专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

EP3336082B1 CLEAVABLE LIPIDS 有权
公开(公告)号：EP3336082B1
公开(公告)日：2020-04-15
申请号：EP18153312.6
申请日：2012-06-08
申请人： Translate Bio, Inc.
发明人： HEARTLEIN, Michael , GUILD, Braydon, Charles , DEROSA, Frank , ZHANG, Jerry, Chi
IPC分类号： C07D233/64 , C07C323/00 , A61K9/127 , A61K31/4164 , A61K47/60 , A61K47/69

2. 发明授权

EP2738160B1 HALOGEN-TERMINATED SULFUR-CONTAINING POLYMER 有权转让
标题翻译：卤素封端的含硫聚合物
公开(公告)号：EP2738160B1
公开(公告)日：2018-02-14
申请号：EP12819938.7
申请日：2012-07-06
申请人： Toray Fine Chemicals Co., Ltd.
发明人： HAMADA, Yukiko , SUGA, Yasukazu , ECHIGOYA, Koki , MATSUMOTO, Kazunori , OBA, Tomohiro
IPC分类号： C07C323/12 , C08G75/02 , C08G75/14 , C08K5/36 , C08L81/02 , C08L81/04 , C08G75/00 , C08L81/00 , C08K5/00 , C07C323/00
CPC分类号： C08L81/04 , C07C323/12 , C08G75/14 , C08K5/0016 , C08K5/372 , G02B6/02033 , C08L81/02 , C08L27/06
摘要： The halogen-terminated sulfur-containing polymer of the present invention is a halogen-terminated sulfur-containing polymer represented by the following formula: €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒX-(R-S r ) n -R-X wherein R is an ether bond-containing alkyl group having 3 to 26 carbon atoms, X is a halogen atom, n is an integer of 1 to 200, and r has an average of 1 to 5. The halogen-terminated sulfur-containing polymer of the present invention is industrially very useful as a plasticizer of a polysulfide polymer. In addition, the halogen-terminated sulfur-containing polymer of the present invention can be used as a plasticizer for thioether polymers and high polar resins such as vinyl chloride, and an additive for materials that require a high refractive index such as an optical fiber. The halogen-terminated sulfur-containing polymer of the present invention is effective as an intermediate of a thiol group-terminated polysulfide polymer and the like.

3. 发明授权

EP1023310B2 IMPROVED SYNTHESIS OF SULFURIZED OLIGONUCLEOTIDES 有权
标题翻译：合成寡核苷酸硫化的
公开(公告)号：EP1023310B2
公开(公告)日：2014-05-21
申请号：EP98953408.6
申请日：1998-10-13
申请人： Isis Pharmaceuticals, Inc.
发明人： COLE, Douglas, L. , RAVIKUMAR, Vasulinga, T. , CHERUVALLATH, Zacharia, S.
IPC分类号： C07H21/00 , C07H21/02 , C07H21/04 , C07C321/00 , C07C323/00 , C07C381/00
CPC分类号： C07H21/00

4. 发明授权

EP2351736B1 Lösungen von Thioethern und ihre Verwendung zur Herstellung von Leder 有权
标题翻译：硫醚的解决方案及其对皮革生产中的应用
公开(公告)号：EP2351736B1
公开(公告)日：2013-03-06
申请号：EP11163456.4
申请日：2009-03-09
申请人： BASF SE
发明人： Hüffer, Stephan , Garnier, Sebastien , Bette, Virginie , Bohres, Edward , Wolf, Gerhard , Annen, Ulrich , Glocknitzer, Franz
IPC分类号： C14C3/06 , C07C321/30 , C14C9/00 , C07C323/12 , C07C323/20 , C07C323/52 , C07C323/00
CPC分类号： C14C3/06 , C07C323/12 , C07C323/20 , C07C323/52 , C14C9/00

