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1. 发明专利

JP2009207493A Method for producing biosurfactant using fermentation product of plant as medium 审中-公开
标题翻译：使用植物发酵产物生产生物活性剂的方法
公开(公告)号：JP2009207493A
公开(公告)日：2009-09-17
申请号：JP2009026973
申请日：2009-02-09
申请人： National Institute Of Advanced Industrial & Technology , Sanwa Shurui Co Ltd , 三和酒類株式会社 , 独立行政法人産業技術総合研究所
发明人： OMORI TOSHIRO , TAKESHIMA NAOKI , HAYASHI KEI , MARUOKA IKUYUKI , KONISHI MASAO , FUKUOKA TOKUMA , MORITA TOMOTAKE , IMURA TOMOHIRO , KITAMOTO MASARU
IPC分类号： C12P19/00
摘要： PROBLEM TO BE SOLVED: To provide a method for efficiently producing a highly functional microbial surface active substance (biosurfactant) by efficiently making use of compositions being byproducts in the processes of producing the liquors, excluding liquors, as unused resource.
SOLUTION: The biosurfactant is produced by fermentation at lower cost in a shorter period of time and more efficiently by using a medium containing a composition excluding liquor which is a byproduct in the process of producing the liquor, compared with a process using a conventional production medium, and in addition, the compositions excluding liquors which have been the unused resource of the byproducts in the process of producing the liquor is effectively used.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种通过在生产不含酒的液体的过程中有效地利用作为副产物的组合物来有效地生产高功能微生物表面活性物质（生物表面活性剂）的方法作为未使用的资源。解决方案：生物表面活性剂通过在较短的时间内以更低的成本发酵，并且通过使用含有不含作为生产液体中副产物的液体的组合物的培养基，与使用常规的生产介质，另外，在生产液体的过程中，除了已经是副产物的未使用资源的液体组合物被有效地使用。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2007084504A Composition containing fermentation product of barley as active ingredient and having neovascularization inhibitory action 有权
标题翻译：含有发酵产物的组合物作为活性成分并具有新鲜血液动力学抑制作用
公开(公告)号：JP2007084504A
公开(公告)日：2007-04-05
申请号：JP2005277653
申请日：2005-09-26
申请人： National Institute Of Advanced Industrial & Technology , Omugi Hakko Kenkyusho:Kk , Sanwa Shiyurui Kk , 三和酒類株式会社 , 株式会社大麦発酵研究所 , 独立行政法人産業技術総合研究所
发明人： OMORI TOSHIRO , SOTOZONO HIDEKI , KODERA MIHOKO , OBA HIDEKI , TAKESHIMA NAOKI
IPC分类号： A61K36/899 , A23K1/06 , A23K1/16 , A23K1/18 , A23L1/30 , A61P27/02 , A61P29/00 , A61P35/00 , C12F3/10
CPC分类号： Y02P60/873
摘要： PROBLEM TO BE SOLVED: To provide a composition having an excellent neovascularization inhibitory action from an inexpensive and relatively easily available material not having a problem on safety, preferably distillation residual liquids of barley Shochu (white distilled liquor), by a simple treatment method suitable for practical production in a factory scale without passing through a troublesome purification process. SOLUTION: This composition for inhibiting neovascularization contains the fermentation product of barley, preferably an ingredient originated from distillation residual liquids of barley Shochu, as active ingredient. The composition is a composition for treating or preventing diseases having neovascularization to be inhibited, concretely diseases caused by abnormal neovascularization in tumors or cancers, chronic inflammations or retinopathy. The composition is in a form selected from the group consisting of food additives, food materials, foods, drinks, medicines/quasi-drugs, and feeds for inhibiting the neovascularization. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：通过简单的处理，从不具有安全性问题的廉价且相对容易获得的材料提供具有优异的新生血管形成抑制作用的组合物，优选大麦烧酒（白蒸馏液）的蒸馏残余液体方法适用于工厂规模的实际生产，而不会经历麻烦的净化过程。解决方案：用于抑制新生血管形成的组合物含有大麦的发酵产物，优选来自大麦烧酒的蒸馏残余液体的成分作为活性成分。该组合物是用于治疗或预防具有新血管形成被抑制的疾病的组合物，具体是由肿瘤或癌症中的新生血管形成异常引起的疾病，慢性炎症或视网膜病变。组合物为选自食品添加剂，食品材料，食品，饮料，药物/准药物和用于抑制新血管形成的饲料的形式。版权所有（C）2007，JPO＆INPIT

