C07D211/46 , C07D213/53 , C07D213/81 , C07D213/82 , C07D249/12 , C07D261/18 , C07D307/38 , C07D307/52 , C07D307/71 , C07D333/22 , C07D333/38 , C07D333/68 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04 , C07D491/10 , C07D495/04
摘要： PROBLEM TO BE SOLVED: To provide a compound which effectively lowers the phosphorus concentration in blood serum and hence can effectively prevent or cure diseases caused by an increase in the phosphorus concentration in blood serum.
SOLUTION: The compound is represented by formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种有效降低血清中磷浓度的化合物，因此可有效预防或治愈由血清中磷浓度增加引起的疾病。溶液：该化合物由式（I）表示，其药学上可接受的盐或其溶剂合物。版权所有（C）2011，JPO＆INPIT

16. 发明专利

JP2010154857A Useful polypeptide 审中-公开
标题翻译：有用的多糖
公开(公告)号：JP2010154857A
公开(公告)日：2010-07-15
申请号：JP2010004295
申请日：2010-01-12
申请人： Kyowa Hakko Kirin Co Ltd , 協和発酵キリン株式会社
发明人： SASAKI KATSUTOSHI , SHIRAISHI NORIHIKO , NATSUME AYUMI , YAMADA AKISHI , NAKAGAWA SATOSHI , SEKINE SUSUMU
IPC分类号： C12N15/09 , A01H5/00 , A61K31/715 , A61K38/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N15/54 , C12P19/26 , C12Q1/02 , C12Q1/48 , C12Q1/68 , G01N33/574
CPC分类号： C12N9/1051 , A61K38/00 , C07K2319/02 , C12N9/1085
摘要： PROBLEM TO BE SOLVED: To provide a medicament for anti-inflammatory, anti-infectious, cancer metastasis-inhibiting etc., to provide a food such as a dairy product, to provide a method for improving a protein, and to provide a method for diagnosing inflammatory diseases or malignancy of cancers. SOLUTION: There are provided: a new polypeptide having β1,3-N-acetylglucosaminyltransferase activity; a method for producing the polypeptide; a DNA encoding the polypeptide; a recombinant vector having the DNA integrated therein; a transformant having the recombinant vector; a method for producing a sugar chain or complex carbohydrate using the polypeptide; a method for producing the sugar chain or complex carbohydrate utilizing the transformant; an antibody recognizing the polypeptide; a method for screening a substance changing the expression of the gene encoding the polypeptide; and a method for screening a substance changing the activity possessed by the polypeptide. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供一种抗炎，抗感染，癌转移抑制等药物，以提供诸如乳制品的食品，以提供改善蛋白质的方法，并提供用于诊断炎症性疾病或癌症恶性肿瘤的方法。提供：具有β1,3-N-乙酰葡糖胺基转移酶活性的新多肽; 一种生产该多肽的方法; 编码该多肽的DNA; 其中整合有DNA的重组载体; 具有重组载体的转化体; 使用该多肽制备糖链或复合碳水化合物的方法; 利用转化体生产糖链或复合碳水化合物的方法; 识别多肽的抗体; 筛选改变编码该多肽的基因的表达的物质的方法; 以及筛选改变多肽所具有的活性的物质的方法。版权所有（C）2010，JPO＆INPIT

17. 发明专利

JP2010100645A Method of coating fine particles with lipid membrane 有权
标题翻译：用脂肪膜涂覆精细颗粒的方法
公开(公告)号：JP2010100645A
公开(公告)日：2010-05-06
申请号：JP2010000240
申请日：2010-01-04
申请人： Kyowa Hakko Kirin Co Ltd , 協和発酵キリン株式会社
发明人： KATO YASUKI , YAMAUCHI MASAHIRO , KUSANO HIROKO , IWATA TAKESHI , UOCHI TAKASATO , AKINAGA SHIRO
IPC分类号： A61K9/127 , A61K9/50 , A61K47/24 , A61K47/26 , A61K47/28 , A61K47/34 , B01J13/12
CPC分类号： A61K9/5123 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K9/141 , A61K9/146 , A61K9/5015 , A61K9/5192 , A61K31/7088 , A61K47/6911 , B01J13/12
摘要： PROBLEM TO BE SOLVED: To provide a safe, simple and efficient method of coating fine particles with a lipid membrane for stabilizing medications contained in the fine particles in vivo. SOLUTION: The method of coating fine particles with a lipid membrane is characterized in that an aqueous polar organic solvent solution which contains fine particles dispersed therein and a lipid dissolved therein is modified by reducing the proportion of the polar organic solvent. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种安全，简单和有效的用脂质膜涂覆细颗粒的方法，用于稳定体内微粒中所含的药物。解决方案：用脂质膜涂覆微粒的方法的特征在于通过减少极性有机溶剂的比例来改变含有分散在其中的微粒的水性极性有机溶剂溶液和溶解在其中的脂质。版权所有（C）2010，JPO＆INPIT