5. 发明公开

EP2046736A1 ARYLSULFANYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS 有权
标题翻译：芳基硫烷基化合物和组合物用于提供活性剂
公开(公告)号：EP2046736A1
公开(公告)日：2009-04-15
申请号：EP07799859.9
申请日：2007-07-27
申请人： Emisphere Technologies, Inc. , Wang, Nai Fang , Saraf, Sushma , Pusztay, Stephen V.
发明人： WANG, Nai, Fang , SARAF, Sushma , PUSZTAY, Stephen, V.
IPC分类号： C07C323/00 , A61K31/19
CPC分类号： C07C323/52 , A61K47/20 , C07C323/56 , C07C323/62
摘要： Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are also provided.
摘要翻译：提供了用于递送活性剂的化合物和组合物。还提供了施用和制备方法。

6. 发明公开

EP1730106A4 DENDRON AND DENDRIMER, METHOD OF PRODUCING THE SAME, AND METHOD OF PRODUCING A THIOACETAL COMPOUND 审中-公开
标题翻译： DENDRON和树枝状聚合物制造方法，和一种用于生产THIOACETALVERBINDUNG
公开(公告)号：EP1730106A4
公开(公告)日：2007-12-12
申请号：EP05727688
申请日：2005-03-28
申请人： FUJIFILM CORP
发明人： NAKAMURA KOKI
IPC分类号： C07C323/09 , C07C213/00 , C07C319/14 , C07C323/00 , C07C323/12 , C07C323/20 , C07D213/70 , C07D271/00 , C07D271/12 , C08G83/00
CPC分类号： C08G83/003 , C07C319/14 , C07D271/12 , C07C323/12 , C07C323/20
摘要： A dendron or dendrimer, which has, as a recurring unit of each branch, a structure of formula (I): Wherein TC designates a linkage to a former generation in the direction to a focal point of the dendron or a core of the dendrimer; TT designates a linkage to a next generation in the direction to a terminal; X is a divalent group comprised of at least one heteroatom; L1 and L2 each are a divalent linking group; R is a hydrogen atom or a substituent; and a method of producing a dendron or a dendrimer; and a method of producing a thioacetal compound.

7. 发明公开

EP1656127A1 COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS 失效转让
标题翻译：用于治疗代谢性疾病的化合物
公开(公告)号：EP1656127A1
公开(公告)日：2006-05-17
申请号：EP04781277.1
申请日：2004-08-16
申请人： Wellstat Therapeutics Corporation
发明人： SHARMA, Shalini , VON BORSTEL, Reid, W. , HODGE, Kirvin, L.
IPC分类号： A61K31/19 , A61K31/235 , C07C323/00
CPC分类号： C07C323/62
摘要： Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. Formula (I), wherein n is 1 or 2; m is 0 or 1; q is 0 or 1; t is 0 or 1; R5 is alkyl having from 1 to 3 carbon atoms; R9 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms; A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from: halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; or cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently monosubstituted by methyl or ethyl; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and 0 and the heteroaromatic ring is covalently bound to the remainder of the compound of formula I by a ring carbon; and X is -CH2-, Q is -OR1and R1 is methyl or ethyl; or X is -CH2CR12R13- or - CH2CH(NHAc)-wherein each of R12 and R13 is independently hydrogen or methyl, Q is OR1 and R1 is hydrogen or alkyl having from 1 to 7 carbon atoms; or X is -CH2CH2- and Q is NR10R1' wherein one of R10 and R11 is hydrogen, alkyl having from 1 to 3 carbon atoms or hydroxy, and the other is hydrogen. Alternatively, when R1 is hydrogen, the biologically active agent can be a pharmaceutically acceptable salt of the compound of Formula (I).
摘要翻译：公开了用于治疗各种代谢疾病如胰岛素抵抗综合征，糖尿病，高脂血症，脂肪肝疾病，恶病质，肥胖症，动脉粥样硬化和动脉硬化的药物。式（I），其中n是1或2; m是0或1; q是0或1; t是0或1; R5是具有1至3个碳原子的烷基; R9为氢，卤素，具有1至3个碳原子的烷基或具有1至3个碳原子的烷氧基; A是未取代的或被1或2个选自以下的基团取代的苯基：卤素，具有1或2个碳原子的烷基，全氟甲基，具有1或2个碳原子的烷氧基和全氟甲氧基; 或具有3至6个环碳原子的环烷基，其中所述环烷基未被取代或者一个或两个环碳原子独立地被甲基或乙基单取代; 或具有1或2个选自N，S和O的环杂原子的5或6元杂芳族环，并且所述杂芳族环通过环碳与式I化合物的其余部分共价结合; 且X是-CH 2 - ，Q是-OR 1且R 1是甲基或乙基; 或X为-CH 2 CR 12 R 13 - 或-CH 2 CH（NHAc） - 其中R 12和R 13各自独立地为氢或甲基，Q为OR 1且R 1为氢或具有1至7个碳原子的烷基; 或X是-CH 2 CH 2 - ，并且Q是NR 10 R 1'，其中R 10和R 11之一是氢，具有1至3个碳原子的烷基或羟基，另一个是氢。或者，当R 1为氢时，生物活性剂可以是式（I）化合物的药学上可接受的盐。