3. 发明专利

JP2005104957A Composition having activity for activating natural killer cell, method for producing the same, activated natural killer cell-containing composition and method for producing the same 审中-公开
标题翻译：具有用于激活自然杀伤细胞的活性的组合物，其生产方法，活化的自然杀伤细胞含有组合物及其生产方法
公开(公告)号：JP2005104957A
公开(公告)日：2005-04-21
申请号：JP2003429972
申请日：2003-12-25
申请人： National Institute Of Advanced Industrial & Technology , Omugi Hakko Kenkyusho:Kk , Sanwa Shiyurui Kk , 三和酒類株式会社 , 株式会社大麦発酵研究所 , 独立行政法人産業技術総合研究所
发明人： OMORI TOSHIRO , UMEMOTO YASUSHI , FURUTA YOSHIFUMI , SOTOZONO HIDEKI , KODERA MIHOKO , OBA HIDEKI
IPC分类号： A61K31/716 , A61K35/14 , A61K36/00 , A61K36/06 , A61K36/899 , A61P1/16 , A61P31/12 , A61P35/00 , A61P35/02 , A61P37/02 , A61P43/00 , C12N5/0783 , C12P1/00 , A61K35/78 , A61K35/72 , C12N5/06
CPC分类号： C12N5/0646 , A61K36/8998 , C12N2500/34
摘要： PROBLEM TO BE SOLVED: To obtain a composition fractionated from a barley-distilled white liquor residual liquid and having an activity of activating natural killer (NK) cells, and an activated NK cell-containing composition. SOLUTION: The composition having the activity for activating the NK cells consisting of a fraction insoluble to an organic solvent is obtained by the solid-liquid separation of the barley-distilled white liquor residual liquid produced as a byproduct in the distilled white liquor production by using the barley as a raw material to obtain a liquid portion, performing an ion exchange treatment to the liquid portion or a non-adsorbed fraction obtained by performing an adsorptive separation of the liquid portion by using a synthetic adsorbent, by using an ion-exchanging resin to obtain a non-adsorbed fraction to the ion-exchanging resin, performing a concentrating treatment of the non-adsorbed fraction to the ion-exchanging resin by an ultrafiltration using an ultrafiltration membrane to obtain concentrated liquid and adding the above organic solvent to the concentrated liquid, and a method for producing the same is also provided. The activated NK cell-containing composition containing the NK cells activated by the above composition, and a method for producing the same are also provided. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：获得从大麦蒸馏白液残液中分级分离并具有活化自然杀伤（NK）细胞活性的组合物和活化的含有NK细胞的组合物。解决方案：通过将蒸馏白液中作为副产物产生的大麦蒸馏白液残留液体的固液分离，获得具有活化由不溶于有机溶剂的级分组成的NK细胞活性的组合物通过使用大麦作为原料以获得液体部分，通过使用合成吸附剂对液体部分进行离子交换处理或通过使用合成吸附剂进行液体部分的吸附分离而获得的非吸附级分来生产改性树脂，以获得离子交换树脂的非吸附级分，通过使用超滤膜进行超滤，对离子交换树脂进行非吸附级分的浓缩处理，得到浓缩液，加入上述有机溶剂与浓缩液相同，也提供了其制造方法。还提供了含有通过上述组合物活化的NK细胞的活化的含有NK细胞的组合物及其制备方法。版权所有（C）2005，JPO＆NCIPI

