基本信息:
- 专利标题： CLEAVABLE LIPIDS
- 申请号：EP18153312.6 申请日：2012-06-08
- 公开(公告)号：EP3336082A1 公开(公告)日：2018-06-20
- 发明人： HEARTLEIN, Michael , GUILD, Braydon, Charles , DEROSA, Frank , ZHANG, Jerry, Chi
- 申请人： Translate Bio, Inc.
- 申请人地址： 200 Sidney Street, Suite 310 Cambridge, MA 02139 US
- 专利权人： Translate Bio, Inc.
- 当前专利权人： Translate Bio, Inc.
- 当前专利权人地址： 200 Sidney Street, Suite 310 Cambridge, MA 02139 US
- 代理机构： Carpmaels & Ransford LLP
- 优先权： US201161494882P 20110608; US201161494745P 20110608
- 主分类号： C07D233/64
- IPC分类号： C07D233/64 ; C07C323/00 ; A61K9/127 ; A61K31/4164 ; A61K47/60 ; A61K47/69
摘要：
Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.
公开/授权文献:
- EP3336082B1 CLEAVABLE LIPIDS 公开/授权日：2020-04-15
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D233/00 | 杂环化合物，含1,3-二唑或氢化1,3-二唑环、不与其他环稠合 |
| --------C07D233/04 | .环原子间或环原子与非环原子间有1个双键 |
| ----------C07D233/64 | ..有取代的烃基连在环碳原子上，例如组氨酸 |