8. 发明公开

EP1558572A2 NOVEL COMPOUNDS AND THEIR USE AS PRAR-MODULATORS 有权
标题翻译：新化合物和它们作为PPAR调节因子
公开(公告)号：EP1558572A2
公开(公告)日：2005-08-03
申请号：EP03757741.8
申请日：2003-10-27
申请人： NOVO NORDISK A/S
发明人： JEPPESEN, Lone , MOGENSEN, John, Patrick , PETTERSSON, Ingrid , SAUERBERG, Per , PIHERA, Pavel , HAVRANEK, Miroslav
IPC分类号： C07C323/00
CPC分类号： C07D307/38 , C07C59/68 , C07C69/712 , C07C323/20 , C07D307/42 , C07D333/16 , C07D333/18 , C07D333/54 , C07D409/06
摘要： Novel compounds of the general formula (I), the use of these compounds as pharma-ceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR), in particular the PPARδ suptype.

9. 发明公开

EP1272463A1 ENHANCED PROPERTIED PHARMACEUTICALS 审中-公开
标题翻译：具有改进性能的药剂制品
公开(公告)号：EP1272463A1
公开(公告)日：2003-01-08
申请号：EP01904803.2
申请日：2001-01-26
申请人： ROHM AND HAAS COMPANY
发明人： MULVIHILL, Mark, Joseph , SHABER, Steven, Howard
IPC分类号： C07C323/00
CPC分类号： C07C271/16 , C07C233/25 , C07C323/12 , C07C327/20 , C07C327/36 , C07D211/90 , C07D213/30 , C07D213/84 , C07D215/48 , C07D215/56 , C07D239/34 , C07D241/18 , C07D249/08 , C07D249/14 , C07D261/16 , C07D401/04 , C07D401/10 , C07D413/12

10. 发明公开

EP0983233A4 REAGENT USEFUL FOR SYNTHESIZING SULFURIZED OLIGONUCLEOTIDE ANALOGS 失效
标题翻译：用于生产硫化寡核苷酸
公开(公告)号：EP0983233A4
公开(公告)日：2002-03-20
申请号：EP98908882
申请日：1998-03-03
申请人： ISIS PHARMACEUTICALS INC
发明人： CHERUVALLATH ZACHARIA S , CAPALDI DANIEL C , RAVIKUMAR VASULINGA T , COLE DOUGLAS L
IPC分类号： C07H21/04 , C07C329/14 , C07H21/00 , C07H21/02 , C07C321/00 , C07C323/00 , C07C381/00
CPC分类号： C07H21/00 , C07C329/14
摘要： The present invention is directed to a method of synthesizing sulfurized oligonucleotide analogs by reacting an oligonucleotide analog containing a phosphorous (III) linkage with a dithiocarbonic acid diester polysulfide having formula (I) to produce a sulfurized oligonucleotide analog. The diester polysulfide reagent is useful in solution and solid phase oligonucleotide analog synthesis.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式