4. 发明专利

JP2003073294A Leukemic cell growth inhibitor and method for manufacturing the same 有权
标题翻译： LEUKEMIC细胞生长抑制剂及其制备方法
公开(公告)号：JP2003073294A
公开(公告)日：2003-03-12
申请号：JP2001268595
申请日：2001-09-05
申请人： National Institute Of Advanced Industrial & Technology , Sanwa Shiyurui Kk , 三和酒類株式会社 , 独立行政法人産業技術総合研究所
发明人： OMORI TOSHIRO , GOTO RISA , SOTOZONO HIDEKI , OBA HIDEKI
IPC分类号： A61K36/899 , A61P35/02 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a leukemic cell growth inhibitor fractionally collected from a residual liquid of distillation of barley SYOUTYUU (distilled spirit in Japan) and a method for manufacturing the same. SOLUTION: The manufacturing method of the leukemic cell growth inhibitor comprising an organic solvent-insoluble fraction which is fractionally collected as follows: a residual liquid of barley SYOUTYUU distillation which is by- produced in the SYOUTYUU manufacturing by using barley as a raw material, is subjected to a solid-liquid separation to obtain a liquid component; and an organic solvent is added to the liquid component. The leukemic cell growth inhibitor comprising the organic solvent-insoluble fraction which is obtained through the manufacturing method.
摘要翻译：要解决的问题：提供从大麦SYOUTYUU（日本蒸馏酒）的蒸馏残余液中分选收集的白血病细胞生长抑制剂及其制造方法。解决方案：包含有机溶剂不溶性级分的白血病细胞生长抑制剂的制造方法，其如下分批收集：在以大麦为原料的SYOUTYUU制造中副产的大麦SYOUTYUU蒸馏残留液为进行固液分离，得到液体成分; 并向液体组分中加入有机溶剂。白血病细胞生长抑制剂包含通过制造方法获得的有机溶剂不溶性级分。

5. 发明专利

JP2007084503A Composition containing ingredient originated from grain as active ingredient and having neovascularization inhibitory action 有权
标题翻译：含有成分作为活性成分并具有新生血管抑制作用的成分组成
公开(公告)号：JP2007084503A
公开(公告)日：2007-04-05
申请号：JP2005277652
申请日：2005-09-26
申请人： National Institute Of Advanced Industrial & Technology , Omugi Hakko Kenkyusho:Kk , Sanwa Shiyurui Kk , 三和酒類株式会社 , 株式会社大麦発酵研究所 , 独立行政法人産業技術総合研究所
发明人： OMORI TOSHIRO , SOTOZONO HIDEKI , KODERA MIHOKO , UMEMOTO YASUSHI , HAYASHI KEI , OBA HIDEKI , TAKESHIMA NAOKI
IPC分类号： A61K36/899 , A23K1/16 , A23K1/18 , A23L1/30 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a composition having an excellent neovascularization inhibitory action from an inexpensive and relatively easily available material not having a problem on safety, preferably barley, by a simple treatment method suitable for practical production in a factory scale without passing through a troublesome purification process. SOLUTION: This composition for inhibiting neovascularization contains an ingredient originated from a gramineae plant, preferably an ingredient originated from barley, as active ingredient having a neovascularization inhibitory action. The ingredient originated from barley is selected from the group consisting of an unmilled barley ethyl alcohol extraction fraction and an unmilled barley alkali extraction fraction. The composition for inhibiting the neovascularization is a composition for treating or preventing diseases having neovascularization to be inhibited, concretely diseases caused by abnormal neovascularization in tumors or cancers, chronic inflammations or retinopathy. The composition is in a form selected from the group consisting of food additives, food materials, foods, drinks, medicines/quasi-drugs, and feeds for inhibiting neovascularization. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：通过适用于工厂规模的实际生产的简单的处理方法，从不具有安全性问题的廉价且相对容易获得的材料，优选大麦提供具有优异的新血管形成抑制作用的组合物，没有通过一个麻烦的净化过程。解决方案：用于抑制新生血管形成的组合物含有起源于禾本科植物，优选来自大麦的成分的成分，作为具有新血管形成抑制作用的活性成分。起源于大麦的成分选自未熟化的大麦乙醇提取级分和未熟化的大麦碱提取级分。用于抑制新血管形成的组合物是用于治疗或预防具有新血管形成被抑制的疾病的组合物，具体是由肿瘤或癌症中的异常新血管形成引起的疾病，慢性炎症或视网膜病变。组合物为选自食品添加剂，食品材料，食品，饮料，药物/准药物和用于抑制新血管形成的饲料的形式。版权所有（C）2007，JPO＆INPIT