18. 发明专利

JP2009275049A Method for controlling activity of immunologically functional molecule 有权
标题翻译：用于控制免疫功能分子活性的方法
公开(公告)号：JP2009275049A
公开(公告)日：2009-11-26
申请号：JP2009160787
申请日：2009-07-07
申请人： Kyowa Hakko Kirin Co Ltd , 協和発酵キリン株式会社
发明人： HANAI NOBUO , NAKAMURA KAZUYASU , SHOJI EMI , YAMAZAKI MOTOO , UCHIDA KAZUHISA , SHINKAWA TOYOHIDE , IMABEPPU SUSUMU , KANDA YUTAKA , YAMANE NAOKO , ANAZAWA HIDEJI
IPC分类号： C07K16/32 , A61K39/395 , A61P9/00 , A61P29/00 , A61P31/00 , A61P37/00 , A61P37/08 , C07K16/08 , C07K16/12 , C07K16/28 , C07K16/30 , C07K16/46 , C12N15/09 , C12P21/08 , G01N33/53
CPC分类号： C07K16/3084 , A61K2039/505 , C07K16/2866 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2319/00 , C12P21/005 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide: a method for controlling the activity of an immunologically functional molecule such as an antibody, a protein, or a peptide; a promotor of the activity of an immunologically functional molecule; and an immunologically functional molecule having a promoted immunologically functional activity. SOLUTION: As a result of activity evaluation in in vitro of various humanized antibodies of Homo sapiens IgG1 subclass produced in CHO/dhFr cells and CHO/DG44 cells, mouse myeloma NS0 cells, and mouse myeloma SP2/O-Ag14 cells, the ADCC activity of a humanized antibody produced in rat myeloma YB2/O cells is found to be higher than that of a humanized antibody produced in other cells. Further, as the result of activity evaluation in in vivo by using macaca fascicularis, a humanized antibody produced in YB2/O cells is found to exhibit the highest effect. Thus, an antibody with a high ADCC activity in clinical applications is useful. Furthermore, a sugar chain having a function of enhancing the ADCC activity of a humanized antibody produced in various animal cells is specified. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供：控制抗体，蛋白质或肽等免疫功能性分子的活性的方法; 免疫功能分子活性的启动子; 和具有促进的免疫功能活性的免疫功能分子。解决方案：作为在CHO / dhFr细胞和CHO / DG44细胞，小鼠骨髓瘤NS0细胞和小鼠骨髓瘤SP2 / O-Ag14细胞中产生的智人IgG1亚类的各种人源化抗体体外活性评估的结果，发现在大鼠骨髓瘤YB2 / O细胞中产生的人源化抗体的ADCC活性高于在其它细胞中产生的人源化抗体的ADCC活性。此外，作为通过使用猕猴桃筋膜体内活性评价的结果，发现在YB2 / O细胞中产生的人源化抗体具有最高的效果。因此，在临床应用中具有高ADCC活性的抗体是有用的。此外，规定了具有增强各种动物细胞中产生的人源化抗体的ADCC活性的功能的糖链。版权所有（C）2010，JPO＆INPIT

19. 发明专利

JP2009256372A Tablet rapidly disintegrating in buccal cavity 审中-公开
标题翻译：片剂快速消毒
公开(公告)号：JP2009256372A
公开(公告)日：2009-11-05
申请号：JP2009179843
申请日：2009-07-31
申请人： Kyowa Hakko Kirin Co Ltd , 協和発酵キリン株式会社
发明人： OTA MOTOHIRO , HAYAKAWA EIJI , ITO KUNIO , TOKUNO SANJI , MORIMOTO KIYOSHI , WATANABE YASUSHI
IPC分类号： A61K47/10 , A61J3/10 , A61K9/00 , A61K9/20 , A61K47/26 , A61K47/32 , A61K47/38
CPC分类号： A61J3/10 , A61K9/0056 , A61K9/2018 , A61K9/2027
摘要： PROBLEM TO BE SOLVED: To provide a tablet rapidly disintegrating in buccal cavity or the like. SOLUTION: This tablet rapidly disintegrating in the buccal cavity or the like contains a sugar alcohol or a sugar having an average particle diameter of not greater than 30 μm, an active component, and a disintegrant, and is simply and easily prepared in general facilities without requiring a special formulation technology. COPYRIGHT: (C)2010,JPO&INPIT

20. 发明专利

JP2009189376A New anti-cd98 antibody 有权
标题翻译：新抗CD98抗体
公开(公告)号：JP2009189376A
公开(公告)日：2009-08-27
申请号：JP2009135435
申请日：2009-06-04
申请人： Kyowa Hakko Kirin Co Ltd , 協和発酵キリン株式会社
发明人： TAHARA TOMOYUKI , KANAI YOSHIKATSU , ENDO HITOSHI , KATAOKA YUKIO , HASEGAWA KAZUMASA , YOSHINO TETSUYA
IPC分类号： C12N15/09 , A61K39/395 , A61P35/00 , C07K16/32 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： PROBLEM TO BE SOLVED: To provide a cancer preventing and treating agent containing an antibody or its fragment, acting on various cancers, specific to cancers and showing no side effect, based on the findings that the antibody binding to CD98 forms a dimer on the cancer cell surface with LAT1 to specifically attack the CD98-expressing cancer cell by an immunological system of ADCC and CDC and further inhibiting the LAT1-mediated amino acid intake by the cancer cells to inhibit the proliferation of the cell. SOLUTION: Provided are a human antibody and a functional fragment of the human antibody binding specifically to CD98 which is originated from the cell membrane of cancer cells and forming a complex with a protein (e.g. LAT1) having amino acid transport activity. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：基于结合CD98的抗体形成二聚体的发现，提供含有抗体或其片段的癌症预防和治疗剂，其作用于各种癌症，特异性癌症并且不显示副作用在具有LAT1的癌细胞表面上通过ADCC和CDC的免疫系统特异性攻击表达CD98的癌细胞，并进一步抑制癌细胞的LAT1介导的氨基酸摄取以抑制细胞的增殖。解决方案：提供人抗体和特异性结合CD98的人抗体的功能片段，其起源于癌细胞的细胞膜并与具有氨基酸转运活性的蛋白质（例如LAT1）形成复合物。版权所有（C）2009，JPO＆INPIT

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