6. 发明专利

JP2003073295A Natural killer cell activator, method for manufacturing the activator, composition containing activated natural killer cell and method for manufacturing the composition 审中-公开
标题翻译：自然杀伤细胞活化剂，制备活化剂的方法，包含活化的自然杀伤细胞的组合物和制备组合物的方法
公开(公告)号：JP2003073295A
公开(公告)日：2003-03-12
申请号：JP2001268596
申请日：2001-09-05
申请人： National Institute Of Advanced Industrial & Technology , Sanwa Shiyurui Kk , 三和酒類株式会社 , 独立行政法人産業技術総合研究所
发明人： OMORI TOSHIRO , GOTO RISA , SOTOZONO HIDEKI , OBA HIDEKI , KAWAHARA HIROMI
IPC分类号： A61K36/899 , A61P35/02 , A61P43/00 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide an NK cell activator fractionally collected from a residual liquid of distillation of barley SYOUTYUU (distilled spirit in Japan) and an activated natural killer cell-containing composition. SOLUTION: The natural killer cell activator comprising an organic solvent- insoluble fraction which is fractionally collected as follows: a residual liquid of barley SYOUTYUU distillation which is byproduced in the SYOUTYUU manufacturing using barley as a raw material, is subjected to a solid-liquid separation to obtain a liquid component; and an organic solvent is added to the liquid component. The activated natural killer cell-containing composition which contains natural killer cells activated by using the organic solvent- insoluble fraction.
摘要翻译：要解决的问题：提供从大麦SYOUTYUU（日本蒸馏酒）的蒸馏残余液中分选收集的NK细胞活化剂和含活性天然杀伤细胞的组合物。解决方案：包含有机溶剂不溶级分的天然杀伤细胞活化剂，其分级收集如下：在使用大麦作为原料的SYOUTYUU制造中副产的大麦SYOUTYUU蒸馏的残余液体进行固液分离以获得液体组分; 并向液体组分中加入有机溶剂。含有天然杀伤细胞的组合物含有通过使用有机溶剂不溶性级分活化的天然杀伤细胞。

7. 发明专利

JP2004217928A Production method for composition having activating action of natural killer cell and production method for activated natural killer cell-containing composition 审中-公开
标题翻译：具有自然杀伤细胞活化作用的组合物的生产方法和用于活化的天然杀伤细胞含有组合物的生产方法
公开(公告)号：JP2004217928A
公开(公告)日：2004-08-05
申请号：JP2003433294
申请日：2003-12-26
申请人： National Institute Of Advanced Industrial & Technology , Omugi Hakko Kenkyusho:Kk , Sanwa Shiyurui Kk , 三和酒類株式会社 , 株式会社大麦発酵研究所 , 独立行政法人産業技術総合研究所
发明人： OMORI TOSHIRO , UMEMOTO YASUSHI , FURUTA YOSHIFUMI , SOTOZONO HIDEKI , KODERA MIHOKO , OBA HIDEKI
IPC分类号： A61K31/715 , A61K35/14 , A61K36/06 , A61K36/899 , A61P35/00 , A61P35/02 , A61P43/00 , C08B37/14 , C12N5/07 , C12N5/071 , C12N5/0783 , A61K35/70 , A61K35/72 , A61K35/78 , C12N5/06
摘要： PROBLEM TO BE SOLVED: To provide a production method for a composition having an activating action of a dispensed NK cell from a barley shochu distillation residual liquid, and to provide a production method for an activated NK cell-containing composition. SOLUTION: The producing method of a composition having an activating action of a NK cell comprises at least the steps of: obtaining a liquid component by solid-liquid separating the barley shochu distillation residual liquid by-produced in a producing method of the shochu using barley as a raw material, and applying a thickening treatment to the liquid component by ultrafiltrating using an ultrafiltration membrane, and in the thickening treatment to the liquid component by ultrafiltrating, containing substantially no uronic acid, but containing a polysaccharide consisting of xylose, arabinose and glucose, obtaining a thickened liquid having the activating action of the NK cell, and obtaining the composition comprising the thickened liquid. The producing method of the activated NK cell-containing composition comprises containing the activated NK cell with the composition having the activating action of the NK cell. COPYRIGHT: (C)2004,JPO&NCIPI
摘要翻译：解决问题的方法：提供从大麦烧酒蒸馏残留液中分配的NK细胞的活化作用的组合物的制造方法，提供含活性NK细胞的组合物的制造方法。解决方案：具有NK细胞活化作用的组合物的制备方法至少包括以下步骤：通过以下方法获得液体成分：将生产的副产的大麦烧酒蒸馏残余液体固液分离，使用大麦作为原料的烧酒，通过使用超滤膜进行超滤处理，对液体成分进行增稠处理，在通过超滤的液体成分的粗化处理中，基本上不含糖醛酸，但含有由木糖，阿拉伯糖和葡萄糖，得到具有NK细胞活化作用的增稠液，得到包含增稠液体的组合物。活化的含有NK细胞的组合物的制备方法包括含有具有NK细胞活化作用的组合物的活化的NK细胞。版权所有（C）2004，JPO＆NCIPI

8. 发明专利

JP2010158192A Microorganism having ability of producing saccharide type biosurfactant and method for producing saccharide type biosurfactant using the same 有权
标题翻译：具有生产SACCHARIDE型生物交换剂的能力的微生物和使用其生产SACCHARIDE型生物交换剂的方法
公开(公告)号：JP2010158192A
公开(公告)日：2010-07-22
申请号：JP2009001914
申请日：2009-01-07
申请人： National Institute Of Advanced Industrial Science & Technology , Sanwa Shurui Co Ltd , 三和酒類株式会社 , 独立行政法人産業技術総合研究所
发明人： OMORI TOSHIRO , MARUOKA IKUYUKI , FURUTA YOSHIFUMI , KONISHI MASAO , FUKUOKA TOKUMA , MORITA TOMOTAKE , IMURA TOMOHIRO , KITAMOTO MASARU
IPC分类号： C12N1/14 , A23K1/16 , A23L1/30 , A61K8/60 , C12P19/04
摘要： PROBLEM TO BE SOLVED: To provide a microorganism having ability of producing a biosurfactant isolated from an edible plant so as to provide a biosurfactant having more excellent adaptability than that of the conventional one for uses more requiring safety to living organisms in cosmetics, foods, agricultural and stock raising industries and a method for producing a biosurfactant using the microorganism.
SOLUTION: The microorganism belongs to the genus Ustilago having ability of producing a biosurfactant without producing a mannosylerythritol lipid. The method for producing a biosurfactant includes culturing the microorganism and producing the biosurfactant.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种具有从食用植物分离的生物表面活性剂的生产能力的微生物，以提供具有比常规的生物表面活性剂更好的适用性的生物表面活性剂，其用于对化妆品中生物体的安全性更高，食品，农业和畜牧业以及使用微生物生产生物表面活性剂的方法。解决方案：微生物属于具有生产生物表面活性剂而不产生甘露糖酯类脂质的能力的乌斯特里亚属。制备生物表面活性剂的方法包括培养微生物并生产生物表面活性剂。版权所有（C）2010，JPO＆INPIT

9. 发明专利

JP2005065647A Method for producing useful substance by utilizing bacterium that can produce useful product that produces bacteriocin 有权
标题翻译：通过利用细菌生产有用的物质的方法，可以生产有用的产品，生产细菌
公开(公告)号：JP2005065647A
公开(公告)日：2005-03-17
申请号：JP2003303560
申请日：2003-08-27
申请人： Omugi Hakko Kenkyusho:Kk , Sanwa Shiyurui Kk , Shinseiki Hakko Kenkyusho:Kk , 三和酒類株式会社 , 有限会社新世紀発酵研究所 , 株式会社大麦発酵研究所
发明人： ISHIZAKI FUMIAKI , KONO AKIHIKO , OMORI TOSHIRO , FURUTA YOSHIFUMI , NAKAMURA TERUHIRO , UMEMOTO YASUSHI
IPC分类号： C12P7/56 , C12P1/04 , C12R1/01
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a useful substance by utilizing a bacterium that produce the useful substance producing bacteriocin in no need of heat sterilization, inhibits metal corrosion to prevent individual parts of the plant installation from deterioration, suppress the decomposition of culture medium compositions and the production hindrance of the useful substance and can carry out the production of the useful substance without production of by-product hazardous to human body. SOLUTION: In the method for producing a useful substance by utilizing a bacterium that produces the useful substance, the useful substance-producing bacterium forms the useful substance and produces the bacteriocin that has anti-bacterial and/or bacteriocidal effect. Thus, the culture medium is prepared by this bacteriocin formed here and simultaneously the culture apparatus can be subjected to pasteurization treatment. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供一种通过利用不需要加热灭菌来生产产生细菌素的有用物质的细菌来生产有用物质的方法，抑制金属腐蚀以防止植物装置的各个部件劣化，抑制培养基组合物的分解和有用物质的生产阻碍，并且可以在不产生对人体有害的副产物的情况下进行有用物质的生产。解决方案：在通过利用产生有用物质的细菌生产有用物质的方法中，有用的物质产生细菌形成有用物质并产生具有抗细菌和/或杀菌作用的细菌素。因此，通过这里形成的这种细菌素制备培养基，同时可以对培养装置进行巴氏灭菌处理。版权所有（C）2005，JPO＆NCIPI

10. 发明专利

JP2005130736A Composition obtained from barley shochu distillation residual liquid, having vasodepressor activity and excellent gustatory 有权
标题翻译：从BARLEY SHOCHU蒸馏残留液中获得的组合物，具有VASODEPRESSOR活性和优异的监测
公开(公告)号：JP2005130736A
公开(公告)日：2005-05-26
申请号：JP2003368502
申请日：2003-10-29
申请人： Omugi Hakko Kenkyusho:Kk , Sanwa Shiyurui Kk , 三和酒類株式会社 , 株式会社大麦発酵研究所
发明人： OMORI TOSHIRO , MOCHIZUKI SATOSHI
IPC分类号： A23L1/305 , A23L1/221 , A61K36/899 , A61P9/12 , C12F3/10 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To obtain a composition having remarkable vasodepressor activity and excellent gustatory using barley Shochu distillation residual liquid which is a by-product in a manufacturing process of Shochu (distilled alcoholic drink in Japan) made from barley. SOLUTION: This composition comprises a non-adsorptive fraction which is collected via an adsorption/separation treatment using a synthetic adsorbent, of a liquid fraction obtained by subjecting the distillation residual liquid of barley Shochu which is a by-product in a manufacturing process of Shochu made from barley to solid-liquid separation. The non-adsorptive fraction contains several kinds of peptides having an average chain length of 3.0 to 5.0, and the amino acids of these peptides are composed of 24 to 38% of glutamic acid, 4 to 20% of glycine, 5 to 10% of aspartic acid, 4 to 9% of proline and 4 to 8% of serine in 100% of the total content of the amino acids derived from the peptides. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：为了获得具有显着的血管抑制剂活性的组合物，并且使用大麦Shochu蒸馏残留液体，并且是由大麦制造的Shochu（日本的蒸馏酒精饮料）的制造过程中的副产物，具有优异的味觉。解决方案：该组合物包括通过使用合成吸附剂的吸附/分离处理而收集的非吸附级分，其通过在制造中将作为副产物的大麦Shochu的蒸馏残余液体从大麦制成的烧酒到固液分离。非吸附级分含有平均链长为3.0〜5.0的多种肽，这些肽的氨基酸为24〜38％的谷氨酸，4〜20％的甘氨酸，5〜10％的甘氨酸天冬氨酸，4至9％的脯氨酸和4至8％的丝氨酸，占衍生自肽的氨基酸总量的100％。版权所有（C）2005，JPO＆NCIPI

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